Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHM9_LEIDO

TriTrypDb:

LdBPK_350180.1 , LdCL_350006800 , LDHU3_35.0250

Length:

862

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.700
CLV_C14_Caspase3-7	408	412	PF00656	0.486
CLV_NRD_NRD_1	166	168	PF00675	0.547
CLV_NRD_NRD_1	219	221	PF00675	0.532
CLV_NRD_NRD_1	244	246	PF00675	0.655
CLV_NRD_NRD_1	500	502	PF00675	0.628
CLV_NRD_NRD_1	639	641	PF00675	0.571
CLV_NRD_NRD_1	683	685	PF00675	0.572
CLV_NRD_NRD_1	691	693	PF00675	0.573
CLV_NRD_NRD_1	714	716	PF00675	0.565
CLV_NRD_NRD_1	782	784	PF00675	0.589
CLV_NRD_NRD_1	810	812	PF00675	0.615
CLV_PCSK_KEX2_1	244	246	PF00082	0.692
CLV_PCSK_KEX2_1	367	369	PF00082	0.474
CLV_PCSK_KEX2_1	385	387	PF00082	0.482
CLV_PCSK_KEX2_1	638	640	PF00082	0.504
CLV_PCSK_KEX2_1	683	685	PF00082	0.572
CLV_PCSK_KEX2_1	691	693	PF00082	0.572
CLV_PCSK_KEX2_1	782	784	PF00082	0.648
CLV_PCSK_KEX2_1	794	796	PF00082	0.536
CLV_PCSK_KEX2_1	852	854	PF00082	0.638
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.524
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.558
CLV_PCSK_PC1ET2_1	638	640	PF00082	0.513
CLV_PCSK_PC1ET2_1	683	685	PF00082	0.572
CLV_PCSK_PC1ET2_1	691	693	PF00082	0.572
CLV_PCSK_PC1ET2_1	794	796	PF00082	0.602
CLV_PCSK_PC1ET2_1	852	854	PF00082	0.627
CLV_PCSK_PC7_1	848	854	PF00082	0.619
CLV_PCSK_SKI1_1	161	165	PF00082	0.573
CLV_PCSK_SKI1_1	208	212	PF00082	0.599
CLV_PCSK_SKI1_1	277	281	PF00082	0.668
CLV_PCSK_SKI1_1	313	317	PF00082	0.613
CLV_PCSK_SKI1_1	391	395	PF00082	0.574
CLV_PCSK_SKI1_1	44	48	PF00082	0.559
CLV_PCSK_SKI1_1	501	505	PF00082	0.571
CLV_PCSK_SKI1_1	733	737	PF00082	0.434
CLV_PCSK_SKI1_1	751	755	PF00082	0.531
CLV_Separin_Metazoa	327	331	PF03568	0.562
DEG_APCC_DBOX_1	500	508	PF00400	0.630
DEG_APCC_DBOX_1	542	550	PF00400	0.508
DEG_APCC_DBOX_1	65	73	PF00400	0.603
DEG_APCC_DBOX_1	732	740	PF00400	0.561
DEG_SPOP_SBC_1	855	859	PF00917	0.551
DOC_CYCLIN_RxL_1	39	50	PF00134	0.460
DOC_CYCLIN_RxL_1	499	509	PF00134	0.527
DOC_CYCLIN_RxL_1	748	758	PF00134	0.524
DOC_MAPK_gen_1	818	825	PF00069	0.540
DOC_MAPK_MEF2A_6	342	349	PF00069	0.418
DOC_MAPK_MEF2A_6	591	599	PF00069	0.544
DOC_MAPK_MEF2A_6	794	801	PF00069	0.594
DOC_MAPK_NFAT4_5	794	802	PF00069	0.594
DOC_MAPK_RevD_3	625	640	PF00069	0.395
DOC_USP7_MATH_1	134	138	PF00917	0.570
DOC_USP7_MATH_1	163	167	PF00917	0.586
