Mitochondrial RNA binding complex 1 subunit, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHV0_LEIDO

TriTrypDb:

LdBPK_331830.1 , LdCL_330025100 , LDHU3_33.2720

Length:

893

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHV0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016553	base conversion or substitution editing	6	1
GO:0016554	cytidine to uridine editing	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	499	503	PF00656	0.514
CLV_C14_Caspase3-7	641	645	PF00656	0.575
CLV_C14_Caspase3-7	879	883	PF00656	0.695
CLV_NRD_NRD_1	129	131	PF00675	0.515
CLV_NRD_NRD_1	13	15	PF00675	0.595
CLV_NRD_NRD_1	512	514	PF00675	0.496
CLV_NRD_NRD_1	761	763	PF00675	0.551
CLV_NRD_NRD_1	79	81	PF00675	0.471
CLV_NRD_NRD_1	809	811	PF00675	0.500
CLV_NRD_NRD_1	851	853	PF00675	0.497
CLV_NRD_NRD_1	860	862	PF00675	0.459
CLV_NRD_NRD_1	874	876	PF00675	0.491
CLV_PCSK_KEX2_1	129	131	PF00082	0.524
CLV_PCSK_KEX2_1	395	397	PF00082	0.517
CLV_PCSK_KEX2_1	553	555	PF00082	0.552
CLV_PCSK_KEX2_1	723	725	PF00082	0.407
CLV_PCSK_KEX2_1	761	763	PF00082	0.551
CLV_PCSK_KEX2_1	79	81	PF00082	0.452
CLV_PCSK_KEX2_1	809	811	PF00082	0.449
CLV_PCSK_KEX2_1	851	853	PF00082	0.484
CLV_PCSK_KEX2_1	860	862	PF00082	0.441
CLV_PCSK_KEX2_1	874	876	PF00082	0.488
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.544
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.552
CLV_PCSK_PC1ET2_1	723	725	PF00082	0.407
CLV_PCSK_SKI1_1	15	19	PF00082	0.525
CLV_PCSK_SKI1_1	246	250	PF00082	0.578
CLV_PCSK_SKI1_1	287	291	PF00082	0.479
CLV_PCSK_SKI1_1	306	310	PF00082	0.226
CLV_PCSK_SKI1_1	419	423	PF00082	0.388
CLV_PCSK_SKI1_1	523	527	PF00082	0.426
CLV_PCSK_SKI1_1	586	590	PF00082	0.520
CLV_PCSK_SKI1_1	666	670	PF00082	0.433
CLV_PCSK_SKI1_1	675	679	PF00082	0.405
CLV_PCSK_SKI1_1	681	685	PF00082	0.397
CLV_PCSK_SKI1_1	772	776	PF00082	0.502
CLV_PCSK_SKI1_1	836	840	PF00082	0.556
CLV_Separin_Metazoa	634	638	PF03568	0.556
DEG_APCC_DBOX_1	305	313	PF00400	0.541
DEG_APCC_DBOX_1	395	403	PF00400	0.537
DEG_APCC_DBOX_1	43	51	PF00400	0.519
DEG_APCC_DBOX_1	585	593	PF00400	0.470
DEG_SCF_FBW7_1	1	7	PF00400	0.592
DEG_SCF_FBW7_1	774	779	PF00400	0.490
DEG_SCF_FBW7_2	618	623	PF00400	0.586
DEG_SPOP_SBC_1	103	107	PF00917	0.528
DOC_ANK_TNKS_1	479	486	PF00023	0.680
DOC_CDC14_PxL_1	342	350	PF14671	0.551
DOC_CKS1_1	1	6	PF01111	0.687
DOC_CKS1_1	115	120	PF01111	0.466
DOC_CKS1_1	754	759	PF01111	0.517
DOC_CKS1_1	773	778	PF01111	0.532
DOC_CKS1_1	820	825	PF01111	0.495
DOC_CKS1_1	829	834	PF01111	0.431
DOC_CYCLIN_RxL_1	416	426	PF00134	0.392
DOC_CYCLIN_RxL_1	833	843	PF00134	0.491
DOC_MAPK_DCC_7	444	454	PF00069	0.443
DOC_MAPK_gen_1	41	50	PF00069	0.564
DOC_MAPK_gen_1	498	507	PF00069	0.540
DOC_PP2B_LxvP_1	387	390	PF13499	0.535
DOC_PP4_FxxP_1	659	662	PF00568	0.544
DOC_PP4_FxxP_1	773	776	PF00568	0.372
DOC_PP4_FxxP_1	820	823	PF00568	0.543
DOC_USP7_MATH_1	151	155	PF00917	0.451
DOC_USP7_MATH_1	160	164	PF00917	0.402
DOC_USP7_MATH_1	25	29	PF00917	0.495
DOC_USP7_MATH_1	64	68	PF00917	0.586
DOC_USP7_MATH_1	8	12	PF00917	0.406
DOC_USP7_MATH_1	82	86	PF00917	0.297
DOC_USP7_MATH_1	883	887	PF00917	0.710
DOC_USP7_MATH_2	558	564	PF00917	0.507
DOC_USP7_UBL2_3	681	685	PF12436	0.544
DOC_USP7_UBL2_3	795	799	PF12436	0.441
DOC_WW_Pin1_4	114	119	PF00397	0.479
DOC_WW_Pin1_4	191	196	PF00397	0.497
DOC_WW_Pin1_4	375	380	PF00397	0.536
DOC_WW_Pin1_4	54	59	PF00397	0.602
DOC_WW_Pin1_4	601	606	PF00397	0.478
DOC_WW_Pin1_4	616	621	PF00397	0.551
DOC_WW_Pin1_4	68	73	PF00397	0.468
DOC_WW_Pin1_4	753	758	PF00397	0.511
DOC_WW_Pin1_4	772	777	PF00397	0.293
DOC_WW_Pin1_4	819	824	PF00397	0.489
DOC_WW_Pin1_4	828	833	PF00397	0.431
LIG_14-3-3_CanoR_1	102	111	PF00244	0.485
LIG_14-3-3_CanoR_1	129	138	PF00244	0.512
LIG_14-3-3_CanoR_1	480	484	PF00244	0.685
LIG_14-3-3_CanoR_1	513	522	PF00244	0.508
LIG_14-3-3_CanoR_1	637	646	PF00244	0.581
LIG_14-3-3_CanoR_1	698	704	PF00244	0.489
LIG_14-3-3_CanoR_1	766	774	PF00244	0.500
LIG_14-3-3_CanoR_1	827	832	PF00244	0.531
LIG_14-3-3_CanoR_1	884	892	PF00244	0.667
LIG_14-3-3_CterR_2	889	893	PF00244	0.762
LIG_Actin_WH2_2	108	124	PF00022	0.505
LIG_Actin_WH2_2	745	763	PF00022	0.511
LIG_APCC_ABBA_1	34	39	PF00400	0.565
LIG_BIR_III_4	180	184	PF00653	0.543
LIG_CSL_BTD_1	115	118	PF09270	0.465
LIG_deltaCOP1_diTrp_1	347	354	PF00928	0.525
LIG_FHA_1	1	7	PF00498	0.590
LIG_FHA_1	106	112	PF00498	0.543
LIG_FHA_1	174	180	PF00498	0.589
LIG_FHA_1	211	217	PF00498	0.535
LIG_FHA_1	33	39	PF00498	0.527
LIG_FHA_1	527	533	PF00498	0.433
LIG_FHA_1	754	760	PF00498	0.511
LIG_FHA_1	820	826	PF00498	0.508
LIG_FHA_1	829	835	PF00498	0.443
LIG_FHA_1	871	877	PF00498	0.478
LIG_FHA_2	115	121	PF00498	0.460
LIG_FHA_2	17	23	PF00498	0.539
LIG_FHA_2	261	267	PF00498	0.559
LIG_FHA_2	342	348	PF00498	0.575
LIG_FHA_2	443	449	PF00498	0.539
LIG_FHA_2	479	485	PF00498	0.696
LIG_FHA_2	636	642	PF00498	0.568
LIG_FHA_2	687	693	PF00498	0.451
LIG_FHA_2	745	751	PF00498	0.517
LIG_FHA_2	773	779	PF00498	0.491
LIG_FHA_2	877	883	PF00498	0.679
LIG_HCF-1_HBM_1	664	667	PF13415	0.501
LIG_LIR_Gen_1	231	241	PF02991	0.381
LIG_LIR_Gen_1	296	305	PF02991	0.503
LIG_LIR_Gen_1	411	420	PF02991	0.501
LIG_LIR_Gen_1	502	511	PF02991	0.398
LIG_LIR_Gen_1	540	551	PF02991	0.497
LIG_LIR_Gen_1	606	614	PF02991	0.544
LIG_LIR_Gen_1	627	636	PF02991	0.422
LIG_LIR_Gen_1	651	660	PF02991	0.402
LIG_LIR_Gen_1	717	726	PF02991	0.481
LIG_LIR_Gen_1	731	742	PF02991	0.291
LIG_LIR_Gen_1	97	104	PF02991	0.533
LIG_LIR_Nem_3	231	236	PF02991	0.392
LIG_LIR_Nem_3	296	300	PF02991	0.488
LIG_LIR_Nem_3	344	348	PF02991	0.542
LIG_LIR_Nem_3	411	415	PF02991	0.493
LIG_LIR_Nem_3	417	423	PF02991	0.406
LIG_LIR_Nem_3	502	507	PF02991	0.411
LIG_LIR_Nem_3	540	546	PF02991	0.502
LIG_LIR_Nem_3	581	585	PF02991	0.426
LIG_LIR_Nem_3	606	611	PF02991	0.541
LIG_LIR_Nem_3	627	632	PF02991	0.417
LIG_LIR_Nem_3	651	656	PF02991	0.406
LIG_LIR_Nem_3	717	722	PF02991	0.509
LIG_LIR_Nem_3	97	103	PF02991	0.538
LIG_LRP6_Inhibitor_1	123	129	PF00058	0.349
LIG_LYPXL_yS_3	345	348	PF13949	0.565
LIG_LYPXL_yS_3	582	585	PF13949	0.440
LIG_PCNA_TLS_4	498	505	PF02747	0.446
LIG_Pex14_1	350	354	PF04695	0.498
LIG_SH2_SRC	37	40	PF00017	0.593
LIG_SH2_STAP1	134	138	PF00017	0.523
LIG_SH2_STAT5	330	333	PF00017	0.483
LIG_SH2_STAT5	37	40	PF00017	0.503
LIG_SH2_STAT5	437	440	PF00017	0.521
LIG_SH2_STAT5	549	552	PF00017	0.428
LIG_SH2_STAT5	667	670	PF00017	0.475
LIG_SH2_STAT5	718	721	PF00017	0.517
LIG_SH3_3	112	118	PF00018	0.542
LIG_SH3_3	169	175	PF00018	0.500
LIG_SH3_3	277	283	PF00018	0.504
LIG_SH3_3	831	837	PF00018	0.447
LIG_SUMO_SIM_anti_2	337	342	PF11976	0.517
LIG_SUMO_SIM_par_1	160	167	PF11976	0.449
LIG_SUMO_SIM_par_1	282	288	PF11976	0.424
LIG_SUMO_SIM_par_1	30	35	PF11976	0.434
LIG_SUMO_SIM_par_1	333	339	PF11976	0.480
LIG_TRAF2_1	218	221	PF00917	0.391
LIG_TRAF2_1	263	266	PF00917	0.557
LIG_TRAF2_1	367	370	PF00917	0.540
LIG_UBA3_1	745	751	PF00899	0.491
LIG_WRC_WIRS_1	415	420	PF05994	0.512
MOD_CK1_1	105	111	PF00069	0.503
MOD_CK1_1	163	169	PF00069	0.474
MOD_CK1_1	208	214	PF00069	0.551
MOD_CK1_1	374	380	PF00069	0.561
MOD_CK1_1	411	417	PF00069	0.530
MOD_CK1_1	563	569	PF00069	0.456
MOD_CK1_1	57	63	PF00069	0.609
MOD_CK1_1	601	607	PF00069	0.560
MOD_CK1_1	700	706	PF00069	0.372
MOD_CK1_1	727	733	PF00069	0.544
MOD_CK1_1	753	759	PF00069	0.485
MOD_CK1_1	821	827	PF00069	0.561
MOD_CK2_1	134	140	PF00069	0.483
MOD_CK2_1	16	22	PF00069	0.575
MOD_CK2_1	164	170	PF00069	0.461
MOD_CK2_1	260	266	PF00069	0.555
MOD_CK2_1	472	478	PF00069	0.624
MOD_CK2_1	827	833	PF00069	0.572
MOD_Cter_Amidation	77	80	PF01082	0.453
MOD_GlcNHglycan	131	134	PF01048	0.570
MOD_GlcNHglycan	153	156	PF01048	0.425
MOD_GlcNHglycan	250	253	PF01048	0.467
MOD_GlcNHglycan	27	30	PF01048	0.448
MOD_GlcNHglycan	276	279	PF01048	0.454
MOD_GlcNHglycan	319	322	PF01048	0.526
MOD_GlcNHglycan	373	376	PF01048	0.565
MOD_GlcNHglycan	474	477	PF01048	0.718
MOD_GlcNHglycan	562	565	PF01048	0.454
MOD_GlcNHglycan	600	603	PF01048	0.547
MOD_GlcNHglycan	699	702	PF01048	0.392
MOD_GlcNHglycan	842	845	PF01048	0.598
MOD_GlcNHglycan	855	858	PF01048	0.378
MOD_GlcNHglycan	861	864	PF01048	0.298
MOD_GlcNHglycan	92	95	PF01048	0.571
MOD_GSK3_1	160	167	PF00069	0.419
MOD_GSK3_1	371	378	PF00069	0.530
MOD_GSK3_1	4	11	PF00069	0.606
MOD_GSK3_1	467	474	PF00069	0.607
MOD_GSK3_1	612	619	PF00069	0.614
MOD_GSK3_1	64	71	PF00069	0.605
MOD_GSK3_1	703	710	PF00069	0.420
MOD_GSK3_1	772	779	PF00069	0.377
MOD_GSK3_1	90	97	PF00069	0.579
MOD_GSK3_1	98	105	PF00069	0.520
MOD_LATS_1	127	133	PF00433	0.480
MOD_N-GLC_1	205	210	PF02516	0.500
MOD_N-GLC_2	274	276	PF02516	0.480
MOD_N-GLC_2	407	409	PF02516	0.585
MOD_NEK2_1	189	194	PF00069	0.550
MOD_NEK2_1	205	210	PF00069	0.318
MOD_NEK2_1	32	37	PF00069	0.429
MOD_NEK2_1	336	341	PF00069	0.485
MOD_NEK2_1	442	447	PF00069	0.446
MOD_NEK2_1	635	640	PF00069	0.438
MOD_NEK2_1	725	730	PF00069	0.476
MOD_NEK2_1	840	845	PF00069	0.554
MOD_NEK2_1	876	881	PF00069	0.611
MOD_NEK2_2	718	723	PF00069	0.424
MOD_PIKK_1	467	473	PF00454	0.629
MOD_PIKK_1	514	520	PF00454	0.536
MOD_PIKK_1	603	609	PF00454	0.540
MOD_PIKK_1	845	851	PF00454	0.527
MOD_PKA_1	129	135	PF00069	0.490
MOD_PKA_2	129	135	PF00069	0.567
MOD_PKA_2	260	266	PF00069	0.518
MOD_PKA_2	4	10	PF00069	0.608
MOD_PKA_2	40	46	PF00069	0.522
MOD_PKA_2	479	485	PF00069	0.684
MOD_PKA_2	537	543	PF00069	0.556
MOD_PKA_2	625	631	PF00069	0.368
MOD_PKA_2	697	703	PF00069	0.502
MOD_PKA_2	765	771	PF00069	0.504
MOD_PKA_2	859	865	PF00069	0.454
MOD_PKA_2	883	889	PF00069	0.675
MOD_Plk_1	134	140	PF00069	0.475
MOD_Plk_1	205	211	PF00069	0.505
MOD_Plk_1	32	38	PF00069	0.426
MOD_Plk_1	336	342	PF00069	0.471
MOD_Plk_1	812	818	PF00069	0.436
MOD_Plk_2-3	268	274	PF00069	0.505
MOD_Plk_2-3	388	394	PF00069	0.545
MOD_Plk_4	134	140	PF00069	0.405
MOD_Plk_4	160	166	PF00069	0.527
MOD_Plk_4	32	38	PF00069	0.512
MOD_Plk_4	336	342	PF00069	0.435
MOD_Plk_4	686	692	PF00069	0.528
MOD_Plk_4	703	709	PF00069	0.416
MOD_Plk_4	755	761	PF00069	0.476
MOD_ProDKin_1	114	120	PF00069	0.474
MOD_ProDKin_1	191	197	PF00069	0.490
MOD_ProDKin_1	375	381	PF00069	0.536
MOD_ProDKin_1	54	60	PF00069	0.599
MOD_ProDKin_1	601	607	PF00069	0.483
MOD_ProDKin_1	616	622	PF00069	0.544
MOD_ProDKin_1	68	74	PF00069	0.461
MOD_ProDKin_1	753	759	PF00069	0.504
MOD_ProDKin_1	772	778	PF00069	0.290
MOD_ProDKin_1	819	825	PF00069	0.487
MOD_ProDKin_1	828	834	PF00069	0.425
MOD_SUMO_rev_2	388	397	PF00179	0.542
MOD_SUMO_rev_2	663	668	PF00179	0.395
TRG_DiLeu_BaEn_1	732	737	PF01217	0.550
TRG_DiLeu_BaEn_2	292	298	PF01217	0.407
TRG_DiLeu_BaEn_2	583	589	PF01217	0.509
TRG_DiLeu_BaEn_2	768	774	PF01217	0.475
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.576
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.503
TRG_DiLeu_BaLyEn_6	834	839	PF01217	0.445
TRG_ENDOCYTIC_2	345	348	PF00928	0.553
TRG_ENDOCYTIC_2	582	585	PF00928	0.440
TRG_ENDOCYTIC_2	653	656	PF00928	0.387
TRG_ER_diArg_1	128	130	PF00400	0.515
TRG_ER_diArg_1	636	639	PF00400	0.569
TRG_ER_diArg_1	760	762	PF00400	0.555
TRG_ER_diArg_1	79	81	PF00400	0.583
TRG_ER_diArg_1	809	811	PF00400	0.500
TRG_ER_diArg_1	859	861	PF00400	0.526
TRG_ER_diArg_1	874	876	PF00400	0.507
TRG_ER_diArg_1	889	892	PF00400	0.508
TRG_NES_CRM1_1	292	307	PF08389	0.428
TRG_NES_CRM1_1	499	510	PF08389	0.433
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	836	841	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	866	870	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAS6	Leptomonas seymouri	61%	98%
A0A0S4JFF4	Bodo saltans	34%	85%
A0A1X0P174	Trypanosomatidae	42%	100%
A0A3R7M0F7	Trypanosoma rangeli	41%	100%
A4HLN4	Leishmania braziliensis	89%	100%
A4I969	Leishmania infantum	100%	100%
C9ZIW5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B410	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q414	Leishmania major	95%	100%
V5AXB1	Trypanosoma cruzi	42%	100%