EF-hand domain pair/EF-hand domain/EF hand, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF-hand domain pair, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHP2_LEIDO

TriTrypDb:

LdBPK_342780.1 , LdCL_340035900 , LDHU3_34.4780

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IHP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHP2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.460
CLV_C14_Caspase3-7	309	313	PF00656	0.328
CLV_C14_Caspase3-7	345	349	PF00656	0.474
CLV_NRD_NRD_1	104	106	PF00675	0.412
CLV_NRD_NRD_1	151	153	PF00675	0.555
CLV_NRD_NRD_1	359	361	PF00675	0.597
CLV_PCSK_KEX2_1	104	106	PF00082	0.338
CLV_PCSK_KEX2_1	19	21	PF00082	0.425
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.508
CLV_PCSK_SKI1_1	19	23	PF00082	0.406
CLV_PCSK_SKI1_1	242	246	PF00082	0.492
CLV_PCSK_SKI1_1	332	336	PF00082	0.426
CLV_PCSK_SKI1_1	370	374	PF00082	0.462
DEG_APCC_DBOX_1	104	112	PF00400	0.328
DEG_APCC_DBOX_1	241	249	PF00400	0.505
DEG_Nend_UBRbox_3	1	3	PF02207	0.697
DOC_CYCLIN_RxL_1	16	26	PF00134	0.430
DOC_CYCLIN_RxL_1	262	270	PF00134	0.436
DOC_PP2B_LxvP_1	296	299	PF13499	0.504
DOC_PP2B_LxvP_1	323	326	PF13499	0.456
DOC_USP7_MATH_1	179	183	PF00917	0.480
DOC_USP7_MATH_1	202	206	PF00917	0.504
DOC_USP7_MATH_1	234	238	PF00917	0.578
DOC_USP7_MATH_1	240	244	PF00917	0.494
DOC_USP7_MATH_1	299	303	PF00917	0.577
DOC_WW_Pin1_4	23	28	PF00397	0.624
DOC_WW_Pin1_4	363	368	PF00397	0.590
DOC_WW_Pin1_4	98	103	PF00397	0.390
LIG_Actin_WH2_2	88	106	PF00022	0.490
LIG_BRCT_BRCA1_1	204	208	PF00533	0.532
LIG_BRCT_BRCA1_1	340	344	PF00533	0.514
LIG_eIF4E_1	319	325	PF01652	0.481
LIG_FHA_1	291	297	PF00498	0.478
LIG_FHA_1	299	305	PF00498	0.238
LIG_FHA_1	88	94	PF00498	0.368
LIG_FHA_2	145	151	PF00498	0.558
LIG_FHA_2	161	167	PF00498	0.457
LIG_FHA_2	307	313	PF00498	0.340
LIG_FHA_2	373	379	PF00498	0.478
LIG_FHA_2	50	56	PF00498	0.354
LIG_FHA_2	75	81	PF00498	0.449
LIG_LIR_Apic_2	348	354	PF02991	0.512
LIG_LIR_Gen_1	188	198	PF02991	0.396
LIG_LIR_Gen_1	406	413	PF02991	0.440
LIG_LIR_Gen_1	90	100	PF02991	0.447
LIG_LIR_Nem_3	173	177	PF02991	0.378
LIG_LIR_Nem_3	188	194	PF02991	0.326
LIG_LIR_Nem_3	406	412	PF02991	0.474
LIG_LIR_Nem_3	90	95	PF02991	0.447
LIG_Pex14_1	340	344	PF04695	0.487
LIG_Pex14_2	155	159	PF04695	0.432
LIG_Pex14_2	373	377	PF04695	0.393
LIG_RPA_C_Fungi	233	245	PF08784	0.544
LIG_SH2_CRK	178	182	PF00017	0.386
LIG_SH2_CRK	351	355	PF00017	0.503
LIG_SH2_STAP1	320	324	PF00017	0.479
LIG_SH2_STAT3	396	399	PF00017	0.466
LIG_SH2_STAT5	297	300	PF00017	0.417
LIG_SH2_STAT5	396	399	PF00017	0.413
LIG_SUMO_SIM_anti_2	188	196	PF11976	0.371
LIG_SUMO_SIM_anti_2	90	97	PF11976	0.475
