Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHM8_LEIDO

TriTrypDb:

LdBPK_330650.1 , LdCL_330012000 , LDHU3_33.0940

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	215	217	PF00675	0.448
CLV_NRD_NRD_1	29	31	PF00675	0.578
CLV_NRD_NRD_1	324	326	PF00675	0.501
CLV_PCSK_KEX2_1	193	195	PF00082	0.629
CLV_PCSK_KEX2_1	215	217	PF00082	0.480
CLV_PCSK_KEX2_1	29	31	PF00082	0.578
CLV_PCSK_KEX2_1	62	64	PF00082	0.610
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.505
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.443
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.610
CLV_PCSK_SKI1_1	254	258	PF00082	0.348
CLV_PCSK_SKI1_1	29	33	PF00082	0.494
DEG_Nend_Nbox_1	1	3	PF02207	0.585
DOC_CYCLIN_RxL_1	26	37	PF00134	0.506
DOC_CYCLIN_RxL_1	91	102	PF00134	0.547
DOC_CYCLIN_yCln2_LP_2	340	346	PF00134	0.498
DOC_MAPK_gen_1	193	202	PF00069	0.469
DOC_MAPK_gen_1	239	246	PF00069	0.461
DOC_PP1_RVXF_1	418	425	PF00149	0.513
DOC_PP2B_LxvP_1	340	343	PF13499	0.507
DOC_USP7_MATH_1	353	357	PF00917	0.638
DOC_USP7_MATH_1	398	402	PF00917	0.512
DOC_USP7_MATH_1	72	76	PF00917	0.392
DOC_USP7_UBL2_3	193	197	PF12436	0.561
DOC_WW_Pin1_4	246	251	PF00397	0.521
DOC_WW_Pin1_4	34	39	PF00397	0.605
LIG_14-3-3_CanoR_1	176	180	PF00244	0.558
LIG_14-3-3_CanoR_1	294	303	PF00244	0.533
LIG_14-3-3_CanoR_1	373	379	PF00244	0.421
LIG_14-3-3_CanoR_1	412	422	PF00244	0.425
LIG_Actin_WH2_2	114	129	PF00022	0.428
LIG_Clathr_ClatBox_1	308	312	PF01394	0.424
LIG_EH1_1	220	228	PF00400	0.480
LIG_eIF4E_1	221	227	PF01652	0.476
LIG_FHA_1	123	129	PF00498	0.462
LIG_FHA_1	148	154	PF00498	0.640
LIG_FHA_1	56	62	PF00498	0.529
LIG_FHA_1	74	80	PF00498	0.304
LIG_FHA_2	302	308	PF00498	0.468
LIG_FHA_2	367	373	PF00498	0.395
LIG_GBD_Chelix_1	104	112	PF00786	0.535
LIG_LIR_Nem_3	177	182	PF02991	0.521
LIG_NBox_RRM_1	182	192	PF00076	0.358
LIG_Pex14_1	64	68	PF04695	0.430
LIG_PTB_Apo_2	164	171	PF02174	0.662
LIG_SH2_CRK	233	237	PF00017	0.397
LIG_SH2_STAP1	219	223	PF00017	0.426
LIG_SH2_STAP1	338	342	PF00017	0.477
LIG_SH2_STAT5	179	182	PF00017	0.539
LIG_SH3_3	356	362	PF00018	0.526
LIG_SUMO_SIM_par_1	37	42	PF11976	0.528
LIG_TRAF2_1	172	175	PF00917	0.488
LIG_UBA3_1	95	100	PF00899	0.491
LIG_WRC_WIRS_1	276	281	PF05994	0.457
MOD_CK1_1	148	154	PF00069	0.662
MOD_CK1_1	264	270	PF00069	0.480
MOD_CK1_1	299	305	PF00069	0.542
MOD_CK1_1	347	353	PF00069	0.589
MOD_CK1_1	355	361	PF00069	0.650
MOD_CK1_1	414	420	PF00069	0.469
MOD_CK1_1	9	15	PF00069	0.694
MOD_CK2_1	151	157	PF00069	0.655
MOD_CK2_1	237	243	PF00069	0.485
MOD_CK2_1	295	301	PF00069	0.438
MOD_CK2_1	398	404	PF00069	0.440
MOD_GlcNHglycan	101	104	PF01048	0.493
MOD_GlcNHglycan	183	186	PF01048	0.497
MOD_GlcNHglycan	331	334	PF01048	0.548
MOD_GSK3_1	147	154	PF00069	0.692
MOD_GSK3_1	2	9	PF00069	0.601
MOD_GSK3_1	248	255	PF00069	0.370
MOD_GSK3_1	260	267	PF00069	0.349
MOD_GSK3_1	275	282	PF00069	0.473
MOD_GSK3_1	295	302	PF00069	0.523
MOD_GSK3_1	347	354	PF00069	0.495
MOD_GSK3_1	360	367	PF00069	0.508
MOD_GSK3_1	373	380	PF00069	0.429
MOD_GSK3_1	414	421	PF00069	0.616
MOD_N-GLC_1	148	153	PF02516	0.678
MOD_N-GLC_1	158	163	PF02516	0.605
MOD_NEK2_1	10	15	PF00069	0.554
MOD_NEK2_1	145	150	PF00069	0.686
MOD_NEK2_1	2	7	PF00069	0.630
MOD_NEK2_1	252	257	PF00069	0.382
MOD_NEK2_1	275	280	PF00069	0.426
MOD_NEK2_1	288	293	PF00069	0.522
MOD_NEK2_1	345	350	PF00069	0.516
MOD_NEK2_1	351	356	PF00069	0.574
MOD_NEK2_1	364	369	PF00069	0.519
MOD_NEK2_1	374	379	PF00069	0.463
MOD_NEK2_1	411	416	PF00069	0.488
MOD_NEK2_1	49	54	PF00069	0.551
MOD_NEK2_2	122	127	PF00069	0.496
MOD_PIKK_1	377	383	PF00454	0.571
MOD_PIKK_1	41	47	PF00454	0.516
MOD_PIKK_1	49	55	PF00454	0.539
MOD_PK_1	310	316	PF00069	0.385
MOD_PK_1	63	69	PF00069	0.570
MOD_PKA_2	175	181	PF00069	0.568
MOD_PKA_2	411	417	PF00069	0.446
MOD_PKB_1	156	164	PF00069	0.513
MOD_Plk_1	148	154	PF00069	0.711
MOD_Plk_1	174	180	PF00069	0.556
MOD_Plk_1	264	270	PF00069	0.469
MOD_Plk_1	299	305	PF00069	0.495
MOD_Plk_4	148	154	PF00069	0.750
MOD_Plk_4	248	254	PF00069	0.454
MOD_Plk_4	310	316	PF00069	0.427
MOD_Plk_4	355	361	PF00069	0.559
MOD_Plk_4	374	380	PF00069	0.297
MOD_Plk_4	389	395	PF00069	0.445
MOD_Plk_4	414	420	PF00069	0.446
MOD_Plk_4	63	69	PF00069	0.522
MOD_ProDKin_1	246	252	PF00069	0.514
MOD_ProDKin_1	34	40	PF00069	0.606
MOD_SUMO_rev_2	337	343	PF00179	0.492
TRG_DiLeu_BaEn_1	317	322	PF01217	0.533
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.420
TRG_ENDOCYTIC_2	179	182	PF00928	0.539
TRG_ENDOCYTIC_2	233	236	PF00928	0.457
TRG_ER_diArg_1	28	30	PF00400	0.572
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R7	Leptomonas seymouri	54%	99%
A0A1X0P0P1	Trypanosomatidae	30%	98%
A0A3S5IQQ0	Trypanosoma rangeli	27%	100%
A4HLA0	Leishmania braziliensis	79%	100%
A4I8S6	Leishmania infantum	99%	100%
D0A4S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	99%
E9B3P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q4E5	Leishmania major	91%	100%
V5BFC5	Trypanosoma cruzi	27%	98%