Squalene/phytoene synthase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phytoene synthase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHI9_LEIDO

TriTrypDb:

LdBPK_363720.1 , LdCL_360044200 , LDHU3_36.5010

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHI9

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	91	95	PF00656	0.634
CLV_C14_Caspase3-7	99	103	PF00656	0.549
CLV_NRD_NRD_1	159	161	PF00675	0.547
CLV_NRD_NRD_1	16	18	PF00675	0.512
CLV_NRD_NRD_1	170	172	PF00675	0.509
CLV_NRD_NRD_1	262	264	PF00675	0.518
CLV_NRD_NRD_1	314	316	PF00675	0.262
CLV_NRD_NRD_1	365	367	PF00675	0.362
CLV_NRD_NRD_1	503	505	PF00675	0.220
CLV_NRD_NRD_1	551	553	PF00675	0.219
CLV_NRD_NRD_1	625	627	PF00675	0.621
CLV_PCSK_KEX2_1	15	17	PF00082	0.516
CLV_PCSK_KEX2_1	159	161	PF00082	0.574
CLV_PCSK_KEX2_1	262	264	PF00082	0.425
CLV_PCSK_KEX2_1	314	316	PF00082	0.263
CLV_PCSK_KEX2_1	365	367	PF00082	0.280
CLV_PCSK_KEX2_1	551	553	PF00082	0.219
CLV_PCSK_KEX2_1	577	579	PF00082	0.314
CLV_PCSK_KEX2_1	627	629	PF00082	0.518
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.428
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.204
CLV_PCSK_PC1ET2_1	577	579	PF00082	0.276
CLV_PCSK_PC1ET2_1	627	629	PF00082	0.518
CLV_PCSK_SKI1_1	2	6	PF00082	0.617
CLV_PCSK_SKI1_1	208	212	PF00082	0.526
CLV_PCSK_SKI1_1	241	245	PF00082	0.517
CLV_PCSK_SKI1_1	341	345	PF00082	0.438
CLV_PCSK_SKI1_1	351	355	PF00082	0.321
CLV_PCSK_SKI1_1	399	403	PF00082	0.233
CLV_PCSK_SKI1_1	504	508	PF00082	0.204
CLV_PCSK_SKI1_1	523	527	PF00082	0.204
DEG_APCC_DBOX_1	503	511	PF00400	0.204
DEG_Nend_UBRbox_1	1	4	PF02207	0.454
DOC_ANK_TNKS_1	228	235	PF00023	0.489
DOC_CYCLIN_RxL_1	499	509	PF00134	0.205
DOC_MAPK_gen_1	171	177	PF00069	0.610
DOC_MAPK_gen_1	329	337	PF00069	0.293
DOC_MAPK_gen_1	466	473	PF00069	0.204
DOC_MAPK_gen_1	499	508	PF00069	0.233
DOC_PP1_RVXF_1	349	356	PF00149	0.280
DOC_PP1_RVXF_1	468	474	PF00149	0.219
DOC_PP1_RVXF_1	502	509	PF00149	0.335
DOC_PP4_FxxP_1	85	88	PF00568	0.583
DOC_USP7_MATH_1	134	138	PF00917	0.612
DOC_USP7_MATH_1	188	192	PF00917	0.625
DOC_USP7_MATH_1	209	213	PF00917	0.718
DOC_USP7_MATH_1	232	236	PF00917	0.615
DOC_USP7_MATH_1	278	282	PF00917	0.435
DOC_USP7_MATH_1	42	46	PF00917	0.554
DOC_USP7_MATH_1	495	499	PF00917	0.335
DOC_WW_Pin1_4	132	137	PF00397	0.486
DOC_WW_Pin1_4	166	171	PF00397	0.599
DOC_WW_Pin1_4	183	188	PF00397	0.518
DOC_WW_Pin1_4	213	218	PF00397	0.754
DOC_WW_Pin1_4	30	35	PF00397	0.566
DOC_WW_Pin1_4	53	58	PF00397	0.705
LIG_14-3-3_CanoR_1	208	214	PF00244	0.532
LIG_14-3-3_CanoR_1	229	237	PF00244	0.492
LIG_14-3-3_CanoR_1	26	35	PF00244	0.570
LIG_14-3-3_CanoR_1	331	335	PF00244	0.270
