TPR-repeat_protein_putative/GeneDB:LmjF.27.2390

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR-repeat protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHU4_LEIDO

TriTrypDb:

LdBPK_272340.1 , LdCL_270031800 , LDHU3_27.3570

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0101031	protein folding chaperone complex	3	1
GO:0140535	intracellular protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8IHU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHU4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.685
CLV_NRD_NRD_1	167	169	PF00675	0.291
CLV_NRD_NRD_1	171	173	PF00675	0.291
CLV_NRD_NRD_1	272	274	PF00675	0.561
CLV_NRD_NRD_1	277	279	PF00675	0.553
CLV_NRD_NRD_1	301	303	PF00675	0.637
CLV_NRD_NRD_1	381	383	PF00675	0.338
CLV_NRD_NRD_1	39	41	PF00675	0.602
CLV_NRD_NRD_1	483	485	PF00675	0.518
CLV_PCSK_FUR_1	299	303	PF00082	0.606
CLV_PCSK_KEX2_1	167	169	PF00082	0.291
CLV_PCSK_KEX2_1	212	214	PF00082	0.605
CLV_PCSK_KEX2_1	230	232	PF00082	0.397
CLV_PCSK_KEX2_1	272	274	PF00082	0.566
CLV_PCSK_KEX2_1	298	300	PF00082	0.609
CLV_PCSK_KEX2_1	301	303	PF00082	0.601
CLV_PCSK_KEX2_1	381	383	PF00082	0.338
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.605
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.397
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.601
CLV_PCSK_SKI1_1	149	153	PF00082	0.475
CLV_PCSK_SKI1_1	484	488	PF00082	0.474
DEG_APCC_DBOX_1	16	24	PF00400	0.594
DEG_APCC_DBOX_1	171	179	PF00400	0.312
DEG_APCC_DBOX_1	181	189	PF00400	0.291
DEG_Nend_UBRbox_2	1	3	PF02207	0.592
DEG_SPOP_SBC_1	219	223	PF00917	0.469
DEG_SPOP_SBC_1	345	349	PF00917	0.772
DEG_SPOP_SBC_1	350	354	PF00917	0.781
DOC_CKS1_1	370	375	PF01111	0.536
DOC_CKS1_1	472	477	PF01111	0.539
DOC_MAPK_gen_1	228	234	PF00069	0.633
DOC_MAPK_gen_1	298	308	PF00069	0.571
DOC_MAPK_MEF2A_6	445	453	PF00069	0.479
DOC_USP7_MATH_1	214	218	PF00917	0.591
DOC_USP7_MATH_1	249	253	PF00917	0.706
DOC_USP7_MATH_1	326	330	PF00917	0.682
DOC_USP7_MATH_1	345	349	PF00917	0.718
DOC_USP7_MATH_1	366	370	PF00917	0.659
DOC_USP7_MATH_1	76	80	PF00917	0.666
DOC_USP7_UBL2_3	173	177	PF12436	0.380
DOC_USP7_UBL2_3	37	41	PF12436	0.601
DOC_WW_Pin1_4	312	317	PF00397	0.729
DOC_WW_Pin1_4	322	327	PF00397	0.673
DOC_WW_Pin1_4	333	338	PF00397	0.628
DOC_WW_Pin1_4	340	345	PF00397	0.670
DOC_WW_Pin1_4	346	351	PF00397	0.750
DOC_WW_Pin1_4	369	374	PF00397	0.460
DOC_WW_Pin1_4	411	416	PF00397	0.463
DOC_WW_Pin1_4	471	476	PF00397	0.526
LIG_APCC_ABBA_1	449	454	PF00400	0.436
LIG_FHA_1	113	119	PF00498	0.472
LIG_FHA_1	124	130	PF00498	0.457
LIG_FHA_1	150	156	PF00498	0.472
LIG_FHA_1	204	210	PF00498	0.426
LIG_FHA_1	334	340	PF00498	0.720
LIG_FHA_1	429	435	PF00498	0.526
LIG_FHA_2	143	149	PF00498	0.533
LIG_FHA_2	256	262	PF00498	0.664
LIG_LIR_Gen_1	375	383	PF02991	0.453
LIG_LIR_Gen_1	394	402	PF02991	0.434
LIG_LIR_Nem_3	375	379	PF02991	0.453
LIG_LIR_Nem_3	380	386	PF02991	0.450
LIG_LIR_Nem_3	394	399	PF02991	0.434
LIG_PCNA_PIPBox_1	389	398	PF02747	0.557
LIG_Pex14_2	379	383	PF04695	0.463
LIG_SH2_GRB2like	131	134	PF00017	0.435
LIG_SH2_NCK_1	161	165	PF00017	0.371
LIG_SH2_PTP2	396	399	PF00017	0.436
LIG_SH2_STAP1	131	135	PF00017	0.430
LIG_SH2_STAP1	161	165	PF00017	0.371
LIG_SH2_STAT5	114	117	PF00017	0.475
LIG_SH2_STAT5	138	141	PF00017	0.401
LIG_SH2_STAT5	396	399	PF00017	0.463
LIG_SH3_1	469	475	PF00018	0.597
LIG_SH3_2	472	477	PF14604	0.617
LIG_SH3_3	334	340	PF00018	0.753
LIG_SH3_3	384	390	PF00018	0.549
LIG_SH3_3	39	45	PF00018	0.651
LIG_SH3_3	469	475	PF00018	0.597
LIG_SUMO_SIM_anti_2	304	313	PF11976	0.663
LIG_SUMO_SIM_anti_2	463	470	PF11976	0.459
LIG_TRAF2_1	198	201	PF00917	0.538
LIG_TRAF2_1	257	260	PF00917	0.662
LIG_TRAF2_1	280	283	PF00917	0.626
LIG_TRAF2_1	316	319	PF00917	0.781
LIG_UBA3_1	417	426	PF00899	0.452
LIG_WRC_WIRS_1	425	430	PF05994	0.538
LIG_WW_2	337	340	PF00397	0.549
MOD_CDK_SPK_2	369	374	PF00069	0.493
MOD_CDK_SPxK_1	471	477	PF00069	0.529
MOD_CK1_1	124	130	PF00069	0.482
MOD_CK1_1	217	223	PF00069	0.672
MOD_CK1_1	325	331	PF00069	0.693
MOD_CK1_1	348	354	PF00069	0.679
MOD_CK1_1	369	375	PF00069	0.485
MOD_CK1_1	411	417	PF00069	0.507
MOD_CK2_1	1	7	PF00069	0.637
MOD_CK2_1	142	148	PF00069	0.466
MOD_CK2_1	286	292	PF00069	0.530
MOD_CK2_1	312	318	PF00069	0.755
MOD_CK2_1	372	378	PF00069	0.306
MOD_CK2_1	441	447	PF00069	0.501
MOD_CK2_1	58	64	PF00069	0.551
MOD_GlcNHglycan	103	106	PF01048	0.551
MOD_GlcNHglycan	123	126	PF01048	0.572
MOD_GlcNHglycan	195	199	PF01048	0.435
MOD_GlcNHglycan	251	254	PF01048	0.726
MOD_GlcNHglycan	328	331	PF01048	0.688
MOD_GlcNHglycan	353	356	PF01048	0.725
MOD_GlcNHglycan	46	49	PF01048	0.721
MOD_GlcNHglycan	469	472	PF01048	0.531
MOD_GlcNHglycan	78	81	PF01048	0.612
MOD_GSK3_1	214	221	PF00069	0.636
MOD_GSK3_1	251	258	PF00069	0.603
MOD_GSK3_1	322	329	PF00069	0.679
MOD_GSK3_1	340	347	PF00069	0.694
MOD_GSK3_1	350	357	PF00069	0.663
MOD_GSK3_1	368	375	PF00069	0.519
MOD_GSK3_1	424	431	PF00069	0.516
MOD_GSK3_1	467	474	PF00069	0.411
MOD_N-GLC_1	411	416	PF02516	0.263
MOD_N-GLC_1	428	433	PF02516	0.263
MOD_NEK2_1	1	6	PF00069	0.642
MOD_NEK2_1	101	106	PF00069	0.505
MOD_NEK2_1	251	256	PF00069	0.544
MOD_NEK2_1	35	40	PF00069	0.565
MOD_NEK2_1	408	413	PF00069	0.500
MOD_NEK2_1	428	433	PF00069	0.321
MOD_NEK2_1	467	472	PF00069	0.466
MOD_PIKK_1	214	220	PF00454	0.581
MOD_PIKK_1	251	257	PF00454	0.536
MOD_PIKK_1	286	292	PF00454	0.536
MOD_PIKK_1	35	41	PF00454	0.606
MOD_PKA_2	55	61	PF00069	0.561
MOD_Plk_1	1	7	PF00069	0.637
MOD_Plk_2-3	236	242	PF00069	0.727
MOD_ProDKin_1	312	318	PF00069	0.733
MOD_ProDKin_1	322	328	PF00069	0.674
MOD_ProDKin_1	333	339	PF00069	0.629
MOD_ProDKin_1	340	346	PF00069	0.672
MOD_ProDKin_1	369	375	PF00069	0.457
MOD_ProDKin_1	411	417	PF00069	0.463
MOD_ProDKin_1	471	477	PF00069	0.529
MOD_SUMO_rev_2	13	23	PF00179	0.500
MOD_SUMO_rev_2	312	322	PF00179	0.727
MOD_SUMO_rev_2	478	486	PF00179	0.549
TRG_DiLeu_BaLyEn_6	395	400	PF01217	0.474
TRG_ENDOCYTIC_2	138	141	PF00928	0.430
TRG_ENDOCYTIC_2	396	399	PF00928	0.432
TRG_ER_diArg_1	166	168	PF00400	0.291
TRG_ER_diArg_1	271	273	PF00400	0.619
TRG_ER_diArg_1	299	302	PF00400	0.589
TRG_ER_diArg_1	359	362	PF00400	0.725
TRG_ER_diArg_1	381	383	PF00400	0.538
TRG_ER_diLys_1	485	489	PF00400	0.561
TRG_NLS_Bipartite_1	212	233	PF00514	0.649
TRG_NLS_MonoCore_2	227	232	PF00514	0.627
TRG_NLS_MonoExtC_3	297	302	PF00514	0.578
TRG_NLS_MonoExtN_4	228	233	PF00514	0.581
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.274

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF88	Leptomonas seymouri	62%	99%
A0A0S4J9Z5	Bodo saltans	40%	100%
A0A1X0NH58	Trypanosomatidae	39%	100%
A0A3R7KY85	Trypanosoma rangeli	39%	100%
A4HG19	Leishmania braziliensis	82%	99%
A4I340	Leishmania infantum	99%	100%
C9ZJL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ACV9	Leishmania major	93%	100%
E9AZE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q28IV3	Xenopus tropicalis	25%	74%
Q5ZKQ3	Gallus gallus	24%	74%
Q68FQ7	Rattus norvegicus	26%	74%
Q6NU95	Xenopus laevis	26%	74%
Q9D706	Mus musculus	25%	74%
V5AR46	Trypanosoma cruzi	38%	100%