LeishMANIAdb
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Serine/threonine-protein kinase, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein kinase, putative
Gene product:
serine/threonine-protein kinase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IHH8_LEIDO
TriTrypDb:
LdBPK_292680.1 * , LdCL_290032900 , LDHU3_29.3950
Length:
501

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 14
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3Q8IHH8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHH8

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 20
GO:0006793 phosphorus metabolic process 3 20
GO:0006796 phosphate-containing compound metabolic process 4 20
GO:0006807 nitrogen compound metabolic process 2 20
GO:0008152 metabolic process 1 20
GO:0009987 cellular process 1 20
GO:0016310 phosphorylation 5 20
GO:0019538 protein metabolic process 3 20
GO:0036211 protein modification process 4 20
GO:0043170 macromolecule metabolic process 3 20
GO:0043412 macromolecule modification 4 20
GO:0044237 cellular metabolic process 2 20
GO:0044238 primary metabolic process 2 20
GO:0071704 organic substance metabolic process 2 20
GO:1901564 organonitrogen compound metabolic process 3 20
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 20
GO:0003824 catalytic activity 1 20
GO:0004672 protein kinase activity 3 20
GO:0004674 protein serine/threonine kinase activity 4 19
GO:0005488 binding 1 20
GO:0005524 ATP binding 5 20
GO:0016301 kinase activity 4 20
GO:0016740 transferase activity 2 20
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 20
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 20
GO:0017076 purine nucleotide binding 4 20
GO:0030554 adenyl nucleotide binding 5 20
GO:0032553 ribonucleotide binding 3 20
GO:0032555 purine ribonucleotide binding 4 20
GO:0032559 adenyl ribonucleotide binding 5 20
GO:0035639 purine ribonucleoside triphosphate binding 4 20
GO:0036094 small molecule binding 2 20
GO:0043167 ion binding 2 20
GO:0043168 anion binding 3 20
GO:0097159 organic cyclic compound binding 2 20
GO:0097367 carbohydrate derivative binding 2 20
GO:0140096 catalytic activity, acting on a protein 2 20
GO:1901265 nucleoside phosphate binding 3 20
GO:1901363 heterocyclic compound binding 2 20

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 39 43 PF00656 0.242
CLV_C14_Caspase3-7 411 415 PF00656 0.433
CLV_C14_Caspase3-7 97 101 PF00656 0.273
CLV_NRD_NRD_1 302 304 PF00675 0.489
CLV_NRD_NRD_1 61 63 PF00675 0.234
CLV_PCSK_KEX2_1 44 46 PF00082 0.226
CLV_PCSK_KEX2_1 61 63 PF00082 0.222
CLV_PCSK_PC1ET2_1 44 46 PF00082 0.226
CLV_PCSK_SKI1_1 109 113 PF00082 0.273
CLV_PCSK_SKI1_1 147 151 PF00082 0.300
CLV_PCSK_SKI1_1 21 25 PF00082 0.293
CLV_PCSK_SKI1_1 226 230 PF00082 0.221
