Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHU7_LEIDO

TriTrypDb:

LdBPK_301230.1 , LdCL_300017500 , LDHU3_30.1610

Length:

682

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IHU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHU7

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016409	palmitoyltransferase activity	5	8
GO:0016417	S-acyltransferase activity	5	8
GO:0016740	transferase activity	2	8
GO:0016746	acyltransferase activity	3	8
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	8
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	8
GO:0019707	protein-cysteine S-acyltransferase activity	3	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	376	380	PF00656	0.598
CLV_C14_Caspase3-7	648	652	PF00656	0.650
CLV_NRD_NRD_1	112	114	PF00675	0.510
CLV_NRD_NRD_1	236	238	PF00675	0.487
CLV_NRD_NRD_1	326	328	PF00675	0.418
CLV_NRD_NRD_1	525	527	PF00675	0.417
CLV_NRD_NRD_1	643	645	PF00675	0.440
CLV_PCSK_KEX2_1	20	22	PF00082	0.516
CLV_PCSK_KEX2_1	236	238	PF00082	0.475
CLV_PCSK_KEX2_1	325	327	PF00082	0.413
CLV_PCSK_KEX2_1	405	407	PF00082	0.488
CLV_PCSK_KEX2_1	525	527	PF00082	0.450
CLV_PCSK_KEX2_1	575	577	PF00082	0.355
CLV_PCSK_KEX2_1	676	678	PF00082	0.434
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.516
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.459
CLV_PCSK_PC1ET2_1	575	577	PF00082	0.355
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.434
CLV_PCSK_SKI1_1	185	189	PF00082	0.494
CLV_PCSK_SKI1_1	329	333	PF00082	0.427
CLV_PCSK_SKI1_1	422	426	PF00082	0.557
CLV_PCSK_SKI1_1	525	529	PF00082	0.417
CLV_PCSK_SKI1_1	562	566	PF00082	0.288
CLV_Separin_Metazoa	668	672	PF03568	0.639
DEG_APCC_DBOX_1	324	332	PF00400	0.658
DEG_APCC_DBOX_1	524	532	PF00400	0.217
DEG_APCC_DBOX_1	53	61	PF00400	0.655
DEG_APCC_KENBOX_2	180	184	PF00400	0.707
DEG_COP1_1	431	440	PF00400	0.657
DOC_CYCLIN_yCln2_LP_2	440	446	PF00134	0.605
DOC_MAPK_FxFP_2	548	551	PF00069	0.361
DOC_MAPK_gen_1	525	536	PF00069	0.318
DOC_MAPK_MEF2A_6	334	342	PF00069	0.642
DOC_MAPK_MEF2A_6	529	538	PF00069	0.265
DOC_PP1_RVXF_1	630	636	PF00149	0.634
DOC_PP2B_LxvP_1	435	438	PF13499	0.655
DOC_PP2B_LxvP_1	637	640	PF13499	0.627
DOC_PP4_FxxP_1	317	320	PF00568	0.574
DOC_PP4_FxxP_1	548	551	PF00568	0.361
DOC_USP7_MATH_1	176	180	PF00917	0.670
DOC_USP7_MATH_1	290	294	PF00917	0.330
DOC_USP7_MATH_1	378	382	PF00917	0.686
DOC_USP7_MATH_1	387	391	PF00917	0.604
DOC_USP7_MATH_1	45	49	PF00917	0.742
DOC_USP7_MATH_1	65	69	PF00917	0.608
DOC_USP7_MATH_1	72	76	PF00917	0.745
DOC_USP7_MATH_1	82	86	PF00917	0.677
DOC_USP7_UBL2_3	181	185	PF12436	0.669
DOC_USP7_UBL2_3	571	575	PF12436	0.506
DOC_WW_Pin1_4	1	6	PF00397	0.670
DOC_WW_Pin1_4	48	53	PF00397	0.793
DOC_WW_Pin1_4	9	14	PF00397	0.686
LIG_14-3-3_CanoR_1	21	28	PF00244	0.748
LIG_14-3-3_CanoR_1	329	338	PF00244	0.573
LIG_14-3-3_CanoR_1	33	42	PF00244	0.675
LIG_14-3-3_CanoR_1	406	410	PF00244	0.666
LIG_14-3-3_CanoR_1	429	437	PF00244	0.631
LIG_14-3-3_CanoR_1	514	518	PF00244	0.365
LIG_14-3-3_CanoR_1	54	60	PF00244	0.806
LIG_14-3-3_CanoR_1	562	570	PF00244	0.500
LIG_BIR_II_1	1	5	PF00653	0.728
LIG_BRCT_BRCA1_1	240	244	PF00533	0.699
LIG_BRCT_BRCA1_1	492	496	PF00533	0.378
LIG_BRCT_BRCA1_1	576	580	PF00533	0.609
LIG_deltaCOP1_diTrp_1	292	302	PF00928	0.310
LIG_eIF4E_1	489	495	PF01652	0.361
LIG_FHA_1	175	181	PF00498	0.723
LIG_FHA_1	418	424	PF00498	0.644
LIG_FHA_1	447	453	PF00498	0.448
LIG_FHA_2	195	201	PF00498	0.657
LIG_FHA_2	563	569	PF00498	0.464
LIG_GBD_Chelix_1	299	307	PF00786	0.326
LIG_Integrin_RGD_1	334	336	PF01839	0.479
LIG_LIR_Apic_2	516	520	PF02991	0.282
LIG_LIR_Gen_1	200	209	PF02991	0.625
LIG_LIR_Gen_1	292	303	PF02991	0.323
LIG_LIR_Gen_1	308	317	PF02991	0.282
LIG_LIR_Gen_1	493	504	PF02991	0.378
LIG_LIR_Nem_3	200	206	PF02991	0.624
LIG_LIR_Nem_3	292	298	PF02991	0.382
LIG_LIR_Nem_3	308	314	PF02991	0.264
LIG_LIR_Nem_3	439	445	PF02991	0.640
LIG_LIR_Nem_3	493	499	PF02991	0.357
LIG_LIR_Nem_3	541	545	PF02991	0.358
LIG_LIR_Nem_3	577	583	PF02991	0.636
LIG_LIR_Nem_3	616	622	PF02991	0.582
LIG_LIR_Nem_3	8	14	PF02991	0.705
LIG_LYPXL_S_1	280	284	PF13949	0.361
LIG_MLH1_MIPbox_1	492	496	PF16413	0.378
LIG_MLH1_MIPbox_1	576	580	PF16413	0.609
LIG_MYND_3	437	441	PF01753	0.642
LIG_PCNA_PIPBox_1	409	418	PF02747	0.599
LIG_Pex14_1	269	273	PF04695	0.361
LIG_Pex14_2	442	446	PF04695	0.593
LIG_Pex14_2	491	495	PF04695	0.378
LIG_SH2_CRK	203	207	PF00017	0.649
LIG_SH2_CRK	275	279	PF00017	0.398
LIG_SH2_CRK	503	507	PF00017	0.361
LIG_SH2_CRK	532	536	PF00017	0.306
LIG_SH2_CRK	592	596	PF00017	0.599
LIG_SH2_GRB2like	592	595	PF00017	0.567
LIG_SH2_NCK_1	11	15	PF00017	0.701
LIG_SH2_NCK_1	203	207	PF00017	0.646
LIG_SH2_SRC	517	520	PF00017	0.342
LIG_SH2_SRC	530	533	PF00017	0.217
LIG_SH2_SRC	592	595	PF00017	0.567
LIG_SH2_STAP1	203	207	PF00017	0.646
LIG_SH2_STAP1	383	387	PF00017	0.687
LIG_SH2_STAP1	503	507	PF00017	0.378
LIG_SH2_STAP1	596	600	PF00017	0.565
LIG_SH2_STAP1	91	95	PF00017	0.702
LIG_SH2_STAT5	383	386	PF00017	0.691
LIG_SH2_STAT5	415	418	PF00017	0.672
LIG_SH2_STAT5	489	492	PF00017	0.385
LIG_SH2_STAT5	517	520	PF00017	0.307
LIG_SH2_STAT5	530	533	PF00017	0.281
LIG_SH2_STAT5	539	542	PF00017	0.388
LIG_SH2_STAT5	579	582	PF00017	0.639
LIG_SH3_3	130	136	PF00018	0.708
LIG_SH3_3	227	233	PF00018	0.682
LIG_SH3_3	260	266	PF00018	0.610
LIG_SH3_3	337	343	PF00018	0.602
LIG_SH3_3	36	42	PF00018	0.735
LIG_SH3_3	57	63	PF00018	0.713
LIG_SUMO_SIM_anti_2	305	311	PF11976	0.375
LIG_SUMO_SIM_anti_2	336	341	PF11976	0.639
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.655
LIG_SxIP_EBH_1	185	199	PF03271	0.695
LIG_TRAF2_1	198	201	PF00917	0.669
LIG_TRAF2_1	605	608	PF00917	0.631
LIG_TRAF2_1	640	643	PF00917	0.611
LIG_TYR_ITIM	501	506	PF00017	0.361
LIG_WRC_WIRS_1	539	544	PF05994	0.361
MOD_CDC14_SPxK_1	51	54	PF00782	0.560
