LeishMANIAdb
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DNA repair metallo-beta-lactamase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DNA repair metallo-beta-lactamase, putative
Gene product:
DNA repair metallo-beta-lactamase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IHR3_LEIDO
TriTrypDb:
LdBPK_343040.1 * , LdCL_340039200 , LDHU3_34.5170
Length:
664

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 11
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043231 intracellular membrane-bounded organelle 4 11
GO:0110165 cellular anatomical entity 1 12
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1

Expansion

Sequence features

A0A3Q8IHR3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHR3

Function

Biological processes
Term Name Level Count
GO:0006950 response to stress 2 12
GO:0006974 DNA damage response 4 12
GO:0009987 cellular process 1 12
GO:0033554 cellular response to stress 3 12
GO:0050896 response to stimulus 1 12
GO:0051716 cellular response to stimulus 2 12
GO:0000723 telomere maintenance 5 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006259 DNA metabolic process 4 1
GO:0006281 DNA repair 5 1
GO:0006302 double-strand break repair 6 1
GO:0006303 double-strand break repair via nonhomologous end joining 7 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006996 organelle organization 4 1
GO:0008152 metabolic process 1 1
GO:0016043 cellular component organization 3 1
GO:0031848 protection from non-homologous end joining at telomere 6 1
GO:0032200 telomere organization 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0036297 interstrand cross-link repair 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043247 telomere maintenance in response to DNA damage 5 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0046483 heterocycle metabolic process 3 1
GO:0051276 chromosome organization 5 1
GO:0071704 organic substance metabolic process 2 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 1
GO:0003677 DNA binding 4 1
GO:0003684 damaged DNA binding 5 1
GO:0003824 catalytic activity 1 1
GO:0004518 nuclease activity 4 1
GO:0004527 exonuclease activity 5 1
GO:0004529 DNA exonuclease activity 5 1
GO:0004536 DNA nuclease activity 4 1
GO:0005488 binding 1 1
GO:0008409 5'-3' exonuclease activity 6 1
GO:0016787 hydrolase activity 2 1
GO:0016788 hydrolase activity, acting on ester bonds 3 1
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 1
GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 6 1
GO:0035312 5'-3' DNA exonuclease activity 7 1
GO:0097159 organic cyclic compound binding 2 1
GO:0140097 catalytic activity, acting on DNA 3 1
GO:0140640 catalytic activity, acting on a nucleic acid 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 298 302 PF00656 0.609
CLV_C14_Caspase3-7 369 373 PF00656 0.696
CLV_C14_Caspase3-7 550 554 PF00656 0.723
CLV_MEL_PAP_1 506 512 PF00089 0.662
CLV_NRD_NRD_1 337 339 PF00675 0.756
CLV_NRD_NRD_1 535 537 PF00675 0.734
CLV_NRD_NRD_1 583 585 PF00675 0.729
CLV_PCSK_KEX2_1 116 118 PF00082 0.733
CLV_PCSK_KEX2_1 339 341 PF00082 0.558
CLV_PCSK_KEX2_1 444 446 PF00082 0.332
CLV_PCSK_KEX2_1 535 537 PF00082 0.728
CLV_PCSK_KEX2_1 585 587 PF00082 0.776
CLV_PCSK_KEX2_1 624 626 PF00082 0.673
CLV_PCSK_PC1ET2_1 116 118 PF00082 0.665
CLV_PCSK_PC1ET2_1 339 341 PF00082 0.558
CLV_PCSK_PC1ET2_1 444 446 PF00082 0.344
CLV_PCSK_PC1ET2_1 585 587 PF00082 0.776
CLV_PCSK_PC1ET2_1 624 626 PF00082 0.702
CLV_PCSK_SKI1_1 149 153 PF00082 0.522
CLV_PCSK_SKI1_1 183 187 PF00082 0.458
CLV_PCSK_SKI1_1 223 227 PF00082 0.387
CLV_PCSK_SKI1_1 229 233 PF00082 0.431
CLV_PCSK_SKI1_1 270 274 PF00082 0.500
CLV_PCSK_SKI1_1 549 553 PF00082 0.624
CLV_Separin_Metazoa 180 184 PF03568 0.502
DEG_APCC_DBOX_1 148 156 PF00400 0.527
DEG_APCC_DBOX_1 633 641 PF00400 0.767
DEG_Nend_UBRbox_2 1 3 PF02207 0.432
DEG_SCF_FBW7_1 606 613 PF00400 0.541
DEG_SPOP_SBC_1 598 602 PF00917 0.683
DOC_CKS1_1 21 26 PF01111 0.482
DOC_CYCLIN_RxL_1 144 153 PF00134 0.528
DOC_MAPK_gen_1 206 214 PF00069 0.435
DOC_MAPK_gen_1 221 228 PF00069 0.281
DOC_MAPK_gen_1 588 596 PF00069 0.693
DOC_MAPK_MEF2A_6 149 156 PF00069 0.473
DOC_MAPK_MEF2A_6 221 228 PF00069 0.399
DOC_MAPK_MEF2A_6 361 370 PF00069 0.688
DOC_PP2B_LxvP_1 33 36 PF13499 0.665
DOC_PP2B_LxvP_1 458 461 PF13499 0.487
DOC_PP4_FxxP_1 161 164 PF00568 0.399
DOC_PP4_FxxP_1 394 397 PF00568 0.398
DOC_PP4_FxxP_1 477 480 PF00568 0.487
DOC_PP4_FxxP_1 71 74 PF00568 0.382
DOC_USP7_MATH_1 196 200 PF00917 0.627
DOC_USP7_MATH_1 243 247 PF00917 0.671
DOC_USP7_MATH_1 289 293 PF00917 0.658
DOC_USP7_MATH_1 36 40 PF00917 0.705
DOC_USP7_MATH_1 397 401 PF00917 0.431
DOC_USP7_MATH_1 485 489 PF00917 0.476
DOC_USP7_MATH_1 608 612 PF00917 0.731
DOC_USP7_MATH_2 564 570 PF00917 0.501
DOC_WW_Pin1_4 20 25 PF00397 0.524
DOC_WW_Pin1_4 264 269 PF00397 0.406
DOC_WW_Pin1_4 31 36 PF00397 0.627
DOC_WW_Pin1_4 411 416 PF00397 0.584
DOC_WW_Pin1_4 606 611 PF00397 0.612
DOC_WW_Pin1_4 628 633 PF00397 0.794
DOC_WW_Pin1_4 70 75 PF00397 0.407
LIG_14-3-3_CanoR_1 104 108 PF00244 0.546
LIG_14-3-3_CanoR_1 291 297 PF00244 0.587
LIG_14-3-3_CanoR_1 353 360 PF00244 0.697
LIG_14-3-3_CanoR_1 459 468 PF00244 0.513
LIG_14-3-3_CanoR_1 518 523 PF00244 0.599
LIG_14-3-3_CanoR_1 591 597 PF00244 0.526
LIG_BIR_III_2 230 234 PF00653 0.525
LIG_BRCT_BRCA1_1 275 279 PF00533 0.528
LIG_BRCT_BRCA1_1 72 76 PF00533 0.411
LIG_deltaCOP1_diTrp_1 92 97 PF00928 0.511
LIG_FHA_1 173 179 PF00498 0.421
LIG_FHA_1 312 318 PF00498 0.610
LIG_FHA_1 382 388 PF00498 0.509
LIG_FHA_1 607 613 PF00498 0.713
LIG_FHA_2 296 302 PF00498 0.780
LIG_FHA_2 484 490 PF00498 0.562
LIG_FHA_2 548 554 PF00498 0.612
LIG_Integrin_isoDGR_2 102 104 PF01839 0.489
LIG_LIR_Apic_2 106 110 PF02991 0.517
LIG_LIR_Apic_2 158 164 PF02991 0.383
LIG_LIR_Apic_2 392 397 PF02991 0.424
LIG_LIR_Apic_2 476 480 PF02991 0.497
LIG_LIR_Gen_1 269 279 PF02991 0.426
LIG_LIR_Gen_1 400 410 PF02991 0.503
LIG_LIR_Gen_1 429 439 PF02991 0.556
LIG_LIR_Gen_1 473 481 PF02991 0.515
LIG_LIR_Gen_1 494 503 PF02991 0.427
LIG_LIR_Gen_1 517 528 PF02991 0.655
LIG_LIR_Gen_1 617 628 PF02991 0.718
LIG_LIR_Gen_1 92 98 PF02991 0.534
LIG_LIR_Nem_3 230 235 PF02991 0.470
LIG_LIR_Nem_3 269 274 PF02991 0.433
LIG_LIR_Nem_3 281 287 PF02991 0.369
LIG_LIR_Nem_3 400 406 PF02991 0.495
LIG_LIR_Nem_3 429 434 PF02991 0.572
LIG_LIR_Nem_3 473 477 PF02991 0.502
LIG_LIR_Nem_3 489 495 PF02991 0.412
LIG_LIR_Nem_3 517 523 PF02991 0.635
LIG_LIR_Nem_3 617 623 PF02991 0.706
LIG_LIR_Nem_3 73 79 PF02991 0.399
LIG_LIR_Nem_3 92 97 PF02991 0.458
LIG_MYND_1 321 325 PF01753 0.562
LIG_NRBOX 151 157 PF00104 0.430
LIG_PCNA_yPIPBox_3 144 155 PF02747 0.493
LIG_Pex14_2 168 172 PF04695 0.500
LIG_Pex14_2 280 284 PF04695 0.478
LIG_SH2_CRK 166 170 PF00017 0.498
LIG_SH2_CRK 271 275 PF00017 0.491
LIG_SH2_CRK 403 407 PF00017 0.537
LIG_SH2_CRK 431 435 PF00017 0.562
LIG_SH2_PTP2 107 110 PF00017 0.556
LIG_SH2_SRC 107 110 PF00017 0.580
LIG_SH2_STAP1 133 137 PF00017 0.518
LIG_SH2_STAP1 431 435 PF00017 0.562
LIG_SH2_STAP1 495 499 PF00017 0.477
LIG_SH2_STAT5 107 110 PF00017 0.556
LIG_SH2_STAT5 217 220 PF00017 0.410
LIG_SH2_STAT5 7 10 PF00017 0.377
LIG_SH3_3 106 112 PF00018 0.556
LIG_SH3_3 125 131 PF00018 0.509
LIG_SH3_3 18 24 PF00018 0.530
LIG_SH3_3 319 325 PF00018 0.451
LIG_SH3_3 562 568 PF00018 0.676
LIG_SH3_3 593 599 PF00018 0.699
LIG_SUMO_SIM_anti_2 153 158 PF11976 0.426
LIG_SUMO_SIM_anti_2 432 438 PF11976 0.551
LIG_SUMO_SIM_par_1 153 158 PF11976 0.503
LIG_SUMO_SIM_par_1 324 330 PF11976 0.541
LIG_SUMO_SIM_par_1 416 422 PF11976 0.550
LIG_SUMO_SIM_par_1 432 438 PF11976 0.529
LIG_SUMO_SIM_par_1 656 664 PF11976 0.659
LIG_TRAF2_1 636 639 PF00917 0.691
LIG_TYR_ITIM 401 406 PF00017 0.377
LIG_WW_2 109 112 PF00397 0.508
MOD_CDC14_SPxK_1 267 270 PF00782 0.427
MOD_CDC14_SPxK_1 631 634 PF00782 0.683
MOD_CDK_SPxK_1 264 270 PF00069 0.402
MOD_CDK_SPxK_1 628 634 PF00069 0.675
MOD_CK1_1 10 16 PF00069 0.537
MOD_CK1_1 238 244 PF00069 0.667
MOD_CK1_1 290 296 PF00069 0.720
MOD_CK1_1 31 37 PF00069 0.566
MOD_CK1_1 508 514 PF00069 0.679
MOD_CK1_1 555 561 PF00069 0.681
MOD_CK1_1 577 583 PF00069 0.611
MOD_CK1_1 601 607 PF00069 0.715
MOD_CK1_1 90 96 PF00069 0.493
MOD_CK2_1 167 173 PF00069 0.426
MOD_CK2_1 375 381 PF00069 0.718
MOD_CK2_1 483 489 PF00069 0.441
MOD_GlcNHglycan 198 201 PF01048 0.671
MOD_GlcNHglycan 342 345 PF01048 0.704
MOD_GlcNHglycan 354 357 PF01048 0.778
MOD_GlcNHglycan 377 380 PF01048 0.754
MOD_GlcNHglycan 545 548 PF01048 0.738
MOD_GlcNHglycan 579 582 PF01048 0.716
MOD_GSK3_1 234 241 PF00069 0.593
MOD_GSK3_1 243 250 PF00069 0.701
MOD_GSK3_1 3 10 PF00069 0.397
MOD_GSK3_1 305 312 PF00069 0.710
MOD_GSK3_1 449 456 PF00069 0.393
MOD_GSK3_1 514 521 PF00069 0.596
MOD_GSK3_1 539 546 PF00069 0.694
MOD_GSK3_1 597 604 PF00069 0.742
MOD_GSK3_1 606 613 PF00069 0.710
MOD_GSK3_1 75 82 PF00069 0.374
MOD_N-GLC_1 375 380 PF02516 0.710
MOD_N-GLC_1 87 92 PF02516 0.449
MOD_N-GLC_2 61 63 PF02516 0.393
MOD_NEK2_1 157 162 PF00069 0.351
MOD_NEK2_1 247 252 PF00069 0.655
MOD_NEK2_1 273 278 PF00069 0.554
MOD_NEK2_1 287 292 PF00069 0.540
MOD_NEK2_1 3 8 PF00069 0.398
MOD_NEK2_1 552 557 PF00069 0.673
MOD_NEK2_1 9 14 PF00069 0.417
MOD_NEK2_1 97 102 PF00069 0.525
MOD_NEK2_2 243 248 PF00069 0.712
MOD_PIKK_1 167 173 PF00454 0.493
MOD_PIKK_1 247 253 PF00454 0.786
MOD_PK_1 518 524 PF00069 0.689
MOD_PKA_2 235 241 PF00069 0.630
MOD_PKA_2 243 249 PF00069 0.724
MOD_PKA_2 290 296 PF00069 0.658
MOD_PKA_2 352 358 PF00069 0.707
MOD_PKA_2 360 366 PF00069 0.739
MOD_PKA_2 508 514 PF00069 0.609
MOD_PKA_2 90 96 PF00069 0.516
MOD_PKA_2 98 104 PF00069 0.533
MOD_PKB_1 338 346 PF00069 0.559
MOD_Plk_1 157 163 PF00069 0.354
MOD_Plk_1 45 51 PF00069 0.468
MOD_Plk_2-3 381 387 PF00069 0.581
MOD_Plk_2-3 566 572 PF00069 0.645
MOD_Plk_4 103 109 PF00069 0.585
MOD_Plk_4 28 34 PF00069 0.321
MOD_Plk_4 3 9 PF00069 0.402
MOD_Plk_4 389 395 PF00069 0.398
MOD_Plk_4 453 459 PF00069 0.334
MOD_Plk_4 75 81 PF00069 0.386
MOD_ProDKin_1 20 26 PF00069 0.530
MOD_ProDKin_1 264 270 PF00069 0.402
MOD_ProDKin_1 31 37 PF00069 0.638
MOD_ProDKin_1 411 417 PF00069 0.480
MOD_ProDKin_1 606 612 PF00069 0.610
MOD_ProDKin_1 628 634 PF00069 0.797
MOD_ProDKin_1 70 76 PF00069 0.411
TRG_DiLeu_BaEn_1 386 391 PF01217 0.541
TRG_DiLeu_BaEn_1 453 458 PF01217 0.444
TRG_DiLeu_BaEn_2 469 475 PF01217 0.328
TRG_DiLeu_BaLyEn_6 53 58 PF01217 0.452
TRG_ENDOCYTIC_2 133 136 PF00928 0.525
TRG_ENDOCYTIC_2 271 274 PF00928 0.437
TRG_ENDOCYTIC_2 403 406 PF00928 0.369
TRG_ENDOCYTIC_2 431 434 PF00928 0.418
TRG_ENDOCYTIC_2 495 498 PF00928 0.473
TRG_ER_diArg_1 338 341 PF00400 0.553
TRG_ER_diArg_1 504 507 PF00400 0.452
TRG_ER_diArg_1 583 586 PF00400 0.765
TRG_NES_CRM1_1 514 529 PF08389 0.595
TRG_NLS_MonoExtC_3 583 588 PF00514 0.779
TRG_NLS_MonoExtN_4 584 589 PF00514 0.786
TRG_Pf-PMV_PEXEL_1 149 153 PF00026 0.538

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PB91 Leptomonas seymouri 43% 76%
A0A0S4INP1 Bodo saltans 27% 87%
A0A1X0P9Y1 Trypanosomatidae 30% 90%
A0A3R7MJM0 Trypanosoma rangeli 30% 94%
A4HB44 Leishmania braziliensis 66% 98%
A4IA93 Leishmania infantum 99% 100%
C9ZM02 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 92%
E9B5B5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q2L8 Leishmania major 90% 100%
V5BQH0 Trypanosoma cruzi 32% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS