Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHI6_LEIDO

TriTrypDb:

LdBPK_331680.1 , LdCL_330023400 , LDHU3_33.2520

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	221	227	PF00089	0.692
CLV_NRD_NRD_1	272	274	PF00675	0.662
CLV_NRD_NRD_1	29	31	PF00675	0.620
CLV_PCSK_KEX2_1	274	276	PF00082	0.777
CLV_PCSK_KEX2_1	29	31	PF00082	0.620
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.755
CLV_PCSK_SKI1_1	219	223	PF00082	0.755
CLV_PCSK_SKI1_1	22	26	PF00082	0.595
CLV_PCSK_SKI1_1	34	38	PF00082	0.563
CLV_PCSK_SKI1_1	40	44	PF00082	0.535
DEG_APCC_DBOX_1	124	132	PF00400	0.675
DEG_Nend_Nbox_1	1	3	PF02207	0.616
DEG_SCF_FBW7_1	4	11	PF00400	0.643
DEG_SPOP_SBC_1	309	313	PF00917	0.709
DOC_CYCLIN_RxL_1	104	115	PF00134	0.607
DOC_CYCLIN_RxL_1	19	28	PF00134	0.599
DOC_MAPK_gen_1	29	35	PF00069	0.581
DOC_PP1_RVXF_1	105	112	PF00149	0.578
DOC_PP1_RVXF_1	32	39	PF00149	0.565
DOC_PP2B_LxvP_1	323	326	PF13499	0.711
DOC_USP7_MATH_1	172	176	PF00917	0.738
DOC_WW_Pin1_4	4	9	PF00397	0.647
DOC_WW_Pin1_4	59	64	PF00397	0.795
LIG_14-3-3_CanoR_1	120	124	PF00244	0.638
LIG_14-3-3_CanoR_1	184	192	PF00244	0.600
LIG_14-3-3_CanoR_1	34	39	PF00244	0.610
LIG_Actin_WH2_2	135	152	PF00022	0.569
LIG_Actin_WH2_2	71	87	PF00022	0.611
LIG_DCNL_PONY_1	1	4	PF03556	0.624
LIG_FHA_1	116	122	PF00498	0.603
LIG_FHA_1	132	138	PF00498	0.705
LIG_FHA_1	184	190	PF00498	0.672
LIG_FHA_1	199	205	PF00498	0.598
LIG_FHA_1	254	260	PF00498	0.732
LIG_FHA_1	280	286	PF00498	0.717
LIG_FHA_1	5	11	PF00498	0.642
LIG_FHA_1	69	75	PF00498	0.617
LIG_FHA_2	96	102	PF00498	0.602
LIG_LIR_Gen_1	179	189	PF02991	0.690
LIG_LIR_Nem_3	179	185	PF02991	0.709
LIG_LIR_Nem_3	288	292	PF02991	0.654
LIG_SH2_CRK	182	186	PF00017	0.640
LIG_SH2_SRC	284	287	PF00017	0.452
LIG_SH2_STAP1	229	233	PF00017	0.643
LIG_SH2_STAP1	56	60	PF00017	0.699
LIG_SH2_STAT5	158	161	PF00017	0.774
LIG_SH2_STAT5	261	264	PF00017	0.723
LIG_SH2_STAT5	268	271	PF00017	0.650
LIG_SH2_STAT5	284	287	PF00017	0.509
LIG_SH3_3	137	143	PF00018	0.656
LIG_SH3_3	20	26	PF00018	0.478
LIG_SH3_3	222	228	PF00018	0.685
LIG_SH3_3	230	236	PF00018	0.408
LIG_SUMO_SIM_anti_2	136	141	PF11976	0.661
LIG_TRAF2_1	47	50	PF00917	0.708
LIG_WRC_WIRS_1	35	40	PF05994	0.575
MOD_CDC14_SPxK_1	62	65	PF00782	0.695
MOD_CDK_SPxK_1	59	65	PF00069	0.750
MOD_CK1_1	198	204	PF00069	0.608
MOD_CK1_1	217	223	PF00069	0.448
MOD_CK1_1	252	258	PF00069	0.666
MOD_CK1_1	313	319	PF00069	0.691
MOD_CK1_1	41	47	PF00069	0.690
MOD_CK1_1	95	101	PF00069	0.595
MOD_CK2_1	44	50	PF00069	0.698
MOD_CK2_1	95	101	PF00069	0.595
MOD_Cter_Amidation	271	274	PF01082	0.751
MOD_GlcNHglycan	198	201	PF01048	0.636
MOD_GlcNHglycan	256	259	PF01048	0.692
MOD_GlcNHglycan	323	326	PF01048	0.714
MOD_GlcNHglycan	94	97	PF01048	0.613
MOD_GSK3_1	115	122	PF00069	0.603
MOD_GSK3_1	172	179	PF00069	0.731
MOD_GSK3_1	194	201	PF00069	0.608
MOD_GSK3_1	249	256	PF00069	0.666
MOD_GSK3_1	275	282	PF00069	0.746
MOD_GSK3_1	309	316	PF00069	0.704
MOD_GSK3_1	34	41	PF00069	0.596
MOD_GSK3_1	4	11	PF00069	0.643
MOD_LATS_1	160	166	PF00433	0.756
MOD_NEK2_1	196	201	PF00069	0.616
MOD_NEK2_1	319	324	PF00069	0.738
MOD_NEK2_1	38	43	PF00069	0.606
MOD_NEK2_2	243	248	PF00069	0.653
MOD_PKA_2	119	125	PF00069	0.637
MOD_PKA_2	183	189	PF00069	0.627
MOD_PKB_1	273	281	PF00069	0.644
MOD_Plk_1	217	223	PF00069	0.704
MOD_Plk_4	217	223	PF00069	0.733
MOD_Plk_4	243	249	PF00069	0.705
MOD_Plk_4	314	320	PF00069	0.708
MOD_Plk_4	38	44	PF00069	0.609
MOD_ProDKin_1	4	10	PF00069	0.653
MOD_ProDKin_1	59	65	PF00069	0.793
MOD_SUMO_rev_2	110	118	PF00179	0.326
MOD_SUMO_rev_2	91	95	PF00179	0.643
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.611
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.666
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.555
TRG_ENDOCYTIC_2	182	185	PF00928	0.702
TRG_ER_diArg_1	104	107	PF00400	0.591
TRG_ER_diArg_1	20	23	PF00400	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I930	Leishmania infantum	100%	100%
E9B3Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q429	Leishmania major	94%	100%