Metallophos domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHH9_LEIDO

TriTrypDb:

LdBPK_343410.1 , LdCL_340043500 , LDHU3_34.5630

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 14, no: 2
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14

Expansion

Sequence features

A0A3Q8IHH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHH9

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0016787	hydrolase activity	2	14
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	1
GO:0004564	beta-fructofuranosidase activity	5	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	399	401	PF00675	0.576
CLV_NRD_NRD_1	507	509	PF00675	0.463
CLV_PCSK_KEX2_1	230	232	PF00082	0.496
CLV_PCSK_KEX2_1	249	251	PF00082	0.366
CLV_PCSK_KEX2_1	392	394	PF00082	0.605
CLV_PCSK_KEX2_1	507	509	PF00082	0.463
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.526
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.526
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.470
CLV_PCSK_PC7_1	226	232	PF00082	0.526
CLV_PCSK_SKI1_1	277	281	PF00082	0.451
CLV_PCSK_SKI1_1	292	296	PF00082	0.397
CLV_PCSK_SKI1_1	351	355	PF00082	0.575
CLV_PCSK_SKI1_1	382	386	PF00082	0.501
CLV_PCSK_SKI1_1	44	48	PF00082	0.558
DEG_APCC_DBOX_1	218	226	PF00400	0.215
DEG_Nend_UBRbox_1	1	4	PF02207	0.478
DOC_CKS1_1	495	500	PF01111	0.564
DOC_MAPK_gen_1	274	284	PF00069	0.332
DOC_MAPK_gen_1	400	411	PF00069	0.255
DOC_MAPK_MEF2A_6	277	284	PF00069	0.302
DOC_MAPK_MEF2A_6	298	306	PF00069	0.270
DOC_PP2B_LxvP_1	200	203	PF13499	0.278
DOC_PP2B_LxvP_1	294	297	PF13499	0.331
DOC_USP7_MATH_1	168	172	PF00917	0.330
DOC_USP7_MATH_1	203	207	PF00917	0.208
DOC_USP7_MATH_1	433	437	PF00917	0.409
DOC_USP7_MATH_1	73	77	PF00917	0.342
DOC_USP7_MATH_1	95	99	PF00917	0.354
DOC_WW_Pin1_4	307	312	PF00397	0.258
DOC_WW_Pin1_4	494	499	PF00397	0.690
DOC_WW_Pin1_4	50	55	PF00397	0.225
LIG_14-3-3_CanoR_1	367	373	PF00244	0.251
LIG_14-3-3_CanoR_1	382	387	PF00244	0.350
LIG_14-3-3_CanoR_1	440	444	PF00244	0.293
LIG_14-3-3_CanoR_1	468	476	PF00244	0.649
LIG_14-3-3_CanoR_1	507	511	PF00244	0.715
LIG_BRCT_BRCA1_1	108	112	PF00533	0.315
LIG_BRCT_BRCA1_1	309	313	PF00533	0.267
LIG_BRCT_BRCA1_1	393	397	PF00533	0.250
LIG_deltaCOP1_diTrp_1	377	387	PF00928	0.286
LIG_deltaCOP1_diTrp_1	88	94	PF00928	0.297
LIG_FHA_1	18	24	PF00498	0.529
LIG_FHA_1	242	248	PF00498	0.247
LIG_FHA_1	325	331	PF00498	0.245
LIG_FHA_1	444	450	PF00498	0.352
LIG_FHA_1	494	500	PF00498	0.748
LIG_FHA_2	144	150	PF00498	0.250
LIG_FHA_2	336	342	PF00498	0.352
LIG_FHA_2	376	382	PF00498	0.346
LIG_FHA_2	69	75	PF00498	0.215
LIG_LIR_Gen_1	109	117	PF02991	0.265
LIG_LIR_Gen_1	244	252	PF02991	0.298
