Ribonuclease P

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Ribonuclease P

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHV9_LEIDO

TriTrypDb:

LdBPK_332060.1 , LdCL_330027500 , LDHU3_33.2980

Length:

694

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8IHV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHV9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006399	tRNA metabolic process	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008033	tRNA processing	8	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0034470	ncRNA processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034660	ncRNA metabolic process	6	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:0000966	RNA 5'-end processing	7	1
GO:0001682	tRNA 5'-leader removal	9	1
GO:0099116	tRNA 5'-end processing	8	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004518	nuclease activity	4	10
GO:0004519	endonuclease activity	5	9
GO:0004521	RNA endonuclease activity	5	9
GO:0004526	ribonuclease P activity	6	9
GO:0004540	RNA nuclease activity	4	9
GO:0004549	tRNA-specific ribonuclease activity	5	9
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	9
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	9
GO:0140098	catalytic activity, acting on RNA	3	9
GO:0140101	catalytic activity, acting on a tRNA	4	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	410	414	PF00656	0.455
CLV_C14_Caspase3-7	634	638	PF00656	0.746
CLV_C14_Caspase3-7	668	672	PF00656	0.612
CLV_NRD_NRD_1	153	155	PF00675	0.318
CLV_NRD_NRD_1	2	4	PF00675	0.429
CLV_NRD_NRD_1	326	328	PF00675	0.408
CLV_NRD_NRD_1	566	568	PF00675	0.555
CLV_NRD_NRD_1	87	89	PF00675	0.345
CLV_PCSK_FUR_1	324	328	PF00082	0.467
CLV_PCSK_KEX2_1	153	155	PF00082	0.303
CLV_PCSK_KEX2_1	2	4	PF00082	0.409
CLV_PCSK_KEX2_1	326	328	PF00082	0.439
CLV_PCSK_KEX2_1	336	338	PF00082	0.256
CLV_PCSK_KEX2_1	87	89	PF00082	0.369
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.466
CLV_PCSK_SKI1_1	154	158	PF00082	0.311
CLV_PCSK_SKI1_1	21	25	PF00082	0.458
CLV_PCSK_SKI1_1	212	216	PF00082	0.410
CLV_PCSK_SKI1_1	312	316	PF00082	0.411
CLV_PCSK_SKI1_1	326	330	PF00082	0.275
CLV_PCSK_SKI1_1	440	444	PF00082	0.306
CLV_PCSK_SKI1_1	519	523	PF00082	0.387
CLV_PCSK_SKI1_1	529	533	PF00082	0.279
CLV_PCSK_SKI1_1	55	59	PF00082	0.504
DEG_APCC_DBOX_1	425	433	PF00400	0.329
DEG_Nend_UBRbox_1	1	4	PF02207	0.472
DEG_ODPH_VHL_1	675	688	PF01847	0.359
DOC_CDC14_PxL_1	247	255	PF14671	0.523
DOC_CKS1_1	572	577	PF01111	0.791
DOC_MAPK_gen_1	231	239	PF00069	0.507
DOC_MAPK_gen_1	324	332	PF00069	0.487
DOC_MAPK_gen_1	424	432	PF00069	0.238
DOC_MAPK_gen_1	523	532	PF00069	0.279
DOC_MAPK_gen_1	533	543	PF00069	0.295
DOC_MAPK_MEF2A_6	212	221	PF00069	0.445
DOC_MAPK_MEF2A_6	233	241	PF00069	0.484
DOC_MAPK_MEF2A_6	401	409	PF00069	0.387
DOC_MAPK_MEF2A_6	424	432	PF00069	0.234
DOC_PP1_RVXF_1	151	158	PF00149	0.404
DOC_PP1_RVXF_1	527	533	PF00149	0.310
DOC_PP2B_LxvP_1	317	320	PF13499	0.465
DOC_PP2B_LxvP_1	547	550	PF13499	0.381
DOC_USP7_MATH_1	204	208	PF00917	0.410
DOC_USP7_MATH_1	272	276	PF00917	0.647
DOC_USP7_MATH_1	305	309	PF00917	0.485
DOC_USP7_MATH_1	322	326	PF00917	0.486
DOC_USP7_MATH_1	37	41	PF00917	0.734
DOC_USP7_MATH_1	573	577	PF00917	0.683