LIG_TRAF2_1	170	173	PF00917	0.403
LIG_TRAF2_1	52	55	PF00917	0.448
LIG_TRAF2_1	59	62	PF00917	0.402
LIG_TRAF2_1	66	69	PF00917	0.377
LIG_UBA3_1	75	84	PF00899	0.473
LIG_WRC_WIRS_1	33	38	PF05994	0.549
MOD_CDC14_SPxK_1	101	104	PF00782	0.477
MOD_CDK_SPxK_1	98	104	PF00069	0.384
MOD_CDK_SPxxK_3	363	370	PF00069	0.585
MOD_CDK_SPxxK_3	98	105	PF00069	0.425
MOD_CK1_1	222	228	PF00069	0.607
MOD_CK2_1	144	150	PF00069	0.545
MOD_CK2_1	167	173	PF00069	0.411
MOD_CK2_1	225	231	PF00069	0.573
MOD_CK2_1	299	305	PF00069	0.538
MOD_CK2_1	339	345	PF00069	0.501
MOD_CK2_1	49	55	PF00069	0.404
MOD_CK2_1	63	69	PF00069	0.267
MOD_GlcNHglycan	156	159	PF01048	0.521
MOD_GlcNHglycan	169	172	PF01048	0.545
MOD_GlcNHglycan	181	184	PF01048	0.412
MOD_GlcNHglycan	242	245	PF01048	0.559
MOD_GlcNHglycan	259	262	PF01048	0.476
MOD_GlcNHglycan	27	30	PF01048	0.470
MOD_GlcNHglycan	278	281	PF01048	0.467
MOD_GlcNHglycan	328	331	PF01048	0.528
MOD_GlcNHglycan	399	402	PF01048	0.476
MOD_GSK3_1	202	209	PF00069	0.480
MOD_GSK3_1	230	237	PF00069	0.488
MOD_GSK3_1	240	247	PF00069	0.468
MOD_GSK3_1	276	283	PF00069	0.473
MOD_GSK3_1	32	39	PF00069	0.476
MOD_GSK3_1	45	52	PF00069	0.449
MOD_GSK3_1	83	90	PF00069	0.444
MOD_N-GLC_1	159	164	PF02516	0.489
MOD_N-GLC_1	299	304	PF02516	0.486
MOD_N-GLC_1	98	103	PF02516	0.499
MOD_NEK2_1	11	16	PF00069	0.480
MOD_NEK2_1	159	164	PF00069	0.480
MOD_NEK2_1	208	213	PF00069	0.472
MOD_NEK2_1	267	272	PF00069	0.454
MOD_NEK2_1	339	344	PF00069	0.377
MOD_NEK2_1	36	41	PF00069	0.522
MOD_NEK2_1	46	51	PF00069	0.480
MOD_PIKK_1	46	52	PF00454	0.600
MOD_PK_1	206	212	PF00069	0.396
MOD_Plk_1	187	193	PF00069	0.391
MOD_Plk_1	206	212	PF00069	0.504
MOD_Plk_1	225	231	PF00069	0.536
MOD_Plk_1	299	305	PF00069	0.514
MOD_Plk_4	187	193	PF00069	0.377
MOD_Plk_4	244	250	PF00069	0.455
MOD_Plk_4	299	305	PF00069	0.482
MOD_ProDKin_1	23	29	PF00069	0.623
MOD_ProDKin_1	363	369	PF00069	0.585
MOD_ProDKin_1	98	104	PF00069	0.384
MOD_SUMO_for_1	213	216	PF00179	0.516
MOD_SUMO_rev_2	161	170	PF00179	0.567
TRG_DiLeu_BaEn_1	388	393	PF01217	0.449
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.408
TRG_ENDOCYTIC_2	178	181	PF00928	0.386
TRG_ENDOCYTIC_2	320	323	PF00928	0.359
TRG_ER_diArg_1	103	105	PF00400	0.382
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2R2	Leptomonas seymouri	66%	100%
A0A0S4J207	Bodo saltans	35%	97%
A0A1X0PAP2	Trypanosomatidae	42%	100%
A0A422N4H8	Trypanosoma rangeli	42%	100%
A4HB14	Leishmania braziliensis	84%	100%
A4IA71	Leishmania infantum	99%	100%
C9ZM35	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B584	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q2P9	Leishmania major	95%	100%
V5B5A3	Trypanosoma cruzi	42%	100%