Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHQ4_LEIDO

TriTrypDb:

LdBPK_331190.1 , LdCL_330018000 , LDHU3_33.1810

Length:

681

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8IHQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHQ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	610	614	PF00656	0.760
CLV_NRD_NRD_1	2	4	PF00675	0.733
CLV_NRD_NRD_1	450	452	PF00675	0.463
CLV_NRD_NRD_1	560	562	PF00675	0.476
CLV_NRD_NRD_1	567	569	PF00675	0.451
CLV_NRD_NRD_1	583	585	PF00675	0.514
CLV_PCSK_FUR_1	565	569	PF00082	0.536
CLV_PCSK_KEX2_1	2	4	PF00082	0.735
CLV_PCSK_KEX2_1	567	569	PF00082	0.488
CLV_PCSK_KEX2_1	583	585	PF00082	0.521
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.514
CLV_PCSK_PC7_1	565	571	PF00082	0.417
CLV_PCSK_SKI1_1	165	169	PF00082	0.625
CLV_PCSK_SKI1_1	171	175	PF00082	0.601
CLV_PCSK_SKI1_1	272	276	PF00082	0.624
CLV_PCSK_SKI1_1	569	573	PF00082	0.489
CLV_PCSK_SKI1_1	88	92	PF00082	0.616
CLV_Separin_Metazoa	593	597	PF03568	0.749
DEG_Nend_UBRbox_1	1	4	PF02207	0.623
DEG_SCF_FBW7_1	602	609	PF00400	0.719
DEG_SCF_FBW7_2	587	593	PF00400	0.744
DEG_SPOP_SBC_1	445	449	PF00917	0.369
DEG_SPOP_SBC_1	607	611	PF00917	0.650
DOC_CKS1_1	587	592	PF01111	0.798
DOC_CYCLIN_RxL_1	467	475	PF00134	0.394
DOC_MAPK_MEF2A_6	134	142	PF00069	0.351
DOC_MAPK_MEF2A_6	340	349	PF00069	0.417
DOC_PP1_RVXF_1	205	212	PF00149	0.360
DOC_PP1_RVXF_1	468	475	PF00149	0.398
DOC_PP4_FxxP_1	213	216	PF00568	0.371
DOC_USP7_MATH_1	163	167	PF00917	0.385
DOC_USP7_MATH_1	25	29	PF00917	0.533
DOC_USP7_MATH_1	468	472	PF00917	0.359
DOC_USP7_MATH_1	506	510	PF00917	0.420
DOC_USP7_MATH_1	519	523	PF00917	0.438
DOC_USP7_MATH_1	629	633	PF00917	0.728
DOC_USP7_MATH_1	664	668	PF00917	0.777
DOC_USP7_MATH_1	77	81	PF00917	0.247
DOC_USP7_UBL2_3	569	573	PF12436	0.681
DOC_WW_Pin1_4	177	182	PF00397	0.338
DOC_WW_Pin1_4	338	343	PF00397	0.477
DOC_WW_Pin1_4	393	398	PF00397	0.350
DOC_WW_Pin1_4	481	486	PF00397	0.419
DOC_WW_Pin1_4	586	591	PF00397	0.797
DOC_WW_Pin1_4	602	607	PF00397	0.767
DOC_WW_Pin1_4	654	659	PF00397	0.799
LIG_14-3-3_CanoR_1	2	8	PF00244	0.703
LIG_14-3-3_CanoR_1	366	376	PF00244	0.436
LIG_14-3-3_CanoR_1	451	456	PF00244	0.416
LIG_14-3-3_CanoR_1	654	658	PF00244	0.761
LIG_APCC_ABBA_1	492	497	PF00400	0.378
LIG_BRCT_BRCA1_1	470	474	PF00533	0.375
LIG_FHA_1	101	107	PF00498	0.338
LIG_FHA_1	137	143	PF00498	0.440
LIG_FHA_1	145	151	PF00498	0.425
LIG_FHA_1	178	184	PF00498	0.374
LIG_FHA_1	201	207	PF00498	0.448
LIG_FHA_1	223	229	PF00498	0.390
LIG_FHA_1	260	266	PF00498	0.374
LIG_FHA_1	269	275	PF00498	0.355
