Mitotic cyclin, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitotic cyclin, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHJ8_LEIDO

TriTrypDb:

LdBPK_300080.1 , LdCL_300005800 , LDHU3_30.0130

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	7	1
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1902554	serine/threonine protein kinase complex	6	1
GO:1902911	protein kinase complex	5	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A0A3Q8IHJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHJ8

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	1
GO:0001932	regulation of protein phosphorylation	7	1
GO:0009987	cellular process	1	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0022402	cell cycle process	2	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031399	regulation of protein modification process	6	1
GO:0042325	regulation of phosphorylation	7	1
GO:0043549	regulation of kinase activity	5	1
GO:0044770	cell cycle phase transition	3	1
GO:0044772	mitotic cell cycle phase transition	4	1
GO:0045859	regulation of protein kinase activity	6	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051338	regulation of transferase activity	4	1
GO:0051726	regulation of cell cycle	4	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0071900	regulation of protein serine/threonine kinase activity	7	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903047	mitotic cell cycle process	3	1
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	1

Molecular functions
Term	Name	Level	Count
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	5	1
GO:0019207	kinase regulator activity	3	1
GO:0019887	protein kinase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.408
CLV_NRD_NRD_1	140	142	PF00675	0.611
CLV_NRD_NRD_1	283	285	PF00675	0.682
CLV_NRD_NRD_1	359	361	PF00675	0.449
CLV_NRD_NRD_1	417	419	PF00675	0.554
CLV_NRD_NRD_1	72	74	PF00675	0.593
CLV_PCSK_KEX2_1	283	285	PF00082	0.674
CLV_PCSK_KEX2_1	359	361	PF00082	0.476
CLV_PCSK_KEX2_1	417	419	PF00082	0.554
CLV_PCSK_KEX2_1	72	74	PF00082	0.657
CLV_PCSK_SKI1_1	283	287	PF00082	0.654
CLV_PCSK_SKI1_1	359	363	PF00082	0.472
CLV_PCSK_SKI1_1	388	392	PF00082	0.552
CLV_PCSK_SKI1_1	42	46	PF00082	0.629
CLV_PCSK_SKI1_1	51	55	PF00082	0.564
CLV_PCSK_SKI1_1	73	77	PF00082	0.629
DEG_APCC_DBOX_1	264	272	PF00400	0.538
DEG_APCC_DBOX_1	358	366	PF00400	0.640
DOC_CYCLIN_yCln2_LP_2	19	25	PF00134	0.571
DOC_MAPK_DCC_7	51	61	PF00069	0.283
DOC_MAPK_gen_1	51	61	PF00069	0.422
DOC_MAPK_MEF2A_6	218	225	PF00069	0.487
DOC_MAPK_MEF2A_6	54	61	PF00069	0.283
DOC_MAPK_MEF2A_6	89	97	PF00069	0.398
DOC_PP2B_PxIxI_1	56	62	PF00149	0.283
DOC_USP7_MATH_1	203	207	PF00917	0.522
DOC_USP7_UBL2_3	47	51	PF12436	0.451
DOC_WW_Pin1_4	349	354	PF00397	0.648
LIG_14-3-3_CanoR_1	218	224	PF00244	0.527
LIG_14-3-3_CanoR_1	265	275	PF00244	0.504
LIG_14-3-3_CanoR_1	333	338	PF00244	0.544
LIG_14-3-3_CanoR_1	89	94	PF00244	0.456
LIG_14-3-3_CterR_2	417	420	PF00244	0.688
LIG_Actin_WH2_2	126	143	PF00022	0.390
LIG_Actin_WH2_2	75	91	PF00022	0.390
LIG_BIR_II_1	1	5	PF00653	0.549
LIG_BRCT_BRCA1_1	16	20	PF00533	0.551
LIG_eIF4E_1	181	187	PF01652	0.485
LIG_EVH1_1	400	404	PF00568	0.715
LIG_EVH1_2	403	407	PF00568	0.711
LIG_FHA_1	172	178	PF00498	0.404
LIG_FHA_1	267	273	PF00498	0.539
LIG_FHA_1	320	326	PF00498	0.479
LIG_FHA_1	372	378	PF00498	0.686
LIG_FHA_1	74	80	PF00498	0.390
LIG_FHA_1	90	96	PF00498	0.390
LIG_FHA_2	295	301	PF00498	0.532
LIG_FHA_2	325	331	PF00498	0.428
LIG_FHA_2	391	397	PF00498	0.743
LIG_FHA_2	404	410	PF00498	0.716
LIG_IRF3_LxIS_1	365	372	PF10401	0.677
LIG_LIR_Apic_2	36	41	PF02991	0.598
LIG_LIR_Gen_1	219	225	PF02991	0.501
LIG_LIR_Gen_1	250	261	PF02991	0.424
LIG_LIR_Gen_1	303	310	PF02991	0.466
LIG_LIR_Gen_1	312	321	PF02991	0.456
LIG_LIR_Gen_1	330	338	PF02991	0.329
LIG_LIR_Gen_1	43	53	PF02991	0.436
LIG_LIR_Nem_3	165	170	PF02991	0.420
LIG_LIR_Nem_3	219	223	PF02991	0.503
LIG_LIR_Nem_3	250	256	PF02991	0.419
LIG_LIR_Nem_3	303	307	PF02991	0.467
LIG_LIR_Nem_3	312	317	PF02991	0.462
LIG_LIR_Nem_3	330	334	PF02991	0.362
LIG_PCNA_PIPBox_1	232	241	PF02747	0.542
LIG_Pex14_2	256	260	PF04695	0.498
LIG_PTB_Apo_2	175	182	PF02174	0.409
LIG_PTB_Phospho_1	175	181	PF10480	0.408
LIG_SH2_CRK	335	339	PF00017	0.544
LIG_SH2_PTP2	304	307	PF00017	0.489
LIG_SH2_SRC	170	173	PF00017	0.502
LIG_SH2_SRC	38	41	PF00017	0.565
LIG_SH2_STAT5	103	106	PF00017	0.461
LIG_SH2_STAT5	170	173	PF00017	0.462
LIG_SH2_STAT5	181	184	PF00017	0.365
LIG_SH2_STAT5	304	307	PF00017	0.485
LIG_SH2_STAT5	337	340	PF00017	0.544
LIG_SH2_STAT5	413	416	PF00017	0.693
LIG_SH3_1	398	404	PF00018	0.669
LIG_SH3_3	398	404	PF00018	0.728
LIG_SUMO_SIM_anti_2	2	10	PF11976	0.542
LIG_SUMO_SIM_anti_2	206	211	PF11976	0.455
LIG_SUMO_SIM_anti_2	219	227	PF11976	0.465
LIG_SUMO_SIM_anti_2	58	63	PF11976	0.415
LIG_SUMO_SIM_par_1	142	148	PF11976	0.431
LIG_SUMO_SIM_par_1	203	208	PF11976	0.471
LIG_TRAF2_1	158	161	PF00917	0.464
LIG_UBA3_1	44	51	PF00899	0.428
LIG_WRC_WIRS_1	163	168	PF05994	0.362
MOD_CDC14_SPxK_1	352	355	PF00782	0.749
MOD_CDK_SPxK_1	349	355	PF00069	0.652
MOD_CK1_1	12	18	PF00069	0.567
MOD_CK1_1	227	233	PF00069	0.508
MOD_CK1_1	247	253	PF00069	0.311
MOD_CK1_1	289	295	PF00069	0.520
MOD_CK1_1	309	315	PF00069	0.286
MOD_CK1_1	336	342	PF00069	0.469
MOD_CK2_1	192	198	PF00069	0.499
MOD_CK2_1	294	300	PF00069	0.540
MOD_CK2_1	324	330	PF00069	0.429
MOD_CK2_1	390	396	PF00069	0.734
MOD_GlcNHglycan	239	242	PF01048	0.708
MOD_GlcNHglycan	311	314	PF01048	0.686
MOD_GlcNHglycan	370	374	PF01048	0.490
MOD_GSK3_1	244	251	PF00069	0.571
MOD_GSK3_1	288	295	PF00069	0.524
MOD_GSK3_1	403	410	PF00069	0.724
MOD_GSK3_1	6	13	PF00069	0.518
MOD_NEK2_1	192	197	PF00069	0.515
MOD_NEK2_1	239	244	PF00069	0.461
MOD_NEK2_1	245	250	PF00069	0.518
MOD_NEK2_1	255	260	PF00069	0.427
MOD_NEK2_1	286	291	PF00069	0.455
MOD_NEK2_1	369	374	PF00069	0.662
MOD_NEK2_1	382	387	PF00069	0.611
MOD_NEK2_1	407	412	PF00069	0.719
MOD_NEK2_1	62	67	PF00069	0.390
MOD_NEK2_1	88	93	PF00069	0.378
MOD_NEK2_1	99	104	PF00069	0.379
MOD_NEK2_2	162	167	PF00069	0.448
MOD_PIKK_1	192	198	PF00454	0.572
MOD_PIKK_1	289	295	PF00454	0.571
MOD_PIKK_1	319	325	PF00454	0.479
MOD_PIKK_1	371	377	PF00454	0.694
MOD_PKA_2	300	306	PF00069	0.473
MOD_PKA_2	407	413	PF00069	0.725
MOD_PKA_2	88	94	PF00069	0.461
MOD_Plk_1	57	63	PF00069	0.491
MOD_Plk_4	162	168	PF00069	0.374
MOD_Plk_4	172	178	PF00069	0.348
MOD_Plk_4	219	225	PF00069	0.524
MOD_Plk_4	248	254	PF00069	0.519
MOD_Plk_4	300	306	PF00069	0.486
MOD_Plk_4	333	339	PF00069	0.544
MOD_Plk_4	40	46	PF00069	0.573
MOD_Plk_4	62	68	PF00069	0.374
MOD_Plk_4	99	105	PF00069	0.488
MOD_ProDKin_1	349	355	PF00069	0.652
MOD_SUMO_for_1	128	131	PF00179	0.390
MOD_SUMO_for_1	34	37	PF00179	0.645
MOD_SUMO_rev_2	36	44	PF00179	0.569
TRG_DiLeu_BaEn_1	357	362	PF01217	0.692
TRG_DiLeu_LyEn_5	357	362	PF01217	0.692
TRG_ENDOCYTIC_2	181	184	PF00928	0.401
TRG_ENDOCYTIC_2	304	307	PF00928	0.489
TRG_ENDOCYTIC_2	335	338	PF00928	0.544
TRG_ER_diArg_1	283	285	PF00400	0.482
TRG_ER_diArg_1	359	361	PF00400	0.649
TRG_ER_diArg_1	417	419	PF00400	0.754
TRG_ER_diArg_1	72	74	PF00400	0.428
TRG_NES_CRM1_1	136	148	PF08389	0.409
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P2	Leptomonas seymouri	80%	100%
A0A0S4JZZ8	Bodo saltans	46%	99%
A0A1X0P2F8	Trypanosomatidae	46%	100%
A4HHV3	Leishmania braziliensis	91%	100%
A4I503	Leishmania infantum	99%	100%
C9ZQF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	93%
E9B0D3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q7U8	Leishmania major	96%	100%