CLV_PCSK_SKI1_1 233 237 PF00082 0.212
CLV_PCSK_SKI1_1 351 355 PF00082 0.531
CLV_PCSK_SKI1_1 432 436 PF00082 0.413
DOC_CYCLIN_yCln2_LP_2 219 225 PF00134 0.275
DOC_MAPK_gen_1 147 156 PF00069 0.309
DOC_USP7_MATH_1 10 14 PF00917 0.397
DOC_USP7_MATH_1 416 420 PF00917 0.516
DOC_USP7_MATH_1 485 489 PF00917 0.321
DOC_USP7_MATH_1 5 9 PF00917 0.465
DOC_USP7_MATH_1 50 54 PF00917 0.269
DOC_USP7_MATH_2 248 254 PF00917 0.374
DOC_USP7_UBL2_3 109 113 PF12436 0.210
DOC_USP7_UBL2_3 159 163 PF12436 0.297
DOC_USP7_UBL2_3 229 233 PF12436 0.241
DOC_USP7_UBL2_3 24 28 PF12436 0.269
DOC_USP7_UBL2_3 362 366 PF12436 0.676
DOC_USP7_UBL2_3 40 44 PF12436 0.195
DOC_WW_Pin1_4 183 188 PF00397 0.297
DOC_WW_Pin1_4 312 317 PF00397 0.516
DOC_WW_Pin1_4 54 59 PF00397 0.334
LIG_14-3-3_CanoR_1 38 47 PF00244 0.272
LIG_BIR_II_1 1 5 PF00653 0.492
LIG_BRCT_BRCA1_1 12 16 PF00533 0.307
LIG_CtBP_PxDLS_1 248 252 PF00389 0.297
LIG_deltaCOP1_diTrp_1 205 213 PF00928 0.263
LIG_EH1_1 166 174 PF00400 0.213
LIG_FHA_1 149 155 PF00498 0.309
LIG_FHA_1 214 220 PF00498 0.369
LIG_FHA_1 244 250 PF00498 0.300
LIG_FHA_1 394 400 PF00498 0.370
LIG_FHA_2 225 231 PF00498 0.297
LIG_FHA_2 296 302 PF00498 0.432
LIG_FHA_2 466 472 PF00498 0.560
LIG_FHA_2 55 61 PF00498 0.241
LIG_Integrin_isoDGR_2 430 432 PF01839 0.422
LIG_LIR_Apic_2 186 192 PF02991 0.291
LIG_LIR_Gen_1 90 99 PF02991 0.252
LIG_MAD2 234 242 PF02301 0.215
LIG_MAD2 69 77 PF02301 0.226
LIG_NRBOX 227 233 PF00104 0.241
LIG_NRBOX 475 481 PF00104 0.409
LIG_PCNA_yPIPBox_3 473 483 PF02747 0.368
LIG_SH2_CRK 20 24 PF00017 0.226
LIG_SH2_CRK 240 244 PF00017 0.241
LIG_SH2_NCK_1 240 244 PF00017 0.228
LIG_SH2_SRC 240 243 PF00017 0.226
LIG_SH2_SRC 98 101 PF00017 0.322
LIG_SH2_STAT3 385 388 PF00017 0.391
LIG_SH2_STAT5 138 141 PF00017 0.275
LIG_SH2_STAT5 189 192 PF00017 0.304
LIG_SH2_STAT5 263 266 PF00017 0.332
LIG_SH2_STAT5 277 280 PF00017 0.318
LIG_SH2_STAT5 385 388 PF00017 0.391
LIG_SH2_STAT5 46 49 PF00017 0.226
LIG_SH3_2 325 330 PF14604 0.637
LIG_SH3_3 113 119 PF00018 0.258
LIG_SH3_3 322 328 PF00018 0.560
LIG_SH3_3 71 77 PF00018 0.226
LIG_TRAF2_1 358 361 PF00917 0.577
LIG_TYR_ITIM 212 217 PF00017 0.265
LIG_UBA3_1 341 349 PF00899 0.507
LIG_WRC_WIRS_1 282 287 PF05994 0.369
MOD_CDC14_SPxK_1 315 318 PF00782 0.501
MOD_CDK_SPK_2 54 59 PF00069 0.334
MOD_CDK_SPxK_1 312 318 PF00069 0.551
MOD_CDK_SPxxK_3 54 61 PF00069 0.334
MOD_CK1_1 465 471 PF00069 0.420
MOD_CK2_1 27 33 PF00069 0.226
MOD_CK2_1 281 287 PF00069 0.513
MOD_CK2_1 295 301 PF00069 0.401
MOD_CK2_1 303 309 PF00069 0.488
MOD_CK2_1 331 337 PF00069 0.529
MOD_CK2_1 465 471 PF00069 0.453
MOD_CK2_1 54 60 PF00069 0.256
MOD_Cter_Amidation 42 45 PF01082 0.226
MOD_GlcNHglycan 360 365 PF01048 0.608
MOD_GlcNHglycan 418 421 PF01048 0.605
MOD_GlcNHglycan 460 463 PF01048 0.369
MOD_GlcNHglycan 464 467 PF01048 0.413
