LeishMANIAdb
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UDP-glucose 4-epimerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
UDP-glucose 4-epimerase
Gene product:
udp-glc 4'-epimerase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IHM5_LEIDO
TriTrypDb:
LdBPK_332430.1 * , LdCL_330031300 , LDHU3_33.3470
Length:
391

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHM5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHM5

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 12
GO:0005996 monosaccharide metabolic process 3 12
GO:0006012 galactose metabolic process 5 12
GO:0008152 metabolic process 1 12
GO:0019318 hexose metabolic process 4 12
GO:0044238 primary metabolic process 2 12
GO:0044281 small molecule metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0003978 UDP-glucose 4-epimerase activity 5 12
GO:0016853 isomerase activity 2 12
GO:0016854 racemase and epimerase activity 3 12
GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 4 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 76 80 PF00656 0.143
CLV_NRD_NRD_1 328 330 PF00675 0.406
CLV_NRD_NRD_1 342 344 PF00675 0.505
CLV_PCSK_KEX2_1 328 330 PF00082 0.427
CLV_PCSK_KEX2_1 341 343 PF00082 0.438
CLV_PCSK_KEX2_1 63 65 PF00082 0.376
CLV_PCSK_PC1ET2_1 341 343 PF00082 0.636
CLV_PCSK_PC1ET2_1 63 65 PF00082 0.376
CLV_PCSK_SKI1_1 137 141 PF00082 0.327
CLV_PCSK_SKI1_1 18 22 PF00082 0.323
CLV_PCSK_SKI1_1 328 332 PF00082 0.432
CLV_PCSK_SKI1_1 68 72 PF00082 0.454
CLV_Separin_Metazoa 19 23 PF03568 0.392
DEG_Nend_UBRbox_1 1 4 PF02207 0.349
DEG_SCF_FBW7_1 268 273 PF00400 0.323
DOC_CKS1_1 267 272 PF01111 0.307
DOC_CYCLIN_RxL_1 15 24 PF00134 0.323
DOC_MAPK_gen_1 132 140 PF00069 0.378
DOC_MAPK_gen_1 253 262 PF00069 0.427
DOC_MAPK_MEF2A_6 342 351 PF00069 0.475
DOC_PP2B_LxvP_1 234 237 PF13499 0.341
DOC_PP4_FxxP_1 147 150 PF00568 0.307
DOC_USP7_MATH_1 167 171 PF00917 0.438
DOC_USP7_UBL2_3 368 372 PF12436 0.317
DOC_USP7_UBL2_3 379 383 PF12436 0.352
DOC_WW_Pin1_4 175 180 PF00397 0.297
DOC_WW_Pin1_4 21 26 PF00397 0.376
DOC_WW_Pin1_4 266 271 PF00397 0.307
DOC_WW_Pin1_4 296 301 PF00397 0.520
LIG_14-3-3_CanoR_1 125 131 PF00244 0.411
LIG_BIR_III_4 214 218 PF00653 0.415
LIG_CaM_IQ_9 124 139 PF13499 0.427
LIG_deltaCOP1_diTrp_1 375 380 PF00928 0.410
LIG_EH1_1 14 22 PF00400 0.307
LIG_eIF4E_1 133 139 PF01652 0.454
LIG_eIF4E_1 180 186 PF01652 0.323
LIG_FHA_1 12 18 PF00498 0.341
LIG_FHA_1 141 147 PF00498 0.341
LIG_FHA_1 180 186 PF00498 0.344
LIG_FHA_1 307 313 PF00498 0.444
LIG_FHA_2 297 303 PF00498 0.484
LIG_IBAR_NPY_1 149 151 PF08397 0.454
LIG_LIR_Apic_2 265 270 PF02991 0.307
LIG_LIR_Gen_1 258 267 PF02991 0.313
LIG_LIR_Gen_1 277 284 PF02991 0.302
LIG_LIR_Gen_1 304 312 PF02991 0.388
LIG_LIR_Nem_3 258 262 PF02991 0.313
LIG_LIR_Nem_3 277 281 PF02991 0.302
LIG_LIR_Nem_3 304 310 PF02991 0.392
LIG_LIR_Nem_3 366 370 PF02991 0.423
LIG_Pex14_1 363 367 PF04695 0.364
LIG_Pex14_2 306 310 PF04695 0.401
LIG_SH2_CRK 245 249 PF00017 0.434
LIG_SH2_GRB2like 116 119 PF00017 0.323
LIG_SH2_GRB2like 207 210 PF00017 0.307
LIG_SH2_PTP2 259 262 PF00017 0.458
LIG_SH2_PTP2 278 281 PF00017 0.142
LIG_SH2_SRC 278 281 PF00017 0.307
LIG_SH2_STAP1 116 120 PF00017 0.341
LIG_SH2_STAT5 11 14 PF00017 0.307
LIG_SH2_STAT5 207 210 PF00017 0.294
LIG_SH2_STAT5 259 262 PF00017 0.458
LIG_SH2_STAT5 278 281 PF00017 0.142
LIG_SH2_STAT5 294 297 PF00017 0.307
LIG_SH3_1 173 179 PF00018 0.323
LIG_SH3_3 106 112 PF00018 0.307
LIG_SH3_3 161 167 PF00018 0.332
LIG_SH3_3 173 179 PF00018 0.218
LIG_SH3_3 245 251 PF00018 0.454
LIG_SUMO_SIM_par_1 346 353 PF11976 0.451
LIG_TRAF2_1 353 356 PF00917 0.476
LIG_TYR_ITIM 365 370 PF00017 0.407
LIG_UBA3_1 123 132 PF00899 0.372
LIG_WRC_WIRS_1 307 312 PF05994 0.481
MOD_CDK_SPxxK_3 296 303 PF00069 0.517
MOD_CK2_1 155 161 PF00069 0.425
MOD_CK2_1 316 322 PF00069 0.367
MOD_CK2_1 350 356 PF00069 0.451
MOD_GlcNHglycan 285 288 PF01048 0.392
MOD_GlcNHglycan 352 355 PF01048 0.442
MOD_GlcNHglycan 375 378 PF01048 0.373
MOD_GlcNHglycan 64 67 PF01048 0.454
MOD_GSK3_1 175 182 PF00069 0.352
MOD_GSK3_1 258 265 PF00069 0.304
MOD_GSK3_1 266 273 PF00069 0.278
MOD_GSK3_1 30 37 PF00069 0.308
MOD_GSK3_1 312 319 PF00069 0.415
MOD_LATS_1 280 286 PF00433 0.454
MOD_N-GLC_2 209 211 PF02516 0.320
MOD_NEK2_1 138 143 PF00069 0.314
MOD_NEK2_1 306 311 PF00069 0.402
MOD_NEK2_1 312 317 PF00069 0.366
MOD_NEK2_1 34 39 PF00069 0.376
MOD_PK_1 316 322 PF00069 0.413
MOD_PKA_1 328 334 PF00069 0.426
MOD_PKA_2 328 334 PF00069 0.439
MOD_Plk_2-3 366 372 PF00069 0.484
MOD_Plk_4 126 132 PF00069 0.279
MOD_ProDKin_1 175 181 PF00069 0.297
MOD_ProDKin_1 21 27 PF00069 0.376
MOD_ProDKin_1 266 272 PF00069 0.307
MOD_ProDKin_1 296 302 PF00069 0.513
MOD_SUMO_for_1 70 73 PF00179 0.454
MOD_SUMO_rev_2 60 65 PF00179 0.425
TRG_DiLeu_BaLyEn_6 228 233 PF01217 0.364
TRG_ENDOCYTIC_2 151 154 PF00928 0.376
TRG_ENDOCYTIC_2 245 248 PF00928 0.440
TRG_ENDOCYTIC_2 259 262 PF00928 0.432
TRG_ENDOCYTIC_2 278 281 PF00928 0.142
TRG_ENDOCYTIC_2 367 370 PF00928 0.377
TRG_ER_diArg_1 328 330 PF00400 0.431

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6X4 Leptomonas seymouri 84% 100%
A0A0S4JG28 Bodo saltans 53% 100%
A0A1X0NTG2 Trypanosomatidae 23% 90%
A0A1X0P4J8 Trypanosomatidae 67% 100%
A0A3Q8IH81 Leishmania donovani 24% 87%
A0A3R7MTU6 Trypanosoma rangeli 67% 100%
A0QSK6 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) 25% 100%
A4HLU3 Leishmania braziliensis 89% 100%
A4I2F0 Leishmania infantum 24% 100%
B0M3E8 Pisum sativum 32% 100%
B0RVL0 Xanthomonas campestris pv. campestris (strain B100) 24% 100%
D0A685 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 99%
E8MF10 Bifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b) 35% 100%
E9AHP8 Leishmania infantum 99% 100%
E9B469 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
F8C4X8 Thermodesulfobacterium geofontis (strain OPF15) 25% 100%
O54067 Rhizobium meliloti (strain 1021) 22% 100%
O64749 Arabidopsis thaliana 33% 94%
O65780 Cyamopsis tetragonoloba 34% 100%
O65781 Cyamopsis tetragonoloba 34% 100%
O84903 Lactobacillus casei 40% 100%
P09147 Escherichia coli (strain K12) 34% 100%
P0C7J0 Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) 24% 100%
P13226 Streptomyces lividans 37% 100%
P14169 Salmonella typhi 22% 100%
P18645 Rattus norvegicus 30% 100%
P21977 Streptococcus thermophilus 39% 100%
P22715 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 35% 100%
P24325 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 32% 100%
P26391 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 24% 100%
P26503 Rhizobium meliloti (strain 1021) 38% 100%
P27830 Escherichia coli (strain K12) 24% 100%
P33119 Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) 36% 100%
P35673 Erwinia amylovora 34% 100%
P37759 Escherichia coli (strain K12) 24% 100%
P37761 Neisseria gonorrhoeae 24% 100%
P37777 Shigella flexneri 25% 100%
P39630 Bacillus subtilis (strain 168) 22% 100%
P39858 Staphylococcus aureus 22% 100%
P44914 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 26% 100%
P47364 Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) 30% 100%
P55180 Bacillus subtilis (strain 168) 32% 100%
P55293 Escherichia coli 24% 100%
P55294 Neisseria meningitidis serogroup B (strain MC58) 25% 100%
P55462 Sinorhizobium fredii (strain NBRC 101917 / NGR234) 26% 100%
P56985 Neisseria meningitidis serogroup B (strain MC58) 32% 100%
P56986 Neisseria meningitidis serogroup C 33% 100%
P56997 Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) 32% 100%
P75517 Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) 30% 100%
P95780 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) 23% 100%
P96995 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) 41% 100%
P9WN64 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 26% 100%
P9WN65 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 26% 100%
Q04871 Escherichia coli O111:H- 23% 100%
Q05026 Neisseria gonorrhoeae 31% 100%
Q14376 Homo sapiens 31% 100%
Q3T105 Bos taurus 31% 100%
Q42605 Arabidopsis thaliana 33% 100%
Q43070 Pisum sativum 32% 100%
Q45291 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) 37% 100%
Q4Q3V7 Leishmania major 96% 100%
Q4Q8W9 Leishmania major 24% 100%
Q54WS6 Dictyostelium discoideum 23% 90%
Q553X7 Dictyostelium discoideum 32% 100%
Q56093 Salmonella typhi 35% 100%
Q564Q1 Caenorhabditis elegans 31% 100%
Q57301 Yersinia enterocolitica 34% 100%
Q57664 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 28% 100%
Q58455 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 24% 100%
Q59083 Azospirillum brasilense 36% 100%
Q59678 Mannheimia haemolytica 31% 100%
Q59745 Rhizobium leguminosarum bv. trifolii 36% 100%
Q5R8D0 Pongo abelii 31% 100%
Q652A8 Oryza sativa subsp. japonica 35% 100%
Q6E7F4 Escherichia coli 24% 100%
Q6K2E1 Oryza sativa subsp. japonica 35% 100%
Q6ZDJ7 Oryza sativa subsp. japonica 34% 96%
Q7WTB1 Lactobacillus helveticus 40% 100%
Q8H0B2 Oryza sativa subsp. japonica 33% 96%
Q8H0B6 Oryza sativa subsp. japonica 34% 100%
Q8H930 Oryza sativa subsp. japonica 32% 93%
Q8LDN8 Arabidopsis thaliana 34% 100%
Q8LNZ3 Oryza sativa subsp. japonica 34% 100%
Q8R059 Mus musculus 32% 100%
Q9C7W7 Arabidopsis thaliana 33% 100%
Q9CNY5 Pasteurella multocida (strain Pm70) 32% 100%
Q9F7D4 Yersinia pestis 34% 100%
Q9FI17 Arabidopsis thaliana 33% 90%
Q9KDV3 Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) 42% 100%
Q9S642 Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) 25% 100%
Q9SA77 Arabidopsis thaliana 33% 93%
Q9SN58 Arabidopsis thaliana 34% 100%
Q9SUN3 Arabidopsis thaliana 34% 95%
Q9T0A7 Arabidopsis thaliana 35% 100%
Q9W0P5 Drosophila melanogaster 34% 100%
Q9Y7X5 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 100%
Q9ZAE8 Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110) 26% 100%
V5DQC0 Trypanosoma cruzi 68% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS