Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IHI2_LEIDO

TriTrypDb:

LdBPK_341790.1 , LdCL_340025500 , LDHU3_34.3080

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHI2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.534
CLV_NRD_NRD_1	355	357	PF00675	0.526
CLV_NRD_NRD_1	371	373	PF00675	0.434
CLV_NRD_NRD_1	406	408	PF00675	0.665
CLV_NRD_NRD_1	41	43	PF00675	0.510
CLV_NRD_NRD_1	81	83	PF00675	0.530
CLV_PCSK_FUR_1	79	83	PF00082	0.548
CLV_PCSK_KEX2_1	13	15	PF00082	0.531
CLV_PCSK_KEX2_1	355	357	PF00082	0.526
CLV_PCSK_KEX2_1	370	372	PF00082	0.444
CLV_PCSK_KEX2_1	396	398	PF00082	0.651
CLV_PCSK_KEX2_1	81	83	PF00082	0.530
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.651
CLV_PCSK_SKI1_1	118	122	PF00082	0.612
CLV_PCSK_SKI1_1	310	314	PF00082	0.512
CLV_PCSK_SKI1_1	374	378	PF00082	0.266
CLV_PCSK_SKI1_1	393	397	PF00082	0.622
CLV_PCSK_SKI1_1	407	411	PF00082	0.686
CLV_PCSK_SKI1_1	7	11	PF00082	0.482
DEG_APCC_DBOX_1	373	381	PF00400	0.466
DEG_APCC_DBOX_1	388	396	PF00400	0.632
DEG_SPOP_SBC_1	398	402	PF00917	0.424
DOC_ANK_TNKS_1	50	57	PF00023	0.745
DOC_CKS1_1	183	188	PF01111	0.764
DOC_CYCLIN_RxL_1	370	378	PF00134	0.553
DOC_CYCLIN_RxL_1	405	416	PF00134	0.486
DOC_CYCLIN_yCln2_LP_2	388	394	PF00134	0.411
DOC_MAPK_gen_1	370	379	PF00069	0.669
DOC_PP2B_LxvP_1	388	391	PF13499	0.411
DOC_PP4_FxxP_1	116	119	PF00568	0.808
DOC_PP4_FxxP_1	261	264	PF00568	0.741
DOC_USP7_MATH_1	109	113	PF00917	0.805
DOC_USP7_MATH_1	141	145	PF00917	0.710
DOC_USP7_MATH_1	176	180	PF00917	0.773
DOC_USP7_MATH_1	196	200	PF00917	0.754
DOC_USP7_MATH_1	215	219	PF00917	0.700
DOC_USP7_MATH_1	220	224	PF00917	0.755
DOC_USP7_MATH_1	228	232	PF00917	0.737
DOC_USP7_MATH_1	283	287	PF00917	0.729
DOC_USP7_MATH_1	30	34	PF00917	0.685
DOC_WW_Pin1_4	149	154	PF00397	0.753
DOC_WW_Pin1_4	182	187	PF00397	0.743
DOC_WW_Pin1_4	198	203	PF00397	0.741
DOC_WW_Pin1_4	272	277	PF00397	0.801
DOC_WW_Pin1_4	49	54	PF00397	0.724
DOC_WW_Pin1_4	7	12	PF00397	0.753
DOC_WW_Pin1_4	74	79	PF00397	0.759
DOC_WW_Pin1_4	94	99	PF00397	0.570
LIG_14-3-3_CanoR_1	108	116	PF00244	0.754
LIG_14-3-3_CanoR_1	14	20	PF00244	0.721
LIG_14-3-3_CanoR_1	143	151	PF00244	0.804
LIG_14-3-3_CanoR_1	197	202	PF00244	0.760
LIG_14-3-3_CanoR_1	236	241	PF00244	0.766
LIG_14-3-3_CanoR_1	288	295	PF00244	0.799
LIG_14-3-3_CanoR_1	356	362	PF00244	0.774
LIG_14-3-3_CanoR_1	397	406	PF00244	0.457
LIG_14-3-3_CanoR_1	82	88	PF00244	0.732
LIG_Actin_WH2_2	118	136	PF00022	0.760
LIG_Actin_WH2_2	383	398	PF00022	0.432
LIG_BIR_III_2	195	199	PF00653	0.751
LIG_BIR_III_4	268	272	PF00653	0.642
LIG_BRCT_BRCA1_1	200	204	PF00533	0.715
LIG_FHA_1	175	181	PF00498	0.734
LIG_FHA_1	27	33	PF00498	0.778
LIG_FHA_1	39	45	PF00498	0.597
LIG_FHA_1	398	404	PF00498	0.355
LIG_FHA_1	66	72	PF00498	0.676
LIG_FHA_2	156	162	PF00498	0.769
LIG_FHA_2	167	173	PF00498	0.669
LIG_FHA_2	50	56	PF00498	0.801
LIG_LIR_Apic_2	115	119	PF02991	0.742
LIG_LIR_Apic_2	258	264	PF02991	0.715
LIG_LIR_Gen_1	201	208	PF02991	0.742
LIG_LIR_Gen_1	385	395	PF02991	0.450
LIG_LIR_Nem_3	201	207	PF02991	0.742
LIG_LIR_Nem_3	385	390	PF02991	0.450
LIG_SH2_STAT5	206	209	PF00017	0.819
LIG_SUMO_SIM_anti_2	22	29	PF11976	0.694
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.722
LIG_SUMO_SIM_par_1	408	413	PF11976	0.480
LIG_SUMO_SIM_par_1	67	73	PF11976	0.711
LIG_TRAF2_1	35	38	PF00917	0.693
LIG_WW_3	10	14	PF00397	0.770
MOD_CDK_SPK_2	74	79	PF00069	0.797
MOD_CDK_SPK_2	98	103	PF00069	0.736
MOD_CDK_SPxK_1	7	13	PF00069	0.738
MOD_CDK_SPxxK_3	272	279	PF00069	0.802
MOD_CDK_SPxxK_3	7	14	PF00069	0.747
MOD_CDK_SPxxK_3	74	81	PF00069	0.724
MOD_CK1_1	112	118	PF00069	0.808
MOD_CK1_1	124	130	PF00069	0.749
MOD_CK1_1	170	176	PF00069	0.832
MOD_CK1_1	20	26	PF00069	0.595
MOD_CK1_1	200	206	PF00069	0.747
MOD_CK1_1	218	224	PF00069	0.632
MOD_CK1_1	282	288	PF00069	0.751
MOD_CK1_1	5	11	PF00069	0.752
MOD_CK1_1	62	68	PF00069	0.804
MOD_CK1_1	86	92	PF00069	0.795
MOD_CK2_1	155	161	PF00069	0.827
MOD_CK2_1	166	172	PF00069	0.683
MOD_CK2_1	399	405	PF00069	0.386
MOD_CMANNOS	381	384	PF00535	0.299
MOD_DYRK1A_RPxSP_1	7	11	PF00069	0.674
MOD_GlcNHglycan	145	148	PF01048	0.554
MOD_GlcNHglycan	169	172	PF01048	0.630
MOD_GlcNHglycan	174	177	PF01048	0.577
MOD_GlcNHglycan	19	22	PF01048	0.557
MOD_GlcNHglycan	209	212	PF01048	0.601
MOD_GlcNHglycan	217	221	PF01048	0.570
MOD_GlcNHglycan	281	284	PF01048	0.483
MOD_GlcNHglycan	7	10	PF01048	0.545
MOD_GlcNHglycan	72	75	PF01048	0.504
MOD_GSK3_1	104	111	PF00069	0.664
MOD_GSK3_1	121	128	PF00069	0.808
MOD_GSK3_1	149	156	PF00069	0.731
MOD_GSK3_1	166	173	PF00069	0.806
MOD_GSK3_1	196	203	PF00069	0.671
MOD_GSK3_1	215	222	PF00069	0.756
MOD_GSK3_1	26	33	PF00069	0.774
MOD_GSK3_1	278	285	PF00069	0.727
MOD_GSK3_1	61	68	PF00069	0.721
MOD_GSK3_1	70	77	PF00069	0.730
MOD_GSK3_1	82	89	PF00069	0.763
MOD_GSK3_1	94	101	PF00069	0.716
MOD_N-GLC_1	141	146	PF02516	0.593
MOD_N-GLC_1	15	20	PF02516	0.503
MOD_N-GLC_1	253	258	PF02516	0.556
MOD_N-GLC_1	357	362	PF02516	0.449
MOD_N-GLC_1	49	54	PF02516	0.522
MOD_N-GLC_1	62	67	PF02516	0.534
MOD_NEK2_1	121	126	PF00069	0.730
MOD_NEK2_1	155	160	PF00069	0.742
MOD_NEK2_1	235	240	PF00069	0.760
MOD_NEK2_1	382	387	PF00069	0.418
MOD_NEK2_1	399	404	PF00069	0.508
MOD_NEK2_1	87	92	PF00069	0.665
MOD_PIKK_1	283	289	PF00454	0.767
MOD_PIKK_1	410	416	PF00454	0.493
MOD_PK_1	236	242	PF00069	0.780
MOD_PKA_2	112	118	PF00069	0.726
MOD_PKA_2	142	148	PF00069	0.757
MOD_PKA_2	196	202	PF00069	0.795
MOD_PKA_2	235	241	PF00069	0.803
MOD_PKA_2	278	284	PF00069	0.809
MOD_PKA_2	287	293	PF00069	0.736
MOD_Plk_1	15	21	PF00069	0.744
MOD_Plk_1	164	170	PF00069	0.735
MOD_Plk_1	23	29	PF00069	0.672
MOD_Plk_1	310	316	PF00069	0.696
MOD_Plk_1	357	363	PF00069	0.647
MOD_Plk_1	62	68	PF00069	0.761
MOD_Plk_4	185	191	PF00069	0.695
MOD_Plk_4	23	29	PF00069	0.702
MOD_Plk_4	375	381	PF00069	0.457
MOD_Plk_4	44	50	PF00069	0.763
MOD_Plk_4	87	93	PF00069	0.666
MOD_ProDKin_1	149	155	PF00069	0.755
MOD_ProDKin_1	182	188	PF00069	0.744
MOD_ProDKin_1	198	204	PF00069	0.745
MOD_ProDKin_1	272	278	PF00069	0.801
MOD_ProDKin_1	49	55	PF00069	0.726
MOD_ProDKin_1	7	13	PF00069	0.753
MOD_ProDKin_1	74	80	PF00069	0.760
MOD_ProDKin_1	94	100	PF00069	0.570
MOD_SUMO_rev_2	256	262	PF00179	0.741
TRG_ER_diArg_1	12	14	PF00400	0.732
TRG_ER_diArg_1	370	372	PF00400	0.644
TRG_ER_diArg_1	78	81	PF00400	0.743
TRG_NES_CRM1_1	24	38	PF08389	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8U0	Leptomonas seymouri	30%	95%
A4HBI6	Leishmania braziliensis	56%	100%
A4I9Y1	Leishmania infantum	100%	100%
E9B4Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q2Z7	Leishmania major	85%	100%