MOD_GSK3_1 179 186 PF00069 0.301
MOD_GSK3_1 250 257 PF00069 0.369
MOD_GSK3_1 273 280 PF00069 0.349
MOD_GSK3_1 360 367 PF00069 0.634
MOD_GSK3_1 430 437 PF00069 0.425
MOD_GSK3_1 458 465 PF00069 0.403
MOD_GSK3_1 485 492 PF00069 0.311
MOD_GSK3_1 50 57 PF00069 0.275
MOD_N-GLC_1 201 206 PF02516 0.215
MOD_NEK2_1 155 160 PF00069 0.319
MOD_NEK2_1 167 172 PF00069 0.295
MOD_NEK2_1 173 178 PF00069 0.233
MOD_NEK2_1 194 199 PF00069 0.286
MOD_NEK2_1 213 218 PF00069 0.419
MOD_NEK2_1 254 259 PF00069 0.283
MOD_NEK2_1 273 278 PF00069 0.307
MOD_NEK2_1 36 41 PF00069 0.252
MOD_NEK2_1 458 463 PF00069 0.411
MOD_PKA_1 303 309 PF00069 0.578
MOD_PKA_2 265 271 PF00069 0.272
MOD_Plk_1 273 279 PF00069 0.225
MOD_Plk_1 87 93 PF00069 0.355
MOD_Plk_4 10 16 PF00069 0.467
MOD_Plk_4 168 174 PF00069 0.231
MOD_Plk_4 254 260 PF00069 0.294
MOD_Plk_4 273 279 PF00069 0.247
MOD_Plk_4 87 93 PF00069 0.290
MOD_ProDKin_1 183 189 PF00069 0.297
MOD_ProDKin_1 312 318 PF00069 0.521
MOD_ProDKin_1 54 60 PF00069 0.334
TRG_DiLeu_BaEn_1 475 480 PF01217 0.354
TRG_DiLeu_BaEn_1 87 92 PF01217 0.269
TRG_DiLeu_BaEn_4 6 12 PF01217 0.354
TRG_ENDOCYTIC_2 20 23 PF00928 0.221
TRG_ENDOCYTIC_2 214 217 PF00928 0.295
TRG_ENDOCYTIC_2 240 243 PF00928 0.226
TRG_Pf-PMV_PEXEL_1 303 307 PF00026 0.457

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2D3 Leptomonas seymouri 30% 96%
A0A0N1HY86 Leptomonas seymouri 79% 96%
A0A0N1I9A0 Leptomonas seymouri 31% 77%
A0A0S4IKH2 Bodo saltans 69% 100%
A0A0S4JIJ6 Bodo saltans 30% 89%
A0A0S4JNA1 Bodo saltans 37% 100%
A0A1X0NLY7 Trypanosomatidae 27% 74%
A0A1X0NUB2 Trypanosomatidae 31% 86%
A0A1X0P863 Trypanosomatidae 32% 100%
A0A1X0P9C4 Trypanosomatidae 74% 100%
A0A3Q8IAQ1 Leishmania donovani 37% 100%
A0A3Q8IB30 Leishmania donovani 31% 100%
A0A3Q8IC87 Leishmania donovani 27% 100%
A0A3Q8IFK8 Leishmania donovani 38% 100%
A0A3Q8IIG1 Leishmania donovani 29% 100%
A0A3R7RIN5 Trypanosoma rangeli 73% 100%
A0A3S5H5G0 Leishmania donovani 25% 100%
A0A3S7WWE7 Leishmania donovani 26% 100%
A0A3S7WYP4 Leishmania donovani 29% 100%
A0A3S7X2W3 Leishmania donovani 26% 100%
A0A3S7X5M4 Leishmania donovani 31% 76%
A0A3S7X7D5 Leishmania donovani 25% 100%
A0A3S7X7Y2 Leishmania donovani 27% 100%
A0A3S7X9S2 Leishmania donovani 31% 100%
A0A422NH41 Trypanosoma rangeli 33% 87%
A0A422NT89 Trypanosoma rangeli 29% 76%
A4H9L8 Leishmania braziliensis 32% 100%
A4HAS1 Leishmania braziliensis 28% 100%
A4HBL4 Leishmania braziliensis 24% 100%
A4HCE6 Leishmania braziliensis 36% 100%
A4HDU3 Leishmania braziliensis 30% 100%
A4HH03 Leishmania braziliensis 30% 100%
A4HHN1 Leishmania braziliensis 27% 100%
A4HHQ5 Leishmania braziliensis 86% 100%
A4HJT5 Leishmania braziliensis 39% 100%
A4HKG9 Leishmania braziliensis 33% 76%
A4HSE2 Leishmania infantum 25% 100%
A4HWS9 Leishmania infantum 26% 100%
