Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHT7_LEIDO

TriTrypDb:

LdBPK_365300.1 , LdCL_360060200 , LDHU3_36.7080

Length:

393

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHT7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	329	331	PF00675	0.420
CLV_NRD_NRD_1	373	375	PF00675	0.430
CLV_NRD_NRD_1	57	59	PF00675	0.558
CLV_PCSK_FUR_1	55	59	PF00082	0.578
CLV_PCSK_KEX2_1	160	162	PF00082	0.464
CLV_PCSK_KEX2_1	329	331	PF00082	0.483
CLV_PCSK_KEX2_1	373	375	PF00082	0.498
CLV_PCSK_KEX2_1	57	59	PF00082	0.547
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.464
CLV_PCSK_SKI1_1	10	14	PF00082	0.725
CLV_PCSK_SKI1_1	160	164	PF00082	0.472
CLV_PCSK_SKI1_1	373	377	PF00082	0.419
CLV_PCSK_SKI1_1	379	383	PF00082	0.449
CLV_PCSK_SKI1_1	46	50	PF00082	0.570
DOC_CDC14_PxL_1	305	313	PF14671	0.560
DOC_CKS1_1	318	323	PF01111	0.420
DOC_MAPK_gen_1	248	257	PF00069	0.578
DOC_MAPK_gen_1	329	340	PF00069	0.463
DOC_MAPK_gen_1	34	42	PF00069	0.574
DOC_MAPK_gen_1	373	382	PF00069	0.430
DOC_MAPK_gen_1	97	105	PF00069	0.558
DOC_MAPK_MEF2A_6	376	384	PF00069	0.464
DOC_PP1_RVXF_1	208	215	PF00149	0.432
DOC_PP4_FxxP_1	346	349	PF00568	0.378
DOC_USP7_MATH_1	133	137	PF00917	0.685
DOC_USP7_MATH_1	174	178	PF00917	0.451
DOC_WW_Pin1_4	198	203	PF00397	0.528
DOC_WW_Pin1_4	250	255	PF00397	0.525
DOC_WW_Pin1_4	317	322	PF00397	0.376
LIG_14-3-3_CanoR_1	14	19	PF00244	0.598
LIG_14-3-3_CanoR_1	165	170	PF00244	0.454
LIG_14-3-3_CanoR_1	315	321	PF00244	0.436
LIG_14-3-3_CanoR_1	379	385	PF00244	0.483
LIG_BIR_II_1	1	5	PF00653	0.699
LIG_Clathr_ClatBox_1	368	372	PF01394	0.495
LIG_CSL_BTD_1	154	157	PF09270	0.463
LIG_FHA_1	199	205	PF00498	0.359
LIG_FHA_1	317	323	PF00498	0.407
LIG_FHA_1	87	93	PF00498	0.451
LIG_FHA_2	251	257	PF00498	0.570
LIG_LIR_Apic_2	168	174	PF02991	0.353
LIG_LIR_Gen_1	116	125	PF02991	0.457
LIG_LIR_Gen_1	166	176	PF02991	0.491
LIG_LIR_Gen_1	73	79	PF02991	0.389
LIG_LIR_Nem_3	116	120	PF02991	0.449
LIG_LIR_Nem_3	166	172	PF02991	0.453
LIG_LIR_Nem_3	73	78	PF02991	0.374
LIG_PTB_Apo_2	299	306	PF02174	0.525
LIG_PTB_Apo_2	340	347	PF02174	0.536
LIG_SH2_CRK	167	171	PF00017	0.508
LIG_SH2_GRB2like	233	236	PF00017	0.424
LIG_SH2_SRC	171	174	PF00017	0.434
LIG_SH2_STAP1	167	171	PF00017	0.446
LIG_SH2_STAP1	245	249	PF00017	0.376
LIG_SH2_STAT5	167	170	PF00017	0.375
LIG_SH2_STAT5	171	174	PF00017	0.416
LIG_SH2_STAT5	28	31	PF00017	0.682
LIG_SH3_2	292	297	PF14604	0.621
LIG_SH3_2	321	326	PF14604	0.421
LIG_SH3_3	205	211	PF00018	0.520
LIG_SH3_3	244	250	PF00018	0.468
LIG_SH3_3	285	291	PF00018	0.469
LIG_SH3_3	315	321	PF00018	0.451
LIG_SUMO_SIM_anti_2	253	259	PF11976	0.582
LIG_SUMO_SIM_anti_2	363	370	PF11976	0.430
LIG_SUMO_SIM_par_1	380	386	PF11976	0.495
LIG_TRAF2_1	179	182	PF00917	0.589
LIG_WRC_WIRS_1	368	373	PF05994	0.421
MOD_CK1_1	106	112	PF00069	0.585
MOD_CK1_1	113	119	PF00069	0.551
MOD_CK1_1	136	142	PF00069	0.659
MOD_CK1_1	177	183	PF00069	0.441
MOD_CK1_1	296	302	PF00069	0.637
MOD_CK2_1	106	112	PF00069	0.510
MOD_CK2_1	176	182	PF00069	0.557
MOD_CK2_1	250	256	PF00069	0.564
MOD_CK2_1	380	386	PF00069	0.480
MOD_Cter_Amidation	389	392	PF01082	0.561
MOD_GlcNHglycan	106	109	PF01048	0.564
MOD_GlcNHglycan	305	308	PF01048	0.626
MOD_GlcNHglycan	333	336	PF01048	0.468
MOD_GlcNHglycan	94	97	PF01048	0.462
MOD_GSK3_1	10	17	PF00069	0.584
MOD_GSK3_1	106	113	PF00069	0.547
MOD_GSK3_1	133	140	PF00069	0.605
MOD_GSK3_1	176	183	PF00069	0.435
MOD_GSK3_1	222	229	PF00069	0.389
MOD_LATS_1	143	149	PF00433	0.577
MOD_LATS_1	44	50	PF00433	0.571
MOD_N-GLC_1	235	240	PF02516	0.522
MOD_N-GLC_1	360	365	PF02516	0.439
MOD_NEK2_1	134	139	PF00069	0.734
MOD_NEK2_1	163	168	PF00069	0.488
MOD_NEK2_1	316	321	PF00069	0.439
MOD_NEK2_1	331	336	PF00069	0.465
MOD_NEK2_1	380	385	PF00069	0.559
MOD_NEK2_1	86	91	PF00069	0.509
MOD_NEK2_1	92	97	PF00069	0.441
MOD_PIKK_1	110	116	PF00454	0.492
MOD_PIKK_1	86	92	PF00454	0.455
MOD_PK_1	14	20	PF00069	0.598
MOD_PKA_2	296	302	PF00069	0.607
MOD_Plk_1	226	232	PF00069	0.415
MOD_Plk_1	235	241	PF00069	0.397
MOD_Plk_1	265	271	PF00069	0.584
MOD_Plk_4	151	157	PF00069	0.481
MOD_Plk_4	165	171	PF00069	0.398
MOD_Plk_4	226	232	PF00069	0.431
MOD_Plk_4	348	354	PF00069	0.509
MOD_Plk_4	70	76	PF00069	0.422
MOD_ProDKin_1	198	204	PF00069	0.525
MOD_ProDKin_1	250	256	PF00069	0.529
MOD_ProDKin_1	317	323	PF00069	0.376
TRG_DiLeu_BaEn_1	313	318	PF01217	0.510
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.588
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.574
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.442
TRG_DiLeu_BaLyEn_6	318	323	PF01217	0.402
TRG_ENDOCYTIC_2	167	170	PF00928	0.355
TRG_ENDOCYTIC_2	75	78	PF00928	0.388
TRG_ER_diArg_1	329	331	PF00400	0.480
TRG_ER_diArg_1	373	375	PF00400	0.498
TRG_ER_diArg_1	54	57	PF00400	0.582
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSQ0	Leptomonas seymouri	75%	99%
A0A0S4JP54	Bodo saltans	37%	81%
A0A1X0NDW4	Trypanosomatidae	52%	93%
A0A3R7K3H2	Trypanosoma rangeli	56%	95%
A4HQ23	Leishmania braziliensis	88%	100%
A4IDT0	Leishmania infantum	100%	100%
D0A8U6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	94%
E9ATU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q0Q5	Leishmania major	95%	100%
V5AZJ2	Trypanosoma cruzi	55%	86%