CSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHU8_LEIDO

TriTrypDb:

LdBPK_120780.1 , LdCL_120019700 , LDHU3_12.1540

Length:

877

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHU8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.667
CLV_C14_Caspase3-7	201	205	PF00656	0.639
CLV_C14_Caspase3-7	502	506	PF00656	0.700
CLV_C14_Caspase3-7	730	734	PF00656	0.552
CLV_C14_Caspase3-7	789	793	PF00656	0.464
CLV_NRD_NRD_1	186	188	PF00675	0.659
CLV_NRD_NRD_1	195	197	PF00675	0.687
CLV_NRD_NRD_1	77	79	PF00675	0.677
CLV_NRD_NRD_1	821	823	PF00675	0.664
CLV_NRD_NRD_1	854	856	PF00675	0.606
CLV_PCSK_KEX2_1	185	187	PF00082	0.618
CLV_PCSK_KEX2_1	195	197	PF00082	0.702
CLV_PCSK_KEX2_1	761	763	PF00082	0.465
CLV_PCSK_KEX2_1	77	79	PF00082	0.677
CLV_PCSK_KEX2_1	820	822	PF00082	0.663
CLV_PCSK_KEX2_1	856	858	PF00082	0.597
CLV_PCSK_PC1ET2_1	761	763	PF00082	0.541
CLV_PCSK_PC1ET2_1	856	858	PF00082	0.597
CLV_PCSK_PC7_1	181	187	PF00082	0.671
CLV_PCSK_SKI1_1	200	204	PF00082	0.629
CLV_PCSK_SKI1_1	221	225	PF00082	0.604
CLV_PCSK_SKI1_1	449	453	PF00082	0.370
CLV_PCSK_SKI1_1	762	766	PF00082	0.497
CLV_PCSK_SKI1_1	78	82	PF00082	0.664
CLV_PCSK_SKI1_1	8	12	PF00082	0.486
CLV_PCSK_SKI1_1	856	860	PF00082	0.639
DEG_SPOP_SBC_1	150	154	PF00917	0.580
DEG_SPOP_SBC_1	489	493	PF00917	0.564
DEG_SPOP_SBC_1	678	682	PF00917	0.707
DOC_CYCLIN_RxL_1	75	83	PF00134	0.670
DOC_CYCLIN_yClb1_LxF_4	805	811	PF00134	0.612
DOC_CYCLIN_yCln2_LP_2	378	384	PF00134	0.668
DOC_CYCLIN_yCln2_LP_2	402	405	PF00134	0.512
DOC_MAPK_gen_1	761	770	PF00069	0.474
DOC_MAPK_MEF2A_6	273	280	PF00069	0.551
DOC_MAPK_MEF2A_6	636	645	PF00069	0.480
DOC_PP2B_LxvP_1	402	405	PF13499	0.512
DOC_PP2B_LxvP_1	643	646	PF13499	0.443
DOC_PP4_FxxP_1	426	429	PF00568	0.392
DOC_USP7_MATH_1	101	105	PF00917	0.641
DOC_USP7_MATH_1	150	154	PF00917	0.648
DOC_USP7_MATH_1	251	255	PF00917	0.568
DOC_USP7_MATH_1	265	269	PF00917	0.608
DOC_USP7_MATH_1	276	280	PF00917	0.586
DOC_USP7_MATH_1	322	326	PF00917	0.658
DOC_USP7_MATH_1	327	331	PF00917	0.653
DOC_USP7_MATH_1	345	349	PF00917	0.637
DOC_USP7_MATH_1	362	366	PF00917	0.686
DOC_USP7_MATH_1	476	480	PF00917	0.681
DOC_USP7_MATH_1	489	493	PF00917	0.511
DOC_USP7_MATH_1	64	68	PF00917	0.667
DOC_USP7_MATH_1	679	683	PF00917	0.725
DOC_USP7_MATH_1	700	704	PF00917	0.633