LIG_LIR_Gen_1	266	276	PF02991	0.235
LIG_LIR_Gen_1	377	387	PF02991	0.292
LIG_LIR_Gen_1	473	483	PF02991	0.555
LIG_LIR_LC3C_4	278	282	PF02991	0.215
LIG_LIR_Nem_3	109	115	PF02991	0.265
LIG_LIR_Nem_3	138	143	PF02991	0.291
LIG_LIR_Nem_3	244	248	PF02991	0.279
LIG_LIR_Nem_3	266	272	PF02991	0.204
LIG_LIR_Nem_3	275	279	PF02991	0.270
LIG_LIR_Nem_3	288	294	PF02991	0.196
LIG_LIR_Nem_3	33	39	PF02991	0.264
LIG_LIR_Nem_3	377	383	PF02991	0.255
LIG_NRBOX	190	196	PF00104	0.275
LIG_PDZ_Class_1	506	511	PF00595	0.607
LIG_Pex14_1	261	265	PF04695	0.205
LIG_Pex14_2	324	328	PF04695	0.292
LIG_Pex14_2	383	387	PF04695	0.265
LIG_PTB_Apo_2	172	179	PF02174	0.309
LIG_PTB_Phospho_1	172	178	PF10480	0.309
LIG_SH2_CRK	245	249	PF00017	0.322
LIG_SH2_CRK	269	273	PF00017	0.271
LIG_SH2_CRK	36	40	PF00017	0.222
LIG_SH2_CRK	429	433	PF00017	0.304
LIG_SH2_PTP2	408	411	PF00017	0.327
LIG_SH2_SRC	408	411	PF00017	0.173
LIG_SH2_STAP1	179	183	PF00017	0.284
LIG_SH2_STAP1	265	269	PF00017	0.333
LIG_SH2_STAT3	56	59	PF00017	0.200
LIG_SH2_STAT5	179	182	PF00017	0.235
LIG_SH2_STAT5	319	322	PF00017	0.243
LIG_SH2_STAT5	337	340	PF00017	0.204
LIG_SH2_STAT5	408	411	PF00017	0.327
LIG_SH2_STAT5	421	424	PF00017	0.379
LIG_SH2_STAT5	85	88	PF00017	0.285
LIG_SH3_3	199	205	PF00018	0.251
LIG_SUMO_SIM_anti_2	278	283	PF11976	0.253
LIG_SUMO_SIM_par_1	187	193	PF11976	0.202
LIG_SUMO_SIM_par_1	463	469	PF11976	0.548
LIG_TRAF2_1	148	151	PF00917	0.307
LIG_TRFH_1	429	433	PF08558	0.289
LIG_TYR_ITIM	34	39	PF00017	0.250
LIG_WW_2	202	205	PF00397	0.178
MOD_CK1_1	206	212	PF00069	0.322
MOD_CK1_1	335	341	PF00069	0.362
MOD_CK1_1	346	352	PF00069	0.293
MOD_CK1_1	436	442	PF00069	0.473
MOD_CK1_1	469	475	PF00069	0.607
MOD_CK1_1	487	493	PF00069	0.694
MOD_CK1_1	494	500	PF00069	0.699
MOD_CK1_1	50	56	PF00069	0.225
MOD_CK2_1	143	149	PF00069	0.330
MOD_CK2_1	163	169	PF00069	0.162
MOD_CK2_1	335	341	PF00069	0.358
MOD_CK2_1	346	352	PF00069	0.354
MOD_CK2_1	410	416	PF00069	0.317
MOD_GlcNHglycan	126	129	PF01048	0.522
MOD_GlcNHglycan	253	256	PF01048	0.540
MOD_GlcNHglycan	345	348	PF01048	0.578
MOD_GlcNHglycan	468	471	PF01048	0.417
MOD_GlcNHglycan	480	483	PF01048	0.449
MOD_GlcNHglycan	74	78	PF01048	0.493
MOD_GSK3_1	113	120	PF00069	0.259
MOD_GSK3_1	139	146	PF00069	0.257
MOD_GSK3_1	213	220	PF00069	0.305
MOD_GSK3_1	368	375	PF00069	0.316
MOD_GSK3_1	439	446	PF00069	0.464
MOD_GSK3_1	46	53	PF00069	0.271
MOD_GSK3_1	466	473	PF00069	0.616
MOD_GSK3_1	474	481	PF00069	0.712
MOD_GSK3_1	487	494	PF00069	0.597
MOD_N-GLC_1	113	118	PF02516	0.377
MOD_N-GLC_1	206	211	PF02516	0.420
MOD_N-GLC_1	322	327	PF02516	0.559
MOD_N-GLC_1	375	380	PF02516	0.484
MOD_N-GLC_1	417	422	PF02516	0.552