DOC_USP7_MATH_1	281	285	PF00917	0.726
DOC_USP7_MATH_1	453	457	PF00917	0.376
DOC_USP7_MATH_1	485	489	PF00917	0.415
DOC_USP7_MATH_1	651	655	PF00917	0.576
DOC_USP7_UBL2_3	44	48	PF12436	0.541
LIG_14-3-3_CanoR_1	15	23	PF00244	0.457
LIG_14-3-3_CanoR_1	178	182	PF00244	0.612
LIG_14-3-3_CanoR_1	220	227	PF00244	0.566
LIG_14-3-3_CanoR_1	244	254	PF00244	0.648
LIG_14-3-3_CanoR_1	368	374	PF00244	0.624
LIG_14-3-3_CanoR_1	489	497	PF00244	0.582
LIG_14-3-3_CanoR_1	501	507	PF00244	0.625
LIG_14-3-3_CanoR_1	591	599	PF00244	0.507
LIG_14-3-3_CanoR_1	742	750	PF00244	0.520
LIG_14-3-3_CanoR_1	811	821	PF00244	0.627
LIG_14-3-3_CanoR_1	839	847	PF00244	0.663
LIG_Actin_WH2_2	504	521	PF00022	0.631
LIG_Actin_WH2_2	803	820	PF00022	0.509
LIG_Actin_WH2_2	9	26	PF00022	0.604
LIG_APCC_ABBA_1	821	826	PF00400	0.684
LIG_BIR_II_1	1	5	PF00653	0.545
LIG_CaM_IQ_9	153	169	PF13499	0.435
LIG_Clathr_ClatBox_1	360	364	PF01394	0.588
LIG_FHA_1	141	147	PF00498	0.570
LIG_FHA_1	169	175	PF00498	0.534
LIG_FHA_1	232	238	PF00498	0.591
LIG_FHA_1	408	414	PF00498	0.555
LIG_FHA_1	610	616	PF00498	0.446
LIG_FHA_2	107	113	PF00498	0.530
LIG_FHA_2	15	21	PF00498	0.554
LIG_FHA_2	278	284	PF00498	0.686
LIG_FHA_2	289	295	PF00498	0.612
LIG_FHA_2	494	500	PF00498	0.588
LIG_FHA_2	614	620	PF00498	0.475
LIG_FHA_2	630	636	PF00498	0.458
LIG_FHA_2	647	653	PF00498	0.342
LIG_FHA_2	747	753	PF00498	0.536
LIG_GBD_Chelix_1	789	797	PF00786	0.600
LIG_LIR_Gen_1	148	156	PF02991	0.560
LIG_LIR_Gen_1	348	357	PF02991	0.476
LIG_LIR_Gen_1	380	387	PF02991	0.547
LIG_LIR_Gen_1	400	409	PF02991	0.522
LIG_LIR_Gen_1	445	453	PF02991	0.479
LIG_LIR_Gen_1	49	60	PF02991	0.586
LIG_LIR_Gen_1	769	778	PF02991	0.454
LIG_LIR_Nem_3	148	152	PF02991	0.557
LIG_LIR_Nem_3	348	352	PF02991	0.474
LIG_LIR_Nem_3	380	384	PF02991	0.603
LIG_LIR_Nem_3	400	406	PF02991	0.529
LIG_LIR_Nem_3	445	451	PF02991	0.484
LIG_LIR_Nem_3	49	55	PF02991	0.587
LIG_LIR_Nem_3	769	774	PF02991	0.468
LIG_LIR_Nem_3	776	781	PF02991	0.516
LIG_NRBOX	548	554	PF00104	0.557
LIG_PCNA_yPIPBox_3	4	12	PF02747	0.632
LIG_Pex14_2	444	448	PF04695	0.583
LIG_SH2_CRK	771	775	PF00017	0.434
LIG_SH2_STAP1	107	111	PF00017	0.561
LIG_SH2_STAP1	149	153	PF00017	0.481
LIG_SH2_STAP1	356	360	PF00017	0.454
LIG_SH2_STAT5	697	700	PF00017	0.552
LIG_SUMO_SIM_anti_2	673	682	PF11976	0.471
LIG_SUMO_SIM_par_1	304	312	PF11976	0.677
LIG_SUMO_SIM_par_1	611	617	PF11976	0.449
LIG_TRAF2_1	285	288	PF00917	0.699
LIG_TRAF2_1	40	43	PF00917	0.548
LIG_TRAF2_1	405	408	PF00917	0.491
LIG_UBA3_1	360	367	PF00899	0.622
MOD_CK1_1	355	361	PF00069	0.546
MOD_CK1_1	428	434	PF00069	0.579
MOD_CK1_1	484	490	PF00069	0.645
MOD_CK1_1	493	499	PF00069	0.607
MOD_CK1_1	509	515	PF00069	0.538
MOD_CK1_1	671	677	PF00069	0.552
MOD_CK1_1	745	751	PF00069	0.505
MOD_CK1_1	802	808	PF00069	0.568
MOD_CK1_1	854	860	PF00069	0.669
MOD_CK2_1	106	112	PF00069	0.587
MOD_CK2_1	14	20	PF00069	0.470
MOD_CK2_1	197	203	PF00069	0.645
MOD_CK2_1	258	264	PF00069	0.694
MOD_CK2_1	288	294	PF00069	0.683
MOD_CK2_1	402	408	PF00069	0.578
MOD_CK2_1	493	499	PF00069	0.539
MOD_CK2_1	502	508	PF00069	0.478
MOD_CK2_1	597	603	PF00069	0.472
MOD_CK2_1	613	619	PF00069	0.425
MOD_CK2_1	746	752	PF00069	0.514
MOD_CK2_1	854	860	PF00069	0.669
MOD_GlcNHglycan	227	230	PF01048	0.655
MOD_GlcNHglycan	254	257	PF01048	0.740
MOD_GlcNHglycan	283	286	PF01048	0.726
MOD_GlcNHglycan	31	34	PF01048	0.630
MOD_GlcNHglycan	483	486	PF01048	0.642
MOD_GlcNHglycan	58	61	PF01048	0.585
MOD_GlcNHglycan	655	658	PF01048	0.492
MOD_GlcNHglycan	719	722	PF01048	0.509
MOD_GlcNHglycan	75	78	PF01048	0.619
MOD_GlcNHglycan	826	829	PF01048	0.650
MOD_GlcNHglycan	853	856	PF01048	0.628
MOD_GSK3_1	101	108	PF00069	0.472
MOD_GSK3_1	134	141	PF00069	0.539
MOD_GSK3_1	277	284	PF00069	0.581
MOD_GSK3_1	398	405	PF00069	0.603
MOD_GSK3_1	481	488	PF00069	0.623
MOD_GSK3_1	489	496	PF00069	0.554
MOD_GSK3_1	502	509	PF00069	0.489
MOD_GSK3_1	56	63	PF00069	0.509
MOD_GSK3_1	609	616	PF00069	0.467
MOD_GSK3_1	630	637	PF00069	0.577
MOD_GSK3_1	674	681	PF00069	0.529
MOD_GSK3_1	742	749	PF00069	0.523
MOD_GSK3_1	802	809	PF00069	0.572
MOD_GSK3_1	813	820	PF00069	0.551
MOD_GSK3_1	851	858	PF00069	0.743
MOD_LATS_1	366	372	PF00433	0.493
MOD_LATS_1	849	855	PF00433	0.744
MOD_N-GLC_1	196	201	PF02516	0.669
MOD_N-GLC_1	215	220	PF02516	0.539
MOD_N-GLC_1	397	402	PF02516	0.566
MOD_N-GLC_1	570	575	PF02516	0.659
MOD_N-GLC_1	628	633	PF02516	0.574
MOD_N-GLC_1	813	818	PF02516	0.597
MOD_N-GLC_1	840	845	PF02516	0.661
MOD_NEK2_1	128	133	PF00069	0.621
MOD_NEK2_1	177	182	PF00069	0.536
MOD_NEK2_1	286	291	PF00069	0.650
MOD_NEK2_1	506	511	PF00069	0.659
MOD_NEK2_1	552	557	PF00069	0.561
MOD_NEK2_1	595	600	PF00069	0.571
MOD_NEK2_1	634	639	PF00069	0.554
MOD_NEK2_1	817	822	PF00069	0.646
MOD_NEK2_1	824	829	PF00069	0.691
MOD_PIKK_1	14	20	PF00454	0.459
MOD_PIKK_1	140	146	PF00454	0.375
MOD_PIKK_1	336	342	PF00454	0.629
MOD_PIKK_1	506	512	PF00454	0.570
MOD_PIKK_1	668	674	PF00454	0.480
MOD_PIKK_1	799	805	PF00454	0.516
MOD_PKA_1	168	174	PF00069	0.534
MOD_PKA_1	220	226	PF00069	0.499
MOD_PKA_1	367	373	PF00069	0.589
MOD_PKA_1	385	391	PF00069	0.560
MOD_PKA_1	684	690	PF00069	0.546
MOD_PKA_1	851	857	PF00069	0.699
MOD_PKA_2	101	107	PF00069	0.631
MOD_PKA_2	14	20	PF00069	0.453
MOD_PKA_2	177	183	PF00069	0.577
MOD_PKA_2	367	373	PF00069	0.589
MOD_PKA_2	385	391	PF00069	0.489
MOD_PKA_2	428	434	PF00069	0.511
MOD_PKA_2	490	496	PF00069	0.579
MOD_PKA_2	524	530	PF00069	0.662
MOD_PKA_2	590	596	PF00069	0.536
MOD_Plk_1	215	221	PF00069	0.673
MOD_Plk_1	347	353	PF00069	0.602
MOD_Plk_1	493	499	PF00069	0.565
MOD_Plk_1	570	576	PF00069	0.662
MOD_Plk_1	745	751	PF00069	0.543
MOD_Plk_1	813	819	PF00069	0.602
MOD_Plk_2-3	746	752	PF00069	0.511
MOD_Plk_4	399	405	PF00069	0.447
MOD_Plk_4	428	434	PF00069	0.545
MOD_Plk_4	502	508	PF00069	0.626
MOD_Plk_4	674	680	PF00069	0.596
MOD_SUMO_for_1	212	215	PF00179	0.606
MOD_SUMO_for_1	229	232	PF00179	0.595
MOD_SUMO_for_1	47	50	PF00179	0.596
MOD_SUMO_for_1	830	833	PF00179	0.683
MOD_SUMO_for_1	93	96	PF00179	0.575
MOD_SUMO_rev_2	38	47	PF00179	0.573
MOD_SUMO_rev_2	667	677	PF00179	0.462
MOD_SUMO_rev_2	705	714	PF00179	0.562
MOD_SUMO_rev_2	737	741	PF00179	0.554
MOD_SUMO_rev_2	787	796	PF00179	0.605
TRG_DiLeu_BaEn_1	548	553	PF01217	0.556
TRG_DiLeu_BaEn_1	756	761	PF01217	0.513
TRG_DiLeu_BaEn_4	214	220	PF01217	0.610
TRG_DiLeu_BaEn_4	562	568	PF01217	0.684
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.553
TRG_ENDOCYTIC_2	149	152	PF00928	0.495
TRG_ENDOCYTIC_2	771	774	PF00928	0.433
TRG_ER_diArg_1	781	783	PF00400	0.644
TRG_ER_diArg_1	83	86	PF00400	0.493
TRG_NES_CRM1_1	791	804	PF08389	0.595
TRG_NES_CRM1_1	87	101	PF08389	0.510
TRG_NLS_MonoExtN_4	848	855	PF00514	0.619
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBM4	Leptomonas seymouri	54%	100%
A0A1X0NIX3	Trypanosomatidae	30%	99%
A0A422N7K6	Trypanosoma rangeli	30%	100%
A4HM57	Leishmania braziliensis	76%	100%
A4IAR9	Leishmania infantum	100%	100%
D0A2E3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AEJ5	Leishmania major	91%	100%
E9B5Q6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BIR1	Trypanosoma cruzi	32%	99%