A4HXY2 Leishmania infantum 31% 100%
A4HZA2 Leishmania infantum 26% 100%
A4HZV1 Leishmania infantum 27% 100%
A4HZW8 Leishmania infantum 37% 100%
A4I140 Leishmania infantum 29% 100%
A4I435 Leishmania infantum 29% 100%
A4I4U6 Leishmania infantum 26% 100%
A4I4X0 Leishmania infantum 100% 100%
A4I7A1 Leishmania infantum 38% 100%
A4I7Z6 Leishmania infantum 31% 76%
A4I9H1 Leishmania infantum 25% 100%
A4I9Y5 Leishmania infantum 27% 100%
C9ZWK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
D0AA64 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 87%
E9AEB9 Leishmania major 96% 100%
E9AFM1 Leishmania major 31% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9ALG7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9ALJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9ARP5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9ARW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9ASL0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AUY2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9AX78 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B0C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B2V8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 76%
E9B4G9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B5Y5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
F4JBP3 Arabidopsis thaliana 29% 70%
O13839 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 69%
P10665 Xenopus laevis 28% 68%
P10666 Xenopus laevis 28% 80%
P11837 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 34% 72%
P22209 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 100%
P51955 Homo sapiens 36% 100%
P62205 Xenopus tropicalis 26% 84%
P70032 Xenopus laevis 27% 84%
P87248 Colletotrichum lindemuthianum 29% 74%
Q10SC8 Oryza sativa subsp. japonica 26% 100%
Q15349 Homo sapiens 27% 68%
Q27687 Leishmania major 31% 100%
Q2V452 Arabidopsis thaliana 28% 100%
Q4Q2Z2 Leishmania major 27% 100%
Q4Q598 Leishmania major 31% 76%
Q4Q5W2 Leishmania major 38% 100%
Q4Q7W2 Leishmania major 29% 100%
Q4Q9K2 Leishmania major 28% 100%
Q4QA98 Leishmania major 28% 100%
Q4QBQ2 Leishmania major 37% 100%
Q4QBR6 Leishmania major 27% 100%
Q4QCK0 Leishmania major 24% 100%
Q4QJJ0 Leishmania major 25% 100%
Q63531 Rattus norvegicus 27% 68%
Q6P2M8 Homo sapiens 29% 100%
Q6PFQ0 Danio rerio 25% 68%
Q6X4A2 Oryza sativa subsp. japonica 26% 100%
Q7TNJ7 Rattus norvegicus 29% 100%
Q8RXT4 Arabidopsis thaliana 34% 90%
Q8WNU8 Macaca fascicularis 32% 79%
Q91VB2 Mus musculus 29% 100%
Q9N3Z3 Caenorhabditis elegans 27% 100%
Q9SN43 Arabidopsis thaliana 27% 100%
Q9WUT3 Mus musculus 27% 68%
Q9Y077 Leishmania major 26% 100%
V5BHW8 Trypanosoma cruzi 29% 79%
V5BQE9 Trypanosoma cruzi 28% 68%
V5C224 Trypanosoma cruzi 73% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS