Vps52 / Sac2 family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vps52 / Sac2 family, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHM2_LEIDO

TriTrypDb:

LdBPK_342490.1 , LdCL_340032500 , LDHU3_34.4080

Length:

906

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	10
GO:0000938	GARP complex	3	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0099023	vesicle tethering complex	2	1

Expansion

Sequence features

A0A3Q8IHM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHM2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0033036	macromolecule localization	2	10
GO:0045184	establishment of protein localization	3	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0006892	post-Golgi vesicle-mediated transport	6	1
GO:0006896	Golgi to vacuole transport	5	1
GO:0007034	vacuolar transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0016482	cytosolic transport	4	1
GO:0032456	endocytic recycling	5	1
GO:0042147	retrograde transport, endosome to Golgi	5	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0098876	vesicle-mediated transport to the plasma membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019905	syntaxin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	662	666	PF00656	0.578
CLV_NRD_NRD_1	104	106	PF00675	0.342
CLV_NRD_NRD_1	125	127	PF00675	0.410
CLV_NRD_NRD_1	131	133	PF00675	0.321
CLV_NRD_NRD_1	173	175	PF00675	0.410
CLV_NRD_NRD_1	329	331	PF00675	0.521
CLV_NRD_NRD_1	618	620	PF00675	0.568
CLV_NRD_NRD_1	812	814	PF00675	0.514
CLV_NRD_NRD_1	867	869	PF00675	0.476
CLV_PCSK_KEX2_1	131	133	PF00082	0.369
CLV_PCSK_KEX2_1	173	175	PF00082	0.444
CLV_PCSK_KEX2_1	329	331	PF00082	0.521
CLV_PCSK_KEX2_1	617	619	PF00082	0.461
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.461
CLV_PCSK_PC7_1	169	175	PF00082	0.444
CLV_PCSK_PC7_1	325	331	PF00082	0.593
CLV_PCSK_SKI1_1	210	214	PF00082	0.401
CLV_PCSK_SKI1_1	272	276	PF00082	0.351
CLV_PCSK_SKI1_1	299	303	PF00082	0.532
CLV_PCSK_SKI1_1	339	343	PF00082	0.595
CLV_PCSK_SKI1_1	361	365	PF00082	0.495
CLV_PCSK_SKI1_1	444	448	PF00082	0.407
CLV_PCSK_SKI1_1	505	509	PF00082	0.455
CLV_PCSK_SKI1_1	513	517	PF00082	0.461
CLV_PCSK_SKI1_1	792	796	PF00082	0.520
CLV_PCSK_SKI1_1	857	861	PF00082	0.441
CLV_Separin_Metazoa	810	814	PF03568	0.584
DOC_CDC14_PxL_1	489	497	PF14671	0.494
DOC_CDC14_PxL_1	523	531	PF14671	0.497
DOC_CYCLIN_RxL_1	169	179	PF00134	0.405
DOC_CYCLIN_RxL_1	210	222	PF00134	0.441
DOC_CYCLIN_RxL_1	269	279	PF00134	0.374
DOC_MAPK_gen_1	376	384	PF00069	0.508
DOC_MAPK_gen_1	868	874	PF00069	0.546
DOC_MIT_MIM_1	170	178	PF04212	0.444
DOC_PP1_RVXF_1	171	178	PF00149	0.345
DOC_PP1_RVXF_1	180	187	PF00149	0.342
DOC_PP1_RVXF_1	270	276	PF00149	0.272
DOC_USP7_MATH_1	26	30	PF00917	0.616
DOC_USP7_MATH_1	291	295	PF00917	0.485
DOC_USP7_MATH_1	349	353	PF00917	0.686
DOC_USP7_MATH_1	450	454	PF00917	0.433
DOC_USP7_MATH_1	539	543	PF00917	0.515
DOC_USP7_MATH_1	656	660	PF00917	0.737
DOC_USP7_MATH_1	686	690	PF00917	0.755
DOC_USP7_MATH_1	691	695	PF00917	0.782
DOC_USP7_MATH_1	700	704	PF00917	0.599
DOC_USP7_MATH_1	71	75	PF00917	0.485
DOC_USP7_UBL2_3	203	207	PF12436	0.444
DOC_WW_Pin1_4	529	534	PF00397	0.414
DOC_WW_Pin1_4	619	624	PF00397	0.557
DOC_WW_Pin1_4	652	657	PF00397	0.737
DOC_WW_Pin1_4	730	735	PF00397	0.489
LIG_14-3-3_CanoR_1	194	202	PF00244	0.447
LIG_14-3-3_CanoR_1	261	268	PF00244	0.405
LIG_14-3-3_CanoR_1	329	335	PF00244	0.539
LIG_14-3-3_CanoR_1	339	345	PF00244	0.562
LIG_14-3-3_CanoR_1	361	366	PF00244	0.496
LIG_14-3-3_CanoR_1	404	410	PF00244	0.497
LIG_14-3-3_CanoR_1	509	513	PF00244	0.467
LIG_14-3-3_CanoR_1	618	623	PF00244	0.460
LIG_14-3-3_CanoR_1	667	676	PF00244	0.563
LIG_14-3-3_CanoR_1	792	801	PF00244	0.502
LIG_Actin_WH2_2	493	511	PF00022	0.490
LIG_Actin_WH2_2	778	794	PF00022	0.555
LIG_AP2alpha_1	64	68	PF02296	0.562
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_BRCT_BRCA1_1	235	239	PF00533	0.444
LIG_deltaCOP1_diTrp_1	732	741	PF00928	0.406
LIG_DLG_GKlike_1	353	360	PF00625	0.546
LIG_FHA_1	211	217	PF00498	0.401
LIG_FHA_1	352	358	PF00498	0.624
LIG_FHA_1	454	460	PF00498	0.518
LIG_FHA_1	467	473	PF00498	0.389
LIG_FHA_1	526	532	PF00498	0.456
LIG_FHA_1	576	582	PF00498	0.484
LIG_FHA_1	619	625	PF00498	0.476
LIG_FHA_1	707	713	PF00498	0.460
LIG_FHA_1	8	14	PF00498	0.665
LIG_FHA_1	890	896	PF00498	0.508
LIG_FHA_2	224	230	PF00498	0.410
LIG_FHA_2	362	368	PF00498	0.432
LIG_FHA_2	435	441	PF00498	0.551
LIG_FHA_2	485	491	PF00498	0.520
LIG_FHA_2	512	518	PF00498	0.538
LIG_FHA_2	638	644	PF00498	0.556
LIG_FHA_2	660	666	PF00498	0.583
LIG_FHA_2	860	866	PF00498	0.552
LIG_IRF3_LxIS_1	497	504	PF10401	0.412
LIG_LIR_Gen_1	140	149	PF02991	0.345
LIG_LIR_Gen_1	150	155	PF02991	0.347
LIG_LIR_Gen_1	397	406	PF02991	0.426
LIG_LIR_Gen_1	632	639	PF02991	0.478
LIG_LIR_Gen_1	732	742	PF02991	0.529
LIG_LIR_Nem_3	140	145	PF02991	0.345
LIG_LIR_Nem_3	149	154	PF02991	0.347
LIG_LIR_Nem_3	397	403	PF02991	0.421
LIG_LIR_Nem_3	542	547	PF02991	0.564
LIG_LIR_Nem_3	640	644	PF02991	0.538
LIG_LIR_Nem_3	732	738	PF02991	0.542
LIG_LRP6_Inhibitor_1	188	194	PF00058	0.444
LIG_MAD2	215	223	PF02301	0.444
LIG_PCNA_yPIPBox_3	717	729	PF02747	0.551
LIG_Pex14_1	398	402	PF04695	0.390
LIG_Pex14_2	239	243	PF04695	0.444
LIG_Pex14_2	271	275	PF04695	0.418
LIG_Pex14_2	402	406	PF04695	0.450
LIG_Pex14_2	419	423	PF04695	0.258
LIG_Pex14_2	64	68	PF04695	0.562
LIG_PTB_Apo_2	547	554	PF02174	0.537
LIG_PTB_Phospho_1	547	553	PF10480	0.542
LIG_RPA_C_Fungi	348	360	PF08784	0.575
LIG_SH2_CRK	142	146	PF00017	0.369
LIG_SH2_CRK	247	251	PF00017	0.321
LIG_SH2_GRB2like	575	578	PF00017	0.486
LIG_SH2_SRC	711	714	PF00017	0.546
LIG_SH2_STAP1	635	639	PF00017	0.430
LIG_SH2_STAT3	262	265	PF00017	0.407
LIG_SH2_STAT3	267	270	PF00017	0.356
LIG_SH2_STAT5	142	145	PF00017	0.429
LIG_SH2_STAT5	164	167	PF00017	0.344
LIG_SH2_STAT5	259	262	PF00017	0.361
LIG_SH2_STAT5	267	270	PF00017	0.381
LIG_SH2_STAT5	383	386	PF00017	0.453
LIG_SH2_STAT5	43	46	PF00017	0.603
LIG_SH2_STAT5	553	556	PF00017	0.473
LIG_SH2_STAT5	575	578	PF00017	0.484
LIG_SH2_STAT5	635	638	PF00017	0.381
LIG_SH2_STAT5	711	714	PF00017	0.527
LIG_SH2_STAT5	737	740	PF00017	0.447
LIG_SH3_3	285	291	PF00018	0.444
LIG_SH3_3	317	323	PF00018	0.510
LIG_SH3_3	650	656	PF00018	0.739
LIG_SH3_3	771	777	PF00018	0.681
LIG_Sin3_3	443	450	PF02671	0.503
LIG_SUMO_SIM_anti_2	460	467	PF11976	0.459
LIG_SUMO_SIM_par_1	215	222	PF11976	0.416
LIG_SUMO_SIM_par_1	249	254	PF11976	0.408
LIG_SUMO_SIM_par_1	492	498	PF11976	0.383
LIG_SUMO_SIM_par_1	499	504	PF11976	0.382
LIG_TRAF2_1	232	235	PF00917	0.463
LIG_TRAF2_1	294	297	PF00917	0.560
LIG_TRAF2_1	55	58	PF00917	0.592
LIG_WRC_WIRS_1	341	346	PF05994	0.505
LIG_WRC_WIRS_1	598	603	PF05994	0.495
MOD_CDK_SPxxK_3	529	536	PF00069	0.516
MOD_CK1_1	156	162	PF00069	0.485
MOD_CK1_1	279	285	PF00069	0.414
MOD_CK1_1	343	349	PF00069	0.689
MOD_CK1_1	453	459	PF00069	0.442
MOD_CK1_1	511	517	PF00069	0.497
MOD_CK1_1	52	58	PF00069	0.594
MOD_CK1_1	584	590	PF00069	0.647
MOD_CK1_1	597	603	PF00069	0.396
MOD_CK1_1	654	660	PF00069	0.763
MOD_CK1_1	680	686	PF00069	0.560
MOD_CK1_1	703	709	PF00069	0.630
MOD_CK1_1	825	831	PF00069	0.699
MOD_CK1_1	861	867	PF00069	0.549
MOD_CK1_1	890	896	PF00069	0.490
MOD_CK2_1	223	229	PF00069	0.386
MOD_CK2_1	26	32	PF00069	0.521
MOD_CK2_1	291	297	PF00069	0.511
MOD_CK2_1	3	9	PF00069	0.655
MOD_CK2_1	349	355	PF00069	0.670
MOD_CK2_1	434	440	PF00069	0.517
MOD_CK2_1	511	517	PF00069	0.540
MOD_CK2_1	52	58	PF00069	0.582
MOD_CK2_1	637	643	PF00069	0.487
MOD_CK2_1	686	692	PF00069	0.783
MOD_CK2_1	71	77	PF00069	0.312
MOD_CK2_1	859	865	PF00069	0.555
MOD_GlcNHglycan	1	4	PF01048	0.767
MOD_GlcNHglycan	108	112	PF01048	0.384
MOD_GlcNHglycan	178	181	PF01048	0.394
MOD_GlcNHglycan	186	189	PF01048	0.337
MOD_GlcNHglycan	234	238	PF01048	0.436
MOD_GlcNHglycan	28	31	PF01048	0.645
MOD_GlcNHglycan	280	284	PF01048	0.485
MOD_GlcNHglycan	293	296	PF01048	0.565
MOD_GlcNHglycan	310	313	PF01048	0.382
MOD_GlcNHglycan	437	440	PF01048	0.567
MOD_GlcNHglycan	448	451	PF01048	0.406
MOD_GlcNHglycan	497	500	PF01048	0.405
MOD_GlcNHglycan	505	508	PF01048	0.417
MOD_GlcNHglycan	51	54	PF01048	0.582
MOD_GlcNHglycan	583	586	PF01048	0.561
MOD_GlcNHglycan	647	650	PF01048	0.628
MOD_GlcNHglycan	669	672	PF01048	0.782
MOD_GlcNHglycan	692	696	PF01048	0.673
MOD_GlcNHglycan	702	705	PF01048	0.666
MOD_GlcNHglycan	755	758	PF01048	0.619
MOD_GlcNHglycan	770	773	PF01048	0.534
MOD_GlcNHglycan	778	781	PF01048	0.555
MOD_GlcNHglycan	827	830	PF01048	0.745
MOD_GlcNHglycan	878	881	PF01048	0.564
MOD_GSK3_1	156	163	PF00069	0.474
MOD_GSK3_1	229	236	PF00069	0.454
MOD_GSK3_1	3	10	PF00069	0.667
MOD_GSK3_1	32	39	PF00069	0.669
MOD_GSK3_1	339	346	PF00069	0.708
MOD_GSK3_1	349	356	PF00069	0.557
MOD_GSK3_1	361	368	PF00069	0.299
MOD_GSK3_1	405	412	PF00069	0.489
MOD_GSK3_1	446	453	PF00069	0.515
MOD_GSK3_1	525	532	PF00069	0.433
MOD_GSK3_1	629	636	PF00069	0.513
MOD_GSK3_1	652	659	PF00069	0.754
MOD_GSK3_1	702	709	PF00069	0.566
MOD_GSK3_1	792	799	PF00069	0.493
MOD_GSK3_1	816	823	PF00069	0.490
MOD_GSK3_1	825	832	PF00069	0.646
MOD_GSK3_1	859	866	PF00069	0.494
MOD_GSK3_1	883	890	PF00069	0.522
MOD_LATS_1	337	343	PF00433	0.600
MOD_LATS_1	798	804	PF00433	0.383
MOD_N-GLC_1	156	161	PF02516	0.471
MOD_N-GLC_1	540	545	PF02516	0.507
MOD_N-GLC_1	667	672	PF02516	0.700
MOD_N-GLC_1	767	772	PF02516	0.760
MOD_N-GLC_1	825	830	PF02516	0.758
MOD_N-GLC_1	890	895	PF02516	0.454
MOD_N-GLC_2	411	413	PF02516	0.430
MOD_NEK2_1	107	112	PF00069	0.423
MOD_NEK2_1	184	189	PF00069	0.361
MOD_NEK2_1	233	238	PF00069	0.376
MOD_NEK2_1	24	29	PF00069	0.596
MOD_NEK2_1	263	268	PF00069	0.460
MOD_NEK2_1	365	370	PF00069	0.498
MOD_NEK2_1	495	500	PF00069	0.386
MOD_NEK2_1	501	506	PF00069	0.394
MOD_NEK2_1	508	513	PF00069	0.403
MOD_NEK2_1	629	634	PF00069	0.495
MOD_NEK2_1	64	69	PF00069	0.631
MOD_NEK2_1	753	758	PF00069	0.629
MOD_NEK2_1	820	825	PF00069	0.608
MOD_NEK2_1	863	868	PF00069	0.499
MOD_PIKK_1	261	267	PF00454	0.477
MOD_PIKK_1	32	38	PF00454	0.674
MOD_PIKK_1	332	338	PF00454	0.560
MOD_PIKK_1	706	712	PF00454	0.559
MOD_PIKK_1	71	77	PF00454	0.496
MOD_PIKK_1	755	761	PF00454	0.732
MOD_PIKK_1	792	798	PF00454	0.492
MOD_PIKK_1	800	806	PF00454	0.483
MOD_PK_1	330	336	PF00069	0.558
MOD_PKA_1	126	132	PF00069	0.408
MOD_PKA_1	618	624	PF00069	0.489
MOD_PKA_2	508	514	PF00069	0.461
MOD_PKA_2	581	587	PF00069	0.662
MOD_PKA_2	618	624	PF00069	0.567
MOD_PKA_2	64	70	PF00069	0.561
MOD_PKA_2	659	665	PF00069	0.690
MOD_PKB_1	330	338	PF00069	0.559
MOD_Plk_1	156	162	PF00069	0.454
MOD_Plk_1	279	285	PF00069	0.485
MOD_Plk_1	365	371	PF00069	0.386
MOD_Plk_1	454	460	PF00069	0.475
MOD_Plk_1	539	545	PF00069	0.511
MOD_Plk_1	849	855	PF00069	0.510
MOD_Plk_1	890	896	PF00069	0.457
MOD_Plk_2-3	229	235	PF00069	0.452
MOD_Plk_4	160	166	PF00069	0.369
MOD_Plk_4	263	269	PF00069	0.466
MOD_Plk_4	340	346	PF00069	0.501
MOD_Plk_4	405	411	PF00069	0.413
MOD_Plk_4	454	460	PF00069	0.428
MOD_Plk_4	597	603	PF00069	0.457
MOD_Plk_4	633	639	PF00069	0.459
MOD_Plk_4	64	70	PF00069	0.595
MOD_Plk_4	850	856	PF00069	0.546
MOD_Plk_4	890	896	PF00069	0.484
MOD_ProDKin_1	529	535	PF00069	0.424
MOD_ProDKin_1	619	625	PF00069	0.554
MOD_ProDKin_1	652	658	PF00069	0.737
MOD_ProDKin_1	730	736	PF00069	0.486
TRG_DiLeu_BaEn_1	20	25	PF01217	0.521
TRG_DiLeu_BaEn_1	355	360	PF01217	0.621
TRG_DiLeu_BaEn_1	850	855	PF01217	0.432
TRG_DiLeu_BaEn_1	9	14	PF01217	0.662
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.408
TRG_DiLeu_BaLyEn_6	490	495	PF01217	0.392
TRG_DiLeu_LyEn_5	355	360	PF01217	0.621
TRG_ENDOCYTIC_2	142	145	PF00928	0.344
TRG_ENDOCYTIC_2	635	638	PF00928	0.397
TRG_ENDOCYTIC_2	83	86	PF00928	0.344
TRG_ER_diArg_1	173	175	PF00400	0.444
TRG_ER_diArg_1	329	332	PF00400	0.553
TRG_ER_diArg_1	375	378	PF00400	0.589
TRG_ER_diArg_1	843	846	PF00400	0.517
TRG_Pf-PMV_PEXEL_1	272	277	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	747	751	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P609	Leptomonas seymouri	64%	100%
A0A0S4JX74	Bodo saltans	34%	100%
A0A1X0PA29	Trypanosomatidae	37%	100%
A0A422NRZ3	Trypanosoma rangeli	36%	100%
A4HAY3	Leishmania braziliensis	77%	99%
A4IA42	Leishmania infantum	100%	100%
E9B556	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q2S9	Leishmania major	92%	100%