Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHW0_LEIDO

TriTrypDb:

LdBPK_301460.1 , LdCL_300019800 , LDHU3_30.1860

Length:

553

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	9
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	9
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3Q8IHW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHW0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.619
CLV_C14_Caspase3-7	184	188	PF00656	0.490
CLV_C14_Caspase3-7	417	421	PF00656	0.363
CLV_NRD_NRD_1	270	272	PF00675	0.325
CLV_PCSK_KEX2_1	270	272	PF00082	0.325
CLV_PCSK_KEX2_1	388	390	PF00082	0.387
CLV_PCSK_KEX2_1	464	466	PF00082	0.442
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.387
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.428
CLV_PCSK_SKI1_1	245	249	PF00082	0.464
CLV_PCSK_SKI1_1	428	432	PF00082	0.391
CLV_PCSK_SKI1_1	529	533	PF00082	0.344
DEG_Kelch_Keap1_1	511	516	PF01344	0.430
DEG_SPOP_SBC_1	319	323	PF00917	0.443
DEG_SPOP_SBC_1	58	62	PF00917	0.529
DOC_PP4_FxxP_1	10	13	PF00568	0.584
DOC_PP4_FxxP_1	532	535	PF00568	0.363
DOC_USP7_MATH_1	185	189	PF00917	0.437
DOC_USP7_MATH_1	200	204	PF00917	0.711
DOC_USP7_MATH_1	220	224	PF00917	0.661
DOC_USP7_MATH_1	319	323	PF00917	0.485
DOC_USP7_MATH_1	49	53	PF00917	0.612
DOC_USP7_MATH_1	533	537	PF00917	0.375
DOC_USP7_MATH_1	58	62	PF00917	0.740
DOC_WW_Pin1_4	131	136	PF00397	0.583
DOC_WW_Pin1_4	146	151	PF00397	0.614
DOC_WW_Pin1_4	206	211	PF00397	0.583
DOC_WW_Pin1_4	221	226	PF00397	0.461
DOC_WW_Pin1_4	445	450	PF00397	0.360
DOC_WW_Pin1_4	531	536	PF00397	0.343
DOC_WW_Pin1_4	89	94	PF00397	0.764
LIG_14-3-3_CanoR_1	138	145	PF00244	0.719
LIG_14-3-3_CanoR_1	166	172	PF00244	0.502
LIG_14-3-3_CanoR_1	265	273	PF00244	0.525
LIG_14-3-3_CanoR_1	422	431	PF00244	0.434
LIG_14-3-3_CanoR_1	50	54	PF00244	0.645
LIG_14-3-3_CanoR_1	57	67	PF00244	0.575
LIG_14-3-3_CanoR_1	91	97	PF00244	0.805
LIG_APCC_ABBA_1	406	411	PF00400	0.425
LIG_BIR_III_4	420	424	PF00653	0.412
LIG_BRCT_BRCA1_1	6	10	PF00533	0.558
LIG_Clathr_ClatBox_1	190	194	PF01394	0.309
LIG_deltaCOP1_diTrp_1	259	266	PF00928	0.430
LIG_FHA_1	132	138	PF00498	0.605
LIG_FHA_1	140	146	PF00498	0.519
LIG_FHA_1	256	262	PF00498	0.447
LIG_FHA_1	29	35	PF00498	0.583
LIG_FHA_1	300	306	PF00498	0.460
LIG_FHA_1	325	331	PF00498	0.464
LIG_FHA_1	358	364	PF00498	0.504
LIG_FHA_1	368	374	PF00498	0.485
LIG_FHA_1	512	518	PF00498	0.523
LIG_FHA_1	62	68	PF00498	0.620
LIG_FHA_2	103	109	PF00498	0.602
LIG_FHA_2	241	247	PF00498	0.347
LIG_FHA_2	415	421	PF00498	0.320
LIG_FHA_2	480	486	PF00498	0.324
LIG_Integrin_isoDGR_2	504	506	PF01839	0.441
LIG_LIR_Apic_2	169	175	PF02991	0.437
LIG_LIR_Apic_2	530	535	PF02991	0.356
LIG_LIR_Apic_2	7	13	PF02991	0.580
LIG_LIR_Gen_1	353	363	PF02991	0.459
LIG_LIR_Nem_3	119	125	PF02991	0.621
LIG_LIR_Nem_3	353	358	PF02991	0.459
LIG_PCNA_PIPBox_1	244	253	PF02747	0.450
LIG_SH2_CRK	122	126	PF00017	0.534
LIG_SH2_STAP1	324	328	PF00017	0.430
LIG_SH2_STAP1	489	493	PF00017	0.503
LIG_SH2_STAP1	519	523	PF00017	0.355
LIG_SH2_STAT5	251	254	PF00017	0.275
LIG_SH3_1	172	178	PF00018	0.511
LIG_SH3_3	172	178	PF00018	0.473
LIG_SH3_3	192	198	PF00018	0.280
LIG_SH3_3	449	455	PF00018	0.457
LIG_SH3_3	77	83	PF00018	0.652
LIG_SH3_4	428	435	PF00018	0.393
LIG_SUMO_SIM_par_1	453	459	PF11976	0.388
LIG_UBA3_1	517	522	PF00899	0.331
