PHD-like zinc-binding domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PHD-like zinc-binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHQ6_LEIDO

TriTrypDb:

LdBPK_364820.1 , LdCL_360055300 , LDHU3_36.6480

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHQ6

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.791
CLV_C14_Caspase3-7	258	262	PF00656	0.606
CLV_C14_Caspase3-7	430	434	PF00656	0.640
CLV_C14_Caspase3-7	50	54	PF00656	0.590
CLV_C14_Caspase3-7	569	573	PF00656	0.615
CLV_C14_Caspase3-7	62	66	PF00656	0.626
CLV_C14_Caspase3-7	636	640	PF00656	0.590
CLV_NRD_NRD_1	402	404	PF00675	0.438
CLV_NRD_NRD_1	481	483	PF00675	0.269
CLV_NRD_NRD_1	498	500	PF00675	0.269
CLV_NRD_NRD_1	558	560	PF00675	0.698
CLV_NRD_NRD_1	601	603	PF00675	0.483
CLV_NRD_NRD_1	646	648	PF00675	0.606
CLV_NRD_NRD_1	679	681	PF00675	0.407
CLV_NRD_NRD_1	683	685	PF00675	0.458
CLV_NRD_NRD_1	755	757	PF00675	0.567
CLV_NRD_NRD_1	762	764	PF00675	0.564
CLV_NRD_NRD_1	798	800	PF00675	0.474
CLV_NRD_NRD_1	93	95	PF00675	0.668
CLV_PCSK_FUR_1	796	800	PF00082	0.473
CLV_PCSK_KEX2_1	110	112	PF00082	0.641
CLV_PCSK_KEX2_1	298	300	PF00082	0.579
CLV_PCSK_KEX2_1	343	345	PF00082	0.673
CLV_PCSK_KEX2_1	404	406	PF00082	0.434
CLV_PCSK_KEX2_1	481	483	PF00082	0.286
CLV_PCSK_KEX2_1	498	500	PF00082	0.269
CLV_PCSK_KEX2_1	558	560	PF00082	0.634
CLV_PCSK_KEX2_1	648	650	PF00082	0.587
CLV_PCSK_KEX2_1	679	681	PF00082	0.401
CLV_PCSK_KEX2_1	683	685	PF00082	0.458
CLV_PCSK_KEX2_1	762	764	PF00082	0.543
CLV_PCSK_KEX2_1	798	800	PF00082	0.474
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.641
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.579
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.591
CLV_PCSK_PC1ET2_1	404	406	PF00082	0.405
CLV_PCSK_PC1ET2_1	648	650	PF00082	0.587
CLV_PCSK_PC7_1	679	685	PF00082	0.433
CLV_PCSK_SKI1_1	158	162	PF00082	0.441
CLV_PCSK_SKI1_1	181	185	PF00082	0.476
CLV_PCSK_SKI1_1	196	200	PF00082	0.550
CLV_PCSK_SKI1_1	201	205	PF00082	0.493
CLV_PCSK_SKI1_1	343	347	PF00082	0.576
DEG_APCC_DBOX_1	157	165	PF00400	0.424
DEG_APCC_DBOX_1	481	489	PF00400	0.516
DEG_SCF_FBW7_1	202	208	PF00400	0.607
DEG_SPOP_SBC_1	309	313	PF00917	0.632
DOC_ANK_TNKS_1	696	703	PF00023	0.459
DOC_CKS1_1	202	207	PF01111	0.638
DOC_CKS1_1	440	445	PF01111	0.587
DOC_MAPK_gen_1	717	726	PF00069	0.495
DOC_PP2B_LxvP_1	338	341	PF13499	0.739
DOC_PP2B_LxvP_1	466	469	PF13499	0.516
DOC_PP2B_LxvP_1	742	745	PF13499	0.548
DOC_PP4_FxxP_1	126	129	PF00568	0.568
DOC_PP4_FxxP_1	381	384	PF00568	0.497
DOC_USP7_MATH_1	189	193	PF00917	0.425
DOC_USP7_MATH_1	205	209	PF00917	0.609
DOC_USP7_MATH_1	212	216	PF00917	0.580
