GMP-PDE_delta_subunit_putative/Pfam:PF05351

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GMP-PDE, delta subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHR5_LEIDO

TriTrypDb:

LdBPK_271920.1 , LdCL_270026400 , LDHU3_27.2900

Length:

197

Annotations

Annotations by Jardim et al.

Phosphodiesterase, GMP-PDE, delta subunit, putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IHR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHR5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0033036	macromolecule localization	2	1
GO:0042953	lipoprotein transport	5	1
GO:0044782	cilium organization	5	1
GO:0044872	lipoprotein localization	5	1
GO:0045184	establishment of protein localization	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0060271	cilium assembly	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070925	organelle assembly	5	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0008289	lipid binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.571
CLV_NRD_NRD_1	93	95	PF00675	0.279
CLV_PCSK_SKI1_1	101	105	PF00082	0.276
CLV_PCSK_SKI1_1	124	128	PF00082	0.315
CLV_PCSK_SKI1_1	46	50	PF00082	0.277
DOC_CYCLIN_RxL_1	40	53	PF00134	0.543
DOC_PP1_RVXF_1	44	50	PF00149	0.465
DOC_PP1_RVXF_1	99	105	PF00149	0.477
DOC_PP4_FxxP_1	137	140	PF00568	0.456
DOC_PP4_FxxP_1	14	17	PF00568	0.556
DOC_PP4_FxxP_1	21	24	PF00568	0.551
DOC_USP7_MATH_1	171	175	PF00917	0.543
DOC_USP7_MATH_1	55	59	PF00917	0.511
DOC_USP7_MATH_2	167	173	PF00917	0.494
DOC_WW_Pin1_4	163	168	PF00397	0.512
DOC_WW_Pin1_4	4	9	PF00397	0.523
LIG_14-3-3_CanoR_1	94	102	PF00244	0.490
LIG_BIR_II_1	1	5	PF00653	0.560
LIG_BRCT_BRCA1_1	129	133	PF00533	0.477
LIG_BRCT_BRCA1_1	171	175	PF00533	0.463
LIG_eIF4E_1	122	128	PF01652	0.463
LIG_FHA_2	36	42	PF00498	0.477
LIG_LIR_Apic_2	134	140	PF02991	0.483
LIG_LIR_Apic_2	147	153	PF02991	0.407
LIG_LIR_Apic_2	18	24	PF02991	0.551
LIG_LIR_Gen_1	143	153	PF02991	0.459
LIG_LIR_Nem_3	143	149	PF02991	0.463
LIG_LIR_Nem_3	172	178	PF02991	0.477
LIG_LIR_Nem_3	33	37	PF02991	0.455
LIG_MLH1_MIPbox_1	173	177	PF16413	0.463
LIG_MYND_1	153	157	PF01753	0.515
LIG_Pex14_1	146	150	PF04695	0.463
LIG_Pex14_2	131	135	PF04695	0.463
LIG_Pex14_2	88	92	PF04695	0.543
LIG_PTB_Apo_2	183	190	PF02174	0.494
LIG_PTB_Phospho_1	183	189	PF10480	0.543
LIG_SH2_CRK	150	154	PF00017	0.471
LIG_SH2_NCK_1	150	154	PF00017	0.492
LIG_SH2_STAT5	122	125	PF00017	0.463
LIG_SH2_STAT5	176	179	PF00017	0.459
LIG_SH3_3	161	167	PF00018	0.538
LIG_TRAF2_1	74	77	PF00917	0.543
LIG_WRC_WIRS_1	128	133	PF05994	0.460
MOD_CK1_1	142	148	PF00069	0.463
MOD_CK1_1	2	8	PF00069	0.638
MOD_CK2_1	163	169	PF00069	0.564
MOD_CK2_1	71	77	PF00069	0.543
MOD_GlcNHglycan	56	60	PF01048	0.343
MOD_GlcNHglycan	95	98	PF01048	0.282
MOD_NEK2_1	1	6	PF00069	0.653
MOD_NEK2_1	12	17	PF00069	0.417
MOD_NEK2_1	93	98	PF00069	0.572
MOD_NEK2_2	171	176	PF00069	0.543
MOD_NEK2_2	35	40	PF00069	0.515
MOD_NEK2_2	80	85	PF00069	0.494
MOD_PKA_2	93	99	PF00069	0.499
MOD_Plk_4	171	177	PF00069	0.463
MOD_Plk_4	88	94	PF00069	0.463
MOD_ProDKin_1	163	169	PF00069	0.512
MOD_ProDKin_1	4	10	PF00069	0.523
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.300

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF99	Leptomonas seymouri	87%	100%
A0A0S4IN63	Bodo saltans	61%	92%
A0A1X0NR59	Trypanosomatidae	62%	100%
A0A3R7R7R0	Trypanosoma rangeli	64%	100%
A4HFX7	Leishmania braziliensis	90%	100%
A4I307	Leishmania infantum	100%	100%
A6NIH7	Homo sapiens	47%	78%
C9ZJG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9ADI0	Leishmania major	97%	100%
E9AZA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O19177	Canis lupus familiaris	48%	82%
Q10658	Caenorhabditis elegans	45%	90%
Q13432	Homo sapiens	48%	82%
Q17297	Caenorhabditis briggsae	46%	91%
Q3SYR2	Bos taurus	48%	82%
Q62885	Rattus norvegicus	48%	82%
Q66JA9	Xenopus laevis	46%	81%
Q6INE2	Xenopus laevis	48%	82%
Q8C4B4	Mus musculus	45%	78%
Q90Z08	Danio rerio	49%	81%
Q9XYQ2	Drosophila melanogaster	52%	74%
Q9Z2R6	Mus musculus	48%	82%