Trypsin-like peptidase domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Trypsin-like peptidase domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHS3_LEIDO

TriTrypDb:

LdBPK_333280.1 , LdCL_330040400 , LDHU3_33.4760

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IHS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHS3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004252	serine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008236	serine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0017171	serine hydrolase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.412
CLV_C14_Caspase3-7	231	235	PF00656	0.474
CLV_NRD_NRD_1	224	226	PF00675	0.435
CLV_NRD_NRD_1	298	300	PF00675	0.508
CLV_PCSK_KEX2_1	224	226	PF00082	0.412
CLV_PCSK_KEX2_1	300	302	PF00082	0.591
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.622
CLV_PCSK_SKI1_1	209	213	PF00082	0.449
CLV_PCSK_SKI1_1	224	228	PF00082	0.449
DOC_AGCK_PIF_2	78	83	PF00069	0.388
DOC_ANK_TNKS_1	107	114	PF00023	0.412
DOC_CYCLIN_RxL_1	36	47	PF00134	0.478
DOC_MAPK_gen_1	222	232	PF00069	0.445
DOC_MAPK_JIP1_4	39	45	PF00069	0.487
DOC_MAPK_MEF2A_6	21	30	PF00069	0.451
DOC_MAPK_MEF2A_6	36	45	PF00069	0.356
DOC_PP2B_LxvP_1	31	34	PF13499	0.392
DOC_PP2B_LxvP_1	90	93	PF13499	0.328
DOC_SPAK_OSR1_1	100	104	PF12202	0.363
DOC_USP7_MATH_1	15	19	PF00917	0.499
DOC_USP7_MATH_1	174	178	PF00917	0.449
DOC_USP7_MATH_1	65	69	PF00917	0.630
DOC_USP7_MATH_1	74	78	PF00917	0.436
DOC_USP7_UBL2_3	94	98	PF12436	0.412
DOC_WW_Pin1_4	151	156	PF00397	0.401
DOC_WW_Pin1_4	279	284	PF00397	0.406
DOC_WW_Pin1_4	76	81	PF00397	0.391
LIG_14-3-3_CanoR_1	224	233	PF00244	0.475
LIG_BIR_II_1	1	5	PF00653	0.743
LIG_BIR_III_4	110	114	PF00653	0.412
LIG_BIR_III_4	119	123	PF00653	0.279
LIG_BIR_III_4	234	238	PF00653	0.474
LIG_BIR_III_4	274	278	PF00653	0.553
LIG_Clathr_ClatBox_1	136	140	PF01394	0.474
LIG_FHA_1	225	231	PF00498	0.398
LIG_FHA_1	36	42	PF00498	0.486
LIG_FHA_2	107	113	PF00498	0.474
LIG_LIR_Apic_2	151	155	PF02991	0.305
LIG_LIR_Apic_2	58	64	PF02991	0.464
LIG_LIR_Apic_2	95	99	PF02991	0.371
LIG_LIR_Gen_1	29	37	PF02991	0.390
LIG_LIR_Nem_3	29	33	PF02991	0.368
LIG_LYPXL_SIV_4	172	180	PF13949	0.412
LIG_LYPXL_yS_3	25	28	PF13949	0.294
LIG_SH2_CRK	152	156	PF00017	0.268
LIG_SH2_CRK	61	65	PF00017	0.490
LIG_SH2_CRK	96	100	PF00017	0.440
LIG_SH2_NCK_1	152	156	PF00017	0.268
LIG_SH2_STAP1	83	87	PF00017	0.474
LIG_SH2_STAT5	281	284	PF00017	0.352
LIG_SH2_STAT5	83	86	PF00017	0.385
LIG_SH3_1	61	67	PF00018	0.469
LIG_SH3_3	270	276	PF00018	0.537
LIG_SH3_3	61	67	PF00018	0.649
LIG_SUMO_SIM_anti_2	133	138	PF11976	0.385
LIG_SUMO_SIM_anti_2	227	234	PF11976	0.468
LIG_SUMO_SIM_par_1	135	140	PF11976	0.443
LIG_SUMO_SIM_par_1	227	234	PF11976	0.474
LIG_UBA3_1	27	36	PF00899	0.512
LIG_WRC_WIRS_1	27	32	PF05994	0.383
MOD_GlcNHglycan	252	255	PF01048	0.345
MOD_GSK3_1	192	199	PF00069	0.404
MOD_GSK3_1	224	231	PF00069	0.449
MOD_GSK3_1	66	73	PF00069	0.447
MOD_GSK3_1	81	88	PF00069	0.276
MOD_NEK2_1	257	262	PF00069	0.423
MOD_NEK2_1	44	49	PF00069	0.360
MOD_NEK2_1	70	75	PF00069	0.329
MOD_PIKK_1	15	21	PF00454	0.594
MOD_PIKK_1	85	91	PF00454	0.449
MOD_PKA_1	224	230	PF00069	0.412
MOD_PKA_2	224	230	PF00069	0.470
MOD_Plk_1	57	63	PF00069	0.597
MOD_Plk_1	85	91	PF00069	0.449
MOD_Plk_2-3	192	198	PF00069	0.374
MOD_Plk_4	196	202	PF00069	0.385
MOD_Plk_4	228	234	PF00069	0.449
MOD_Plk_4	26	32	PF00069	0.363
MOD_Plk_4	66	72	PF00069	0.504
MOD_ProDKin_1	151	157	PF00069	0.401
MOD_ProDKin_1	279	285	PF00069	0.412
MOD_ProDKin_1	76	82	PF00069	0.391
TRG_DiLeu_BaEn_1	208	213	PF01217	0.413
TRG_DiLeu_BaLyEn_6	121	126	PF01217	0.474
TRG_ENDOCYTIC_2	249	252	PF00928	0.363
TRG_ENDOCYTIC_2	25	28	PF00928	0.366
TRG_ER_diArg_1	298	301	PF00400	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6J2	Leptomonas seymouri	58%	100%
A0A0S4J2F7	Bodo saltans	36%	100%
A0A0S4JI53	Bodo saltans	37%	100%
A0A1X0NRD6	Trypanosomatidae	42%	100%
A4HM21	Leishmania braziliensis	80%	100%
A4I9F4	Leishmania infantum	99%	100%
C9ZJS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	99%
E9B4F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q3M3	Leishmania major	94%	100%
V5D3Q6	Trypanosoma cruzi	41%	100%