DOC_USP7_MATH_1	239	243	PF00917	0.590
DOC_USP7_MATH_1	268	272	PF00917	0.433
DOC_USP7_MATH_1	309	313	PF00917	0.665
DOC_USP7_MATH_1	333	337	PF00917	0.611
DOC_USP7_MATH_1	354	358	PF00917	0.576
DOC_WW_Pin1_4	196	201	PF00397	0.547
DOC_WW_Pin1_4	230	235	PF00397	0.716
DOC_WW_Pin1_4	310	315	PF00397	0.665
DOC_WW_Pin1_4	352	357	PF00397	0.580
DOC_WW_Pin1_4	439	444	PF00397	0.620
DOC_WW_Pin1_4	553	558	PF00397	0.636
DOC_WW_Pin1_4	583	588	PF00397	0.576
DOC_WW_Pin1_4	595	600	PF00397	0.396
DOC_WW_Pin1_4	640	645	PF00397	0.593
DOC_WW_Pin1_4	74	79	PF00397	0.665
LIG_14-3-3_CanoR_1	181	186	PF00244	0.431
LIG_14-3-3_CanoR_1	224	234	PF00244	0.556
LIG_14-3-3_CanoR_1	328	333	PF00244	0.607
LIG_14-3-3_CanoR_1	366	373	PF00244	0.585
LIG_14-3-3_CanoR_1	403	412	PF00244	0.409
LIG_14-3-3_CanoR_1	448	456	PF00244	0.517
LIG_14-3-3_CanoR_1	719	727	PF00244	0.489
LIG_14-3-3_CanoR_1	798	803	PF00244	0.466
LIG_14-3-3_CanoR_1	94	101	PF00244	0.586
LIG_Actin_WH2_2	483	500	PF00022	0.516
LIG_BIR_II_1	1	5	PF00653	0.614
LIG_BIR_III_3	1	5	PF00653	0.614
LIG_CtBP_PxDLS_1	577	581	PF00389	0.604
LIG_deltaCOP1_diTrp_1	729	732	PF00928	0.453
LIG_FHA_1	197	203	PF00498	0.566
LIG_FHA_1	288	294	PF00498	0.623
LIG_FHA_1	573	579	PF00498	0.645
LIG_FHA_1	630	636	PF00498	0.493
LIG_FHA_1	640	646	PF00498	0.644
LIG_FHA_1	684	690	PF00498	0.397
LIG_FHA_1	765	771	PF00498	0.535
LIG_FHA_2	182	188	PF00498	0.437
LIG_FHA_2	202	208	PF00498	0.625
LIG_FHA_2	32	38	PF00498	0.552
LIG_FHA_2	634	640	PF00498	0.565
LIG_GBD_Chelix_1	627	635	PF00786	0.447
LIG_LIR_Gen_1	721	728	PF02991	0.522
LIG_LIR_Gen_1	729	738	PF02991	0.430
LIG_LIR_Gen_1	746	755	PF02991	0.593
LIG_LIR_Gen_1	769	779	PF02991	0.504
LIG_LIR_Nem_3	721	726	PF02991	0.528
LIG_LIR_Nem_3	729	735	PF02991	0.425
LIG_LIR_Nem_3	746	752	PF02991	0.591
LIG_NRBOX	630	636	PF00104	0.457
LIG_SH2_CRK	145	149	PF00017	0.567
LIG_SH2_NCK_1	49	53	PF00017	0.588
LIG_SH2_NCK_1	749	753	PF00017	0.542
LIG_SH2_PTP2	493	496	PF00017	0.430
LIG_SH2_SRC	20	23	PF00017	0.567
LIG_SH2_SRC	399	402	PF00017	0.450
LIG_SH2_SRC	423	426	PF00017	0.355
LIG_SH2_SRC	49	52	PF00017	0.587
LIG_SH2_SRC	493	496	PF00017	0.503
LIG_SH2_SRC	749	752	PF00017	0.539
LIG_SH2_STAP1	190	194	PF00017	0.430
LIG_SH2_STAP1	27	31	PF00017	0.576
LIG_SH2_STAT5	159	162	PF00017	0.446
LIG_SH2_STAT5	185	188	PF00017	0.442
LIG_SH2_STAT5	20	23	PF00017	0.567
LIG_SH2_STAT5	423	426	PF00017	0.432
LIG_SH2_STAT5	493	496	PF00017	0.471
LIG_SH2_STAT5	600	603	PF00017	0.421
LIG_SH3_3	199	205	PF00018	0.665
LIG_SH3_3	382	388	PF00018	0.424
LIG_SH3_3	416	422	PF00018	0.360
LIG_SH3_3	546	552	PF00018	0.586
LIG_SH3_3	638	644	PF00018	0.565
