CST complex subunit CTC1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHL1_LEIDO

TriTrypDb:

LdBPK_343980.1 , LdCL_340049200 , LDHU3_34.6290

Length:

658

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHL1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.516
CLV_C14_Caspase3-7	228	232	PF00656	0.420
CLV_NRD_NRD_1	209	211	PF00675	0.575
CLV_NRD_NRD_1	403	405	PF00675	0.467
CLV_NRD_NRD_1	573	575	PF00675	0.457
CLV_PCSK_KEX2_1	209	211	PF00082	0.575
CLV_PCSK_KEX2_1	342	344	PF00082	0.518
CLV_PCSK_KEX2_1	573	575	PF00082	0.585
CLV_PCSK_KEX2_1	614	616	PF00082	0.519
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.544
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.519
CLV_PCSK_SKI1_1	218	222	PF00082	0.381
CLV_PCSK_SKI1_1	390	394	PF00082	0.405
CLV_PCSK_SKI1_1	461	465	PF00082	0.481
CLV_PCSK_SKI1_1	574	578	PF00082	0.584
CLV_Separin_Metazoa	488	492	PF03568	0.335
DEG_APCC_DBOX_1	403	411	PF00400	0.448
DEG_Nend_UBRbox_2	1	3	PF02207	0.500
DOC_CDC14_PxL_1	585	593	PF14671	0.359
DOC_CYCLIN_RxL_1	218	228	PF00134	0.477
DOC_MAPK_gen_1	345	353	PF00069	0.433
DOC_MAPK_gen_1	461	471	PF00069	0.661
DOC_MAPK_MEF2A_6	27	36	PF00069	0.401
DOC_MAPK_MEF2A_6	365	373	PF00069	0.409
DOC_MAPK_MEF2A_6	464	473	PF00069	0.537
DOC_MAPK_MEF2A_6	584	592	PF00069	0.373
DOC_MAPK_NFAT4_5	464	472	PF00069	0.493
DOC_PP1_RVXF_1	183	189	PF00149	0.313
DOC_PP2B_LxvP_1	68	71	PF13499	0.331
DOC_USP7_MATH_1	154	158	PF00917	0.608
DOC_USP7_MATH_1	194	198	PF00917	0.651
DOC_USP7_MATH_1	208	212	PF00917	0.762
DOC_USP7_MATH_1	357	361	PF00917	0.602
DOC_USP7_MATH_1	446	450	PF00917	0.706
DOC_USP7_MATH_1	453	457	PF00917	0.475
DOC_USP7_MATH_1	46	50	PF00917	0.702
DOC_USP7_MATH_1	523	527	PF00917	0.506
DOC_USP7_MATH_1	555	559	PF00917	0.409
DOC_USP7_UBL2_3	461	465	PF12436	0.474
DOC_WW_Pin1_4	147	152	PF00397	0.701
DOC_WW_Pin1_4	213	218	PF00397	0.619
DOC_WW_Pin1_4	431	436	PF00397	0.694
DOC_WW_Pin1_4	456	461	PF00397	0.572
DOC_WW_Pin1_4	474	479	PF00397	0.570
DOC_WW_Pin1_4	560	565	PF00397	0.493
LIG_14-3-3_CanoR_1	209	213	PF00244	0.566
LIG_14-3-3_CanoR_1	345	351	PF00244	0.459
LIG_14-3-3_CanoR_1	404	414	PF00244	0.371
LIG_14-3-3_CanoR_1	430	437	PF00244	0.592
LIG_14-3-3_CanoR_1	503	509	PF00244	0.487
LIG_14-3-3_CanoR_1	573	581	PF00244	0.432
LIG_APCC_ABBA_1	490	495	PF00400	0.387
LIG_BIR_III_2	445	449	PF00653	0.651
LIG_BRCT_BRCA1_1	215	219	PF00533	0.516
LIG_BRCT_BRCA1_1	366	370	PF00533	0.502
LIG_BRCT_BRCA1_1	4	8	PF00533	0.405
LIG_deltaCOP1_diTrp_1	23	29	PF00928	0.455
LIG_deltaCOP1_diTrp_1	389	393	PF00928	0.340
LIG_eIF4E_1	238	244	PF01652	0.366
LIG_FAT_LD_1	578	586	PF03623	0.309
LIG_FHA_1	117	123	PF00498	0.570
LIG_FHA_1	181	187	PF00498	0.458
LIG_FHA_1	31	37	PF00498	0.408
LIG_FHA_1	315	321	PF00498	0.506
LIG_FHA_1	411	417	PF00498	0.515
LIG_FHA_1	477	483	PF00498	0.406
LIG_FHA_1	531	537	PF00498	0.480
LIG_FHA_2	72	78	PF00498	0.476
LIG_LIR_Gen_1	367	375	PF02991	0.463
LIG_LIR_Gen_1	53	63	PF02991	0.409
LIG_LIR_Gen_1	630	639	PF02991	0.606
LIG_LIR_Gen_1	64	75	PF02991	0.369
LIG_LIR_Nem_3	367	373	PF02991	0.459
LIG_LIR_Nem_3	374	379	PF02991	0.372
LIG_LIR_Nem_3	53	59	PF02991	0.421
LIG_LIR_Nem_3	630	635	PF02991	0.599
LIG_LIR_Nem_3	64	70	PF02991	0.342
LIG_LYPXL_yS_3	42	45	PF13949	0.553
LIG_PDZ_Class_3	653	658	PF00595	0.544
LIG_SH2_CRK	56	60	PF00017	0.332
LIG_SH2_GRB2like	115	118	PF00017	0.488
LIG_SH2_PTP2	323	326	PF00017	0.406
LIG_SH2_STAT5	323	326	PF00017	0.507
LIG_SH2_STAT5	618	621	PF00017	0.539
LIG_SH3_3	104	110	PF00018	0.364
LIG_SH3_3	389	395	PF00018	0.442
LIG_SH3_3	40	46	PF00018	0.545
LIG_SH3_3	454	460	PF00018	0.693
LIG_SH3_3	475	481	PF00018	0.494
LIG_SH3_3	486	492	PF00018	0.369
LIG_SH3_3	583	589	PF00018	0.390
LIG_SH3_3	66	72	PF00018	0.376
LIG_SUMO_SIM_par_1	310	317	PF11976	0.540
LIG_SUMO_SIM_par_1	349	355	PF11976	0.410
LIG_SUMO_SIM_par_1	469	475	PF11976	0.441
LIG_TRAF2_1	279	282	PF00917	0.456
LIG_WRC_WIRS_1	629	634	PF05994	0.591
MOD_CDK_SPK_2	213	218	PF00069	0.619
MOD_CDK_SPK_2	456	461	PF00069	0.488
MOD_CK1_1	116	122	PF00069	0.515
MOD_CK1_1	136	142	PF00069	0.518
MOD_CK1_1	197	203	PF00069	0.654
MOD_CK1_1	286	292	PF00069	0.566
MOD_CK1_1	349	355	PF00069	0.508
MOD_CK1_1	409	415	PF00069	0.446
MOD_CK1_1	449	455	PF00069	0.711
MOD_CK1_1	456	462	PF00069	0.429
MOD_CK1_1	49	55	PF00069	0.465
MOD_CK1_1	507	513	PF00069	0.606
MOD_CK2_1	124	130	PF00069	0.458
MOD_CK2_1	276	282	PF00069	0.546
MOD_CK2_1	352	358	PF00069	0.427
MOD_CK2_1	555	561	PF00069	0.444
MOD_CK2_1	57	63	PF00069	0.457
MOD_CK2_1	631	637	PF00069	0.584
MOD_CK2_1	71	77	PF00069	0.357
MOD_GlcNHglycan	135	138	PF01048	0.538
MOD_GlcNHglycan	266	269	PF01048	0.579
MOD_GlcNHglycan	285	288	PF01048	0.614
MOD_GlcNHglycan	297	300	PF01048	0.361
MOD_GlcNHglycan	358	362	PF01048	0.634
MOD_GlcNHglycan	366	369	PF01048	0.475
MOD_GlcNHglycan	448	451	PF01048	0.698
MOD_GlcNHglycan	525	528	PF01048	0.585
MOD_GlcNHglycan	574	577	PF01048	0.471
MOD_GlcNHglycan	619	622	PF01048	0.634
MOD_GlcNHglycan	626	629	PF01048	0.565
