Dynein regulatory complex subunit, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nexin-dynein regulatory complex 2

Species:

Leishmania donovani

UniProt:

A0A3Q8IHV5_LEIDO

TriTrypDb:

LdBPK_280050.1 , LdCL_280005400 , LDHU3_28.0070

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005858	axonemal dynein complex	4	12
GO:0005875	microtubule associated complex	2	12
GO:0030286	dynein complex	3	12
GO:0032991	protein-containing complex	1	12
GO:1902494	catalytic complex	2	12
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	3
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	3
GO:0031514	motile cilium	5	2

Expansion

Sequence features

A0A3Q8IHV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHV5

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0070286	axonemal dynein complex assembly	6	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0003352	regulation of cilium movement	6	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0048870	cell motility	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0060632	regulation of microtubule-based movement	5	1
GO:0065007	biological regulation	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	374	378	PF00656	0.648
CLV_NRD_NRD_1	239	241	PF00675	0.530
CLV_NRD_NRD_1	358	360	PF00675	0.639
CLV_NRD_NRD_1	62	64	PF00675	0.269
CLV_NRD_NRD_1	70	72	PF00675	0.265
CLV_NRD_NRD_1	8	10	PF00675	0.218
CLV_PCSK_KEX2_1	164	166	PF00082	0.423
CLV_PCSK_KEX2_1	318	320	PF00082	0.531
CLV_PCSK_KEX2_1	357	359	PF00082	0.534
CLV_PCSK_KEX2_1	62	64	PF00082	0.277
CLV_PCSK_KEX2_1	8	10	PF00082	0.246
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.423
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.531
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.534
CLV_PCSK_SKI1_1	149	153	PF00082	0.471
CLV_PCSK_SKI1_1	258	262	PF00082	0.462
CLV_PCSK_SKI1_1	274	278	PF00082	0.365
CLV_PCSK_SKI1_1	282	286	PF00082	0.437
CLV_PCSK_SKI1_1	398	402	PF00082	0.410
CLV_PCSK_SKI1_1	410	414	PF00082	0.410
CLV_PCSK_SKI1_1	91	95	PF00082	0.249
CLV_Separin_Metazoa	59	63	PF03568	0.442
DEG_APCC_DBOX_1	148	156	PF00400	0.544
DEG_Nend_UBRbox_1	1	4	PF02207	0.496
DOC_ANK_TNKS_1	358	365	PF00023	0.463
DOC_CYCLIN_RxL_1	318	328	PF00134	0.417
DOC_CYCLIN_RxL_1	407	416	PF00134	0.556
DOC_CYCLIN_RxL_1	8	18	PF00134	0.555
DOC_MAPK_gen_1	318	329	PF00069	0.438
DOC_MAPK_gen_1	8	16	PF00069	0.418
DOC_SPAK_OSR1_1	391	395	PF12202	0.502
DOC_USP7_MATH_1	3	7	PF00917	0.555
DOC_USP7_MATH_1	362	366	PF00917	0.667
DOC_USP7_MATH_1	460	464	PF00917	0.652
DOC_USP7_MATH_1	93	97	PF00917	0.499
DOC_USP7_UBL2_3	283	287	PF12436	0.506
LIG_14-3-3_CanoR_1	439	445	PF00244	0.631
LIG_14-3-3_CanoR_1	62	66	PF00244	0.510
LIG_Actin_WH2_2	135	151	PF00022	0.530
LIG_Actin_WH2_2	178	195	PF00022	0.617
LIG_APCC_ABBA_1	105	110	PF00400	0.353
LIG_BIR_III_2	377	381	PF00653	0.616
LIG_deltaCOP1_diTrp_1	384	393	PF00928	0.455
LIG_deltaCOP1_diTrp_1	39	45	PF00928	0.450
LIG_FHA_1	110	116	PF00498	0.541
LIG_FHA_1	230	236	PF00498	0.556
LIG_FHA_1	441	447	PF00498	0.544
LIG_FHA_1	75	81	PF00498	0.499
LIG_FHA_2	174	180	PF00498	0.591
LIG_FHA_2	333	339	PF00498	0.454
LIG_FHA_2	76	82	PF00498	0.535
LIG_LIR_Gen_1	384	394	PF02991	0.556
LIG_LIR_Gen_1	39	46	PF02991	0.450
LIG_LIR_Nem_3	204	210	PF02991	0.499
LIG_LIR_Nem_3	384	389	PF02991	0.480
LIG_LIR_Nem_3	39	45	PF02991	0.450
LIG_PCNA_PIPBox_1	421	430	PF02747	0.443
LIG_PCNA_yPIPBox_3	11	24	PF02747	0.430
LIG_PCNA_yPIPBox_3	410	424	PF02747	0.435
LIG_SH2_NCK_1	132	136	PF00017	0.550
LIG_SH2_NCK_1	469	473	PF00017	0.673
LIG_SH2_STAT5	221	224	PF00017	0.595
LIG_SH2_STAT5	427	430	PF00017	0.442
LIG_SUMO_SIM_anti_2	57	62	PF11976	0.461
LIG_SUMO_SIM_par_1	441	447	PF11976	0.531
LIG_TRAF2_1	308	311	PF00917	0.551
LIG_UBA3_1	323	331	PF00899	0.430
MOD_CK1_1	248	254	PF00069	0.424
MOD_CK2_1	173	179	PF00069	0.634
MOD_CK2_1	332	338	PF00069	0.450
MOD_CK2_1	75	81	PF00069	0.551
MOD_GlcNHglycan	34	37	PF01048	0.337
MOD_GlcNHglycan	348	351	PF01048	0.653
MOD_GlcNHglycan	373	376	PF01048	0.641
MOD_GSK3_1	247	254	PF00069	0.454
MOD_GSK3_1	28	35	PF00069	0.457
MOD_GSK3_1	440	447	PF00069	0.588
MOD_GSK3_1	61	68	PF00069	0.510
MOD_N-GLC_1	306	311	PF02516	0.534
MOD_N-GLC_1	345	350	PF02516	0.574
MOD_NEK2_1	15	20	PF00069	0.527
MOD_NEK2_1	210	215	PF00069	0.456
MOD_NEK2_1	245	250	PF00069	0.434
MOD_NEK2_1	313	318	PF00069	0.461
MOD_NEK2_1	438	443	PF00069	0.514
MOD_NEK2_1	444	449	PF00069	0.510
MOD_NEK2_1	75	80	PF00069	0.499
MOD_PIKK_1	404	410	PF00454	0.424
MOD_PIKK_1	444	450	PF00454	0.599
MOD_PKA_2	438	444	PF00069	0.613
MOD_PKA_2	61	67	PF00069	0.510
MOD_Plk_1	274	280	PF00069	0.448
MOD_Plk_1	429	435	PF00069	0.482
MOD_Plk_1	461	467	PF00069	0.668
MOD_Plk_1	65	71	PF00069	0.510
MOD_Plk_1	81	87	PF00069	0.486
MOD_Plk_2-3	429	435	PF00069	0.524
MOD_Plk_2-3	81	87	PF00069	0.563
MOD_Plk_4	100	106	PF00069	0.554
MOD_Plk_4	440	446	PF00069	0.546
MOD_Plk_4	461	467	PF00069	0.590
MOD_Plk_4	75	81	PF00069	0.499
MOD_SUMO_rev_2	133	142	PF00179	0.487
TRG_DiLeu_BaEn_2	472	478	PF01217	0.610
TRG_DiLeu_BaEn_4	415	421	PF01217	0.418
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.524
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.527
TRG_ENDOCYTIC_2	207	210	PF00928	0.501
TRG_ENDOCYTIC_2	469	472	PF00928	0.577
TRG_ER_diArg_1	358	360	PF00400	0.639
TRG_ER_diArg_1	61	63	PF00400	0.461
TRG_ER_diArg_1	8	11	PF00400	0.447
TRG_NES_CRM1_1	422	435	PF08389	0.561
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	52	57	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5X5	Leptomonas seymouri	74%	95%
A0A0S4J2B0	Bodo saltans	48%	94%
A0A1X0NVC5	Trypanosomatidae	54%	96%
A0A3R7MHP0	Trypanosoma rangeli	53%	96%
A4HG48	Leishmania braziliensis	81%	100%
A4I378	Leishmania infantum	100%	100%
A8JB22	Chlamydomonas reinhardtii	28%	85%
D0A7Q6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	96%
E9AZG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q2TA16	Bos taurus	30%	98%
Q4Q8R5	Leishmania major	95%	100%
Q4R7G7	Macaca fascicularis	30%	100%
Q5XIJ8	Rattus norvegicus	29%	97%
Q6DHI2	Danio rerio	26%	99%
Q8IXS2	Homo sapiens	31%	100%
Q8VHI7	Mus musculus	29%	99%
V5AS08	Trypanosoma cruzi	53%	95%