Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHN4_LEIDO

TriTrypDb:

LdBPK_332560.1 , LdCL_330032700 , LDHU3_33.3650

Length:

650

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IHN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHN4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.556
CLV_C14_Caspase3-7	9	13	PF00656	0.331
CLV_NRD_NRD_1	279	281	PF00675	0.377
CLV_NRD_NRD_1	537	539	PF00675	0.449
CLV_NRD_NRD_1	541	543	PF00675	0.436
CLV_NRD_NRD_1	575	577	PF00675	0.464
CLV_NRD_NRD_1	613	615	PF00675	0.449
CLV_NRD_NRD_1	99	101	PF00675	0.484
CLV_PCSK_FUR_1	277	281	PF00082	0.443
CLV_PCSK_FUR_1	535	539	PF00082	0.489
CLV_PCSK_KEX2_1	279	281	PF00082	0.411
CLV_PCSK_KEX2_1	537	539	PF00082	0.455
CLV_PCSK_KEX2_1	541	543	PF00082	0.443
CLV_PCSK_KEX2_1	575	577	PF00082	0.464
CLV_PCSK_KEX2_1	99	101	PF00082	0.484
CLV_PCSK_PC7_1	537	543	PF00082	0.502
CLV_PCSK_SKI1_1	197	201	PF00082	0.490
CLV_PCSK_SKI1_1	280	284	PF00082	0.388
CLV_PCSK_SKI1_1	455	459	PF00082	0.410
CLV_PCSK_SKI1_1	537	541	PF00082	0.448
CLV_PCSK_SKI1_1	67	71	PF00082	0.367
CLV_Separin_Metazoa	426	430	PF03568	0.467
DEG_APCC_DBOX_1	279	287	PF00400	0.413
DEG_APCC_DBOX_1	536	544	PF00400	0.501
DEG_Nend_Nbox_1	1	3	PF02207	0.334
DEG_SPOP_SBC_1	388	392	PF00917	0.535
DEG_SPOP_SBC_1	620	624	PF00917	0.392
DOC_CKS1_1	16	21	PF01111	0.377
DOC_CYCLIN_RxL_1	450	461	PF00134	0.447
DOC_CYCLIN_yCln2_LP_2	384	387	PF00134	0.533
DOC_CYCLIN_yCln2_LP_2	409	415	PF00134	0.346
DOC_MAPK_gen_1	161	171	PF00069	0.644
DOC_MAPK_gen_1	185	193	PF00069	0.370
DOC_MAPK_gen_1	99	107	PF00069	0.449
DOC_MAPK_MEF2A_6	99	107	PF00069	0.402
DOC_MAPK_NFAT4_5	100	108	PF00069	0.406
DOC_PP1_SILK_1	286	291	PF00149	0.448
DOC_PP2B_LxvP_1	362	365	PF13499	0.480
DOC_PP2B_LxvP_1	384	387	PF13499	0.533
DOC_PP2B_LxvP_1	409	412	PF13499	0.323
DOC_USP7_MATH_1	394	398	PF00917	0.727
DOC_USP7_MATH_1	559	563	PF00917	0.621
DOC_USP7_MATH_1	613	617	PF00917	0.518
DOC_USP7_UBL2_3	611	615	PF12436	0.383
DOC_WW_Pin1_4	15	20	PF00397	0.362
DOC_WW_Pin1_4	240	245	PF00397	0.447
DOC_WW_Pin1_4	29	34	PF00397	0.382
DOC_WW_Pin1_4	477	482	PF00397	0.608
DOC_WW_Pin1_4	82	87	PF00397	0.583
LIG_14-3-3_CanoR_1	148	156	PF00244	0.567
LIG_14-3-3_CanoR_1	217	222	PF00244	0.360
LIG_14-3-3_CanoR_1	280	289	PF00244	0.451
LIG_14-3-3_CanoR_1	39	48	PF00244	0.375
LIG_14-3-3_CanoR_1	462	467	PF00244	0.548
LIG_14-3-3_CanoR_1	614	621	PF00244	0.623
LIG_Actin_WH2_2	44	59	PF00022	0.432
LIG_APCC_ABBA_1	515	520	PF00400	0.507
LIG_BRCT_BRCA1_1	31	35	PF00533	0.476
LIG_BRCT_BRCA1_1	416	420	PF00533	0.417
LIG_BRCT_BRCA1_1	439	443	PF00533	0.358
LIG_BRCT_BRCA1_2	439	445	PF00533	0.376
LIG_deltaCOP1_diTrp_1	467	474	PF00928	0.573
LIG_DLG_GKlike_1	217	225	PF00625	0.352
LIG_DLG_GKlike_1	563	570	PF00625	0.473
LIG_eIF4E_1	331	337	PF01652	0.432
LIG_FHA_1	151	157	PF00498	0.474
LIG_FHA_1	331	337	PF00498	0.501
LIG_FHA_1	376	382	PF00498	0.655
LIG_FHA_1	51	57	PF00498	0.467
LIG_FHA_1	544	550	PF00498	0.547
LIG_FHA_1	602	608	PF00498	0.460
LIG_FHA_2	172	178	PF00498	0.452
LIG_FHA_2	184	190	PF00498	0.342
LIG_FHA_2	50	56	PF00498	0.375
LIG_FHA_2	509	515	PF00498	0.424
LIG_FHA_2	620	626	PF00498	0.501
LIG_FHA_2	634	640	PF00498	0.473
LIG_FHA_2	7	13	PF00498	0.415
LIG_GBD_Chelix_1	403	411	PF00786	0.393
LIG_Integrin_isoDGR_2	23	25	PF01839	0.483
LIG_KLC1_Yacidic_2	189	194	PF13176	0.462
LIG_LIR_Gen_1	215	226	PF02991	0.456
LIG_LIR_Gen_1	440	448	PF02991	0.452
LIG_LIR_Gen_1	566	574	PF02991	0.534
LIG_LIR_Nem_3	189	195	PF02991	0.329
LIG_LIR_Nem_3	220	225	PF02991	0.355
LIG_LIR_Nem_3	3	8	PF02991	0.441
LIG_LIR_Nem_3	32	38	PF02991	0.386
LIG_LIR_Nem_3	440	446	PF02991	0.434
LIG_LIR_Nem_3	516	521	PF02991	0.420
LIG_LIR_Nem_3	566	570	PF02991	0.533
LIG_LIR_Nem_3	583	589	PF02991	0.462
LIG_LIR_Nem_3	60	66	PF02991	0.392
LIG_LIR_Nem_3	72	76	PF02991	0.462
LIG_MLH1_MIPbox_1	416	420	PF16413	0.417
LIG_NRBOX	358	364	PF00104	0.435
LIG_NRBOX	453	459	PF00104	0.483
LIG_NRBOX	602	608	PF00104	0.479
LIG_Pex14_1	271	275	PF04695	0.352
LIG_Pex14_1	470	474	PF04695	0.582
LIG_Pex14_2	416	420	PF04695	0.338
LIG_PTB_Apo_2	585	592	PF02174	0.428
LIG_PTB_Phospho_1	585	591	PF10480	0.434
LIG_SH2_CRK	499	503	PF00017	0.424
LIG_SH2_NCK_1	609	613	PF00017	0.398
LIG_SH2_SRC	26	29	PF00017	0.492
LIG_SH2_SRC	293	296	PF00017	0.498
LIG_SH2_STAP1	127	131	PF00017	0.397
LIG_SH2_STAP1	233	237	PF00017	0.347
LIG_SH2_STAP1	331	335	PF00017	0.457
LIG_SH2_STAP1	513	517	PF00017	0.413
LIG_SH2_STAP1	567	571	PF00017	0.501
LIG_SH2_STAP1	609	613	PF00017	0.398
LIG_SH2_STAT3	331	334	PF00017	0.479
LIG_SH2_STAT5	108	111	PF00017	0.337
LIG_SH2_STAT5	192	195	PF00017	0.402
LIG_SH2_STAT5	228	231	PF00017	0.323
LIG_SH2_STAT5	26	29	PF00017	0.415
LIG_SH2_STAT5	275	278	PF00017	0.421
LIG_SH2_STAT5	419	422	PF00017	0.402
LIG_SH2_STAT5	456	459	PF00017	0.368
LIG_SH2_STAT5	591	594	PF00017	0.368
LIG_SH2_STAT5	76	79	PF00017	0.479
LIG_SH3_3	238	244	PF00018	0.447
LIG_SH3_3	260	266	PF00018	0.511
LIG_SH3_3	382	388	PF00018	0.673
LIG_SH3_3	553	559	PF00018	0.596
LIG_SH3_3	59	65	PF00018	0.351
LIG_SUMO_SIM_par_1	103	109	PF11976	0.327
LIG_SUMO_SIM_par_1	243	249	PF11976	0.501
LIG_TRAF2_1	465	468	PF00917	0.432
LIG_TRFH_1	64	68	PF08558	0.281
LIG_TYR_ITIM	226	231	PF00017	0.450
LIG_UBA3_1	246	252	PF00899	0.443
LIG_WW_3	96	100	PF00397	0.520
MOD_CDK_SPK_2	477	482	PF00069	0.587
MOD_CDK_SPxK_1	15	21	PF00069	0.367
MOD_CK1_1	106	112	PF00069	0.327
MOD_CK1_1	150	156	PF00069	0.538
MOD_CK1_1	330	336	PF00069	0.369
MOD_CK1_1	449	455	PF00069	0.398
MOD_CK1_1	548	554	PF00069	0.481
MOD_CK2_1	183	189	PF00069	0.425
MOD_CK2_1	392	398	PF00069	0.544
MOD_CK2_1	462	468	PF00069	0.412
MOD_CK2_1	477	483	PF00069	0.483
MOD_CK2_1	508	514	PF00069	0.450
MOD_CK2_1	563	569	PF00069	0.617
MOD_CK2_1	619	625	PF00069	0.566
MOD_GlcNHglycan	128	131	PF01048	0.490
MOD_GlcNHglycan	157	161	PF01048	0.705
MOD_GlcNHglycan	177	180	PF01048	0.238
MOD_GlcNHglycan	200	203	PF01048	0.495
MOD_GlcNHglycan	576	579	PF01048	0.538
MOD_GlcNHglycan	646	649	PF01048	0.704
MOD_GSK3_1	11	18	PF00069	0.331
MOD_GSK3_1	171	178	PF00069	0.434
MOD_GSK3_1	375	382	PF00069	0.585
MOD_GSK3_1	388	395	PF00069	0.618
MOD_GSK3_1	437	444	PF00069	0.405
MOD_GSK3_1	559	566	PF00069	0.571
MOD_GSK3_1	570	577	PF00069	0.534
MOD_GSK3_1	82	89	PF00069	0.597
MOD_N-GLC_2	47	49	PF02516	0.302
MOD_NEK2_1	103	108	PF00069	0.302
MOD_NEK2_1	11	16	PF00069	0.330
MOD_NEK2_1	246	251	PF00069	0.559
MOD_NEK2_1	374	379	PF00069	0.631
MOD_NEK2_1	543	548	PF00069	0.540
MOD_NEK2_1	570	575	PF00069	0.533
MOD_NEK2_1	601	606	PF00069	0.445
MOD_NEK2_1	69	74	PF00069	0.441
MOD_NEK2_2	513	518	PF00069	0.411
MOD_OFUCOSY	170	175	PF10250	0.381
MOD_PIKK_1	212	218	PF00454	0.437
MOD_PIKK_1	305	311	PF00454	0.689
MOD_PIKK_1	330	336	PF00454	0.500
MOD_PIKK_1	484	490	PF00454	0.464
MOD_PIKK_1	527	533	PF00454	0.515
MOD_PIKK_1	543	549	PF00454	0.403
MOD_PK_1	462	468	PF00069	0.533
MOD_PK_1	545	551	PF00069	0.457
MOD_PKA_2	147	153	PF00069	0.509
MOD_PKA_2	171	177	PF00069	0.353
MOD_PKA_2	374	380	PF00069	0.602
MOD_PKA_2	574	580	PF00069	0.471
MOD_PKA_2	613	619	PF00069	0.525
MOD_Plk_1	375	381	PF00069	0.673
MOD_Plk_1	513	519	PF00069	0.412
MOD_Plk_2-3	265	271	PF00069	0.329
MOD_Plk_4	103	109	PF00069	0.384
MOD_Plk_4	11	17	PF00069	0.351
MOD_Plk_4	117	123	PF00069	0.337
MOD_Plk_4	150	156	PF00069	0.498
MOD_Plk_4	217	223	PF00069	0.505
MOD_Plk_4	251	257	PF00069	0.539
MOD_Plk_4	437	443	PF00069	0.395
MOD_Plk_4	513	519	PF00069	0.412
MOD_ProDKin_1	15	21	PF00069	0.367
MOD_ProDKin_1	240	246	PF00069	0.452
MOD_ProDKin_1	29	35	PF00069	0.380
MOD_ProDKin_1	477	483	PF00069	0.599
MOD_ProDKin_1	82	88	PF00069	0.595
MOD_SUMO_for_1	165	168	PF00179	0.391
MOD_SUMO_rev_2	265	273	PF00179	0.515
MOD_SUMO_rev_2	302	307	PF00179	0.595
TRG_DiLeu_BaEn_1	324	329	PF01217	0.474
TRG_DiLeu_BaEn_4	467	473	PF01217	0.481
TRG_DiLeu_BaLyEn_6	241	246	PF01217	0.452
TRG_ENDOCYTIC_2	218	221	PF00928	0.317
TRG_ENDOCYTIC_2	228	231	PF00928	0.323
TRG_ENDOCYTIC_2	26	29	PF00928	0.396
TRG_ENDOCYTIC_2	499	502	PF00928	0.456
TRG_ENDOCYTIC_2	5	8	PF00928	0.428
TRG_ENDOCYTIC_2	567	570	PF00928	0.538
TRG_ENDOCYTIC_2	63	66	PF00928	0.340
TRG_ER_diArg_1	184	187	PF00400	0.382
TRG_ER_diArg_1	276	279	PF00400	0.420
TRG_ER_diArg_1	535	538	PF00400	0.468
TRG_ER_diArg_1	540	542	PF00400	0.469
TRG_ER_diArg_1	574	576	PF00400	0.472
TRG_ER_diArg_1	98	100	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.389
TRG_PTS1	647	650	PF00515	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF78	Leptomonas seymouri	63%	100%
A0A0S4IPL3	Bodo saltans	31%	100%
A0A1X0P3T8	Trypanosomatidae	34%	100%
A0A3R7MTT7	Trypanosoma rangeli	36%	100%
A4HLV4	Leishmania braziliensis	75%	100%
D0A669	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AHR1	Leishmania infantum	100%	100%
E9B482	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q3U4	Leishmania major	93%	100%