LIG_14-3-3_CanoR_1	341	350	PF00244	0.204
LIG_14-3-3_CanoR_1	399	408	PF00244	0.217
LIG_14-3-3_CanoR_1	470	476	PF00244	0.241
LIG_14-3-3_CterR_2	626	629	PF00244	0.601
LIG_BRCT_BRCA1_1	556	560	PF00533	0.334
LIG_BRCT_BRCA1_1	68	72	PF00533	0.500
LIG_CtBP_PxDLS_1	174	178	PF00389	0.556
LIG_EH1_1	507	515	PF00400	0.241
LIG_eIF4E_1	428	434	PF01652	0.219
LIG_FHA_1	128	134	PF00498	0.482
LIG_FHA_1	152	158	PF00498	0.565
LIG_FHA_1	442	448	PF00498	0.216
LIG_FHA_1	530	536	PF00498	0.341
LIG_FHA_2	97	103	PF00498	0.690
LIG_FXI_DFP_1	293	297	PF00024	0.297
LIG_LIR_Apic_2	83	88	PF02991	0.584
LIG_LIR_Gen_1	283	293	PF02991	0.285
LIG_LIR_Gen_1	295	303	PF02991	0.281
LIG_LIR_Gen_1	420	430	PF02991	0.275
LIG_LIR_Gen_1	582	591	PF02991	0.451
LIG_LIR_Nem_3	244	250	PF02991	0.400
LIG_LIR_Nem_3	258	264	PF02991	0.386
LIG_LIR_Nem_3	283	289	PF02991	0.492
LIG_LIR_Nem_3	295	299	PF02991	0.349
LIG_LIR_Nem_3	316	320	PF02991	0.241
LIG_LIR_Nem_3	420	425	PF02991	0.204
LIG_LIR_Nem_3	532	536	PF02991	0.243
LIG_LIR_Nem_3	538	544	PF02991	0.230
LIG_LIR_Nem_3	571	575	PF02991	0.390
LIG_LIR_Nem_3	580	584	PF02991	0.381
LIG_LIR_Nem_3	69	75	PF02991	0.610
LIG_MYND_1	378	382	PF01753	0.219
LIG_Pex14_2	397	401	PF04695	0.204
LIG_Pex14_2	425	429	PF04695	0.275
LIG_PTB_Apo_2	564	571	PF02174	0.311
LIG_PTB_Apo_2	598	605	PF02174	0.455
LIG_Rb_pABgroove_1	413	421	PF01858	0.204
LIG_SH2_CRK	247	251	PF00017	0.432
LIG_SH2_CRK	468	472	PF00017	0.204
LIG_SH2_GRB2like	541	544	PF00017	0.293
LIG_SH2_GRB2like	599	602	PF00017	0.455
LIG_SH2_PTP2	286	289	PF00017	0.313
LIG_SH2_STAP1	541	545	PF00017	0.219
LIG_SH2_STAT3	308	311	PF00017	0.327
LIG_SH2_STAT5	286	289	PF00017	0.284
LIG_SH2_STAT5	428	431	PF00017	0.219
LIG_SH2_STAT5	545	548	PF00017	0.204
LIG_SH2_STAT5	599	602	PF00017	0.615
LIG_SH3_1	16	22	PF00018	0.449
LIG_SH3_3	16	22	PF00018	0.465
LIG_SH3_3	167	173	PF00018	0.601
LIG_SH3_3	376	382	PF00018	0.204
LIG_SUMO_SIM_par_1	333	339	PF11976	0.323
LIG_SUMO_SIM_par_1	432	437	PF11976	0.219
LIG_TRFH_1	18	22	PF08558	0.449
LIG_TYR_ITIM	284	289	PF00017	0.321
LIG_UBA3_1	507	515	PF00899	0.335
LIG_WRC_WIRS_1	1	6	PF05994	0.454
MOD_CDC14_SPxK_1	135	138	PF00782	0.519
MOD_CDK_SPK_2	166	171	PF00069	0.663
MOD_CDK_SPK_2	213	218	PF00069	0.542
MOD_CDK_SPxK_1	132	138	PF00069	0.497
MOD_CDK_SPxK_1	166	172	PF00069	0.554
MOD_CK1_1	152	158	PF00069	0.612
MOD_CK1_1	183	189	PF00069	0.630
MOD_CK1_1	212	218	PF00069	0.660
MOD_CK1_1	228	234	PF00069	0.483
MOD_CK1_1	29	35	PF00069	0.500
MOD_CK1_1	36	42	PF00069	0.530
MOD_CK2_1	330	336	PF00069	0.347
MOD_CK2_1	429	435	PF00069	0.219
MOD_GlcNHglycan	188	191	PF01048	0.649
MOD_GlcNHglycan	198	201	PF01048	0.569
MOD_GlcNHglycan	266	270	PF01048	0.542
MOD_GlcNHglycan	280	283	PF01048	0.420
MOD_GlcNHglycan	44	47	PF01048	0.602
MOD_GlcNHglycan	556	559	PF01048	0.342
MOD_GlcNHglycan	614	617	PF01048	0.480
MOD_GlcNHglycan	618	621	PF01048	0.493
MOD_GlcNHglycan	82	85	PF01048	0.503
MOD_GSK3_1	123	130	PF00069	0.511
MOD_GSK3_1	149	156	PF00069	0.603
MOD_GSK3_1	182	189	PF00069	0.588
MOD_GSK3_1	208	215	PF00069	0.631
MOD_GSK3_1	228	235	PF00069	0.555
MOD_GSK3_1	26	33	PF00069	0.517
MOD_GSK3_1	274	281	PF00069	0.447
MOD_GSK3_1	367	374	PF00069	0.216
MOD_GSK3_1	37	44	PF00069	0.559
MOD_GSK3_1	47	54	PF00069	0.459
MOD_GSK3_1	612	619	PF00069	0.461
MOD_LATS_1	610	616	PF00433	0.460
MOD_N-GLC_1	166	171	PF02516	0.655
MOD_N-GLC_1	554	559	PF02516	0.194
MOD_N-GLC_1	600	605	PF02516	0.414
MOD_N-GLC_2	459	461	PF02516	0.335
MOD_NEK2_1	323	328	PF00069	0.250
MOD_NEK2_1	343	348	PF00069	0.316
MOD_NEK2_1	373	378	PF00069	0.204
MOD_NEK2_1	429	434	PF00069	0.281
MOD_NEK2_1	471	476	PF00069	0.339
MOD_NEK2_1	554	559	PF00069	0.221
MOD_PIKK_1	109	115	PF00454	0.588
MOD_PIKK_1	336	342	PF00454	0.371
MOD_PK_1	583	589	PF00069	0.311
MOD_PKA_2	193	199	PF00069	0.594
MOD_PKA_2	228	234	PF00069	0.513
MOD_PKA_2	330	336	PF00069	0.275
MOD_PKA_2	452	458	PF00069	0.335
MOD_PKA_2	60	66	PF00069	0.576
MOD_PKA_2	606	612	PF00069	0.421
MOD_Plk_1	434	440	PF00069	0.300
MOD_Plk_1	554	560	PF00069	0.204
MOD_Plk_1	600	606	PF00069	0.518
MOD_Plk_1	93	99	PF00069	0.499
MOD_Plk_4	429	435	PF00069	0.227
MOD_ProDKin_1	132	138	PF00069	0.492
MOD_ProDKin_1	166	172	PF00069	0.599
MOD_ProDKin_1	183	189	PF00069	0.520
MOD_ProDKin_1	213	219	PF00069	0.753
MOD_ProDKin_1	30	36	PF00069	0.567
MOD_ProDKin_1	53	59	PF00069	0.703
MOD_SUMO_for_1	287	290	PF00179	0.284
MOD_SUMO_for_1	439	442	PF00179	0.241
MOD_SUMO_for_1	514	517	PF00179	0.219
MOD_SUMO_for_1	52	55	PF00179	0.553
MOD_SUMO_rev_2	176	184	PF00179	0.657
TRG_ENDOCYTIC_2	18	21	PF00928	0.467
TRG_ENDOCYTIC_2	247	250	PF00928	0.409
TRG_ENDOCYTIC_2	286	289	PF00928	0.284
TRG_ENDOCYTIC_2	317	320	PF00928	0.228
TRG_ENDOCYTIC_2	426	429	PF00928	0.282
TRG_ENDOCYTIC_2	468	471	PF00928	0.204
TRG_ENDOCYTIC_2	545	548	PF00928	0.282
TRG_ENDOCYTIC_2	584	587	PF00928	0.448
TRG_ER_diArg_1	158	160	PF00400	0.575
TRG_ER_diArg_1	16	18	PF00400	0.505
TRG_ER_diArg_1	261	263	PF00400	0.524
TRG_ER_diArg_1	313	315	PF00400	0.271
TRG_ER_diArg_1	405	408	PF00400	0.241
TRG_NLS_MonoExtC_3	14	19	PF00514	0.428
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.337
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX38	Leptomonas seymouri	68%	97%
A0A0S4JIB4	Bodo saltans	51%	100%
A0A1X0P3G5	Trypanosomatidae	59%	100%
D0A8J3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
V5B709	Trypanosoma cruzi	61%	100%