LIG_WRC_WIRS_1	440	445	PF05994	0.446
MOD_CDK_SPxxK_3	131	138	PF00069	0.588
MOD_CDK_SPxxK_3	146	153	PF00069	0.618
MOD_CDK_SPxxK_3	206	213	PF00069	0.539
MOD_CK1_1	124	130	PF00069	0.808
MOD_CK1_1	141	147	PF00069	0.524
MOD_CK1_1	167	173	PF00069	0.535
MOD_CK1_1	221	227	PF00069	0.530
MOD_CK1_1	59	65	PF00069	0.795
MOD_CK1_1	92	98	PF00069	0.701
MOD_CK2_1	167	173	PF00069	0.560
MOD_CK2_1	240	246	PF00069	0.326
MOD_CK2_1	303	309	PF00069	0.446
MOD_CK2_1	353	359	PF00069	0.435
MOD_DYRK1A_RPxSP_1	445	449	PF00069	0.350
MOD_GlcNHglycan	145	148	PF01048	0.582
MOD_GlcNHglycan	202	205	PF01048	0.714
MOD_GlcNHglycan	220	223	PF01048	0.576
MOD_GlcNHglycan	230	233	PF01048	0.212
MOD_GlcNHglycan	273	276	PF01048	0.238
MOD_GlcNHglycan	345	348	PF01048	0.380
MOD_GlcNHglycan	363	366	PF01048	0.158
MOD_GlcNHglycan	425	428	PF01048	0.599
MOD_GlcNHglycan	452	455	PF01048	0.424
MOD_GlcNHglycan	499	502	PF01048	0.339
MOD_GlcNHglycan	6	9	PF01048	0.588
MOD_GSK3_1	139	146	PF00069	0.614
MOD_GSK3_1	161	168	PF00069	0.536
MOD_GSK3_1	179	186	PF00069	0.384
MOD_GSK3_1	251	258	PF00069	0.308
MOD_GSK3_1	26	33	PF00069	0.603
MOD_GSK3_1	299	306	PF00069	0.432
MOD_GSK3_1	320	327	PF00069	0.471
MOD_GSK3_1	353	360	PF00069	0.543
MOD_GSK3_1	57	64	PF00069	0.722
MOD_GSK3_1	81	88	PF00069	0.727
MOD_N-GLC_2	311	313	PF02516	0.262
MOD_NEK2_1	121	126	PF00069	0.618
MOD_NEK2_1	165	170	PF00069	0.541
MOD_NEK2_1	299	304	PF00069	0.441
MOD_NEK2_1	318	323	PF00069	0.486
MOD_NEK2_1	383	388	PF00069	0.437
MOD_NEK2_1	456	461	PF00069	0.466
MOD_NEK2_1	497	502	PF00069	0.257
MOD_NEK2_1	56	61	PF00069	0.645
MOD_NEK2_1	85	90	PF00069	0.762
MOD_NEK2_2	324	329	PF00069	0.430
MOD_PIKK_1	303	309	PF00454	0.430
MOD_PIKK_1	350	356	PF00454	0.495
MOD_PK_1	30	36	PF00069	0.616
MOD_PKA_2	165	171	PF00069	0.516
MOD_PKA_2	35	41	PF00069	0.778
MOD_PKA_2	4	10	PF00069	0.817
MOD_PKA_2	49	55	PF00069	0.796
MOD_PKA_2	56	62	PF00069	0.822
MOD_PKB_1	55	63	PF00069	0.536
MOD_PKB_1	76	84	PF00069	0.540
MOD_Plk_1	324	330	PF00069	0.430
MOD_Plk_2-3	240	246	PF00069	0.356
MOD_Plk_4	167	173	PF00069	0.535
MOD_Plk_4	246	252	PF00069	0.438
MOD_Plk_4	414	420	PF00069	0.356
MOD_Plk_4	439	445	PF00069	0.451
MOD_Plk_4	533	539	PF00069	0.387
MOD_Plk_4	81	87	PF00069	0.735
MOD_ProDKin_1	131	137	PF00069	0.586
MOD_ProDKin_1	146	152	PF00069	0.620
MOD_ProDKin_1	206	212	PF00069	0.584
MOD_ProDKin_1	221	227	PF00069	0.448
MOD_ProDKin_1	445	451	PF00069	0.362
MOD_ProDKin_1	531	537	PF00069	0.342
MOD_ProDKin_1	89	95	PF00069	0.762
MOD_SUMO_rev_2	240	250	PF00179	0.319
MOD_SUMO_rev_2	274	281	PF00179	0.430
MOD_SUMO_rev_2	516	523	PF00179	0.330
TRG_DiLeu_BaEn_1	513	518	PF01217	0.380
TRG_DiLeu_BaLyEn_6	452	457	PF01217	0.378
TRG_DiLeu_BaLyEn_6	503	508	PF01217	0.400
TRG_ENDOCYTIC_2	122	125	PF00928	0.522
TRG_ER_diArg_1	270	272	PF00400	0.525
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	506	511	PF00026	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMQ0	Leptomonas seymouri	69%	100%
A0A1X0P1V8	Trypanosomatidae	56%	100%
A0A3R7MF36	Trypanosoma rangeli	51%	100%
A4H666	Leishmania braziliensis	24%	100%
A4HI91	Leishmania braziliensis	80%	100%
A4I5H1	Leishmania infantum	99%	100%
C9ZQV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B0R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q7G4	Leishmania major	93%	100%
V5BYY0	Trypanosoma cruzi	51%	100%