LeishMANIAdb
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DUF4139 domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DUF4139 domain-containing protein
Gene product:
hypothetical protein, conserved (fragment)
Species:
Leishmania donovani
UniProt:
A0A3Q8IHT6_LEIDO
TriTrypDb:
LdBPK_300990.1 * , LdCL_300015100 , LDHU3_30.1300
Length:
579

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 12
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0005741 mitochondrial outer membrane 5 1
GO:0016020 membrane 2 1
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Phosphorylation

Amastigote: 325

Expansion

Sequence features

A0A3Q8IHT6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHT6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0016829 lyase activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 166 168 PF00675 0.440
CLV_NRD_NRD_1 319 321 PF00675 0.370
CLV_NRD_NRD_1 462 464 PF00675 0.328
CLV_PCSK_KEX2_1 166 168 PF00082 0.486
CLV_PCSK_KEX2_1 318 320 PF00082 0.451
CLV_PCSK_KEX2_1 462 464 PF00082 0.328
CLV_PCSK_KEX2_1 98 100 PF00082 0.554
CLV_PCSK_PC1ET2_1 98 100 PF00082 0.414
CLV_PCSK_PC7_1 458 464 PF00082 0.330
CLV_PCSK_SKI1_1 166 170 PF00082 0.489
CLV_PCSK_SKI1_1 209 213 PF00082 0.436
DEG_APCC_DBOX_1 177 185 PF00400 0.558
DEG_APCC_KENBOX_2 333 337 PF00400 0.291
DEG_SCF_FBW7_2 340 346 PF00400 0.271
DEG_SPOP_SBC_1 471 475 PF00917 0.299
DOC_CKS1_1 340 345 PF01111 0.271
DOC_CKS1_1 571 576 PF01111 0.492
DOC_CYCLIN_yClb1_LxF_4 387 392 PF00134 0.457
DOC_MAPK_gen_1 383 392 PF00069 0.373
DOC_MAPK_gen_1 555 565 PF00069 0.529
DOC_MAPK_MEF2A_6 397 404 PF00069 0.441
DOC_PP1_RVXF_1 387 393 PF00149 0.457
DOC_PP4_FxxP_1 24 27 PF00568 0.421
DOC_PP4_FxxP_1 328 331 PF00568 0.585
DOC_PP4_FxxP_1 337 340 PF00568 0.269
DOC_PP4_FxxP_1 490 493 PF00568 0.279
DOC_USP7_MATH_1 158 162 PF00917 0.443
DOC_USP7_MATH_1 418 422 PF00917 0.359
DOC_USP7_MATH_1 491 495 PF00917 0.496
DOC_USP7_UBL2_3 555 559 PF12436 0.276
DOC_USP7_UBL2_3 94 98 PF12436 0.500
DOC_WW_Pin1_4 239 244 PF00397 0.344
DOC_WW_Pin1_4 280 285 PF00397 0.393
DOC_WW_Pin1_4 286 291 PF00397 0.440
DOC_WW_Pin1_4 339 344 PF00397 0.348
DOC_WW_Pin1_4 436 441 PF00397 0.461
DOC_WW_Pin1_4 570 575 PF00397 0.573
DOC_WW_Pin1_4 73 78 PF00397 0.443
LIG_14-3-3_CanoR_1 166 174 PF00244 0.493
LIG_14-3-3_CanoR_1 19 25 PF00244 0.334
LIG_14-3-3_CanoR_1 276 284 PF00244 0.400
LIG_14-3-3_CanoR_1 3 7 PF00244 0.527
LIG_APCC_ABBA_1 13 18 PF00400 0.422
LIG_BIR_II_1 1 5 PF00653 0.490
LIG_BRCT_BRCA1_1 324 328 PF00533 0.291
LIG_BRCT_BRCA1_1 420 424 PF00533 0.402
LIG_deltaCOP1_diTrp_1 44 51 PF00928 0.412
LIG_deltaCOP1_diTrp_1 546 551 PF00928 0.506
LIG_FHA_1 213 219 PF00498 0.469
LIG_FHA_1 340 346 PF00498 0.462
LIG_FHA_1 451 457 PF00498 0.363
LIG_FHA_1 497 503 PF00498 0.373
LIG_FHA_1 51 57 PF00498 0.445
