Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHV2_LEIDO

TriTrypDb:

LdBPK_351500.1 , LdCL_350019900 , LDHU3_35.1990

Length:

283

Annotations

LeishMANIAdb annotations

Secreted protein with ER retention signal

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 4
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHV2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	220	222	PF00675	0.702
CLV_NRD_NRD_1	84	86	PF00675	0.648
CLV_PCSK_KEX2_1	84	86	PF00082	0.635
CLV_PCSK_SKI1_1	37	41	PF00082	0.486
DOC_CKS1_1	42	47	PF01111	0.556
DOC_PP4_FxxP_1	165	168	PF00568	0.587
DOC_PP4_FxxP_1	210	213	PF00568	0.419
DOC_PP4_FxxP_1	260	263	PF00568	0.532
DOC_PP4_FxxP_1	42	45	PF00568	0.529
DOC_PP4_FxxP_1	80	83	PF00568	0.465
DOC_WW_Pin1_4	109	114	PF00397	0.630
DOC_WW_Pin1_4	41	46	PF00397	0.530
LIG_14-3-3_CanoR_1	23	31	PF00244	0.564
LIG_14-3-3_CanoR_1	241	251	PF00244	0.708
LIG_14-3-3_CanoR_1	85	95	PF00244	0.612
LIG_Actin_WH2_2	205	223	PF00022	0.522
LIG_Clathr_ClatBox_1	192	196	PF01394	0.533
LIG_eIF4E_1	109	115	PF01652	0.595
LIG_FHA_1	110	116	PF00498	0.593
LIG_FHA_1	215	221	PF00498	0.586
LIG_FHA_1	246	252	PF00498	0.698
LIG_FHA_1	25	31	PF00498	0.497
LIG_FHA_1	254	260	PF00498	0.509
LIG_FHA_1	72	78	PF00498	0.502
LIG_FHA_2	175	181	PF00498	0.617
LIG_LIR_Apic_2	154	160	PF02991	0.712
LIG_LIR_Apic_2	208	213	PF02991	0.444
LIG_LIR_Apic_2	258	263	PF02991	0.544
LIG_LIR_Nem_3	116	122	PF02991	0.485
LIG_LIR_Nem_3	194	200	PF02991	0.423
LIG_PCNA_PIPBox_1	1	10	PF02747	0.602
LIG_Pex14_1	186	190	PF04695	0.629
LIG_Pex14_2	260	264	PF04695	0.591
LIG_SH2_CRK	190	194	PF00017	0.494
LIG_SH2_NCK_1	157	161	PF00017	0.679
LIG_SH2_SRC	157	160	PF00017	0.609
LIG_SH2_STAT3	22	25	PF00017	0.579
LIG_SH2_STAT5	120	123	PF00017	0.426
LIG_SH2_STAT5	72	75	PF00017	0.579
LIG_SH2_STAT5	8	11	PF00017	0.458
LIG_SH2_STAT5	86	89	PF00017	0.539
LIG_SUMO_SIM_par_1	191	196	PF11976	0.411
LIG_SUMO_SIM_par_1	248	256	PF11976	0.612
LIG_TRAF2_1	177	180	PF00917	0.671
LIG_TRAF2_1	230	233	PF00917	0.652
MOD_CK1_1	142	148	PF00069	0.582
MOD_CK1_1	150	156	PF00069	0.622
MOD_CK1_1	225	231	PF00069	0.704
MOD_CK1_1	245	251	PF00069	0.607
MOD_CK1_1	90	96	PF00069	0.562
MOD_CK2_1	101	107	PF00069	0.464
MOD_CK2_1	142	148	PF00069	0.593
MOD_CK2_1	174	180	PF00069	0.625
MOD_CK2_1	86	92	PF00069	0.615
MOD_GlcNHglycan	103	106	PF01048	0.577
MOD_GlcNHglycan	140	144	PF01048	0.557
MOD_GlcNHglycan	227	230	PF01048	0.656
MOD_GlcNHglycan	232	237	PF01048	0.690
MOD_GlcNHglycan	244	247	PF01048	0.644
MOD_GlcNHglycan	45	48	PF01048	0.690
MOD_GSK3_1	174	181	PF00069	0.663
MOD_GSK3_1	221	228	PF00069	0.679
MOD_GSK3_1	241	248	PF00069	0.746
MOD_GSK3_1	86	93	PF00069	0.616
MOD_N-GLC_1	122	127	PF02516	0.484
MOD_N-GLC_1	268	273	PF02516	0.648
MOD_NEK2_1	139	144	PF00069	0.552
MOD_NEK2_1	147	152	PF00069	0.684
MOD_NEK2_1	173	178	PF00069	0.622
MOD_NEK2_1	71	76	PF00069	0.470
MOD_PKA_1	221	227	PF00069	0.633
MOD_PKA_1	84	90	PF00069	0.644
MOD_PKA_2	101	107	PF00069	0.329
MOD_PKA_2	25	31	PF00069	0.535
MOD_PKA_2	84	90	PF00069	0.638
MOD_PKB_1	239	247	PF00069	0.642
MOD_Plk_1	115	121	PF00069	0.460
MOD_Plk_1	153	159	PF00069	0.666
MOD_Plk_1	232	238	PF00069	0.589
MOD_Plk_1	268	274	PF00069	0.515
MOD_Plk_2-3	191	197	PF00069	0.525
MOD_Plk_2-3	253	259	PF00069	0.562
MOD_Plk_4	115	121	PF00069	0.525
MOD_Plk_4	25	31	PF00069	0.430
MOD_Plk_4	90	96	PF00069	0.502
MOD_ProDKin_1	109	115	PF00069	0.620
MOD_ProDKin_1	41	47	PF00069	0.540
TRG_DiLeu_BaEn_4	232	238	PF01217	0.589
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.630
TRG_ENDOCYTIC_2	190	193	PF00928	0.582
TRG_ER_diArg_1	64	67	PF00400	0.639
TRG_ER_diArg_1	83	85	PF00400	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Y1	Leptomonas seymouri	52%	78%
A0A0S4JB49	Bodo saltans	28%	93%
A0A1X0P5P8	Trypanosomatidae	30%	93%
A0A3R7LR32	Trypanosoma rangeli	33%	93%
A4HMH1	Leishmania braziliensis	74%	100%
A4IB51	Leishmania infantum	100%	100%
C9ZZF6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	90%
E9B628	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%