Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHT5_LEIDO

TriTrypDb:

LdBPK_120661.1 , LdCL_120012800 , LdCL_120013200 , LdCL_120013700 , LdCL_120014200 , LdCL_120014700 , LdCL_120015200 , LdCL_120015700 , LdCL_120016200 , LdCL_120016700 , LdCL_120017200 , LdCL_120017800 , LdCL_120018100 , LDHU3_12.1070

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 23
NetGPI	no	yes: 0, no: 24

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHT5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.619
CLV_C14_Caspase3-7	365	369	PF00656	0.671
CLV_NRD_NRD_1	229	231	PF00675	0.578
CLV_NRD_NRD_1	307	309	PF00675	0.796
CLV_NRD_NRD_1	318	320	PF00675	0.691
CLV_NRD_NRD_1	395	397	PF00675	0.677
CLV_NRD_NRD_1	432	434	PF00675	0.519
CLV_PCSK_FUR_1	393	397	PF00082	0.627
CLV_PCSK_KEX2_1	229	231	PF00082	0.578
CLV_PCSK_KEX2_1	243	245	PF00082	0.627
CLV_PCSK_KEX2_1	307	309	PF00082	0.748
CLV_PCSK_KEX2_1	395	397	PF00082	0.674
CLV_PCSK_KEX2_1	431	433	PF00082	0.515
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.627
CLV_PCSK_SKI1_1	395	399	PF00082	0.674
CLV_Separin_Metazoa	226	230	PF03568	0.579
DEG_Nend_Nbox_1	1	3	PF02207	0.633
DOC_CDC14_PxL_1	419	427	PF14671	0.468
DOC_CYCLIN_RxL_1	392	402	PF00134	0.681
DOC_MAPK_gen_1	319	327	PF00069	0.696
DOC_MAPK_gen_1	34	44	PF00069	0.578
DOC_MAPK_gen_1	417	427	PF00069	0.468
DOC_MAPK_gen_1	8	18	PF00069	0.632
DOC_MAPK_MEF2A_6	11	18	PF00069	0.590
DOC_MAPK_MEF2A_6	420	427	PF00069	0.466
DOC_PP2B_LxvP_1	425	428	PF13499	0.471
DOC_PP4_FxxP_1	148	151	PF00568	0.590
DOC_USP7_MATH_1	295	299	PF00917	0.543
DOC_USP7_MATH_1	321	325	PF00917	0.721
DOC_USP7_MATH_1	426	430	PF00917	0.680
DOC_WW_Pin1_4	10	15	PF00397	0.571
DOC_WW_Pin1_4	103	108	PF00397	0.581
DOC_WW_Pin1_4	352	357	PF00397	0.688
DOC_WW_Pin1_4	61	66	PF00397	0.562
LIG_14-3-3_CanoR_1	30	34	PF00244	0.801
LIG_14-3-3_CanoR_1	431	437	PF00244	0.750
LIG_BRCT_BRCA1_1	323	327	PF00533	0.715
LIG_BRCT_BRCA1_1	6	10	PF00533	0.653
LIG_deltaCOP1_diTrp_1	310	315	PF00928	0.643
LIG_EVH1_1	148	152	PF00568	0.592
LIG_FHA_1	11	17	PF00498	0.614
LIG_FHA_1	243	249	PF00498	0.632
LIG_FHA_2	328	334	PF00498	0.612
LIG_FHA_2	399	405	PF00498	0.683
LIG_LIR_Apic_2	146	151	PF02991	0.600
LIG_LIR_Apic_2	250	255	PF02991	0.642
LIG_LIR_Apic_2	298	303	PF02991	0.645
LIG_LIR_Apic_2	59	65	PF02991	0.555
LIG_LIR_Apic_2	93	97	PF02991	0.589
LIG_LIR_Gen_1	175	181	PF02991	0.701
LIG_LIR_Gen_1	236	247	PF02991	0.619
LIG_LIR_Nem_3	182	188	PF02991	0.610
LIG_LIR_Nem_3	236	242	PF02991	0.613
LIG_LIR_Nem_3	31	36	PF02991	0.618
LIG_LIR_Nem_3	310	314	PF02991	0.642
LIG_LIR_Nem_3	85	90	PF02991	0.575
LIG_PCNA_PIPBox_1	116	125	PF02747	0.668
LIG_Pex14_2	327	331	PF04695	0.748
LIG_SH2_CRK	87	91	PF00017	0.584
LIG_SH2_NCK_1	292	296	PF00017	0.614
LIG_SH2_NCK_1	364	368	PF00017	0.713
LIG_SH2_PTP2	300	303	PF00017	0.663
LIG_SH2_SRC	300	303	PF00017	0.663
LIG_SH2_SRC	364	367	PF00017	0.680
LIG_SH2_STAP1	174	178	PF00017	0.682
LIG_SH2_STAT3	210	213	PF00017	0.691
LIG_SH2_STAT3	70	73	PF00017	0.565
LIG_SH2_STAT5	300	303	PF00017	0.663
LIG_SH2_STAT5	70	73	PF00017	0.587
LIG_SH2_STAT5	94	97	PF00017	0.594
LIG_SH3_1	420	426	PF00018	0.729
LIG_SH3_3	135	141	PF00018	0.587
LIG_SH3_3	146	152	PF00018	0.598
LIG_SH3_3	186	192	PF00018	0.604
LIG_SH3_3	245	251	PF00018	0.634
LIG_SH3_3	342	348	PF00018	0.661
LIG_SH3_3	402	408	PF00018	0.688
LIG_SH3_3	420	426	PF00018	0.722
LIG_TRAF2_1	20	23	PF00917	0.646
LIG_TRAF2_1	223	226	PF00917	0.650
LIG_TRAF2_1	247	250	PF00917	0.733
LIG_TRAF2_1	65	68	PF00917	0.663
LIG_UBA3_1	130	134	PF00899	0.523
MOD_CDC14_SPxK_1	106	109	PF00782	0.571
MOD_CDK_SPK_2	352	357	PF00069	0.697
MOD_CDK_SPxK_1	103	109	PF00069	0.580
MOD_CDK_SPxxK_3	10	17	PF00069	0.587
MOD_CK2_1	158	164	PF00069	0.573
MOD_CK2_1	383	389	PF00069	0.580
MOD_CK2_1	398	404	PF00069	0.608
MOD_CK2_1	432	438	PF00069	0.760
MOD_Cter_Amidation	305	308	PF01082	0.740
MOD_Cter_Amidation	317	320	PF01082	0.559
MOD_Cter_Amidation	429	432	PF01082	0.613
MOD_GlcNHglycan	23	29	PF01048	0.774
MOD_GlcNHglycan	316	319	PF01048	0.708
MOD_GlcNHglycan	400	404	PF01048	0.691
MOD_GlcNHglycan	405	408	PF01048	0.668
MOD_GlcNHglycan	428	431	PF01048	0.759
MOD_GlcNHglycan	434	437	PF01048	0.789
MOD_GlcNHglycan	84	87	PF01048	0.571
MOD_GSK3_1	24	31	PF00069	0.705
MOD_GSK3_1	399	406	PF00069	0.738
MOD_GSK3_1	99	106	PF00069	0.580
MOD_NEK2_1	314	319	PF00069	0.633
MOD_NEK2_1	327	332	PF00069	0.633
MOD_NEK2_1	398	403	PF00069	0.646
MOD_NEK2_1	99	104	PF00069	0.590
MOD_NEK2_2	29	34	PF00069	0.739
MOD_PKA_1	431	437	PF00069	0.510
MOD_PKA_2	281	287	PF00069	0.453
MOD_PKA_2	29	35	PF00069	0.708
MOD_PKA_2	431	437	PF00069	0.738
MOD_Plk_1	158	164	PF00069	0.586
MOD_Plk_1	383	389	PF00069	0.534
MOD_ProDKin_1	10	16	PF00069	0.570
MOD_ProDKin_1	103	109	PF00069	0.580
MOD_ProDKin_1	352	358	PF00069	0.684
MOD_ProDKin_1	61	67	PF00069	0.569
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.590
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.593
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.591
TRG_ENDOCYTIC_2	176	179	PF00928	0.606
TRG_ENDOCYTIC_2	87	90	PF00928	0.580
TRG_ER_diArg_1	228	230	PF00400	0.580
TRG_ER_diArg_1	258	261	PF00400	0.727
TRG_ER_diArg_1	393	396	PF00400	0.621
TRG_ER_diArg_1	431	433	PF00400	0.515
TRG_ER_diArg_1	48	51	PF00400	0.535
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	395	400	PF00026	0.682

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9T4	Leptomonas seymouri	81%	99%
A0A0S4IRN8	Bodo saltans	74%	100%
A0A1X0NP12	Trypanosomatidae	74%	100%
A0A381ME06	Leishmania infantum	99%	100%
A0A3S7WS51	Leishmania donovani	100%	100%
A4H6Y7	Leishmania braziliensis	84%	100%
C9ZHZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
E9AGG3	Leishmania infantum	99%	100%
E9AGG8	Leishmania infantum	99%	100%
E9AP06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QGI1	Leishmania major	97%	100%
Q4QGI3	Leishmania major	94%	100%
Q4QGJ1	Leishmania major	97%	100%
Q4QGJ3	Leishmania major	95%	100%
Q4QGJ5	Leishmania major	94%	100%
Q4QGJ8	Leishmania major	94%	100%
Q4QGK3	Leishmania major	94%	100%
Q4QGK5	Leishmania major	95%	100%
Q4QGK7	Leishmania major	95%	100%
Q4QGL3	Leishmania major	95%	100%
Q4QGL6	Leishmania major	94%	100%
Q4QGM0	Leishmania major	94%	100%
V5BF60	Trypanosoma cruzi	74%	89%