Mediator of RNA polymerase II transcription subunit 15

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IHR4_LEIDO

TriTrypDb:

LdBPK_333150.1 , LdCL_330038800 , LDHU3_33.4580

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.598
CLV_NRD_NRD_1	239	241	PF00675	0.677
CLV_NRD_NRD_1	305	307	PF00675	0.594
CLV_NRD_NRD_1	311	313	PF00675	0.639
CLV_PCSK_KEX2_1	299	301	PF00082	0.626
CLV_PCSK_KEX2_1	305	307	PF00082	0.572
CLV_PCSK_KEX2_1	311	313	PF00082	0.598
CLV_PCSK_KEX2_1	325	327	PF00082	0.621
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.641
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.621
DEG_Nend_UBRbox_3	1	3	PF02207	0.675
DOC_CYCLIN_RxL_1	194	205	PF00134	0.401
DOC_USP7_MATH_1	133	137	PF00917	0.678
DOC_USP7_MATH_1	224	228	PF00917	0.612
DOC_USP7_MATH_1	281	285	PF00917	0.553
DOC_USP7_MATH_1	30	34	PF00917	0.692
LIG_14-3-3_CanoR_1	300	305	PF00244	0.636
LIG_14-3-3_CanoR_1	306	311	PF00244	0.607
LIG_BRCT_BRCA1_1	144	148	PF00533	0.445
LIG_EVH1_1	173	177	PF00568	0.442
LIG_FHA_1	289	295	PF00498	0.727
LIG_FHA_1	41	47	PF00498	0.561
LIG_LIR_Nem_3	145	151	PF02991	0.514
LIG_LIR_Nem_3	205	210	PF02991	0.422
LIG_LIR_Nem_3	212	217	PF02991	0.457
LIG_LYPXL_yS_3	203	206	PF13949	0.413
LIG_Pex14_2	148	152	PF04695	0.518
LIG_RPA_C_Fungi	23	35	PF08784	0.627
LIG_SH2_CRK	196	200	PF00017	0.404
LIG_SH2_CRK	266	270	PF00017	0.634
LIG_SH2_SRC	266	269	PF00017	0.593
LIG_SH2_STAT3	100	103	PF00017	0.570
LIG_SH2_STAT3	188	191	PF00017	0.423
LIG_SH2_STAT3	8	11	PF00017	0.624
LIG_SH2_STAT5	210	213	PF00017	0.519
LIG_SH2_STAT5	214	217	PF00017	0.465
LIG_SH3_1	171	177	PF00018	0.447
LIG_SH3_1	256	262	PF00018	0.653
LIG_SH3_3	171	177	PF00018	0.461
LIG_SH3_3	256	262	PF00018	0.714
LIG_SH3_3	265	271	PF00018	0.539
LIG_TRFH_1	36	40	PF08558	0.590
LIG_TYR_ITIM	193	198	PF00017	0.434
LIG_TYR_ITIM	201	206	PF00017	0.373
LIG_WW_1	185	188	PF00397	0.439
MOD_CK1_1	227	233	PF00069	0.615
MOD_CK1_1	292	298	PF00069	0.614
MOD_GlcNHglycan	135	138	PF01048	0.622
MOD_GlcNHglycan	153	156	PF01048	0.452
MOD_GlcNHglycan	294	297	PF01048	0.629
MOD_GSK3_1	105	112	PF00069	0.695
MOD_GSK3_1	138	145	PF00069	0.563
MOD_GSK3_1	288	295	PF00069	0.612
MOD_N-GLC_1	292	297	PF02516	0.587
MOD_NEK2_1	105	110	PF00069	0.516
MOD_NEK2_1	246	251	PF00069	0.572
MOD_NEK2_1	287	292	PF00069	0.608
MOD_PIKK_1	246	252	PF00454	0.677
MOD_PIKK_1	99	105	PF00454	0.642
MOD_PKA_1	299	305	PF00069	0.628
MOD_PKA_2	288	294	PF00069	0.733
MOD_PKA_2	299	305	PF00069	0.512
MOD_PKA_2	49	55	PF00069	0.615
MOD_SUMO_for_1	318	321	PF00179	0.578
MOD_SUMO_rev_2	163	173	PF00179	0.571
TRG_DiLeu_BaLyEn_6	194	199	PF01217	0.485
TRG_DiLeu_BaLyEn_6	241	246	PF01217	0.578
TRG_ENDOCYTIC_2	195	198	PF00928	0.528
TRG_ENDOCYTIC_2	203	206	PF00928	0.429
TRG_ENDOCYTIC_2	213	216	PF00928	0.271
TRG_ENDOCYTIC_2	218	221	PF00928	0.443
TRG_ER_diArg_1	304	306	PF00400	0.592
TRG_ER_diArg_1	310	312	PF00400	0.612
TRG_Pf-PMV_PEXEL_1	197	202	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I737	Leptomonas seymouri	42%	97%
A4HM09	Leishmania braziliensis	60%	97%
A4I9E1	Leishmania infantum	96%	98%
E9B4E0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q3N7	Leishmania major	82%	100%