MOD_GlcNHglycan	640	643	PF01048	0.630
MOD_GSK3_1	193	200	PF00069	0.556
MOD_GSK3_1	264	271	PF00069	0.612
MOD_GSK3_1	282	289	PF00069	0.449
MOD_GSK3_1	322	329	PF00069	0.426
MOD_GSK3_1	334	341	PF00069	0.415
MOD_GSK3_1	405	412	PF00069	0.377
MOD_GSK3_1	449	456	PF00069	0.681
MOD_GSK3_1	46	53	PF00069	0.582
MOD_GSK3_1	57	64	PF00069	0.369
MOD_GSK3_1	617	624	PF00069	0.599
MOD_GSK3_1	647	654	PF00069	0.603
MOD_N-GLC_1	116	121	PF02516	0.633
MOD_N-GLC_2	179	181	PF02516	0.498
MOD_NEK2_1	13	18	PF00069	0.498
MOD_NEK2_1	295	300	PF00069	0.487
MOD_NEK2_1	410	415	PF00069	0.444
MOD_NEK2_1	608	613	PF00069	0.445
MOD_NEK2_1	647	652	PF00069	0.681
MOD_NEK2_1	76	81	PF00069	0.482
MOD_PIKK_1	154	160	PF00454	0.478
MOD_PIKK_1	286	292	PF00454	0.417
MOD_PIKK_1	334	340	PF00454	0.538
MOD_PIKK_1	501	507	PF00454	0.462
MOD_PKA_2	208	214	PF00069	0.560
MOD_PKA_2	364	370	PF00069	0.625
MOD_PKA_2	403	409	PF00069	0.375
MOD_PKA_2	429	435	PF00069	0.636
MOD_PKA_2	49	55	PF00069	0.596
MOD_PKA_2	572	578	PF00069	0.413
MOD_Plk_1	116	122	PF00069	0.534
MOD_Plk_1	276	282	PF00069	0.483
MOD_Plk_1	371	377	PF00069	0.377
MOD_Plk_1	76	82	PF00069	0.509
MOD_Plk_4	136	142	PF00069	0.515
MOD_Plk_4	322	328	PF00069	0.384
MOD_Plk_4	371	377	PF00069	0.397
MOD_Plk_4	504	510	PF00069	0.610
MOD_Plk_4	555	561	PF00069	0.370
MOD_Plk_4	621	627	PF00069	0.549
MOD_Plk_4	89	95	PF00069	0.325
MOD_ProDKin_1	147	153	PF00069	0.701
MOD_ProDKin_1	213	219	PF00069	0.603
MOD_ProDKin_1	431	437	PF00069	0.698
MOD_ProDKin_1	456	462	PF00069	0.572
MOD_ProDKin_1	474	480	PF00069	0.571
MOD_ProDKin_1	560	566	PF00069	0.498
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.516
TRG_ENDOCYTIC_2	323	326	PF00928	0.446
TRG_ENDOCYTIC_2	42	45	PF00928	0.519
TRG_ENDOCYTIC_2	56	59	PF00928	0.368
TRG_ER_diArg_1	208	210	PF00400	0.556
TRG_ER_diArg_1	246	249	PF00400	0.472
TRG_ER_diArg_1	343	346	PF00400	0.518
TRG_ER_diArg_1	534	537	PF00400	0.344
TRG_NES_CRM1_1	529	542	PF08389	0.477
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	222	227	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7E9	Leptomonas seymouri	53%	100%
A0A0S4KIT9	Bodo saltans	28%	96%
A0A1X0PA76	Trypanosomatidae	33%	100%
A0A422NVA9	Trypanosoma rangeli	34%	100%
A4HBD8	Leishmania braziliensis	76%	100%
A4IAI6	Leishmania infantum	100%	100%
C9ZLQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B5L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4Q2C6	Leishmania major	91%	100%
V5DMS9	Trypanosoma cruzi	34%	100%