Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHL3_LEIDO

TriTrypDb:

LdBPK_120041.1 , LdCL_120005400 , LDHU3_12.0070

Length:

107

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHL3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	46	48	PF00675	0.522
CLV_NRD_NRD_1	7	9	PF00675	0.613
CLV_PCSK_FUR_1	4	8	PF00082	0.697
CLV_PCSK_KEX2_1	20	22	PF00082	0.430
CLV_PCSK_KEX2_1	3	5	PF00082	0.595
CLV_PCSK_KEX2_1	46	48	PF00082	0.522
CLV_PCSK_KEX2_1	6	8	PF00082	0.579
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.502
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.635
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.615
CLV_PCSK_SKI1_1	69	73	PF00082	0.672
CLV_PCSK_SKI1_1	78	82	PF00082	0.484
CLV_PCSK_SKI1_1	8	12	PF00082	0.602
DEG_APCC_DBOX_1	32	40	PF00400	0.555
DOC_MAPK_MEF2A_6	78	87	PF00069	0.621
DOC_MAPK_NFAT4_5	78	86	PF00069	0.551
DOC_MAPK_RevD_3	34	47	PF00069	0.583
DOC_PP2B_LxvP_1	102	105	PF13499	0.630
DOC_USP7_MATH_1	49	53	PF00917	0.638
DOC_USP7_MATH_1	89	93	PF00917	0.582
DOC_WW_Pin1_4	23	28	PF00397	0.558
DOC_WW_Pin1_4	69	74	PF00397	0.634
LIG_14-3-3_CanoR_1	33	37	PF00244	0.562
LIG_APCC_ABBA_1	81	86	PF00400	0.518
LIG_APCC_ABBA_1	91	96	PF00400	0.424
LIG_BIR_II_1	1	5	PF00653	0.695
LIG_BRCT_BRCA1_1	91	95	PF00533	0.616
LIG_FHA_1	7	13	PF00498	0.665
LIG_FHA_1	75	81	PF00498	0.504
LIG_KLC1_Yacidic_2	82	86	PF13176	0.546
LIG_LIR_Gen_1	82	91	PF02991	0.484
LIG_LIR_Nem_3	52	56	PF02991	0.540
LIG_LIR_Nem_3	82	87	PF02991	0.473
LIG_MLH1_MIPbox_1	91	95	PF16413	0.616
LIG_PCNA_TLS_4	78	85	PF02747	0.551
LIG_SH2_CRK	40	44	PF00017	0.647
LIG_SH2_CRK	53	57	PF00017	0.545
LIG_SH2_SRC	23	26	PF00017	0.640
LIG_SH2_SRC	84	87	PF00017	0.579
LIG_SH2_STAP1	44	48	PF00017	0.604
LIG_SH2_STAT5	84	87	PF00017	0.579
LIG_SH2_STAT5	94	97	PF00017	0.567
LIG_SUMO_SIM_par_1	99	106	PF11976	0.606
LIG_WRC_WIRS_1	68	73	PF05994	0.623
LIG_WW_1	37	40	PF00397	0.604
MOD_CK1_1	74	80	PF00069	0.620
MOD_GlcNHglycan	40	43	PF01048	0.665
MOD_GSK3_1	38	45	PF00069	0.546
MOD_GSK3_1	67	74	PF00069	0.541
MOD_NEK2_2	89	94	PF00069	0.538
MOD_PKA_1	6	12	PF00069	0.683
MOD_PKA_2	32	38	PF00069	0.525
MOD_PKA_2	6	12	PF00069	0.683
MOD_Plk_4	89	95	PF00069	0.499
MOD_ProDKin_1	23	29	PF00069	0.555
MOD_ProDKin_1	69	75	PF00069	0.637
TRG_DiLeu_BaEn_1	86	91	PF01217	0.480
TRG_ENDOCYTIC_2	40	43	PF00928	0.640
TRG_ENDOCYTIC_2	53	56	PF00928	0.537
TRG_ENDOCYTIC_2	84	87	PF00928	0.567
TRG_NES_CRM1_1	82	96	PF08389	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3B4	Leptomonas seymouri	78%	100%
A0A1X0NM04	Trypanosomatidae	33%	100%
A0A422N6I2	Trypanosoma rangeli	39%	100%
A4H6R9	Leishmania braziliensis	89%	100%
C9ZQD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AGA3	Leishmania infantum	100%	100%
E9ANT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4QGT9	Leishmania major	97%	100%