Peptidase family C78, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Peptidase family C78, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHV3_LEIDO

TriTrypDb:

LdBPK_343830.1 , LdCL_340047700 , LDHU3_34.6130

Length:

506

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHV3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	265	269	PF00656	0.501
CLV_NRD_NRD_1	230	232	PF00675	0.511
CLV_NRD_NRD_1	261	263	PF00675	0.453
CLV_NRD_NRD_1	353	355	PF00675	0.354
CLV_NRD_NRD_1	473	475	PF00675	0.246
CLV_PCSK_KEX2_1	229	231	PF00082	0.511
CLV_PCSK_KEX2_1	261	263	PF00082	0.540
CLV_PCSK_KEX2_1	353	355	PF00082	0.383
CLV_PCSK_KEX2_1	369	371	PF00082	0.389
CLV_PCSK_KEX2_1	400	402	PF00082	0.324
CLV_PCSK_KEX2_1	84	86	PF00082	0.565
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.343
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.336
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.544
CLV_PCSK_PC7_1	225	231	PF00082	0.581
CLV_PCSK_SKI1_1	176	180	PF00082	0.367
CLV_PCSK_SKI1_1	191	195	PF00082	0.409
CLV_PCSK_SKI1_1	369	373	PF00082	0.361
CLV_PCSK_SKI1_1	56	60	PF00082	0.470
CLV_PCSK_SKI1_1	81	85	PF00082	0.516
DEG_Nend_UBRbox_2	1	3	PF02207	0.712
DOC_CKS1_1	127	132	PF01111	0.629
DOC_CYCLIN_RxL_1	173	182	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	426	432	PF00134	0.421
DOC_MAPK_gen_1	21	28	PF00069	0.417
DOC_MAPK_gen_1	81	90	PF00069	0.508
DOC_PP2B_LxvP_1	237	240	PF13499	0.409
DOC_PP2B_LxvP_1	426	429	PF13499	0.421
DOC_PP2B_LxvP_1	495	498	PF13499	0.331
DOC_PP4_FxxP_1	422	425	PF00568	0.460
DOC_USP7_MATH_1	161	165	PF00917	0.627
DOC_USP7_MATH_1	168	172	PF00917	0.603
DOC_USP7_MATH_1	328	332	PF00917	0.324
DOC_USP7_MATH_1	348	352	PF00917	0.336
DOC_USP7_MATH_1	40	44	PF00917	0.519
DOC_USP7_MATH_1	73	77	PF00917	0.513
DOC_USP7_UBL2_3	481	485	PF12436	0.348
DOC_WW_Pin1_4	126	131	PF00397	0.604
DOC_WW_Pin1_4	282	287	PF00397	0.494
DOC_WW_Pin1_4	421	426	PF00397	0.382
DOC_WW_Pin1_4	59	64	PF00397	0.579
LIG_14-3-3_CanoR_1	21	27	PF00244	0.535
LIG_14-3-3_CanoR_1	280	286	PF00244	0.502
LIG_14-3-3_CanoR_1	330	336	PF00244	0.406
LIG_14-3-3_CanoR_1	74	80	PF00244	0.459
LIG_BRCT_BRCA1_1	214	218	PF00533	0.462
LIG_BRCT_BRCA1_1	483	487	PF00533	0.406
LIG_Clathr_ClatBox_1	416	420	PF01394	0.362
LIG_deltaCOP1_diTrp_1	125	131	PF00928	0.487
LIG_deltaCOP1_diTrp_1	209	218	PF00928	0.471
LIG_deltaCOP1_diTrp_1	377	382	PF00928	0.324
LIG_FHA_1	134	140	PF00498	0.562
LIG_FHA_1	172	178	PF00498	0.493
LIG_FHA_1	23	29	PF00498	0.414
LIG_FHA_1	301	307	PF00498	0.365
LIG_FHA_1	43	49	PF00498	0.460
LIG_FHA_2	154	160	PF00498	0.676
LIG_FHA_2	198	204	PF00498	0.564
LIG_FHA_2	222	228	PF00498	0.576
LIG_FHA_2	254	260	PF00498	0.446
LIG_LIR_Apic_2	125	130	PF02991	0.587
LIG_LIR_Apic_2	420	425	PF02991	0.460
LIG_LIR_Gen_1	114	124	PF02991	0.580
LIG_LIR_Gen_1	381	388	PF02991	0.324
LIG_LIR_Gen_1	452	462	PF02991	0.406
LIG_LIR_Nem_3	114	120	PF02991	0.577
LIG_LIR_Nem_3	255	260	PF02991	0.499
LIG_LIR_Nem_3	307	313	PF02991	0.319
LIG_LIR_Nem_3	452	458	PF02991	0.406
LIG_LIR_Nem_3	459	465	PF02991	0.406
LIG_MLH1_MIPbox_1	483	487	PF16413	0.406
LIG_PCNA_PIPBox_1	385	394	PF02747	0.460
LIG_PCNA_PIPBox_1	415	424	PF02747	0.324
LIG_Pex14_1	127	131	PF04695	0.536
LIG_Pex14_1	325	329	PF04695	0.324
LIG_Pex14_1	378	382	PF04695	0.324
LIG_SH2_CRK	241	245	PF00017	0.497
LIG_SH2_CRK	329	333	PF00017	0.350
LIG_SH2_STAP1	437	441	PF00017	0.324