DOC_USP7_MATH_1	844	848	PF00917	0.719
DOC_USP7_UBL2_3	221	225	PF12436	0.525
DOC_USP7_UBL2_3	4	8	PF12436	0.536
DOC_USP7_UBL2_3	761	765	PF12436	0.502
DOC_WW_Pin1_4	137	142	PF00397	0.703
DOC_WW_Pin1_4	151	156	PF00397	0.561
DOC_WW_Pin1_4	331	336	PF00397	0.585
DOC_WW_Pin1_4	425	430	PF00397	0.473
DOC_WW_Pin1_4	478	483	PF00397	0.637
DOC_WW_Pin1_4	549	554	PF00397	0.662
DOC_WW_Pin1_4	737	742	PF00397	0.614
LIG_14-3-3_CanoR_1	264	274	PF00244	0.599
LIG_14-3-3_CanoR_1	611	615	PF00244	0.440
LIG_14-3-3_CanoR_1	769	775	PF00244	0.535
LIG_Actin_WH2_2	443	460	PF00022	0.579
LIG_Actin_WH2_2	591	609	PF00022	0.512
LIG_APCC_ABBA_1	866	871	PF00400	0.613
LIG_APCC_Cbox_1	180	186	PF00515	0.566
LIG_APCC_Cbox_2	180	186	PF00515	0.566
LIG_BIR_III_2	262	266	PF00653	0.582
LIG_BIR_III_4	191	195	PF00653	0.572
LIG_deltaCOP1_diTrp_1	648	656	PF00928	0.419
LIG_FHA_1	156	162	PF00498	0.627
LIG_FHA_1	309	315	PF00498	0.727
LIG_FHA_1	588	594	PF00498	0.501
LIG_FHA_1	702	708	PF00498	0.519
LIG_FHA_1	710	716	PF00498	0.487
LIG_FHA_1	738	744	PF00498	0.553
LIG_FHA_1	87	93	PF00498	0.653
LIG_FHA_2	167	173	PF00498	0.556
LIG_FHA_2	201	207	PF00498	0.710
LIG_FHA_2	393	399	PF00498	0.490
LIG_FHA_2	492	498	PF00498	0.579
LIG_FHA_2	500	506	PF00498	0.638
LIG_FHA_2	507	513	PF00498	0.608
LIG_FHA_2	569	575	PF00498	0.572
LIG_FHA_2	787	793	PF00498	0.413
LIG_FHA_2	800	806	PF00498	0.484
LIG_Integrin_isoDGR_2	626	628	PF01839	0.581
LIG_LIR_Apic_2	648	654	PF02991	0.493
LIG_LIR_Gen_1	12	23	PF02991	0.499
LIG_LIR_Gen_1	446	455	PF02991	0.446
LIG_LIR_Nem_3	12	18	PF02991	0.478
LIG_LIR_Nem_3	348	352	PF02991	0.553
LIG_LIR_Nem_3	435	440	PF02991	0.443
LIG_LIR_Nem_3	446	450	PF02991	0.468
LIG_LIR_Nem_3	650	655	PF02991	0.455
LIG_LYPXL_yS_3	874	877	PF13949	0.621
LIG_PALB2_WD40_1	647	655	PF16756	0.494
LIG_Pex14_2	11	15	PF04695	0.473
LIG_Pex14_2	652	656	PF04695	0.433
LIG_SH2_CRK	349	353	PF00017	0.549
LIG_SH2_SRC	746	749	PF00017	0.424
LIG_SH2_STAP1	746	750	PF00017	0.420
LIG_SH2_STAT5	151	154	PF00017	0.687
LIG_SH2_STAT5	411	414	PF00017	0.474
LIG_SH2_STAT5	456	459	PF00017	0.612
LIG_SH2_STAT5	711	714	PF00017	0.429
LIG_SH2_STAT5	726	729	PF00017	0.391
LIG_SH2_STAT5	783	786	PF00017	0.489
LIG_SH3_1	673	679	PF00018	0.672
LIG_SH3_3	428	434	PF00018	0.418
LIG_SH3_3	459	465	PF00018	0.570
LIG_SH3_3	511	517	PF00018	0.603