LIG_FHA_1 542 548 PF00498 0.468
LIG_FHA_2 266 272 PF00498 0.320
LIG_FHA_2 410 416 PF00498 0.424
LIG_FHA_2 537 543 PF00498 0.416
LIG_Integrin_RGD_1 133 135 PF01839 0.520
LIG_LIR_Apic_2 23 27 PF02991 0.421
LIG_LIR_Apic_2 298 303 PF02991 0.291
LIG_LIR_Apic_2 325 331 PF02991 0.291
LIG_LIR_Apic_2 335 340 PF02991 0.417
LIG_LIR_Apic_2 360 365 PF02991 0.457
LIG_LIR_Apic_2 488 493 PF02991 0.279
LIG_LIR_Gen_1 269 279 PF02991 0.328
LIG_LIR_Gen_1 412 420 PF02991 0.387
LIG_LIR_Gen_1 48 58 PF02991 0.445
LIG_LIR_LC3C_4 213 218 PF02991 0.532
LIG_LIR_Nem_3 269 275 PF02991 0.322
LIG_LIR_Nem_3 412 417 PF02991 0.399
LIG_LIR_Nem_3 44 49 PF02991 0.442
LIG_LIR_Nem_3 50 54 PF02991 0.459
LIG_MLH1_MIPbox_1 324 328 PF16413 0.271
LIG_MYND_1 291 295 PF01753 0.457
LIG_Pex14_1 241 245 PF04695 0.346
LIG_Pex14_2 561 565 PF04695 0.413
LIG_REV1ctd_RIR_1 160 171 PF16727 0.560
LIG_RPA_C_Plants 167 178 PF08784 0.402
LIG_SH2_CRK 362 366 PF00017 0.457
LIG_SH2_NCK_1 362 366 PF00017 0.457
LIG_SH2_SRC 251 254 PF00017 0.295
LIG_SH2_SRC 362 365 PF00017 0.457
LIG_SH2_STAP1 245 249 PF00017 0.356
LIG_SH2_STAP1 260 264 PF00017 0.315
LIG_SH2_STAP1 414 418 PF00017 0.299
LIG_SH2_STAP1 483 487 PF00017 0.405
LIG_SH2_STAT5 485 488 PF00017 0.401
LIG_SH3_3 26 32 PF00018 0.501
LIG_SH3_3 289 295 PF00018 0.427
LIG_SH3_3 300 306 PF00018 0.392
LIG_SH3_3 337 343 PF00018 0.476
LIG_SH3_3 390 396 PF00018 0.426
LIG_SH3_3 568 574 PF00018 0.563
LIG_SUMO_SIM_anti_2 253 261 PF11976 0.314
LIG_SUMO_SIM_anti_2 513 519 PF11976 0.299
LIG_SUMO_SIM_par_1 228 233 PF11976 0.510
LIG_SUMO_SIM_par_1 35 41 PF11976 0.496
LIG_SUMO_SIM_par_1 498 504 PF11976 0.347
LIG_TRAF2_1 106 109 PF00917 0.555
LIG_TRAF2_1 113 116 PF00917 0.581
LIG_TRAF2_1 440 443 PF00917 0.397
LIG_TYR_ITSM 410 417 PF00017 0.315
LIG_WRC_WIRS_1 159 164 PF05994 0.565
MOD_CDC14_SPxK_1 76 79 PF00782 0.449
MOD_CDK_SPxK_1 73 79 PF00069 0.447
MOD_CK1_1 2 8 PF00069 0.515
MOD_CK1_1 280 286 PF00069 0.327
MOD_CK1_1 357 363 PF00069 0.332
MOD_CK1_1 447 453 PF00069 0.344
MOD_CK1_1 466 472 PF00069 0.356
MOD_CK1_1 474 480 PF00069 0.363
MOD_CK2_1 207 213 PF00069 0.438
MOD_CK2_1 251 257 PF00069 0.518
MOD_CK2_1 409 415 PF00069 0.440
MOD_CK2_1 436 442 PF00069 0.393
MOD_CK2_1 536 542 PF00069 0.432
MOD_CMANNOS 294 297 PF00535 0.457
MOD_GlcNHglycan 129 132 PF01048 0.595
MOD_GlcNHglycan 141 144 PF01048 0.727
MOD_GlcNHglycan 201 204 PF01048 0.749
MOD_GlcNHglycan 209 212 PF01048 0.564
MOD_GlcNHglycan 223 226 PF01048 0.507
MOD_GlcNHglycan 236 239 PF01048 0.531
MOD_GlcNHglycan 24 27 PF01048 0.561
MOD_GlcNHglycan 260 263 PF01048 0.325
MOD_GlcNHglycan 32 35 PF01048 0.705
MOD_GlcNHglycan 404 407 PF01048 0.457
MOD_GSK3_1 158 165 PF00069 0.521
MOD_GSK3_1 230 237 PF00069 0.382
MOD_GSK3_1 322 329 PF00069 0.305
MOD_GSK3_1 353 360 PF00069 0.329