LIG_SH2_STAT3	465	468	PF00017	0.460
LIG_SH2_STAT5	391	394	PF00017	0.406
LIG_SH2_STAT5	455	458	PF00017	0.324
LIG_SH2_STAT5	477	480	PF00017	0.358
LIG_SH3_3	144	150	PF00018	0.548
LIG_SH3_3	207	213	PF00018	0.393
LIG_SH3_3	293	299	PF00018	0.547
LIG_SUMO_SIM_anti_2	383	388	PF11976	0.324
LIG_SUMO_SIM_par_1	302	307	PF11976	0.396
LIG_SUMO_SIM_par_1	415	420	PF11976	0.285
LIG_TYR_ITIM	239	244	PF00017	0.506
LIG_WRC_WIRS_1	379	384	PF05994	0.324
MOD_CDC14_SPxK_1	285	288	PF00782	0.464
MOD_CDK_SPxK_1	282	288	PF00069	0.465
MOD_CK1_1	108	114	PF00069	0.522
MOD_CK1_1	135	141	PF00069	0.441
MOD_CK1_1	171	177	PF00069	0.546
MOD_CK1_1	294	300	PF00069	0.532
MOD_CK1_1	331	337	PF00069	0.324
MOD_CK1_1	42	48	PF00069	0.493
MOD_CK2_1	108	114	PF00069	0.562
MOD_CK2_1	142	148	PF00069	0.591
MOD_CK2_1	179	185	PF00069	0.434
MOD_CK2_1	197	203	PF00069	0.330
MOD_CK2_1	48	54	PF00069	0.470
MOD_CMANNOS	254	257	PF00535	0.491
MOD_GlcNHglycan	121	125	PF01048	0.510
MOD_GlcNHglycan	163	166	PF01048	0.627
MOD_GlcNHglycan	181	184	PF01048	0.305
MOD_GlcNHglycan	293	296	PF01048	0.479
MOD_GlcNHglycan	306	309	PF01048	0.271
MOD_GlcNHglycan	462	465	PF01048	0.406
MOD_GlcNHglycan	50	53	PF01048	0.533
MOD_GlcNHglycan	99	102	PF01048	0.563
MOD_GSK3_1	105	112	PF00069	0.612
MOD_GSK3_1	129	136	PF00069	0.557
MOD_GSK3_1	149	156	PF00069	0.604
MOD_GSK3_1	168	175	PF00069	0.548
MOD_GSK3_1	197	204	PF00069	0.553
MOD_GSK3_1	267	274	PF00069	0.531
MOD_GSK3_1	300	307	PF00069	0.366
MOD_GSK3_1	433	440	PF00069	0.299
MOD_GSK3_1	460	467	PF00069	0.326
MOD_GSK3_1	73	80	PF00069	0.431
MOD_N-GLC_1	91	96	PF02516	0.402
MOD_N-GLC_2	494	496	PF02516	0.324
MOD_NEK2_1	172	177	PF00069	0.464
MOD_NEK2_1	179	184	PF00069	0.371
MOD_NEK2_1	304	309	PF00069	0.360
MOD_NEK2_1	39	44	PF00069	0.411
MOD_NEK2_1	395	400	PF00069	0.329
MOD_NEK2_1	48	53	PF00069	0.434
MOD_NEK2_1	79	84	PF00069	0.503
MOD_OFUCOSY	72	77	PF10250	0.420
MOD_PIKK_1	464	470	PF00454	0.406
MOD_PK_1	267	273	PF00069	0.447
MOD_PKA_2	73	79	PF00069	0.439
MOD_Plk_1	108	114	PF00069	0.589
MOD_Plk_1	168	174	PF00069	0.516
MOD_Plk_1	267	273	PF00069	0.506
MOD_Plk_1	395	401	PF00069	0.303
MOD_Plk_1	410	416	PF00069	0.375
MOD_Plk_2-3	109	115	PF00069	0.492
MOD_Plk_4	112	118	PF00069	0.574
MOD_Plk_4	168	174	PF00069	0.569
MOD_Plk_4	212	218	PF00069	0.545
MOD_Plk_4	267	273	PF00069	0.545
MOD_Plk_4	300	306	PF00069	0.406
MOD_Plk_4	331	337	PF00069	0.324
MOD_Plk_4	437	443	PF00069	0.324
MOD_ProDKin_1	126	132	PF00069	0.615
MOD_ProDKin_1	282	288	PF00069	0.504
MOD_ProDKin_1	421	427	PF00069	0.382
MOD_ProDKin_1	59	65	PF00069	0.576
MOD_SUMO_rev_2	259	269	PF00179	0.408
MOD_SUMO_rev_2	51	58	PF00179	0.457
TRG_DiLeu_BaEn_1	452	457	PF01217	0.324
TRG_DiLeu_BaEn_2	53	59	PF01217	0.495
TRG_ENDOCYTIC_2	241	244	PF00928	0.502
TRG_ENDOCYTIC_2	329	332	PF00928	0.345
TRG_ENDOCYTIC_2	455	458	PF00928	0.406
TRG_ER_diArg_1	229	231	PF00400	0.512
TRG_ER_diArg_1	260	262	PF00400	0.434
TRG_ER_diArg_1	352	354	PF00400	0.389
TRG_NES_CRM1_1	377	390	PF08389	0.324
TRG_Pf-PMV_PEXEL_1	176	181	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0K1	Leptomonas seymouri	59%	99%
A0A1X0PB53	Trypanosomatidae	43%	100%
A4HBC3	Leishmania braziliensis	78%	100%
A4IAH1	Leishmania infantum	99%	100%
C9ZLS0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B5J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q2E1	Leishmania major	91%	100%
Q5XIB4	Rattus norvegicus	33%	100%