DOC_USP7_MATH_1	590	594	PF00917	0.767
DOC_USP7_MATH_1	597	601	PF00917	0.541
DOC_USP7_MATH_1	604	608	PF00917	0.485
DOC_USP7_MATH_1	612	616	PF00917	0.598
DOC_USP7_MATH_1	628	632	PF00917	0.470
DOC_WW_Pin1_4	254	259	PF00397	0.698
DOC_WW_Pin1_4	268	273	PF00397	0.461
DOC_WW_Pin1_4	424	429	PF00397	0.454
DOC_WW_Pin1_4	459	464	PF00397	0.290
DOC_WW_Pin1_4	483	488	PF00397	0.330
DOC_WW_Pin1_4	493	498	PF00397	0.364
DOC_WW_Pin1_4	514	519	PF00397	0.309
DOC_WW_Pin1_4	571	576	PF00397	0.792
DOC_WW_Pin1_4	586	591	PF00397	0.644
DOC_WW_Pin1_4	618	623	PF00397	0.653
LIG_14-3-3_CanoR_1	135	140	PF00244	0.310
LIG_14-3-3_CanoR_1	2	8	PF00244	0.472
LIG_14-3-3_CanoR_1	384	392	PF00244	0.492
LIG_14-3-3_CanoR_1	55	63	PF00244	0.410
LIG_14-3-3_CanoR_1	567	575	PF00244	0.551
LIG_14-3-3_CanoR_1	87	94	PF00244	0.373
LIG_Actin_WH2_2	121	139	PF00022	0.291
LIG_APCC_ABBA_1	349	354	PF00400	0.434
LIG_APCC_ABBA_1	541	546	PF00400	0.218
LIG_APCC_ABBA_1	686	691	PF00400	0.471
LIG_APCC_ABBAyCdc20_2	348	354	PF00400	0.429
LIG_APCC_ABBAyCdc20_2	540	546	PF00400	0.357
LIG_BIR_III_2	637	641	PF00653	0.551
LIG_Clathr_ClatBox_1	329	333	PF01394	0.457
LIG_FHA_1	120	126	PF00498	0.430
LIG_FHA_1	445	451	PF00498	0.418
LIG_FHA_1	593	599	PF00498	0.606
LIG_FHA_1	94	100	PF00498	0.457
LIG_FHA_2	169	175	PF00498	0.406
LIG_FHA_2	384	390	PF00498	0.523
LIG_FHA_2	664	670	PF00498	0.689
LIG_FHA_2	685	691	PF00498	0.496
LIG_HP1_1	217	221	PF01393	0.329
LIG_HP1_1	428	432	PF01393	0.367
LIG_LIR_Apic_2	542	548	PF02991	0.410
LIG_LIR_Apic_2	599	604	PF02991	0.447
LIG_LIR_Gen_1	172	183	PF02991	0.314
LIG_LIR_Gen_1	216	226	PF02991	0.494
LIG_LIR_Gen_1	438	449	PF02991	0.250
LIG_LIR_Nem_3	140	145	PF02991	0.292
LIG_LIR_Nem_3	172	178	PF02991	0.314
LIG_LIR_Nem_3	191	196	PF02991	0.262
LIG_LIR_Nem_3	27	31	PF02991	0.631
LIG_LIR_Nem_3	333	338	PF02991	0.352
LIG_LIR_Nem_3	364	369	PF02991	0.434
LIG_LIR_Nem_3	438	444	PF02991	0.250
LIG_LIR_Nem_3	510	516	PF02991	0.275
LIG_Pex14_1	601	605	PF04695	0.461
LIG_SH2_CRK	460	464	PF00017	0.291
LIG_SH2_CRK	474	478	PF00017	0.291
LIG_SH2_SRC	338	341	PF00017	0.454
LIG_SH2_STAP1	160	164	PF00017	0.291
LIG_SH2_STAP1	551	555	PF00017	0.291
LIG_SH2_STAT3	127	130	PF00017	0.416
LIG_SH2_STAT5	127	130	PF00017	0.410
LIG_SH2_STAT5	145	148	PF00017	0.420
LIG_SH2_STAT5	175	178	PF00017	0.298
LIG_SH2_STAT5	338	341	PF00017	0.454
LIG_SH2_STAT5	460	463	PF00017	0.291
LIG_SH2_STAT5	578	581	PF00017	0.542
LIG_SH3_3	182	188	PF00018	0.367
LIG_SH3_3	211	217	PF00018	0.310
LIG_SH3_3	252	258	PF00018	0.656
LIG_SUMO_SIM_anti_2	78	85	PF11976	0.410
LIG_SUMO_SIM_par_1	427	434	PF11976	0.268
LIG_TRAF2_1	666	669	PF00917	0.771
LIG_TYR_ITIM	358	363	PF00017	0.315
LIG_UBA3_1	310	315	PF00899	0.437
MOD_CDC14_SPxK_1	496	499	PF00782	0.450
MOD_CDK_SPK_2	514	519	PF00069	0.291
MOD_CDK_SPxK_1	493	499	PF00069	0.450
MOD_CK1_1	275	281	PF00069	0.585
MOD_CK1_1	383	389	PF00069	0.558
MOD_CK1_1	40	46	PF00069	0.750
MOD_CK1_1	562	568	PF00069	0.697
MOD_CK1_1	78	84	PF00069	0.426
MOD_CK1_1	92	98	PF00069	0.298
MOD_CK2_1	628	634	PF00069	0.675
MOD_CK2_1	663	669	PF00069	0.791
MOD_CK2_1	684	690	PF00069	0.478
MOD_GlcNHglycan	139	142	PF01048	0.371
MOD_GlcNHglycan	147	150	PF01048	0.349
MOD_GlcNHglycan	264	267	PF01048	0.730
MOD_GlcNHglycan	274	277	PF01048	0.650
MOD_GlcNHglycan	296	300	PF01048	0.440
MOD_GlcNHglycan	39	42	PF01048	0.752
MOD_GlcNHglycan	398	401	PF01048	0.572
MOD_GlcNHglycan	47	50	PF01048	0.508
MOD_GlcNHglycan	493	496	PF01048	0.355
MOD_GlcNHglycan	561	564	PF01048	0.595
MOD_GlcNHglycan	592	595	PF01048	0.646
MOD_GlcNHglycan	606	609	PF01048	0.567
MOD_GlcNHglycan	610	613	PF01048	0.596
MOD_GlcNHglycan	614	617	PF01048	0.706
MOD_GlcNHglycan	630	633	PF01048	0.469
MOD_GlcNHglycan	651	654	PF01048	0.591
MOD_GlcNHglycan	77	80	PF01048	0.403
MOD_GlcNHglycan	91	94	PF01048	0.340
MOD_GSK3_1	254	261	PF00069	0.702
MOD_GSK3_1	268	275	PF00069	0.598
MOD_GSK3_1	40	47	PF00069	0.734
MOD_GSK3_1	440	447	PF00069	0.347
MOD_GSK3_1	482	489	PF00069	0.330
MOD_GSK3_1	493	500	PF00069	0.346
MOD_GSK3_1	562	569	PF00069	0.694
MOD_GSK3_1	573	580	PF00069	0.766
MOD_GSK3_1	582	589	PF00069	0.761
MOD_GSK3_1	592	599	PF00069	0.544
MOD_GSK3_1	604	611	PF00069	0.497
MOD_GSK3_1	612	619	PF00069	0.618
MOD_GSK3_1	623	630	PF00069	0.555
MOD_GSK3_1	88	95	PF00069	0.447
MOD_NEK2_1	42	47	PF00069	0.692
MOD_NEK2_1	444	449	PF00069	0.413
MOD_NEK2_1	532	537	PF00069	0.312
MOD_NEK2_2	188	193	PF00069	0.275
MOD_PIKK_1	281	287	PF00454	0.621
MOD_PK_1	135	141	PF00069	0.311
MOD_PKA_1	87	93	PF00069	0.393
MOD_PKA_2	383	389	PF00069	0.558
MOD_PKA_2	532	538	PF00069	0.387
MOD_PKA_2	566	572	PF00069	0.586
MOD_PKA_2	87	93	PF00069	0.393
MOD_PKB_1	135	143	PF00069	0.328
MOD_Plk_1	623	629	PF00069	0.773
MOD_Plk_4	103	109	PF00069	0.317
MOD_Plk_4	188	194	PF00069	0.398
MOD_Plk_4	3	9	PF00069	0.458
MOD_Plk_4	362	368	PF00069	0.335
MOD_Plk_4	78	84	PF00069	0.391
MOD_ProDKin_1	254	260	PF00069	0.699
MOD_ProDKin_1	268	274	PF00069	0.463
MOD_ProDKin_1	424	430	PF00069	0.454
MOD_ProDKin_1	459	465	PF00069	0.290
MOD_ProDKin_1	483	489	PF00069	0.330
MOD_ProDKin_1	493	499	PF00069	0.364
MOD_ProDKin_1	514	520	PF00069	0.309
MOD_ProDKin_1	571	577	PF00069	0.793
MOD_ProDKin_1	586	592	PF00069	0.642
MOD_ProDKin_1	618	624	PF00069	0.653
MOD_SUMO_rev_2	308	317	PF00179	0.366
MOD_SUMO_rev_2	434	442	PF00179	0.335
MOD_SUMO_rev_2	637	647	PF00179	0.539
TRG_DiLeu_BaEn_1	129	134	PF01217	0.410
TRG_DiLeu_BaEn_1	313	318	PF01217	0.462
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.367
TRG_ENDOCYTIC_2	175	178	PF00928	0.291
TRG_ENDOCYTIC_2	360	363	PF00928	0.329
TRG_ENDOCYTIC_2	474	477	PF00928	0.291
TRG_ER_diArg_1	1	3	PF00400	0.460
TRG_ER_diArg_1	134	137	PF00400	0.328
TRG_ER_diArg_1	153	155	PF00400	0.140
TRG_ER_diArg_1	324	327	PF00400	0.408
TRG_ER_diArg_1	423	426	PF00400	0.294
TRG_ER_diArg_1	527	530	PF00400	0.293
TRG_NES_CRM1_1	468	481	PF08389	0.410
TRG_Pf-PMV_PEXEL_1	312	316	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	553	557	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM55	Leptomonas seymouri	55%	92%
A0A0S4IT05	Bodo saltans	30%	100%
A0A1X0P3X4	Trypanosomatidae	45%	100%
A0A422MWI6	Trypanosoma rangeli	46%	100%
A4HLQ7	Leishmania braziliensis	81%	100%
A4I957	Leishmania infantum	100%	100%
D0A6B5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B432	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
F4JKB6	Arabidopsis thaliana	23%	100%
Q4Q3Z2	Leishmania major	92%	100%
Q680B9	Arabidopsis thaliana	22%	100%
V5BPA7	Trypanosoma cruzi	46%	100%