60S_ribosomal_protein_L34_putative/GeneDB:LmjF.18.1400

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L34, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHK2_LEIDO

TriTrypDb:

LdBPK_363930.1 , LdCL_180019100 , LdCL_360046300 , LDHU3_18.1760 , LDHU3_36.5270

Length:

168

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L34

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	17
GO:0032991	protein-containing complex	1	19
GO:0043226	organelle	2	17
GO:0043228	non-membrane-bounded organelle	3	17
GO:0043229	intracellular organelle	3	17
GO:0043232	intracellular non-membrane-bounded organelle	4	17
GO:0110165	cellular anatomical entity	1	17
GO:1990904	ribonucleoprotein complex	2	19
GO:0016020	membrane	2	1
GO:0015934	large ribosomal subunit	4	2
GO:0022625	cytosolic large ribosomal subunit	5	2
GO:0044391	ribosomal subunit	3	2

Expansion

Sequence features

A0A3Q8IHK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHK2

PDB structure(s): 6az3_h

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	19
GO:0006518	peptide metabolic process	4	19
GO:0006807	nitrogen compound metabolic process	2	19
GO:0008152	metabolic process	1	19
GO:0009058	biosynthetic process	2	19
GO:0009059	macromolecule biosynthetic process	4	19
GO:0009987	cellular process	1	19
GO:0019538	protein metabolic process	3	19
GO:0034641	cellular nitrogen compound metabolic process	3	19
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	19
GO:0043043	peptide biosynthetic process	5	19
GO:0043170	macromolecule metabolic process	3	19
GO:0043603	amide metabolic process	3	19
GO:0043604	amide biosynthetic process	4	19
GO:0044237	cellular metabolic process	2	19
GO:0044238	primary metabolic process	2	19
GO:0044249	cellular biosynthetic process	3	19
GO:0044260	obsolete cellular macromolecule metabolic process	3	19
GO:0044271	cellular nitrogen compound biosynthetic process	4	19
GO:0071704	organic substance metabolic process	2	19
GO:1901564	organonitrogen compound metabolic process	3	19
GO:1901566	organonitrogen compound biosynthetic process	4	19
GO:1901576	organic substance biosynthetic process	3	19
GO:0022613	ribonucleoprotein complex biogenesis	4	2
GO:0042254	ribosome biogenesis	5	2
GO:0044085	cellular component biogenesis	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	19
GO:0005198	structural molecule activity	1	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.315
CLV_PCSK_FUR_1	36	40	PF00082	0.311
CLV_PCSK_KEX2_1	119	121	PF00082	0.591
CLV_PCSK_KEX2_1	35	37	PF00082	0.301
CLV_PCSK_KEX2_1	38	40	PF00082	0.300
CLV_PCSK_KEX2_1	52	54	PF00082	0.297
CLV_PCSK_KEX2_1	9	11	PF00082	0.316
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.565
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.297
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.297
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.297
CLV_PCSK_PC7_1	5	11	PF00082	0.311
CLV_PCSK_SKI1_1	102	106	PF00082	0.468
CLV_PCSK_SKI1_1	152	156	PF00082	0.721
CLV_PCSK_SKI1_1	164	168	PF00082	0.680
CLV_PCSK_SKI1_1	35	39	PF00082	0.341
CLV_PCSK_SKI1_1	94	98	PF00082	0.297
DOC_CKS1_1	24	29	PF01111	0.497
DOC_CKS1_1	43	48	PF01111	0.497
DOC_USP7_MATH_1	160	164	PF00917	0.767
DOC_USP7_MATH_1	37	41	PF00917	0.545
DOC_USP7_UBL2_3	105	109	PF12436	0.523
DOC_USP7_UBL2_3	115	119	PF12436	0.547
DOC_USP7_UBL2_3	124	128	PF12436	0.529
DOC_USP7_UBL2_3	138	142	PF12436	0.551
DOC_USP7_UBL2_3	148	152	PF12436	0.646
DOC_USP7_UBL2_3	164	168	PF12436	0.687
DOC_WW_Pin1_4	23	28	PF00397	0.497
DOC_WW_Pin1_4	42	47	PF00397	0.497
LIG_14-3-3_CanoR_1	36	46	PF00244	0.511
LIG_BIR_II_1	1	5	PF00653	0.590
LIG_FHA_1	139	145	PF00498	0.604
LIG_FHA_1	43	49	PF00498	0.509
LIG_FHA_1	55	61	PF00498	0.497
LIG_LIR_Nem_3	76	82	PF02991	0.512
LIG_SH2_CRK	79	83	PF00017	0.510
LIG_SH3_3	21	27	PF00018	0.511
MOD_CDK_SPxxK_3	23	30	PF00069	0.337
MOD_CK1_1	127	133	PF00069	0.680
MOD_CK1_1	140	146	PF00069	0.664
MOD_CK2_1	127	133	PF00069	0.681
MOD_CK2_1	66	72	PF00069	0.466
MOD_GSK3_1	114	121	PF00069	0.689
MOD_GSK3_1	138	145	PF00069	0.651
MOD_LATS_1	71	77	PF00433	0.357
MOD_NEK2_1	114	119	PF00069	0.686
MOD_NEK2_1	54	59	PF00069	0.337
MOD_PIKK_1	37	43	PF00454	0.358
MOD_PKA_1	124	130	PF00069	0.570
MOD_PKA_1	137	143	PF00069	0.629
MOD_PKA_1	152	158	PF00069	0.724
MOD_Plk_1	71	77	PF00069	0.443
MOD_ProDKin_1	23	29	PF00069	0.337
MOD_ProDKin_1	42	48	PF00069	0.337
TRG_ENDOCYTIC_2	79	82	PF00928	0.355
TRG_ER_diArg_1	8	11	PF00400	0.346
TRG_NLS_Bipartite_1	131	150	PF00514	0.694
TRG_NLS_MonoExtC_3	123	128	PF00514	0.525
TRG_NLS_MonoExtC_3	145	150	PF00514	0.687
TRG_NLS_MonoExtC_3	34	39	PF00514	0.381
TRG_NLS_MonoExtN_4	124	129	PF00514	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5A3	Leptomonas seymouri	90%	100%
A0A0S4JKR1	Bodo saltans	70%	90%
A0A0S4JN23	Bodo saltans	70%	88%
A0A1X0P3Q7	Trypanosomatidae	77%	96%
A0A1X0P7X8	Trypanosomatidae	71%	98%
A0A3R7NEK5	Trypanosoma rangeli	72%	98%
A0A422N1M6	Trypanosoma rangeli	69%	94%
A4H9P3	Leishmania braziliensis	93%	100%
A4HPP2	Leishmania braziliensis	92%	100%
A4HY10	Leishmania infantum	100%	100%
D0A586	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	72%
D0A8H2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	99%
E9ARS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9ATF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O42846	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
P41098	Nicotiana tabacum	50%	100%
Q4Q141	Leishmania major	99%	100%
Q4QDP9	Leishmania major	99%	100%
V5BIP9	Trypanosoma cruzi	68%	100%