TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHN6_LEIDO

TriTrypDb:

LdBPK_364490.1 , LdCL_360052100 , LDHU3_36.6100

Length:

824

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000974	Prp19 complex	2	1
GO:0005681	spliceosomal complex	3	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0071007	U2-type catalytic step 2 spliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0071014	post-mRNA release spliceosomal complex	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8IHN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHN6

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000245	spliceosomal complex assembly	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.679
CLV_NRD_NRD_1	20	22	PF00675	0.549
CLV_NRD_NRD_1	207	209	PF00675	0.468
CLV_NRD_NRD_1	217	219	PF00675	0.327
CLV_NRD_NRD_1	341	343	PF00675	0.412
CLV_NRD_NRD_1	445	447	PF00675	0.523
CLV_NRD_NRD_1	483	485	PF00675	0.418
CLV_NRD_NRD_1	621	623	PF00675	0.410
CLV_NRD_NRD_1	632	634	PF00675	0.505
CLV_NRD_NRD_1	758	760	PF00675	0.560
CLV_NRD_NRD_1	76	78	PF00675	0.504
CLV_NRD_NRD_1	815	817	PF00675	0.541
CLV_NRD_NRD_1	85	87	PF00675	0.533
CLV_NRD_NRD_1	9	11	PF00675	0.559
CLV_PCSK_FUR_1	73	77	PF00082	0.427
CLV_PCSK_KEX2_1	19	21	PF00082	0.536
CLV_PCSK_KEX2_1	2	4	PF00082	0.568
CLV_PCSK_KEX2_1	207	209	PF00082	0.468
CLV_PCSK_KEX2_1	217	219	PF00082	0.327
CLV_PCSK_KEX2_1	445	447	PF00082	0.523
CLV_PCSK_KEX2_1	483	485	PF00082	0.476
CLV_PCSK_KEX2_1	621	623	PF00082	0.418
CLV_PCSK_KEX2_1	632	634	PF00082	0.522
CLV_PCSK_KEX2_1	75	77	PF00082	0.439
CLV_PCSK_KEX2_1	758	760	PF00082	0.623
CLV_PCSK_KEX2_1	814	816	PF00082	0.543
CLV_PCSK_KEX2_1	85	87	PF00082	0.347
CLV_PCSK_KEX2_1	9	11	PF00082	0.547
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.567
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.437
CLV_PCSK_PC1ET2_1	814	816	PF00082	0.561
CLV_PCSK_PC7_1	213	219	PF00082	0.377
CLV_PCSK_PC7_1	5	11	PF00082	0.643
CLV_PCSK_PC7_1	628	634	PF00082	0.484
CLV_PCSK_PC7_1	754	760	PF00082	0.496
CLV_PCSK_SKI1_1	150	154	PF00082	0.373
CLV_PCSK_SKI1_1	179	183	PF00082	0.356
CLV_PCSK_SKI1_1	213	217	PF00082	0.415
CLV_PCSK_SKI1_1	245	249	PF00082	0.335
CLV_PCSK_SKI1_1	288	292	PF00082	0.511
CLV_PCSK_SKI1_1	404	408	PF00082	0.498
CLV_PCSK_SKI1_1	424	428	PF00082	0.208
CLV_PCSK_SKI1_1	483	487	PF00082	0.404
CLV_PCSK_SKI1_1	563	567	PF00082	0.524
CLV_PCSK_SKI1_1	743	747	PF00082	0.421
CLV_PCSK_SKI1_1	811	815	PF00082	0.649
CLV_PCSK_SKI1_1	818	822	PF00082	0.456
CLV_Separin_Metazoa	573	577	PF03568	0.459
DEG_APCC_DBOX_1	643	651	PF00400	0.500
DEG_APCC_DBOX_1	742	750	PF00400	0.522
DEG_Nend_UBRbox_1	1	4	PF02207	0.573
DOC_ANK_TNKS_1	316	323	PF00023	0.486
DOC_CKS1_1	223	228	PF01111	0.423
DOC_CYCLIN_RxL_1	480	490	PF00134	0.509
DOC_MAPK_gen_1	775	784	PF00069	0.522
DOC_PP1_RVXF_1	757	764	PF00149	0.622
DOC_PP2B_LxvP_1	411	414	PF13499	0.555
DOC_PP4_FxxP_1	223	226	PF00568	0.424
DOC_PP4_FxxP_1	49	52	PF00568	0.632
DOC_USP7_MATH_1	154	158	PF00917	0.377
DOC_USP7_MATH_1	280	284	PF00917	0.434
DOC_USP7_MATH_1	369	373	PF00917	0.610
DOC_USP7_MATH_1	386	390	PF00917	0.528
DOC_USP7_MATH_1	400	404	PF00917	0.573
DOC_USP7_MATH_1	52	56	PF00917	0.661
DOC_WW_Pin1_4	222	227	PF00397	0.483
DOC_WW_Pin1_4	392	397	PF00397	0.691
DOC_WW_Pin1_4	398	403	PF00397	0.583
DOC_WW_Pin1_4	48	53	PF00397	0.637
DOC_WW_Pin1_4	522	527	PF00397	0.534
DOC_WW_Pin1_4	702	707	PF00397	0.473
DOC_WW_Pin1_4	782	787	PF00397	0.355
LIG_14-3-3_CanoR_1	150	159	PF00244	0.481
LIG_14-3-3_CanoR_1	342	352	PF00244	0.539
LIG_14-3-3_CanoR_1	445	449	PF00244	0.482
LIG_14-3-3_CanoR_1	475	485	PF00244	0.411
LIG_14-3-3_CanoR_1	594	599	PF00244	0.397
LIG_14-3-3_CanoR_1	710	718	PF00244	0.519
LIG_14-3-3_CanoR_1	724	730	PF00244	0.389
LIG_14-3-3_CanoR_1	758	762	PF00244	0.620
LIG_APCC_ABBA_1	118	123	PF00400	0.509
LIG_APCC_ABBA_1	334	339	PF00400	0.495
LIG_APCC_ABBA_1	496	501	PF00400	0.441
LIG_APCC_ABBAyCdc20_2	20	26	PF00400	0.528
LIG_BIR_III_2	189	193	PF00653	0.515
LIG_BRCT_BRCA1_1	136	140	PF00533	0.480
LIG_BRCT_BRCA1_1	677	681	PF00533	0.476
LIG_deltaCOP1_diTrp_1	789	794	PF00928	0.372
LIG_FHA_1	331	337	PF00498	0.470
LIG_FHA_1	388	394	PF00498	0.619
LIG_FHA_1	491	497	PF00498	0.419
LIG_FHA_1	640	646	PF00498	0.349
LIG_FHA_1	737	743	PF00498	0.482
LIG_FHA_2	585	591	PF00498	0.379
LIG_FHA_2	647	653	PF00498	0.393
LIG_FHA_2	766	772	PF00498	0.591
LIG_LIR_Apic_2	221	226	PF02991	0.483
LIG_LIR_Gen_1	106	114	PF02991	0.391
LIG_LIR_Gen_1	130	136	PF02991	0.350
LIG_LIR_Gen_1	311	319	PF02991	0.395
LIG_LIR_Gen_1	349	358	PF02991	0.380
LIG_LIR_Gen_1	767	776	PF02991	0.475
LIG_LIR_Gen_1	789	796	PF02991	0.514
LIG_LIR_Nem_3	130	134	PF02991	0.348
LIG_LIR_Nem_3	160	165	PF02991	0.335
LIG_LIR_Nem_3	228	232	PF02991	0.343
LIG_LIR_Nem_3	311	315	PF02991	0.368
LIG_LIR_Nem_3	345	351	PF02991	0.374
LIG_LIR_Nem_3	353	358	PF02991	0.327
LIG_LIR_Nem_3	664	669	PF02991	0.325
LIG_LIR_Nem_3	767	773	PF02991	0.487
LIG_LIR_Nem_3	778	782	PF02991	0.411
LIG_LIR_Nem_3	789	794	PF02991	0.365
LIG_LRP6_Inhibitor_1	90	96	PF00058	0.473
LIG_MLH1_MIPbox_1	677	681	PF16413	0.476
LIG_PCNA_PIPBox_1	33	42	PF02747	0.526
LIG_PCNA_PIPBox_1	651	660	PF02747	0.473
LIG_PCNA_yPIPBox_3	28	40	PF02747	0.546
LIG_PCNA_yPIPBox_3	644	658	PF02747	0.467
LIG_Pex14_1	560	564	PF04695	0.441
LIG_Pex14_1	676	680	PF04695	0.497
LIG_Pex14_2	556	560	PF04695	0.358
LIG_Pex14_2	677	681	PF04695	0.476
LIG_PTB_Apo_2	451	458	PF02174	0.489
LIG_RPA_C_Fungi	617	629	PF08784	0.464
LIG_SH2_CRK	602	606	PF00017	0.474
LIG_SH2_CRK	658	662	PF00017	0.425
LIG_SH2_GRB2like	547	550	PF00017	0.463
LIG_SH2_NCK_1	196	200	PF00017	0.449
LIG_SH2_SRC	547	550	PF00017	0.463
LIG_SH2_STAP1	196	200	PF00017	0.456
LIG_SH2_STAP1	337	341	PF00017	0.496
LIG_SH2_STAP1	658	662	PF00017	0.396
LIG_SH2_STAT3	202	205	PF00017	0.476
LIG_SH2_STAT3	358	361	PF00017	0.513
LIG_SH2_STAT3	419	422	PF00017	0.508
LIG_SH2_STAT5	165	168	PF00017	0.330
LIG_SH2_STAT5	351	354	PF00017	0.353
LIG_SH2_STAT5	539	542	PF00017	0.493
LIG_SH2_STAT5	680	683	PF00017	0.518
LIG_SH3_3	390	396	PF00018	0.531
LIG_SH3_3	412	418	PF00018	0.414
LIG_SUMO_SIM_par_1	270	276	PF11976	0.416
LIG_SUMO_SIM_par_1	300	306	PF11976	0.460
LIG_TRAF2_1	471	474	PF00917	0.487
LIG_TRAF2_1	528	531	PF00917	0.628
LIG_TRAF2_1	649	652	PF00917	0.488
LIG_TRAF2_1	65	68	PF00917	0.410
LIG_TYR_ITIM	562	567	PF00017	0.452
LIG_WRC_WIRS_1	585	590	PF05994	0.382
LIG_WRC_WIRS_1	595	600	PF05994	0.431
LIG_WW_3	413	417	PF00397	0.323
MOD_CDC14_SPxK_1	401	404	PF00782	0.526
MOD_CDK_SPxK_1	398	404	PF00069	0.574
MOD_CK1_1	490	496	PF00069	0.506
MOD_CK1_1	702	708	PF00069	0.573
MOD_CK2_1	310	316	PF00069	0.363
MOD_CK2_1	525	531	PF00069	0.523
MOD_CK2_1	62	68	PF00069	0.420
MOD_CK2_1	646	652	PF00069	0.397
MOD_CK2_1	745	751	PF00069	0.478
MOD_CK2_1	789	795	PF00069	0.463
MOD_GlcNHglycan	282	285	PF01048	0.565
MOD_GlcNHglycan	369	372	PF01048	0.683
MOD_GlcNHglycan	527	530	PF01048	0.556
MOD_GlcNHglycan	54	57	PF01048	0.626
MOD_GlcNHglycan	685	689	PF01048	0.580
MOD_GlcNHglycan	725	728	PF01048	0.557
MOD_GSK3_1	146	153	PF00069	0.381
MOD_GSK3_1	387	394	PF00069	0.644
MOD_GSK3_1	48	55	PF00069	0.605
MOD_GSK3_1	521	528	PF00069	0.617
MOD_GSK3_1	696	703	PF00069	0.626
MOD_GSK3_1	705	712	PF00069	0.509
MOD_GSK3_1	732	739	PF00069	0.626
MOD_GSK3_1	757	764	PF00069	0.553
MOD_GSK3_1	794	801	PF00069	0.512
MOD_N-GLC_1	343	348	PF02516	0.480
MOD_N-GLC_1	52	57	PF02516	0.522
MOD_NEK2_1	1	6	PF00069	0.697
MOD_NEK2_1	134	139	PF00069	0.547
MOD_NEK2_1	367	372	PF00069	0.646
MOD_NEK2_1	387	392	PF00069	0.591
MOD_NEK2_1	657	662	PF00069	0.297
MOD_NEK2_1	745	750	PF00069	0.468
MOD_NEK2_1	794	799	PF00069	0.427
MOD_NEK2_1	80	85	PF00069	0.491
MOD_NEK2_2	350	355	PF00069	0.459
MOD_PIKK_1	487	493	PF00454	0.536
MOD_PIKK_1	765	771	PF00454	0.573
MOD_PKA_1	342	348	PF00069	0.413
MOD_PKA_1	814	820	PF00069	0.565
MOD_PKA_2	362	368	PF00069	0.531
MOD_PKA_2	444	450	PF00069	0.479
MOD_PKA_2	709	715	PF00069	0.498
MOD_PKA_2	723	729	PF00069	0.545
MOD_PKA_2	757	763	PF00069	0.607
MOD_PKA_2	814	820	PF00069	0.575
MOD_PKB_1	340	348	PF00069	0.479
MOD_Plk_1	80	86	PF00069	0.499
MOD_Plk_2-3	646	652	PF00069	0.394
MOD_Plk_4	225	231	PF00069	0.418
MOD_Plk_4	350	356	PF00069	0.469
MOD_Plk_4	657	663	PF00069	0.317
MOD_Plk_4	745	751	PF00069	0.470
MOD_ProDKin_1	222	228	PF00069	0.476
MOD_ProDKin_1	392	398	PF00069	0.695
MOD_ProDKin_1	48	54	PF00069	0.639
MOD_ProDKin_1	522	528	PF00069	0.527
MOD_ProDKin_1	702	708	PF00069	0.470
MOD_ProDKin_1	782	788	PF00069	0.356
MOD_SUMO_for_1	565	568	PF00179	0.321
TRG_DiLeu_BaEn_1	778	783	PF01217	0.494
TRG_DiLeu_BaEn_4	652	658	PF01217	0.443
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.501
TRG_DiLeu_BaLyEn_6	481	486	PF01217	0.513
TRG_DiLeu_BaLyEn_6	783	788	PF01217	0.482
TRG_ENDOCYTIC_2	131	134	PF00928	0.338
TRG_ENDOCYTIC_2	165	168	PF00928	0.330
TRG_ENDOCYTIC_2	312	315	PF00928	0.345
TRG_ENDOCYTIC_2	351	354	PF00928	0.413
TRG_ENDOCYTIC_2	564	567	PF00928	0.322
TRG_ENDOCYTIC_2	602	605	PF00928	0.340
TRG_ENDOCYTIC_2	658	661	PF00928	0.324
TRG_ER_diArg_1	18	21	PF00400	0.542
TRG_ER_diArg_1	216	218	PF00400	0.391
TRG_ER_diArg_1	483	485	PF00400	0.482
TRG_ER_diArg_1	621	624	PF00400	0.428
TRG_ER_diArg_1	757	759	PF00400	0.610
TRG_ER_diArg_1	815	818	PF00400	0.544
TRG_ER_diArg_1	84	86	PF00400	0.514
TRG_ER_diArg_1	9	11	PF00400	0.558
TRG_NES_CRM1_1	108	123	PF08389	0.467
TRG_NLS_MonoExtC_3	1	7	PF00514	0.608
TRG_NLS_MonoExtC_3	813	818	PF00514	0.559
TRG_NLS_MonoExtN_4	811	818	PF00514	0.567
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	446	450	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	624	629	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P767	Leptomonas seymouri	74%	99%
A0A0S4JKT1	Bodo saltans	28%	95%
A0A1X0P0C5	Trypanosomatidae	43%	100%
A0A3R7P515	Trypanosoma rangeli	43%	100%
A4HPU7	Leishmania braziliensis	88%	100%
A4IE46	Leishmania infantum	100%	100%
D0A493	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ATL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P63154	Mus musculus	25%	100%
P63155	Rattus norvegicus	25%	100%
P87312	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q4PB37	Ustilago maydis (strain 521 / FGSC 9021)	28%	100%
Q4Q0Y6	Leishmania major	95%	100%
Q4WT84	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
Q5BDX1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	100%
Q5K654	Paracoccidioides brasiliensis	25%	100%
Q6CJK2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	22%	100%
Q7SGD2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	100%
Q9BZJ0	Homo sapiens	25%	97%
V5B545	Trypanosoma cruzi	43%	100%