Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHP4_LEIDO

TriTrypDb:

LdBPK_332710.1 , LdCL_330034200 , LDHU3_33.3850

Length:

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3Q8IHP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHP4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	8	10	PF00675	0.379
CLV_PCSK_KEX2_1	8	10	PF00082	0.379
CLV_PCSK_SKI1_1	63	67	PF00082	0.645
DEG_SCF_FBW7_1	79	85	PF00400	0.534
DOC_CKS1_1	68	73	PF01111	0.469
DOC_CKS1_1	79	84	PF01111	0.454
DOC_WW_Pin1_4	67	72	PF00397	0.457
DOC_WW_Pin1_4	78	83	PF00397	0.472
LIG_FHA_1	28	34	PF00498	0.504
LIG_LIR_Nem_3	30	34	PF02991	0.389
LIG_LIR_Nem_3	42	47	PF02991	0.409
LIG_Pex14_2	53	57	PF04695	0.443
LIG_SH2_PTP2	46	49	PF00017	0.433
LIG_SH2_STAP1	13	17	PF00017	0.391
LIG_SH2_STAT5	46	49	PF00017	0.422
LIG_SH2_STAT5	78	81	PF00017	0.495
LIG_SH2_STAT5	84	87	PF00017	0.503
LIG_TRAF2_1	48	51	PF00917	0.420
MOD_GlcNHglycan	63	66	PF01048	0.697
MOD_GSK3_1	78	85	PF00069	0.506
MOD_NEK2_1	27	32	PF00069	0.475
MOD_NEK2_1	34	39	PF00069	0.387
MOD_Plk_2-3	87	93	PF00069	0.569
MOD_Plk_4	20	26	PF00069	0.391
MOD_ProDKin_1	67	73	PF00069	0.457
MOD_ProDKin_1	78	84	PF00069	0.474
MOD_SUMO_for_1	53	56	PF00179	0.499
TRG_ENDOCYTIC_2	31	34	PF00928	0.394
TRG_ENDOCYTIC_2	46	49	PF00928	0.409
TRG_ER_diArg_1	7	9	PF00400	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8S3	Leptomonas seymouri	90%	100%
A0A0S4J1K9	Bodo saltans	62%	100%
A0A1X0P3U8	Trypanosomatidae	69%	93%
A4HLW8	Leishmania braziliensis	95%	100%
A4I997	Leishmania infantum	100%	100%
E9B497	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4Q3S9	Leishmania major	98%	100%