LIG_SH3_3	73	79	PF00018	0.564
LIG_SUMO_SIM_par_1	31	38	PF11976	0.555
LIG_SUMO_SIM_par_1	733	739	PF11976	0.480
LIG_TRAF2_1	745	748	PF00917	0.547
MOD_CDC14_SPxK_1	556	559	PF00782	0.609
MOD_CDK_SPK_2	196	201	PF00069	0.600
MOD_CDK_SPK_2	553	558	PF00069	0.565
MOD_CDK_SPxK_1	553	559	PF00069	0.602
MOD_CDK_SPxxK_3	310	317	PF00069	0.626
MOD_CDK_SPxxK_3	595	602	PF00069	0.459
MOD_CDK_SPxxK_3	640	647	PF00069	0.578
MOD_CK1_1	226	232	PF00069	0.678
MOD_CK1_1	312	318	PF00069	0.705
MOD_CK1_1	439	445	PF00069	0.613
MOD_CK1_1	583	589	PF00069	0.601
MOD_CK1_1	612	618	PF00069	0.657
MOD_CK1_1	764	770	PF00069	0.533
MOD_CK1_1	96	102	PF00069	0.690
MOD_CK2_1	181	187	PF00069	0.437
MOD_CK2_1	31	37	PF00069	0.607
MOD_CK2_1	464	470	PF00069	0.516
MOD_CK2_1	733	739	PF00069	0.424
MOD_DYRK1A_RPxSP_1	196	200	PF00069	0.559
MOD_DYRK1A_RPxSP_1	201	205	PF00069	0.599
MOD_GlcNHglycan	206	210	PF01048	0.662
MOD_GlcNHglycan	241	244	PF01048	0.609
MOD_GlcNHglycan	247	250	PF01048	0.771
MOD_GlcNHglycan	257	260	PF01048	0.607
MOD_GlcNHglycan	282	285	PF01048	0.668
MOD_GlcNHglycan	330	333	PF01048	0.648
MOD_GlcNHglycan	335	338	PF01048	0.612
MOD_GlcNHglycan	348	352	PF01048	0.555
MOD_GlcNHglycan	405	408	PF01048	0.422
MOD_GlcNHglycan	425	428	PF01048	0.383
MOD_GlcNHglycan	450	453	PF01048	0.648
MOD_GlcNHglycan	560	563	PF01048	0.629
MOD_GlcNHglycan	614	617	PF01048	0.520
MOD_GlcNHglycan	685	689	PF01048	0.504
MOD_GlcNHglycan	713	716	PF01048	0.526
MOD_GlcNHglycan	72	75	PF01048	0.614
MOD_GlcNHglycan	763	766	PF01048	0.549
MOD_GlcNHglycan	776	779	PF01048	0.492
MOD_GlcNHglycan	812	815	PF01048	0.535
MOD_GlcNHglycan	88	91	PF01048	0.599
MOD_GSK3_1	201	208	PF00069	0.637
MOD_GSK3_1	225	232	PF00069	0.722
MOD_GSK3_1	239	246	PF00069	0.604
MOD_GSK3_1	276	283	PF00069	0.620
MOD_GSK3_1	308	315	PF00069	0.604
MOD_GSK3_1	435	442	PF00069	0.608
MOD_GSK3_1	553	560	PF00069	0.706
MOD_GSK3_1	567	574	PF00069	0.535
MOD_GSK3_1	576	583	PF00069	0.541
MOD_GSK3_1	588	595	PF00069	0.496
MOD_GSK3_1	605	612	PF00069	0.450
MOD_GSK3_1	629	636	PF00069	0.492
MOD_GSK3_1	70	77	PF00069	0.683
MOD_GSK3_1	718	725	PF00069	0.496
MOD_GSK3_1	81	88	PF00069	0.545
MOD_GSK3_1	93	100	PF00069	0.587
MOD_LATS_1	326	332	PF00433	0.647
MOD_LATS_1	401	407	PF00433	0.460
MOD_LATS_1	446	452	PF00433	0.560
MOD_N-GLC_1	592	597	PF02516	0.452
MOD_NEK2_1	276	281	PF00069	0.522
MOD_NEK2_1	455	460	PF00069	0.392
MOD_NEK2_1	531	536	PF00069	0.480
MOD_NEK2_1	571	576	PF00069	0.584
MOD_NEK2_1	580	585	PF00069	0.587
MOD_NEK2_1	588	593	PF00069	0.480
MOD_NEK2_1	629	634	PF00069	0.452
MOD_NEK2_1	774	779	PF00069	0.521
MOD_NEK2_2	702	707	PF00069	0.446
MOD_PIKK_1	226	232	PF00454	0.578