LIG_SH3_3	563	569	PF00018	0.667
LIG_SH3_3	651	657	PF00018	0.445
LIG_SH3_3	671	677	PF00018	0.817
LIG_SH3_3	694	700	PF00018	0.679
LIG_SUMO_SIM_anti_2	398	404	PF11976	0.460
LIG_TRAF2_1	572	575	PF00917	0.563
LIG_WW_1	148	151	PF00397	0.694
MOD_CDK_SPxK_1	151	157	PF00069	0.573
MOD_CK1_1	104	110	PF00069	0.614
MOD_CK1_1	140	146	PF00069	0.709
MOD_CK1_1	269	275	PF00069	0.552
MOD_CK1_1	491	497	PF00069	0.808
MOD_CK1_1	584	590	PF00069	0.534
MOD_CK1_1	680	686	PF00069	0.725
MOD_CK1_1	703	709	PF00069	0.596
MOD_CK1_1	732	738	PF00069	0.717
MOD_CK2_1	200	206	PF00069	0.724
MOD_CK2_1	27	33	PF00069	0.521
MOD_CK2_1	280	286	PF00069	0.622
MOD_CK2_1	392	398	PF00069	0.508
MOD_CK2_1	42	48	PF00069	0.593
MOD_CK2_1	491	497	PF00069	0.575
MOD_CK2_1	568	574	PF00069	0.587
MOD_CK2_1	679	685	PF00069	0.703
MOD_CK2_1	690	696	PF00069	0.649
MOD_CK2_1	799	805	PF00069	0.465
MOD_Cter_Amidation	193	196	PF01082	0.580
MOD_GlcNHglycan	105	109	PF01048	0.622
MOD_GlcNHglycan	142	145	PF01048	0.699
MOD_GlcNHglycan	162	165	PF01048	0.551
MOD_GlcNHglycan	175	180	PF01048	0.543
MOD_GlcNHglycan	247	250	PF01048	0.751
MOD_GlcNHglycan	253	256	PF01048	0.716
MOD_GlcNHglycan	268	271	PF01048	0.610
MOD_GlcNHglycan	282	285	PF01048	0.612
MOD_GlcNHglycan	289	292	PF01048	0.535
MOD_GlcNHglycan	325	328	PF01048	0.681
MOD_GlcNHglycan	329	332	PF01048	0.675
MOD_GlcNHglycan	364	367	PF01048	0.728
MOD_GlcNHglycan	458	461	PF01048	0.444
MOD_GlcNHglycan	54	57	PF01048	0.684
MOD_GlcNHglycan	554	557	PF01048	0.584
MOD_GlcNHglycan	587	590	PF01048	0.529
MOD_GlcNHglycan	66	69	PF01048	0.631
MOD_GlcNHglycan	664	667	PF01048	0.733
MOD_GlcNHglycan	682	685	PF01048	0.687
MOD_GlcNHglycan	692	695	PF01048	0.816
MOD_GlcNHglycan	733	737	PF01048	0.767
MOD_GlcNHglycan	82	85	PF01048	0.739
MOD_GlcNHglycan	832	835	PF01048	0.747
MOD_GlcNHglycan	846	849	PF01048	0.581
MOD_GlcNHglycan	95	98	PF01048	0.558
MOD_GSK3_1	136	143	PF00069	0.668
MOD_GSK3_1	151	158	PF00069	0.585
MOD_GSK3_1	23	30	PF00069	0.543
MOD_GSK3_1	265	272	PF00069	0.605
MOD_GSK3_1	276	283	PF00069	0.584
MOD_GSK3_1	295	302	PF00069	0.765
MOD_GSK3_1	304	311	PF00069	0.644
MOD_GSK3_1	323	330	PF00069	0.558
MOD_GSK3_1	43	50	PF00069	0.570
MOD_GSK3_1	439	446	PF00069	0.395
MOD_GSK3_1	488	495	PF00069	0.617
MOD_GSK3_1	564	571	PF00069	0.664
MOD_GSK3_1	581	588	PF00069	0.464
MOD_GSK3_1	610	617	PF00069	0.478
MOD_GSK3_1	702	709	PF00069	0.629
MOD_GSK3_1	770	777	PF00069	0.404
MOD_N-GLC_1	476	481	PF02516	0.627
MOD_N-GLC_1	506	511	PF02516	0.627
MOD_N-GLC_1	64	69	PF02516	0.633
MOD_N-GLC_1	799	804	PF02516	0.515
MOD_NEK2_1	23	28	PF00069	0.639
MOD_NEK2_1	42	47	PF00069	0.479
MOD_NEK2_1	445	450	PF00069	0.359
MOD_NEK2_1	585	590	PF00069	0.518
MOD_NEK2_1	614	619	PF00069	0.442
MOD_NEK2_1	647	652	PF00069	0.446
MOD_NEK2_1	701	706	PF00069	0.593
MOD_NEK2_1	770	775	PF00069	0.590
MOD_PKA_2	156	162	PF00069	0.627
MOD_PKA_2	564	570	PF00069	0.572
MOD_PKA_2	610	616	PF00069	0.485
MOD_PKA_2	709	715	PF00069	0.485
MOD_PKA_2	93	99	PF00069	0.671
MOD_Plk_1	285	291	PF00069	0.621
MOD_Plk_1	647	653	PF00069	0.408
MOD_Plk_1	799	805	PF00069	0.494
MOD_Plk_2-3	799	805	PF00069	0.465
MOD_Plk_4	581	587	PF00069	0.507
MOD_Plk_4	610	616	PF00069	0.485
MOD_Plk_4	647	653	PF00069	0.422
MOD_Plk_4	703	709	PF00069	0.430
MOD_Plk_4	746	752	PF00069	0.411
MOD_Plk_4	783	789	PF00069	0.406
MOD_ProDKin_1	137	143	PF00069	0.706
MOD_ProDKin_1	151	157	PF00069	0.562
MOD_ProDKin_1	331	337	PF00069	0.587
MOD_ProDKin_1	425	431	PF00069	0.478
MOD_ProDKin_1	478	484	PF00069	0.642
MOD_ProDKin_1	549	555	PF00069	0.661
MOD_ProDKin_1	737	743	PF00069	0.595
MOD_SUMO_for_1	31	34	PF00179	0.589
MOD_SUMO_rev_2	849	858	PF00179	0.657
TRG_DiLeu_BaEn_1	398	403	PF01217	0.459
TRG_DiLeu_BaEn_1	862	867	PF01217	0.745
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.656
TRG_DiLeu_BaLyEn_6	589	594	PF01217	0.447
TRG_DiLeu_BaLyEn_6	625	630	PF01217	0.623
TRG_ENDOCYTIC_2	349	352	PF00928	0.554
TRG_ENDOCYTIC_2	874	877	PF00928	0.584
TRG_ER_diArg_1	185	187	PF00400	0.638
TRG_ER_diArg_1	76	78	PF00400	0.686
TRG_ER_diArg_1	820	822	PF00400	0.703
TRG_ER_diArg_1	855	858	PF00400	0.624
TRG_NLS_MonoExtN_4	855	860	PF00514	0.567
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	207	212	PF00026	0.661
TRG_Pf-PMV_PEXEL_1	592	597	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	628	633	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H6Z8	Leishmania braziliensis	69%	99%
C9ZI14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AGI2	Leishmania infantum	99%	100%
E9AP18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4QGH1	Leishmania major	86%	100%