LIG_FHA_1	331	337	PF00498	0.390
LIG_FHA_1	400	406	PF00498	0.420
LIG_FHA_1	478	484	PF00498	0.373
LIG_FHA_1	494	500	PF00498	0.288
LIG_FHA_1	531	537	PF00498	0.562
LIG_FHA_1	607	613	PF00498	0.792
LIG_FHA_1	7	13	PF00498	0.450
LIG_FHA_1	81	87	PF00498	0.417
LIG_FHA_2	106	112	PF00498	0.398
LIG_FHA_2	608	614	PF00498	0.643
LIG_FHA_2	64	70	PF00498	0.403
LIG_LIR_Apic_2	212	216	PF02991	0.402
LIG_LIR_Apic_2	36	42	PF02991	0.366
LIG_LIR_Apic_2	475	479	PF02991	0.315
LIG_LIR_Apic_2	59	64	PF02991	0.392
LIG_LIR_Gen_1	324	334	PF02991	0.458
LIG_LIR_Gen_1	396	406	PF02991	0.314
LIG_LIR_Gen_1	427	437	PF02991	0.342
LIG_LIR_Gen_1	487	495	PF02991	0.362
LIG_LIR_Gen_1	631	642	PF02991	0.735
LIG_LIR_Gen_1	71	77	PF02991	0.251
LIG_LIR_Nem_3	324	330	PF02991	0.400
LIG_LIR_Nem_3	427	433	PF02991	0.322
LIG_LIR_Nem_3	440	446	PF02991	0.323
LIG_LIR_Nem_3	471	476	PF02991	0.327
LIG_LIR_Nem_3	487	492	PF02991	0.320
LIG_LIR_Nem_3	493	498	PF02991	0.416
LIG_LIR_Nem_3	631	637	PF02991	0.733
LIG_LIR_Nem_3	71	76	PF02991	0.424
LIG_MYND_1	250	254	PF01753	0.351
LIG_NRBOX	12	18	PF00104	0.588
LIG_Pex3_1	13	24	PF04882	0.625
LIG_PTAP_UEV_1	216	221	PF05743	0.375
LIG_PTB_Apo_2	196	203	PF02174	0.433
LIG_PTB_Apo_2	454	461	PF02174	0.361
LIG_PTB_Phospho_1	454	460	PF10480	0.363
LIG_RPA_C_Fungi	556	568	PF08784	0.642
LIG_SH2_CRK	39	43	PF00017	0.571
LIG_SH2_CRK	476	480	PF00017	0.443
LIG_SH2_CRK	545	549	PF00017	0.447
LIG_SH2_CRK	61	65	PF00017	0.578
LIG_SH2_CRK	634	638	PF00017	0.673
LIG_SH2_NCK_1	634	638	PF00017	0.770
LIG_SH2_PTP2	346	349	PF00017	0.434
LIG_SH2_PTP2	489	492	PF00017	0.464
LIG_SH2_SRC	489	492	PF00017	0.460
LIG_SH2_STAP1	361	365	PF00017	0.551
LIG_SH2_STAP1	495	499	PF00017	0.371
LIG_SH2_STAP1	634	638	PF00017	0.557
LIG_SH2_STAT5	117	120	PF00017	0.457
LIG_SH2_STAT5	346	349	PF00017	0.473
LIG_SH2_STAT5	39	42	PF00017	0.593
LIG_SH2_STAT5	460	463	PF00017	0.533
LIG_SH2_STAT5	489	492	PF00017	0.453
LIG_SH2_STAT5	495	498	PF00017	0.528
LIG_SH3_3	214	220	PF00018	0.552
LIG_SH3_3	244	250	PF00018	0.571
LIG_SH3_3	339	345	PF00018	0.482
LIG_SH3_3	403	409	PF00018	0.569
LIG_SH3_3	584	590	PF00018	0.769
LIG_SH3_3	656	662	PF00018	0.766
LIG_SH3_5	485	489	PF00018	0.485
LIG_SUMO_SIM_anti_2	139	144	PF11976	0.431
LIG_SUMO_SIM_anti_2	14	21	PF11976	0.590
LIG_SUMO_SIM_par_1	102	108	PF11976	0.472
LIG_SUMO_SIM_par_1	138	144	PF11976	0.470
LIG_SUMO_SIM_par_1	17	23	PF11976	0.472
LIG_SUMO_SIM_par_1	225	231	PF11976	0.537
LIG_TYR_ITIM	543	548	PF00017	0.480
LIG_WRC_WIRS_1	21	26	PF05994	0.564
LIG_WRC_WIRS_1	210	215	PF05994	0.528
