Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHT9_LEIDO

TriTrypDb:

LdBPK_331670.1 , LdCL_330023300 , LDHU3_33.2510

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IHT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHT9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.530
CLV_NRD_NRD_1	462	464	PF00675	0.673
CLV_NRD_NRD_1	487	489	PF00675	0.574
CLV_NRD_NRD_1	496	498	PF00675	0.495
CLV_NRD_NRD_1	8	10	PF00675	0.707
CLV_PCSK_KEX2_1	104	106	PF00082	0.526
CLV_PCSK_KEX2_1	15	17	PF00082	0.695
CLV_PCSK_KEX2_1	462	464	PF00082	0.673
CLV_PCSK_KEX2_1	496	498	PF00082	0.557
CLV_PCSK_KEX2_1	8	10	PF00082	0.720
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.411
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.748
CLV_PCSK_PC7_1	4	10	PF00082	0.625
CLV_PCSK_SKI1_1	244	248	PF00082	0.609
CLV_PCSK_SKI1_1	302	306	PF00082	0.523
CLV_PCSK_SKI1_1	42	46	PF00082	0.794
CLV_PCSK_SKI1_1	8	12	PF00082	0.700
CLV_PCSK_SKI1_1	85	89	PF00082	0.511
DEG_MDM2_SWIB_1	156	163	PF02201	0.525
DEG_Nend_UBRbox_3	1	3	PF02207	0.656
DEG_SPOP_SBC_1	166	170	PF00917	0.683
DEG_SPOP_SBC_1	44	48	PF00917	0.780
DOC_CKS1_1	207	212	PF01111	0.569
DOC_CYCLIN_RxL_1	383	391	PF00134	0.414
DOC_MAPK_MEF2A_6	424	432	PF00069	0.627
DOC_PP1_RVXF_1	7	14	PF00149	0.623
DOC_PP2B_LxvP_1	327	330	PF13499	0.640
DOC_USP7_MATH_1	143	147	PF00917	0.525
DOC_USP7_MATH_1	166	170	PF00917	0.596
DOC_USP7_MATH_1	255	259	PF00917	0.474
DOC_USP7_MATH_1	284	288	PF00917	0.723
DOC_USP7_MATH_1	44	48	PF00917	0.705
DOC_USP7_MATH_1	54	58	PF00917	0.719
DOC_USP7_MATH_1	70	74	PF00917	0.470
DOC_WW_Pin1_4	168	173	PF00397	0.676
DOC_WW_Pin1_4	206	211	PF00397	0.485
DOC_WW_Pin1_4	322	327	PF00397	0.625
DOC_WW_Pin1_4	338	343	PF00397	0.392
DOC_WW_Pin1_4	431	436	PF00397	0.571
DOC_WW_Pin1_4	467	472	PF00397	0.693
DOC_WW_Pin1_4	79	84	PF00397	0.648
LIG_14-3-3_CanoR_1	105	110	PF00244	0.545
LIG_14-3-3_CanoR_1	231	239	PF00244	0.627
LIG_14-3-3_CanoR_1	386	391	PF00244	0.519
LIG_14-3-3_CanoR_1	42	51	PF00244	0.740
LIG_14-3-3_CanoR_1	443	448	PF00244	0.601
LIG_14-3-3_CanoR_1	488	498	PF00244	0.561
LIG_14-3-3_CanoR_1	506	512	PF00244	0.483
LIG_14-3-3_CanoR_1	74	80	PF00244	0.543
LIG_BRCT_BRCA1_1	152	156	PF00533	0.441
LIG_BRCT_BRCA1_1	47	51	PF00533	0.697
LIG_DLG_GKlike_1	386	393	PF00625	0.563
LIG_FHA_1	212	218	PF00498	0.459
LIG_FHA_1	249	255	PF00498	0.445
LIG_FHA_1	396	402	PF00498	0.521
LIG_FHA_1	403	409	PF00498	0.482
LIG_FHA_1	423	429	PF00498	0.594
LIG_FHA_2	293	299	PF00498	0.608
LIG_FHA_2	480	486	PF00498	0.691
LIG_LIR_Apic_2	265	270	PF02991	0.520
LIG_LIR_Gen_1	343	353	PF02991	0.406
LIG_LIR_Nem_3	343	349	PF02991	0.419
LIG_LIR_Nem_3	94	99	PF02991	0.440
LIG_Pex14_1	95	99	PF04695	0.421
LIG_Pex14_2	156	160	PF04695	0.510
LIG_Pex14_2	256	260	PF04695	0.382
LIG_Pex14_2	71	75	PF04695	0.569
LIG_SH2_STAT5	403	406	PF00017	0.420
LIG_SH2_STAT5	99	102	PF00017	0.433
LIG_SH3_2	37	42	PF14604	0.576
LIG_SH3_3	336	342	PF00018	0.424
LIG_SH3_3	34	40	PF00018	0.576
LIG_SH3_3	379	385	PF00018	0.663
LIG_SH3_3	429	435	PF00018	0.524
LIG_SUMO_SIM_par_1	134	140	PF11976	0.462
LIG_SUMO_SIM_par_1	203	209	PF11976	0.499
LIG_TRAF2_1	295	298	PF00917	0.520
LIG_TRAF2_1	342	345	PF00917	0.502
LIG_TRAF2_2	342	347	PF00917	0.544
LIG_WW_3	383	387	PF00397	0.534
MOD_CDC14_SPxK_1	82	85	PF00782	0.677
MOD_CDK_SPxK_1	79	85	PF00069	0.656
MOD_CK1_1	185	191	PF00069	0.638
MOD_CK1_1	234	240	PF00069	0.650
MOD_CK1_1	368	374	PF00069	0.696
MOD_CK1_1	434	440	PF00069	0.528
MOD_CK1_1	446	452	PF00069	0.554
MOD_CK1_1	47	53	PF00069	0.775
MOD_CK1_1	472	478	PF00069	0.707
MOD_CK1_1	479	485	PF00069	0.658
MOD_CK1_1	57	63	PF00069	0.598
MOD_CK1_1	73	79	PF00069	0.347
MOD_CK2_1	284	290	PF00069	0.657
MOD_CK2_1	292	298	PF00069	0.491
MOD_CK2_1	359	365	PF00069	0.457
MOD_CK2_1	446	452	PF00069	0.599
MOD_CK2_1	479	485	PF00069	0.691
MOD_CK2_1	496	502	PF00069	0.392
MOD_DYRK1A_RPxSP_1	431	435	PF00069	0.595
MOD_GlcNHglycan	117	120	PF01048	0.751
MOD_GlcNHglycan	187	190	PF01048	0.583
MOD_GlcNHglycan	233	236	PF01048	0.564
MOD_GlcNHglycan	24	27	PF01048	0.779
MOD_GlcNHglycan	264	267	PF01048	0.505
MOD_GlcNHglycan	270	273	PF01048	0.596
MOD_GlcNHglycan	280	284	PF01048	0.582
MOD_GlcNHglycan	286	289	PF01048	0.576
MOD_GlcNHglycan	361	364	PF01048	0.595
MOD_GlcNHglycan	367	370	PF01048	0.723
MOD_GlcNHglycan	47	50	PF01048	0.768
MOD_GlcNHglycan	471	474	PF01048	0.747
MOD_GlcNHglycan	478	481	PF01048	0.664
MOD_GlcNHglycan	52	55	PF01048	0.735
MOD_GlcNHglycan	75	78	PF01048	0.578
MOD_GSK3_1	111	118	PF00069	0.672
MOD_GSK3_1	158	165	PF00069	0.535
MOD_GSK3_1	168	175	PF00069	0.621
MOD_GSK3_1	230	237	PF00069	0.538
MOD_GSK3_1	244	251	PF00069	0.549
MOD_GSK3_1	279	286	PF00069	0.785
MOD_GSK3_1	288	295	PF00069	0.627
MOD_GSK3_1	364	371	PF00069	0.652
MOD_GSK3_1	43	50	PF00069	0.725
MOD_GSK3_1	441	448	PF00069	0.587
MOD_GSK3_1	472	479	PF00069	0.690
MOD_GSK3_1	54	61	PF00069	0.588
MOD_LATS_1	441	447	PF00433	0.609
MOD_N-GLC_1	288	293	PF02516	0.710
MOD_N-GLC_1	371	376	PF02516	0.620
MOD_NEK2_1	150	155	PF00069	0.395
MOD_NEK2_1	187	192	PF00069	0.530
MOD_NEK2_1	218	223	PF00069	0.465
MOD_NEK2_1	32	37	PF00069	0.622
MOD_NEK2_1	388	393	PF00069	0.403
MOD_NEK2_1	414	419	PF00069	0.594
MOD_NEK2_1	445	450	PF00069	0.603
MOD_NEK2_1	456	461	PF00069	0.656
MOD_NEK2_1	58	63	PF00069	0.644
MOD_PIKK_1	137	143	PF00454	0.616
MOD_PIKK_1	340	346	PF00454	0.516
MOD_PIKK_1	59	65	PF00454	0.589
MOD_PK_1	443	449	PF00069	0.557
MOD_PKA_1	496	502	PF00069	0.548
MOD_PKA_2	182	188	PF00069	0.593
MOD_PKA_2	230	236	PF00069	0.590
MOD_PKA_2	268	274	PF00069	0.697
MOD_PKA_2	32	38	PF00069	0.744
MOD_PKA_2	496	502	PF00069	0.548
MOD_PKA_2	505	511	PF00069	0.579
MOD_PKA_2	73	79	PF00069	0.611
MOD_PKB_1	103	111	PF00069	0.437
MOD_Plk_1	244	250	PF00069	0.675
MOD_Plk_1	451	457	PF00069	0.661
MOD_Plk_1	85	91	PF00069	0.526
MOD_Plk_4	151	157	PF00069	0.400
MOD_Plk_4	182	188	PF00069	0.651
MOD_Plk_4	255	261	PF00069	0.395
MOD_ProDKin_1	168	174	PF00069	0.667
MOD_ProDKin_1	206	212	PF00069	0.481
MOD_ProDKin_1	322	328	PF00069	0.630
MOD_ProDKin_1	338	344	PF00069	0.396
MOD_ProDKin_1	431	437	PF00069	0.573
MOD_ProDKin_1	467	473	PF00069	0.693
MOD_ProDKin_1	79	85	PF00069	0.656
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.451
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.704
TRG_ER_diArg_1	103	106	PF00400	0.404
TRG_ER_diArg_1	495	497	PF00400	0.534
TRG_ER_diArg_1	8	10	PF00400	0.703
TRG_NES_CRM1_1	303	318	PF08389	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U7	Leptomonas seymouri	51%	100%
A0A3R7LW25	Trypanosoma rangeli	29%	100%
A4HLL8	Leishmania braziliensis	75%	100%
A4I929	Leishmania infantum	98%	100%
D0A532	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B3Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q430	Leishmania major	92%	100%
V5DDH0	Trypanosoma cruzi	27%	100%