MOD_PIKK_1	276	282	PF00454	0.582
MOD_PIKK_1	572	578	PF00454	0.603
MOD_PK_1	798	804	PF00069	0.525
MOD_PKA_1	14	20	PF00069	0.575
MOD_PKA_1	403	409	PF00069	0.409
MOD_PKA_1	558	564	PF00069	0.562
MOD_PKA_1	683	689	PF00069	0.471
MOD_PKA_1	798	804	PF00069	0.460
MOD_PKA_2	112	118	PF00069	0.560
MOD_PKA_2	127	133	PF00069	0.562
MOD_PKA_2	223	229	PF00069	0.552
MOD_PKA_2	243	249	PF00069	0.704
MOD_PKA_2	287	293	PF00069	0.741
MOD_PKA_2	327	333	PF00069	0.604
MOD_PKA_2	365	371	PF00069	0.529
MOD_PKA_2	447	453	PF00069	0.547
MOD_PKA_2	557	563	PF00069	0.633
MOD_PKA_2	683	689	PF00069	0.471
MOD_PKA_2	718	724	PF00069	0.496
MOD_PKA_2	761	767	PF00069	0.559
MOD_PKA_2	798	804	PF00069	0.462
MOD_PKA_2	86	92	PF00069	0.657
MOD_PKA_2	93	99	PF00069	0.618
MOD_PKB_1	796	804	PF00069	0.463
MOD_Plk_1	684	690	PF00069	0.397
MOD_Plk_1	702	708	PF00069	0.508
MOD_Plk_2-3	112	118	PF00069	0.560
MOD_Plk_2-3	538	544	PF00069	0.469
MOD_Plk_2-3	81	87	PF00069	0.543
MOD_Plk_4	181	187	PF00069	0.481
MOD_Plk_4	190	196	PF00069	0.418
MOD_Plk_4	212	218	PF00069	0.675
MOD_Plk_4	31	37	PF00069	0.560
MOD_Plk_4	394	400	PF00069	0.426
MOD_Plk_4	475	481	PF00069	0.461
MOD_Plk_4	722	728	PF00069	0.475
MOD_Plk_4	733	739	PF00069	0.480
MOD_ProDKin_1	196	202	PF00069	0.555
MOD_ProDKin_1	230	236	PF00069	0.716
MOD_ProDKin_1	310	316	PF00069	0.664
MOD_ProDKin_1	352	358	PF00069	0.576
MOD_ProDKin_1	439	445	PF00069	0.621
MOD_ProDKin_1	553	559	PF00069	0.640
MOD_ProDKin_1	583	589	PF00069	0.573
MOD_ProDKin_1	595	601	PF00069	0.391
MOD_ProDKin_1	640	646	PF00069	0.595
MOD_ProDKin_1	74	80	PF00069	0.663
MOD_SUMO_for_1	101	104	PF00179	0.657
MOD_SUMO_for_1	109	112	PF00179	0.614
MOD_SUMO_rev_2	77	85	PF00179	0.609
TRG_DiLeu_BaEn_1	685	690	PF01217	0.400
TRG_ENDOCYTIC_2	145	148	PF00928	0.571
TRG_ENDOCYTIC_2	49	52	PF00928	0.587
TRG_ENDOCYTIC_2	749	752	PF00928	0.539
TRG_ENDOCYTIC_2	771	774	PF00928	0.647
TRG_ER_diArg_1	480	482	PF00400	0.469
TRG_ER_diArg_1	497	499	PF00400	0.469
TRG_ER_diArg_1	557	559	PF00400	0.558
TRG_ER_diArg_1	646	649	PF00400	0.592
TRG_ER_diArg_1	651	654	PF00400	0.555
TRG_ER_diArg_1	697	700	PF00400	0.674
TRG_ER_diArg_1	796	799	PF00400	0.482
TRG_NES_CRM1_1	733	748	PF08389	0.506
TRG_NLS_MonoExtC_3	646	651	PF00514	0.589
TRG_NLS_MonoExtN_4	644	651	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	699	703	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	768	772	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA05	Leptomonas seymouri	55%	97%
A4HPX7	Leishmania braziliensis	71%	100%
A4IDN8	Leishmania infantum	98%	100%
E9ATP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q0V5	Leishmania major	89%	100%