LIG_WRC_WIRS_1	223	228	PF05994	0.458
MOD_CDC14_SPxK_1	341	344	PF00782	0.488
MOD_CDK_SPxK_1	338	344	PF00069	0.481
MOD_CK1_1	105	111	PF00069	0.362
MOD_CK1_1	136	142	PF00069	0.496
MOD_CK1_1	144	150	PF00069	0.503
MOD_CK1_1	192	198	PF00069	0.470
MOD_CK1_1	260	266	PF00069	0.429
MOD_CK1_1	356	362	PF00069	0.538
MOD_CK1_1	380	386	PF00069	0.661
MOD_CK1_1	396	402	PF00069	0.524
MOD_CK1_1	423	429	PF00069	0.472
MOD_CK1_1	438	444	PF00069	0.487
MOD_CK1_1	453	459	PF00069	0.394
MOD_CK1_1	493	499	PF00069	0.552
MOD_CK1_1	6	12	PF00069	0.620
MOD_CK1_1	600	606	PF00069	0.786
MOD_CK1_1	653	659	PF00069	0.804
MOD_CK1_1	80	86	PF00069	0.486
MOD_CK2_1	356	362	PF00069	0.561
MOD_DYRK1A_RPxSP_1	654	658	PF00069	0.735
MOD_GlcNHglycan	135	138	PF01048	0.498
MOD_GlcNHglycan	165	168	PF01048	0.423
MOD_GlcNHglycan	185	188	PF01048	0.566
MOD_GlcNHglycan	193	197	PF01048	0.593
MOD_GlcNHglycan	203	206	PF01048	0.413
MOD_GlcNHglycan	27	30	PF01048	0.622
MOD_GlcNHglycan	281	284	PF01048	0.532
MOD_GlcNHglycan	319	322	PF01048	0.667
MOD_GlcNHglycan	379	382	PF01048	0.634
MOD_GlcNHglycan	422	425	PF01048	0.443
MOD_GlcNHglycan	437	440	PF01048	0.447
MOD_GlcNHglycan	502	505	PF01048	0.533
MOD_GlcNHglycan	523	526	PF01048	0.693
MOD_GlcNHglycan	599	602	PF01048	0.682
MOD_GlcNHglycan	631	634	PF01048	0.760
MOD_GlcNHglycan	88	91	PF01048	0.550
MOD_GSK3_1	100	107	PF00069	0.345
MOD_GSK3_1	141	148	PF00069	0.506
MOD_GSK3_1	153	160	PF00069	0.491
MOD_GSK3_1	175	182	PF00069	0.494
MOD_GSK3_1	211	218	PF00069	0.425
MOD_GSK3_1	222	229	PF00069	0.408
MOD_GSK3_1	268	275	PF00069	0.562
MOD_GSK3_1	285	292	PF00069	0.473
MOD_GSK3_1	313	320	PF00069	0.671
MOD_GSK3_1	328	335	PF00069	0.460
MOD_GSK3_1	380	387	PF00069	0.650
MOD_GSK3_1	416	423	PF00069	0.469
MOD_GSK3_1	446	453	PF00069	0.471
MOD_GSK3_1	468	475	PF00069	0.412
MOD_GSK3_1	477	484	PF00069	0.477
MOD_GSK3_1	521	528	PF00069	0.642
MOD_GSK3_1	557	564	PF00069	0.659
MOD_GSK3_1	602	609	PF00069	0.717
MOD_GSK3_1	629	636	PF00069	0.708
MOD_GSK3_1	650	657	PF00069	0.760
MOD_GSK3_1	76	83	PF00069	0.493
MOD_GSK3_1	92	99	PF00069	0.414
MOD_N-GLC_1	289	294	PF02516	0.542
MOD_N-GLC_1	317	322	PF02516	0.697
MOD_N-GLC_1	424	429	PF02516	0.408
MOD_N-GLC_1	456	461	PF02516	0.457
MOD_N-GLC_1	629	634	PF02516	0.713
MOD_N-GLC_1	80	85	PF02516	0.494
MOD_N-GLC_1	96	101	PF02516	0.288
MOD_NEK2_1	102	107	PF00069	0.376
MOD_NEK2_1	12	17	PF00069	0.481
MOD_NEK2_1	200	205	PF00069	0.484
MOD_NEK2_1	209	214	PF00069	0.409
MOD_NEK2_1	222	227	PF00069	0.428
MOD_NEK2_1	228	233	PF00069	0.314
MOD_NEK2_1	259	264	PF00069	0.544
MOD_NEK2_1	289	294	PF00069	0.581
MOD_NEK2_1	334	339	PF00069	0.469
MOD_NEK2_1	472	477	PF00069	0.457
MOD_NEK2_1	544	549	PF00069	0.428
MOD_NEK2_1	672	677	PF00069	0.662
MOD_NEK2_1	76	81	PF00069	0.552
MOD_NEK2_2	409	414	PF00069	0.370
MOD_PK_1	451	457	PF00069	0.581
MOD_PKA_1	451	457	PF00069	0.290
MOD_PKA_1	561	567	PF00069	0.407
MOD_PKA_2	133	139	PF00069	0.461
MOD_PKA_2	313	319	PF00069	0.750
MOD_PKA_2	33	39	PF00069	0.432
MOD_PKA_2	416	422	PF00069	0.480
MOD_PKA_2	450	456	PF00069	0.576
MOD_PKA_2	653	659	PF00069	0.725
MOD_PKA_2	77	83	PF00069	0.581
MOD_PKA_2	92	98	PF00069	0.546
MOD_PKB_1	559	567	PF00069	0.411
MOD_Plk_1	192	198	PF00069	0.469
MOD_Plk_1	289	295	PF00069	0.526
MOD_Plk_1	298	304	PF00069	0.496
MOD_Plk_1	356	362	PF00069	0.587
MOD_Plk_1	424	430	PF00069	0.478
MOD_Plk_1	456	462	PF00069	0.425
MOD_Plk_1	490	496	PF00069	0.499
MOD_Plk_1	80	86	PF00069	0.496
MOD_Plk_1	96	102	PF00069	0.303
MOD_Plk_2-3	353	359	PF00069	0.348
MOD_Plk_4	12	18	PF00069	0.491
MOD_Plk_4	138	144	PF00069	0.376
MOD_Plk_4	179	185	PF00069	0.464
MOD_Plk_4	33	39	PF00069	0.431
MOD_Plk_4	356	362	PF00069	0.566
MOD_Plk_4	396	402	PF00069	0.355
MOD_Plk_4	416	422	PF00069	0.487
MOD_Plk_4	456	462	PF00069	0.481
MOD_Plk_4	490	496	PF00069	0.528
MOD_Plk_4	544	550	PF00069	0.371
MOD_Plk_4	96	102	PF00069	0.415
MOD_ProDKin_1	177	183	PF00069	0.404
MOD_ProDKin_1	338	344	PF00069	0.607
MOD_ProDKin_1	393	399	PF00069	0.434
MOD_ProDKin_1	481	487	PF00069	0.524
MOD_ProDKin_1	586	592	PF00069	0.778
MOD_ProDKin_1	602	608	PF00069	0.736
MOD_ProDKin_1	654	660	PF00069	0.776
MOD_SUMO_for_1	354	357	PF00179	0.438
MOD_SUMO_rev_2	351	356	PF00179	0.572
TRG_DiLeu_BaEn_1	46	51	PF01217	0.472
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.559
TRG_ENDOCYTIC_2	346	349	PF00928	0.551
TRG_ENDOCYTIC_2	398	401	PF00928	0.462
TRG_ENDOCYTIC_2	489	492	PF00928	0.505
TRG_ENDOCYTIC_2	495	498	PF00928	0.540
TRG_ENDOCYTIC_2	545	548	PF00928	0.447
TRG_ENDOCYTIC_2	634	637	PF00928	0.692
TRG_ER_diArg_1	1	3	PF00400	0.697
TRG_ER_diArg_1	294	297	PF00400	0.520
TRG_ER_diArg_1	364	367	PF00400	0.521
TRG_ER_diArg_1	565	568	PF00400	0.604
TRG_NLS_MonoExtN_4	565	572	PF00514	0.483
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILM2	Leptomonas seymouri	49%	100%
A0A0S4J6Q6	Bodo saltans	31%	100%
A0A1X0P168	Trypanosomatidae	34%	100%
A0A3R7N2S1	Trypanosoma rangeli	33%	100%
A4HLG7	Leishmania braziliensis	64%	96%
A4I8X8	Leishmania infantum	99%	100%
E9B3U7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q477	Leishmania major	88%	100%
V5BJT9	Trypanosoma cruzi	31%	100%