MOD_N-GLC_1	427	432	PF02516	0.492
MOD_N-GLC_1	95	100	PF02516	0.480
MOD_NEK2_1	143	148	PF00069	0.239
MOD_NEK2_1	182	187	PF00069	0.240
MOD_NEK2_1	285	290	PF00069	0.268
MOD_NEK2_1	39	44	PF00069	0.327
MOD_NEK2_1	457	462	PF00069	0.368
MOD_NEK2_1	466	471	PF00069	0.604
MOD_NEK2_1	474	479	PF00069	0.469
MOD_NEK2_1	68	73	PF00069	0.198
MOD_NEK2_1	94	99	PF00069	0.278
MOD_PIKK_1	391	397	PF00454	0.215
MOD_PIKK_1	433	439	PF00454	0.389
MOD_PIKK_1	491	497	PF00454	0.561
MOD_PKA_2	335	341	PF00069	0.377
MOD_PKA_2	439	445	PF00069	0.317
MOD_Plk_1	113	119	PF00069	0.204
MOD_Plk_1	143	149	PF00069	0.243
MOD_Plk_1	168	174	PF00069	0.264
MOD_Plk_1	265	271	PF00069	0.339
MOD_Plk_1	375	381	PF00069	0.313
MOD_Plk_1	417	423	PF00069	0.335
MOD_Plk_1	427	433	PF00069	0.386
MOD_Plk_1	61	67	PF00069	0.305
MOD_Plk_1	95	101	PF00069	0.239
MOD_Plk_2-3	145	151	PF00069	0.162
MOD_Plk_4	168	174	PF00069	0.342
MOD_Plk_4	190	196	PF00069	0.212
MOD_Plk_4	268	274	PF00069	0.270
MOD_Plk_4	315	321	PF00069	0.215
MOD_Plk_4	375	381	PF00069	0.319
MOD_Plk_4	382	388	PF00069	0.271
MOD_Plk_4	410	416	PF00069	0.229
MOD_Plk_4	417	423	PF00069	0.247
MOD_Plk_4	427	433	PF00069	0.351
MOD_Plk_4	439	445	PF00069	0.409
MOD_Plk_4	484	490	PF00069	0.739
MOD_Plk_4	78	84	PF00069	0.273
MOD_ProDKin_1	307	313	PF00069	0.263
MOD_ProDKin_1	494	500	PF00069	0.691
MOD_ProDKin_1	50	56	PF00069	0.225
MOD_SUMO_rev_2	271	279	PF00179	0.244
TRG_DiLeu_BaEn_1	275	280	PF01217	0.246
TRG_ENDOCYTIC_2	140	143	PF00928	0.279
TRG_ENDOCYTIC_2	179	182	PF00928	0.212
TRG_ENDOCYTIC_2	245	248	PF00928	0.268
TRG_ENDOCYTIC_2	269	272	PF00928	0.226
TRG_ENDOCYTIC_2	276	279	PF00928	0.259
TRG_ENDOCYTIC_2	36	39	PF00928	0.230
TRG_ENDOCYTIC_2	408	411	PF00928	0.313
TRG_ENDOCYTIC_2	429	432	PF00928	0.295
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYJ4	Leptomonas seymouri	53%	100%
A0A0S4JMD5	Bodo saltans	28%	100%
A0A0S4JQJ5	Bodo saltans	32%	90%
A0A1X0PA11	Trypanosomatidae	27%	100%
A0A1X0PAC3	Trypanosomatidae	34%	98%
A0A3R7K6I9	Trypanosoma rangeli	32%	100%
A0A3R7KT12	Trypanosoma rangeli	26%	99%
A4HB81	Leishmania braziliensis	64%	100%
A4IAC9	Leishmania infantum	99%	100%
C9ZLW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZLW5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AHU3	Leishmania infantum	36%	100%
E9B5F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
P17405	Homo sapiens	22%	81%
P58242	Mus musculus	22%	100%
P70158	Mus musculus	23%	100%
Q04519	Mus musculus	22%	81%
Q10916	Caenorhabditis elegans	20%	91%
Q4Q2I1	Leishmania major	90%	100%
Q55C09	Dictyostelium discoideum	24%	88%
Q641Z7	Rattus norvegicus	22%	100%
Q92484	Homo sapiens	22%	100%
V5DMV6	Trypanosoma cruzi	27%	100%