GIPL galf transferase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GIPL galf transferase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHI5_LEIDO

TriTrypDb:

LdBPK_324140.1 , LdCL_320047400 , LDHU3_32.5340

Length:

661

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A0A3Q8IHI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHI5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016740	transferase activity	2	10
GO:0016757	glycosyltransferase activity	3	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	296	302	PF00089	0.518
CLV_NRD_NRD_1	298	300	PF00675	0.518
CLV_NRD_NRD_1	447	449	PF00675	0.577
CLV_NRD_NRD_1	548	550	PF00675	0.673
CLV_NRD_NRD_1	556	558	PF00675	0.608
CLV_NRD_NRD_1	607	609	PF00675	0.570
CLV_NRD_NRD_1	79	81	PF00675	0.509
CLV_PCSK_KEX2_1	235	237	PF00082	0.604
CLV_PCSK_KEX2_1	298	300	PF00082	0.518
CLV_PCSK_KEX2_1	449	451	PF00082	0.556
CLV_PCSK_KEX2_1	548	550	PF00082	0.686
CLV_PCSK_KEX2_1	556	558	PF00082	0.632
CLV_PCSK_KEX2_1	607	609	PF00082	0.570
CLV_PCSK_KEX2_1	79	81	PF00082	0.498
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.549
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.532
CLV_PCSK_SKI1_1	117	121	PF00082	0.681
CLV_PCSK_SKI1_1	241	245	PF00082	0.565
CLV_PCSK_SKI1_1	402	406	PF00082	0.677
CLV_PCSK_SKI1_1	449	453	PF00082	0.550
CLV_PCSK_SKI1_1	473	477	PF00082	0.656
CLV_PCSK_SKI1_1	548	552	PF00082	0.695
CLV_PCSK_SKI1_1	608	612	PF00082	0.560
CLV_PCSK_SKI1_1	80	84	PF00082	0.554
CLV_PCSK_SKI1_1	85	89	PF00082	0.312
DEG_APCC_DBOX_1	472	480	PF00400	0.367
DEG_APCC_DBOX_1	84	92	PF00400	0.527
DEG_Nend_Nbox_1	1	3	PF02207	0.587
DEG_SPOP_SBC_1	145	149	PF00917	0.556
DOC_CKS1_1	173	178	PF01111	0.531
DOC_CKS1_1	253	258	PF01111	0.375
DOC_CKS1_1	441	446	PF01111	0.359
DOC_MAPK_DCC_7	85	93	PF00069	0.518
DOC_MAPK_gen_1	76	84	PF00069	0.740
DOC_MAPK_HePTP_8	82	94	PF00069	0.518
DOC_MAPK_MEF2A_6	408	416	PF00069	0.432
DOC_MAPK_MEF2A_6	85	94	PF00069	0.518
DOC_PP4_FxxP_1	170	173	PF00568	0.537
DOC_PP4_FxxP_1	532	535	PF00568	0.476
DOC_SPAK_OSR1_1	305	309	PF12202	0.241
DOC_USP7_MATH_1	136	140	PF00917	0.512
DOC_USP7_MATH_1	18	22	PF00917	0.592
DOC_USP7_MATH_1	180	184	PF00917	0.572
DOC_USP7_MATH_1	187	191	PF00917	0.505
DOC_USP7_MATH_1	31	35	PF00917	0.599
DOC_USP7_MATH_1	550	554	PF00917	0.410
DOC_USP7_MATH_2	163	169	PF00917	0.541
DOC_WW_Pin1_4	104	109	PF00397	0.645
DOC_WW_Pin1_4	138	143	PF00397	0.647
DOC_WW_Pin1_4	172	177	PF00397	0.596
DOC_WW_Pin1_4	20	25	PF00397	0.585
DOC_WW_Pin1_4	252	257	PF00397	0.316
DOC_WW_Pin1_4	43	48	PF00397	0.595
DOC_WW_Pin1_4	440	445	PF00397	0.382
DOC_WW_Pin1_4	457	462	PF00397	0.344
DOC_WW_Pin1_4	527	532	PF00397	0.486
LIG_14-3-3_CanoR_1	137	141	PF00244	0.566
LIG_14-3-3_CanoR_1	241	250	PF00244	0.345
LIG_14-3-3_CanoR_1	26	31	PF00244	0.616
LIG_14-3-3_CanoR_1	473	482	PF00244	0.370
LIG_14-3-3_CanoR_1	549	555	PF00244	0.436
LIG_14-3-3_CanoR_1	65	75	PF00244	0.758
LIG_14-3-3_CanoR_1	79	85	PF00244	0.696
LIG_BIR_III_2	248	252	PF00653	0.358
LIG_BRCT_BRCA1_1	100	104	PF00533	0.258
LIG_BRCT_BRCA1_1	302	306	PF00533	0.241
LIG_CSL_BTD_1	121	124	PF09270	0.462
LIG_deltaCOP1_diTrp_1	335	341	PF00928	0.344
LIG_deltaCOP1_diTrp_1	495	505	PF00928	0.463
LIG_FHA_1	100	106	PF00498	0.468
LIG_FHA_1	141	147	PF00498	0.520
LIG_FHA_1	245	251	PF00498	0.381
LIG_FHA_1	256	262	PF00498	0.367
LIG_FHA_1	287	293	PF00498	0.431
LIG_FHA_1	418	424	PF00498	0.458
LIG_FHA_1	466	472	PF00498	0.382
LIG_FHA_1	597	603	PF00498	0.437
LIG_FHA_2	153	159	PF00498	0.537
LIG_FHA_2	183	189	PF00498	0.530
LIG_FHA_2	331	337	PF00498	0.345
LIG_FHA_2	363	369	PF00498	0.333
LIG_FHA_2	441	447	PF00498	0.406
LIG_FHA_2	458	464	PF00498	0.265
LIG_FHA_2	632	638	PF00498	0.522
LIG_LIR_Apic_2	167	173	PF02991	0.558
LIG_LIR_Apic_2	530	535	PF02991	0.463
LIG_LIR_Gen_1	212	221	PF02991	0.443
LIG_LIR_Gen_1	303	313	PF02991	0.241
LIG_LIR_Gen_1	584	595	PF02991	0.473
LIG_LIR_Nem_3	260	266	PF02991	0.366
LIG_LIR_Nem_3	303	309	PF02991	0.241
LIG_LIR_Nem_3	388	394	PF02991	0.447
LIG_LIR_Nem_3	409	414	PF02991	0.484
LIG_LIR_Nem_3	484	490	PF02991	0.517
LIG_LIR_Nem_3	495	501	PF02991	0.349
LIG_LIR_Nem_3	517	522	PF02991	0.487
LIG_LIR_Nem_3	584	590	PF02991	0.566
LIG_LYPXL_yS_3	411	414	PF13949	0.482
LIG_MYND_1	47	51	PF01753	0.592
LIG_OCRL_FandH_1	504	516	PF00620	0.337
LIG_Pex14_2	263	267	PF04695	0.374
LIG_Pex14_2	501	505	PF04695	0.424
LIG_SH2_CRK	277	281	PF00017	0.375
LIG_SH2_CRK	562	566	PF00017	0.444
LIG_SH2_NCK_1	522	526	PF00017	0.449
LIG_SH2_PTP2	2	5	PF00017	0.580
LIG_SH2_SRC	2	5	PF00017	0.580
LIG_SH2_STAP1	394	398	PF00017	0.457
LIG_SH2_STAP1	546	550	PF00017	0.537
LIG_SH2_STAP1	617	621	PF00017	0.405
LIG_SH2_STAT3	279	282	PF00017	0.435
LIG_SH2_STAT3	6	9	PF00017	0.579
LIG_SH2_STAT3	617	620	PF00017	0.499
LIG_SH2_STAT5	12	15	PF00017	0.579
LIG_SH2_STAT5	2	5	PF00017	0.580
LIG_SH2_STAT5	266	269	PF00017	0.393
LIG_SH2_STAT5	279	282	PF00017	0.350
LIG_SH2_STAT5	455	458	PF00017	0.381
LIG_SH2_STAT5	481	484	PF00017	0.433
LIG_SH2_STAT5	486	489	PF00017	0.469
LIG_SH2_STAT5	554	557	PF00017	0.459
LIG_SH2_STAT5	6	9	PF00017	0.578
LIG_SH3_1	419	425	PF00018	0.402
LIG_SH3_2	422	427	PF14604	0.400
LIG_SH3_3	130	136	PF00018	0.562
LIG_SH3_3	139	145	PF00018	0.507
LIG_SH3_3	170	176	PF00018	0.503
LIG_SH3_3	409	415	PF00018	0.480
LIG_SH3_3	419	425	PF00018	0.329
LIG_SUMO_SIM_par_1	250	255	PF11976	0.447
LIG_SUMO_SIM_par_1	467	472	PF11976	0.375
LIG_TRAF2_1	333	336	PF00917	0.345
LIG_TRAF2_1	579	582	PF00917	0.434
LIG_TRAF2_1	634	637	PF00917	0.506
LIG_TYR_ITIM	275	280	PF00017	0.368
LIG_UBA3_1	253	262	PF00899	0.360
LIG_UBA3_1	353	359	PF00899	0.257
LIG_WW_3	23	27	PF00397	0.592
MOD_CDC14_SPxK_1	23	26	PF00782	0.588
MOD_CDK_SPxK_1	20	26	PF00069	0.590
MOD_CDK_SPxxK_3	43	50	PF00069	0.597
MOD_CK1_1	144	150	PF00069	0.567
MOD_CK1_1	17	23	PF00069	0.593
MOD_CK1_1	178	184	PF00069	0.529
MOD_CK1_1	623	629	PF00069	0.537
MOD_CK1_1	71	77	PF00069	0.803
MOD_CK2_1	152	158	PF00069	0.553
MOD_CK2_1	182	188	PF00069	0.530
MOD_CK2_1	330	336	PF00069	0.345
MOD_CK2_1	389	395	PF00069	0.451
MOD_CK2_1	440	446	PF00069	0.433
MOD_CK2_1	457	463	PF00069	0.252
MOD_CK2_1	631	637	PF00069	0.508
MOD_CK2_1	648	654	PF00069	0.368
MOD_GlcNHglycan	124	127	PF01048	0.708
MOD_GlcNHglycan	148	151	PF01048	0.856
MOD_GlcNHglycan	16	19	PF01048	0.392
MOD_GlcNHglycan	177	180	PF01048	0.783
MOD_GlcNHglycan	182	185	PF01048	0.738
MOD_GlcNHglycan	188	192	PF01048	0.684
MOD_GlcNHglycan	302	305	PF01048	0.556
MOD_GlcNHglycan	317	320	PF01048	0.528
MOD_GlcNHglycan	33	36	PF01048	0.395
MOD_GlcNHglycan	408	411	PF01048	0.640
MOD_GlcNHglycan	438	441	PF01048	0.696
MOD_GlcNHglycan	636	640	PF01048	0.768
MOD_GSK3_1	109	116	PF00069	0.485
MOD_GSK3_1	118	125	PF00069	0.459
MOD_GSK3_1	136	143	PF00069	0.480
MOD_GSK3_1	14	21	PF00069	0.590
MOD_GSK3_1	153	160	PF00069	0.517
MOD_GSK3_1	174	181	PF00069	0.599
MOD_GSK3_1	195	202	PF00069	0.483
MOD_GSK3_1	436	443	PF00069	0.403
MOD_GSK3_1	465	472	PF00069	0.385
MOD_GSK3_1	631	638	PF00069	0.475
MOD_GSK3_1	67	74	PF00069	0.695
MOD_GSK3_1	99	106	PF00069	0.359
MOD_LATS_1	78	84	PF00433	0.627
MOD_N-GLC_1	389	394	PF02516	0.646
MOD_N-GLC_1	544	549	PF02516	0.698
MOD_N-GLC_1	590	595	PF02516	0.652
MOD_NEK2_1	128	133	PF00069	0.503
MOD_NEK2_1	300	305	PF00069	0.345
MOD_NEK2_1	474	479	PF00069	0.435
MOD_NEK2_1	590	595	PF00069	0.456
MOD_NEK2_1	611	616	PF00069	0.483
MOD_NEK2_1	635	640	PF00069	0.516
MOD_NEK2_2	504	509	PF00069	0.341
MOD_NEK2_2	99	104	PF00069	0.345
MOD_PK_1	68	74	PF00069	0.709
MOD_PKA_2	136	142	PF00069	0.669
MOD_PKA_2	212	218	PF00069	0.380
MOD_PKA_2	436	442	PF00069	0.510
MOD_PKA_2	555	561	PF00069	0.429
MOD_PKA_2	623	629	PF00069	0.455
MOD_PKB_1	115	123	PF00069	0.467
MOD_Plk_1	117	123	PF00069	0.478
MOD_Plk_1	287	293	PF00069	0.435
MOD_Plk_1	389	395	PF00069	0.451
MOD_Plk_1	590	596	PF00069	0.444
MOD_Plk_1	626	632	PF00069	0.511
MOD_Plk_2-3	654	660	PF00069	0.409
MOD_Plk_4	189	195	PF00069	0.540
MOD_Plk_4	389	395	PF00069	0.451
MOD_Plk_4	550	556	PF00069	0.435
MOD_Plk_4	596	602	PF00069	0.406
MOD_Plk_4	99	105	PF00069	0.363
MOD_ProDKin_1	104	110	PF00069	0.647
MOD_ProDKin_1	138	144	PF00069	0.646
MOD_ProDKin_1	172	178	PF00069	0.595
MOD_ProDKin_1	20	26	PF00069	0.590
MOD_ProDKin_1	252	258	PF00069	0.320
MOD_ProDKin_1	43	49	PF00069	0.596
MOD_ProDKin_1	440	446	PF00069	0.381
MOD_ProDKin_1	457	463	PF00069	0.352
MOD_ProDKin_1	527	533	PF00069	0.491
MOD_SUMO_rev_2	578	588	PF00179	0.439
MOD_SUMO_rev_2	651	658	PF00179	0.397
TRG_DiLeu_BaEn_1	189	194	PF01217	0.478
TRG_DiLeu_BaEn_4	636	642	PF01217	0.493
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.382
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.377
TRG_ENDOCYTIC_2	2	5	PF00928	0.580
TRG_ENDOCYTIC_2	277	280	PF00928	0.463
TRG_ENDOCYTIC_2	411	414	PF00928	0.487
TRG_ENDOCYTIC_2	562	565	PF00928	0.447
TRG_ENDOCYTIC_2	585	588	PF00928	0.471
TRG_ER_diArg_1	236	239	PF00400	0.388
TRG_ER_diArg_1	298	300	PF00400	0.317
TRG_ER_diArg_1	309	312	PF00400	0.345
TRG_ER_diArg_1	399	402	PF00400	0.464
TRG_ER_diArg_1	427	430	PF00400	0.497
TRG_ER_diArg_1	447	450	PF00400	0.302
TRG_ER_diArg_1	555	557	PF00400	0.443
TRG_ER_diArg_1	79	81	PF00400	0.664
TRG_NES_CRM1_1	222	234	PF08389	0.375
TRG_Pf-PMV_PEXEL_1	633	637	PF00026	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6F1	Leishmania donovani	30%	100%
A4HL36	Leishmania braziliensis	63%	96%
A4I8P7	Leishmania infantum	27%	100%
E9AHM5	Leishmania infantum	99%	100%
E9B3H7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
E9B3L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q4QD44	Leishmania major	84%	100%
Q6XFB5	Leishmania major	27%	100%