Cytochrome c domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHS0_LEIDO

TriTrypDb:

LdBPK_350880.1 , LdCL_350013600 , LDHU3_35.1070

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IHS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHS0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006399	tRNA metabolic process	7	11
GO:0006400	tRNA modification	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	4
GO:0005488	binding	1	11
GO:0009055	electron transfer activity	3	4
GO:0016491	oxidoreductase activity	2	4
GO:0020037	heme binding	4	4
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3
GO:0046906	tetrapyrrole binding	3	4
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.700
CLV_C14_Caspase3-7	220	224	PF00656	0.789
CLV_C14_Caspase3-7	290	294	PF00656	0.670
CLV_C14_Caspase3-7	4	8	PF00656	0.750
CLV_NRD_NRD_1	156	158	PF00675	0.650
CLV_NRD_NRD_1	162	164	PF00675	0.614
CLV_NRD_NRD_1	279	281	PF00675	0.563
CLV_NRD_NRD_1	319	321	PF00675	0.596
CLV_NRD_NRD_1	390	392	PF00675	0.525
CLV_PCSK_FUR_1	153	157	PF00082	0.730
CLV_PCSK_FUR_1	317	321	PF00082	0.666
CLV_PCSK_KEX2_1	124	126	PF00082	0.725
CLV_PCSK_KEX2_1	153	155	PF00082	0.641
CLV_PCSK_KEX2_1	156	158	PF00082	0.619
CLV_PCSK_KEX2_1	162	164	PF00082	0.581
CLV_PCSK_KEX2_1	2	4	PF00082	0.758
CLV_PCSK_KEX2_1	319	321	PF00082	0.595
CLV_PCSK_KEX2_1	390	392	PF00082	0.544
CLV_PCSK_KEX2_1	66	68	PF00082	0.517
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.785
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.758
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.517
CLV_PCSK_SKI1_1	19	23	PF00082	0.667
CLV_PCSK_SKI1_1	252	256	PF00082	0.475
CLV_PCSK_SKI1_1	280	284	PF00082	0.499
CLV_PCSK_SKI1_1	307	311	PF00082	0.484
CLV_PCSK_SKI1_1	390	394	PF00082	0.649
DEG_Nend_UBRbox_1	1	4	PF02207	0.738
DEG_SPOP_SBC_1	216	220	PF00917	0.760
DOC_CYCLIN_RxL_1	277	284	PF00134	0.477
DOC_CYCLIN_RxL_1	304	312	PF00134	0.491
DOC_MAPK_gen_1	14	22	PF00069	0.603
DOC_MAPK_gen_1	280	287	PF00069	0.571
DOC_MAPK_gen_1	317	327	PF00069	0.568
DOC_MAPK_gen_1	41	50	PF00069	0.501
DOC_MAPK_MEF2A_6	175	182	PF00069	0.438
DOC_MAPK_MEF2A_6	280	287	PF00069	0.538
DOC_MAPK_MEF2A_6	320	329	PF00069	0.479
DOC_MAPK_NFAT4_5	175	183	PF00069	0.553
DOC_MAPK_NFAT4_5	280	288	PF00069	0.545
DOC_MAPK_RevD_3	327	341	PF00069	0.561
DOC_PP2B_LxvP_1	180	183	PF13499	0.554
DOC_SPAK_OSR1_1	356	360	PF12202	0.444
DOC_USP7_MATH_1	108	112	PF00917	0.538
DOC_USP7_MATH_1	215	219	PF00917	0.747
DOC_USP7_MATH_1	234	238	PF00917	0.343
DOC_USP7_MATH_1	318	322	PF00917	0.658
DOC_USP7_MATH_1	343	347	PF00917	0.560
DOC_USP7_MATH_1	361	365	PF00917	0.398
DOC_USP7_MATH_1	80	84	PF00917	0.761
DOC_USP7_MATH_1	93	97	PF00917	0.570
DOC_WW_Pin1_4	134	139	PF00397	0.792
DOC_WW_Pin1_4	156	161	PF00397	0.699
DOC_WW_Pin1_4	414	419	PF00397	0.665
DOC_WW_Pin1_4	68	73	PF00397	0.640
LIG_14-3-3_CanoR_1	119	126	PF00244	0.729
LIG_14-3-3_CanoR_1	162	170	PF00244	0.632
LIG_14-3-3_CanoR_1	238	244	PF00244	0.609
LIG_14-3-3_CanoR_1	280	286	PF00244	0.495
LIG_14-3-3_CanoR_1	317	323	PF00244	0.590
LIG_14-3-3_CanoR_1	390	398	PF00244	0.641
LIG_14-3-3_CanoR_1	67	72	PF00244	0.545
LIG_BIR_III_2	223	227	PF00653	0.656
LIG_BIR_III_4	78	82	PF00653	0.734
LIG_BRCT_BRCA1_1	163	167	PF00533	0.638
LIG_BRCT_BRCA1_1	283	287	PF00533	0.494
LIG_FHA_1	227	233	PF00498	0.606
LIG_FHA_1	238	244	PF00498	0.525
LIG_FHA_1	322	328	PF00498	0.600
LIG_FHA_1	347	353	PF00498	0.521
LIG_FHA_1	372	378	PF00498	0.475
LIG_FHA_1	52	58	PF00498	0.617
LIG_FHA_2	218	224	PF00498	0.780
LIG_FHA_2	269	275	PF00498	0.468
LIG_FHA_2	333	339	PF00498	0.488
LIG_LIR_Apic_2	164	169	PF02991	0.630
LIG_LIR_Gen_1	241	251	PF02991	0.511
LIG_LIR_Nem_3	164	170	PF02991	0.622
LIG_LIR_Nem_3	241	247	PF02991	0.447
LIG_NRBOX	278	284	PF00104	0.484
LIG_NRBOX	98	104	PF00104	0.681
LIG_PALB2_WD40_1	162	170	PF16756	0.645
LIG_Pex14_2	255	259	PF04695	0.547
LIG_SH2_STAT5	177	180	PF00017	0.463
LIG_SH2_STAT5	49	52	PF00017	0.505
LIG_SH3_3	186	192	PF00018	0.588
LIG_SH3_3	228	234	PF00018	0.542
LIG_SH3_3	357	363	PF00018	0.466
LIG_SH3_3	87	93	PF00018	0.763
LIG_TRAF2_1	36	39	PF00917	0.527
LIG_TRFH_1	259	263	PF08558	0.414
MOD_CDK_SPK_2	414	419	PF00069	0.665
MOD_CDK_SPxK_1	156	162	PF00069	0.711
MOD_CDK_SPxxK_3	156	163	PF00069	0.710
MOD_CK1_1	237	243	PF00069	0.551
MOD_CK1_1	321	327	PF00069	0.536
MOD_CK1_1	346	352	PF00069	0.498
MOD_CK1_1	364	370	PF00069	0.449
MOD_CK1_1	51	57	PF00069	0.622
MOD_CK1_1	68	74	PF00069	0.759
MOD_CK1_1	98	104	PF00069	0.552
MOD_CK2_1	215	221	PF00069	0.708
MOD_CK2_1	268	274	PF00069	0.472
MOD_CK2_1	332	338	PF00069	0.467
MOD_CK2_1	52	58	PF00069	0.603
MOD_GlcNHglycan	110	113	PF01048	0.668
MOD_GlcNHglycan	345	348	PF01048	0.500
MOD_GlcNHglycan	73	76	PF01048	0.810
MOD_GlcNHglycan	95	98	PF01048	0.738
MOD_GSK3_1	108	115	PF00069	0.610
MOD_GSK3_1	142	149	PF00069	0.723
MOD_GSK3_1	181	188	PF00069	0.577
MOD_GSK3_1	264	271	PF00069	0.450
MOD_GSK3_1	288	295	PF00069	0.645
MOD_GSK3_1	367	374	PF00069	0.571
MOD_GSK3_1	390	397	PF00069	0.603
MOD_GSK3_1	48	55	PF00069	0.623
MOD_GSK3_1	67	74	PF00069	0.749
MOD_GSK3_1	93	100	PF00069	0.679
MOD_N-GLC_1	120	125	PF02516	0.731
MOD_N-GLC_1	185	190	PF02516	0.653
MOD_N-GLC_1	332	337	PF02516	0.463
MOD_NEK2_1	1	6	PF00069	0.763
MOD_NEK2_1	120	125	PF00069	0.731
MOD_NEK2_1	30	35	PF00069	0.490
MOD_NEK2_1	327	332	PF00069	0.527
MOD_NEK2_1	408	413	PF00069	0.633
MOD_NEK2_1	48	53	PF00069	0.526
MOD_NEK2_2	318	323	PF00069	0.665
MOD_PKA_1	390	396	PF00069	0.647
MOD_PKA_2	161	167	PF00069	0.678
MOD_PKA_2	237	243	PF00069	0.609
MOD_PKA_2	318	324	PF00069	0.589
MOD_PKA_2	390	396	PF00069	0.647
MOD_PKA_2	81	87	PF00069	0.800
MOD_Plk_1	185	191	PF00069	0.629
MOD_Plk_1	292	298	PF00069	0.727
MOD_Plk_1	332	338	PF00069	0.608
MOD_Plk_1	371	377	PF00069	0.463
MOD_Plk_1	88	94	PF00069	0.738
MOD_Plk_4	226	232	PF00069	0.532
MOD_Plk_4	98	104	PF00069	0.536
MOD_ProDKin_1	134	140	PF00069	0.791
MOD_ProDKin_1	156	162	PF00069	0.699
MOD_ProDKin_1	414	420	PF00069	0.665
MOD_ProDKin_1	68	74	PF00069	0.643
MOD_SUMO_for_1	418	421	PF00179	0.674
MOD_SUMO_rev_2	4	10	PF00179	0.736
TRG_ENDOCYTIC_2	177	180	PF00928	0.493
TRG_ER_diArg_1	153	156	PF00400	0.633
TRG_ER_diArg_1	317	320	PF00400	0.611
TRG_ER_diArg_1	390	392	PF00400	0.522
TRG_NLS_MonoCore_2	123	128	PF00514	0.768
TRG_NLS_MonoExtC_3	123	129	PF00514	0.778
TRG_Pf-PMV_PEXEL_1	423	428	PF00026	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGK4	Leptomonas seymouri	67%	100%
A0A0S4J2S0	Bodo saltans	28%	100%
A0A1X0NJH1	Trypanosomatidae	37%	100%
A0A3R7NE95	Trypanosoma rangeli	40%	100%
A4HMB7	Leishmania braziliensis	80%	99%
A4IAY3	Leishmania infantum	100%	100%
D0A272	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AER1	Leishmania major	90%	99%
E9B5W6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%