DNA-directed RNA polymerase I subunit, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription factor S-II-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IHM6_LEIDO

TriTrypDb:

LdBPK_364350.1 , LdCL_360050600 , LDHU3_36.5890

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	4
GO:0030880	RNA polymerase complex	3	4
GO:0032991	protein-containing complex	1	4
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	4
GO:0140535	intracellular protein-containing complex	2	4
GO:1902494	catalytic complex	2	4
GO:1990234	transferase complex	3	4
GO:0005736	RNA polymerase I complex	4	1
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8IHM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHM6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006351	DNA-templated transcription	7	6
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009059	macromolecule biosynthetic process	4	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0018130	heterocycle biosynthetic process	4	7
GO:0019438	aromatic compound biosynthetic process	4	7
GO:0032774	RNA biosynthetic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034654	nucleobase-containing compound biosynthetic process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:0097659	nucleic acid-templated transcription	6	6
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901362	organic cyclic compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7
GO:0006353	DNA-templated transcription termination	6	1
GO:0006363	termination of RNA polymerase I transcription	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003677	DNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.639
CLV_NRD_NRD_1	141	143	PF00675	0.598
CLV_NRD_NRD_1	45	47	PF00675	0.425
CLV_PCSK_KEX2_1	141	143	PF00082	0.646
CLV_PCSK_KEX2_1	45	47	PF00082	0.425
CLV_PCSK_SKI1_1	167	171	PF00082	0.517
DEG_Nend_Nbox_1	1	3	PF02207	0.461
DEG_SPOP_SBC_1	147	151	PF00917	0.628
DOC_CKS1_1	75	80	PF01111	0.596
DOC_CYCLIN_yCln2_LP_2	33	39	PF00134	0.417
DOC_MAPK_RevD_3	31	46	PF00069	0.423
DOC_PP2B_LxvP_1	33	36	PF13499	0.425
DOC_PP4_FxxP_1	19	22	PF00568	0.481
DOC_USP7_MATH_1	23	27	PF00917	0.467
DOC_USP7_UBL2_3	148	152	PF12436	0.592
DOC_WW_Pin1_4	181	186	PF00397	0.551
DOC_WW_Pin1_4	25	30	PF00397	0.537
DOC_WW_Pin1_4	7	12	PF00397	0.459
DOC_WW_Pin1_4	74	79	PF00397	0.653
LIG_14-3-3_CanoR_1	141	147	PF00244	0.570
LIG_14-3-3_CanoR_1	177	181	PF00244	0.651
LIG_14-3-3_CanoR_1	221	227	PF00244	0.319
LIG_14-3-3_CanoR_1	61	67	PF00244	0.459
LIG_BRCT_BRCA1_1	27	31	PF00533	0.458
LIG_CSL_BTD_1	20	23	PF09270	0.463
LIG_EVH1_1	21	25	PF00568	0.457
LIG_FHA_1	103	109	PF00498	0.451
LIG_FHA_1	168	174	PF00498	0.474
LIG_FHA_1	214	220	PF00498	0.282
LIG_FHA_1	30	36	PF00498	0.431
LIG_FHA_2	121	127	PF00498	0.436
LIG_FHA_2	163	169	PF00498	0.465
LIG_FHA_2	200	206	PF00498	0.655
LIG_LIR_Nem_3	3	9	PF02991	0.458
LIG_Pex14_2	27	31	PF04695	0.458
LIG_REV1ctd_RIR_1	161	171	PF16727	0.539
LIG_SH2_STAT3	175	178	PF00017	0.495
LIG_SH2_STAT5	175	178	PF00017	0.532
LIG_SH2_STAT5	41	44	PF00017	0.429
LIG_SH2_STAT5	86	89	PF00017	0.494
LIG_SH3_2	11	16	PF14604	0.457
LIG_SH3_3	19	25	PF00018	0.474
LIG_SH3_3	216	222	PF00018	0.288
LIG_SH3_3	8	14	PF00018	0.568
LIG_Sin3_3	55	62	PF02671	0.456
LIG_WRC_WIRS_1	24	29	PF05994	0.460
LIG_WW_2	22	25	PF00397	0.464
MOD_CDK_SPxxK_3	9	16	PF00069	0.448
MOD_CK1_1	155	161	PF00069	0.566
MOD_CK1_1	67	73	PF00069	0.665
MOD_CK1_1	93	99	PF00069	0.590
MOD_CK2_1	120	126	PF00069	0.536
MOD_CK2_1	162	168	PF00069	0.472
MOD_CK2_1	229	235	PF00069	0.288
MOD_GlcNHglycan	130	133	PF01048	0.541
MOD_GlcNHglycan	157	161	PF01048	0.613
MOD_GlcNHglycan	197	200	PF01048	0.565
MOD_GlcNHglycan	231	234	PF01048	0.310
MOD_GlcNHglycan	66	69	PF01048	0.640
MOD_GSK3_1	148	155	PF00069	0.648
MOD_GSK3_1	176	183	PF00069	0.662
MOD_GSK3_1	195	202	PF00069	0.595
MOD_GSK3_1	23	30	PF00069	0.500
MOD_GSK3_1	241	248	PF00069	0.310
MOD_GSK3_1	60	67	PF00069	0.469
MOD_N-GLC_2	111	113	PF02516	0.457
MOD_NEK2_1	156	161	PF00069	0.555
MOD_NEK2_1	180	185	PF00069	0.674
MOD_NEK2_1	213	218	PF00069	0.282
MOD_NEK2_1	241	246	PF00069	0.304
MOD_NEK2_2	120	125	PF00069	0.506
MOD_OFUCOSY	113	118	PF10250	0.433
MOD_PKA_1	141	147	PF00069	0.530
MOD_PKA_2	114	120	PF00069	0.459
MOD_PKA_2	140	146	PF00069	0.631
MOD_PKA_2	176	182	PF00069	0.567
MOD_PKA_2	227	233	PF00069	0.310
MOD_PKA_2	60	66	PF00069	0.454
MOD_Plk_4	235	241	PF00069	0.310
MOD_ProDKin_1	181	187	PF00069	0.555
MOD_ProDKin_1	25	31	PF00069	0.539
MOD_ProDKin_1	7	13	PF00069	0.458
MOD_ProDKin_1	74	80	PF00069	0.648
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.429
TRG_ER_diArg_1	140	142	PF00400	0.592
TRG_ER_diArg_1	45	47	PF00400	0.412
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3H9	Leptomonas seymouri	64%	100%
A4HPT3	Leishmania braziliensis	77%	100%
A4IE59	Leishmania infantum	100%	100%
E9ATJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q100	Leishmania major	89%	100%