MOD_GSK3_1 450 457 PF00069 0.401
MOD_GSK3_1 463 470 PF00069 0.357
MOD_N-GLC_1 357 362 PF02516 0.479
MOD_N-GLC_1 409 414 PF02516 0.356
MOD_N-GLC_1 430 435 PF02516 0.389
MOD_N-GLC_1 73 78 PF02516 0.443
MOD_N-GLC_2 529 531 PF02516 0.422
MOD_NEK2_1 114 119 PF00069 0.438
MOD_NEK2_1 127 132 PF00069 0.580
MOD_NEK2_1 162 167 PF00069 0.538
MOD_NEK2_1 212 217 PF00069 0.444
MOD_NEK2_1 22 27 PF00069 0.470
MOD_NEK2_1 277 282 PF00069 0.356
MOD_NEK2_1 404 409 PF00069 0.533
MOD_NEK2_1 444 449 PF00069 0.330
MOD_NEK2_1 472 477 PF00069 0.353
MOD_NEK2_2 158 163 PF00069 0.426
MOD_NEK2_2 322 327 PF00069 0.271
MOD_NEK2_2 366 371 PF00069 0.387
MOD_PIKK_1 430 436 PF00454 0.422
MOD_PIKK_1 474 480 PF00454 0.335
MOD_PKA_1 166 172 PF00069 0.385
MOD_PKA_2 166 172 PF00069 0.570
MOD_PKA_2 193 199 PF00069 0.509
MOD_PKA_2 2 8 PF00069 0.602
MOD_PKA_2 277 283 PF00069 0.388
MOD_PKA_2 295 301 PF00069 0.280
MOD_PKA_2 78 84 PF00069 0.615
MOD_PKB_1 276 284 PF00069 0.457
MOD_Plk_1 212 218 PF00069 0.420
MOD_Plk_1 230 236 PF00069 0.280
MOD_Plk_1 357 363 PF00069 0.432
MOD_Plk_1 430 436 PF00069 0.366
MOD_Plk_1 444 450 PF00069 0.386
MOD_Plk_1 466 472 PF00069 0.528
MOD_Plk_2-3 536 542 PF00069 0.295
MOD_Plk_4 11 17 PF00069 0.415
MOD_Plk_4 158 164 PF00069 0.481
MOD_Plk_4 212 218 PF00069 0.440
MOD_Plk_4 322 328 PF00069 0.571
MOD_Plk_4 357 363 PF00069 0.494
MOD_Plk_4 425 431 PF00069 0.324
MOD_Plk_4 467 473 PF00069 0.464
MOD_Plk_4 496 502 PF00069 0.344
MOD_ProDKin_1 239 245 PF00069 0.344
MOD_ProDKin_1 280 286 PF00069 0.393
MOD_ProDKin_1 339 345 PF00069 0.348
MOD_ProDKin_1 436 442 PF00069 0.461
MOD_ProDKin_1 570 576 PF00069 0.581
MOD_ProDKin_1 73 79 PF00069 0.447
MOD_SUMO_for_1 533 536 PF00179 0.295
MOD_SUMO_for_1 554 557 PF00179 0.279
MOD_SUMO_for_1 8 11 PF00179 0.402
MOD_SUMO_rev_2 552 561 PF00179 0.317
TRG_ENDOCYTIC_2 414 417 PF00928 0.367
TRG_ER_diArg_1 275 278 PF00400 0.459
TRG_ER_diArg_1 318 320 PF00400 0.460
TRG_ER_diArg_1 389 392 PF00400 0.315
TRG_ER_diArg_1 461 463 PF00400 0.338
TRG_Pf-PMV_PEXEL_1 172 176 PF00026 0.469

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3W3 Leptomonas seymouri 23% 92%
A0A0N1IA86 Leptomonas seymouri 60% 100%
A0A0S4JNB4 Bodo saltans 30% 100%
A0A0S4KK03 Bodo saltans 25% 95%
A0A1X0P222 Trypanosomatidae 30% 94%
A0A3Q8IFG9 Leishmania donovani 25% 100%
A0A422P4V3 Trypanosoma rangeli 30% 100%
A4HHL0 Leishmania braziliensis 26% 100%
A4HI48 Leishmania braziliensis 81% 100%
A4I4S0 Leishmania infantum 25% 100%
A4I5C4 Leishmania infantum 100% 100%
C9ZQQ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9AE72 Leishmania major 26% 90%
E9ALL3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B0M2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q7L0 Leishmania major 94% 100%
V5DQS5 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS