Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF962), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHQ7_LEIDO

TriTrypDb:

LdBPK_120680.1 , LdCL_120012400 , LDHU3_12.1000

Length:

108

Annotations

LeishMANIAdb annotations

This small protein is closely similar to a large group of poorly-studied prokaryotic proteins (annotated as DUF962 domain proteins). Some members are also found in plants and slime molds.. Duplicated in Leishmaniids

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3Q8IHQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHQ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	32	34	PF00675	0.284
CLV_NRD_NRD_1	78	80	PF00675	0.278
CLV_PCSK_KEX2_1	32	34	PF00082	0.284
DEG_APCC_DBOX_1	51	59	PF00400	0.211
DOC_PP4_FxxP_1	84	87	PF00568	0.518
DOC_WW_Pin1_4	2	7	PF00397	0.650
LIG_14-3-3_CanoR_1	56	66	PF00244	0.304
LIG_14-3-3_CanoR_1	79	85	PF00244	0.520
LIG_LIR_Apic_2	83	87	PF02991	0.519
LIG_LIR_Nem_3	13	18	PF02991	0.500
LIG_PDZ_Class_3	103	108	PF00595	0.553
LIG_SH2_STAT5	66	69	PF00017	0.279
LIG_WRC_WIRS_1	1	6	PF05994	0.456
MOD_CK1_1	11	17	PF00069	0.405
MOD_CK1_1	60	66	PF00069	0.279
MOD_CK2_1	11	17	PF00069	0.279
MOD_NEK2_1	36	41	PF00069	0.367
MOD_NEK2_1	57	62	PF00069	0.331
MOD_NEK2_1	8	13	PF00069	0.637
MOD_PKA_2	31	37	PF00069	0.326
MOD_ProDKin_1	2	8	PF00069	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C1	Leptomonas seymouri	41%	100%
A0A0N1HYH1	Leptomonas seymouri	55%	100%
A0A1X0NMC7	Trypanosomatidae	31%	99%
A0A3R7N4G9	Trypanosoma rangeli	38%	99%
A0A3S5H6L3	Leishmania donovani	39%	100%
A4H6Y4	Leishmania braziliensis	35%	100%
A4H6Y5	Leishmania braziliensis	88%	100%
E9AGF8	Leishmania infantum	39%	100%
E9AGF9	Leishmania infantum	99%	100%
E9ANZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
Q4QGM2	Leishmania major	40%	100%