MOD_CDK_SPxK_1	48	54	PF00069	0.580
MOD_CK1_1	23	29	PF00069	0.759
MOD_CK1_1	305	311	PF00069	0.361
MOD_CK1_1	381	387	PF00069	0.610
MOD_CK1_1	48	54	PF00069	0.710
MOD_CK1_1	55	61	PF00069	0.658
MOD_CK2_1	172	178	PF00069	0.699
MOD_CK2_1	194	200	PF00069	0.592
MOD_CK2_1	562	568	PF00069	0.301
MOD_CK2_1	82	88	PF00069	0.746
MOD_GlcNHglycan	144	147	PF01048	0.753
MOD_GlcNHglycan	150	153	PF01048	0.637
MOD_GlcNHglycan	174	177	PF01048	0.748
MOD_GlcNHglycan	292	295	PF01048	0.560
MOD_GlcNHglycan	304	307	PF01048	0.361
MOD_GlcNHglycan	373	376	PF01048	0.716
MOD_GlcNHglycan	379	383	PF01048	0.772
MOD_GlcNHglycan	389	392	PF01048	0.559
MOD_GlcNHglycan	47	50	PF01048	0.701
MOD_GlcNHglycan	88	91	PF01048	0.712
MOD_GSK3_1	140	147	PF00069	0.664
MOD_GSK3_1	170	177	PF00069	0.660
MOD_GSK3_1	20	27	PF00069	0.825
MOD_GSK3_1	228	235	PF00069	0.537
MOD_GSK3_1	29	36	PF00069	0.748
MOD_GSK3_1	404	411	PF00069	0.593
MOD_GSK3_1	48	55	PF00069	0.640
MOD_GSK3_1	82	89	PF00069	0.683
MOD_N-GLC_1	329	334	PF02516	0.597
MOD_N-GLC_1	45	50	PF02516	0.655
MOD_N-GLC_2	479	481	PF02516	0.450
MOD_NEK2_1	188	193	PF00069	0.590
MOD_NEK2_1	238	243	PF00069	0.636
MOD_NEK2_1	446	451	PF00069	0.376
MOD_NEK2_1	490	495	PF00069	0.361
MOD_NEK2_1	557	562	PF00069	0.325
MOD_NEK2_1	86	91	PF00069	0.647
MOD_NEK2_2	176	181	PF00069	0.517
MOD_PIKK_1	33	39	PF00454	0.602
MOD_PIKK_1	584	590	PF00454	0.473
MOD_PKA_1	20	26	PF00069	0.656
MOD_PKA_1	405	411	PF00069	0.530
MOD_PKA_2	20	26	PF00069	0.708
MOD_PKA_2	29	35	PF00069	0.623
MOD_PKA_2	405	411	PF00069	0.588
MOD_PKA_2	428	434	PF00069	0.602
MOD_PKA_2	513	519	PF00069	0.443
MOD_PKB_1	327	335	PF00069	0.462
MOD_Plk_1	378	384	PF00069	0.621
MOD_Plk_4	305	311	PF00069	0.399
MOD_Plk_4	397	403	PF00069	0.597
MOD_Plk_4	405	411	PF00069	0.590
MOD_Plk_4	490	496	PF00069	0.363
MOD_Plk_4	513	519	PF00069	0.396
MOD_Plk_4	55	61	PF00069	0.598
MOD_ProDKin_1	1	7	PF00069	0.591
MOD_ProDKin_1	48	54	PF00069	0.765
MOD_ProDKin_1	9	15	PF00069	0.611
MOD_SUMO_rev_2	219	227	PF00179	0.594
MOD_SUMO_rev_2	629	633	PF00179	0.459
MOD_SUMO_rev_2	642	647	PF00179	0.509
TRG_DiLeu_BaLyEn_6	595	600	PF01217	0.398
TRG_ENDOCYTIC_2	11	14	PF00928	0.632
TRG_ENDOCYTIC_2	203	206	PF00928	0.555
TRG_ENDOCYTIC_2	275	278	PF00928	0.398
TRG_ENDOCYTIC_2	281	284	PF00928	0.398
TRG_ENDOCYTIC_2	487	490	PF00928	0.339
TRG_ENDOCYTIC_2	503	506	PF00928	0.339
TRG_ENDOCYTIC_2	539	542	PF00928	0.330
TRG_ENDOCYTIC_2	592	595	PF00928	0.485
TRG_ENDOCYTIC_2	596	599	PF00928	0.372
TRG_ENDOCYTIC_2	619	622	PF00928	0.448
TRG_ER_diArg_1	236	238	PF00400	0.614
TRG_ER_diArg_1	324	327	PF00400	0.507
TRG_ER_diArg_1	524	526	PF00400	0.236

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P984	Leptomonas seymouri	65%	96%
A0A1X0P316	Trypanosomatidae	34%	100%
A4HI71	Leishmania braziliensis	72%	100%
A4I5E8	Leishmania infantum	100%	100%
E9B0P6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q7I6	Leishmania major	92%	100%