Transmembrane amino acid transporter family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid permease-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IHH7_LEIDO

TriTrypDb:

LdBPK_331510.1 , LdCL_330021700 , LDHU3_33.2250

Length:

488

Annotations

LeishMANIAdb annotations

An enormously expanded group of various amino acid transporters.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	21
GO:0110165	cellular anatomical entity	1	21

Expansion

Sequence features

A0A3Q8IHH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHH7

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	4
GO:0006810	transport	3	4
GO:0006865	amino acid transport	5	4
GO:0009987	cellular process	1	4
GO:0015849	organic acid transport	5	4
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0055085	transmembrane transport	2	4
GO:0071702	organic substance transport	4	4
GO:0071705	nitrogen compound transport	4	4
GO:1903825	organic acid transmembrane transport	3	4
GO:1905039	carboxylic acid transmembrane transport	4	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016787	hydrolase activity	2	9
GO:0005215	transporter activity	1	4
GO:0005342	organic acid transmembrane transporter activity	3	4
GO:0015171	amino acid transmembrane transporter activity	5	4
GO:0015179	L-amino acid transmembrane transporter activity	6	4
GO:0022857	transmembrane transporter activity	2	4
GO:0046943	carboxylic acid transmembrane transporter activity	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	236	238	PF00675	0.206
CLV_PCSK_KEX2_1	236	238	PF00082	0.215
CLV_PCSK_SKI1_1	332	336	PF00082	0.197
CLV_PCSK_SKI1_1	80	84	PF00082	0.275
CLV_PCSK_SKI1_1	92	96	PF00082	0.305
CLV_Separin_Metazoa	5	9	PF03568	0.518
CLV_Separin_Metazoa	89	93	PF03568	0.310
DEG_Nend_Nbox_1	1	3	PF02207	0.561
DEG_SCF_FBW7_1	128	134	PF00400	0.377
DOC_ANK_TNKS_1	175	182	PF00023	0.374
DOC_CDC14_PxL_1	146	154	PF14671	0.374
DOC_CDC14_PxL_1	204	212	PF14671	0.262
DOC_CKS1_1	128	133	PF01111	0.403
DOC_CYCLIN_yCln2_LP_2	113	119	PF00134	0.240
DOC_CYCLIN_yCln2_LP_2	210	216	PF00134	0.314
DOC_CYCLIN_yCln2_LP_2	264	270	PF00134	0.266
DOC_MAPK_gen_1	236	243	PF00069	0.427
DOC_MAPK_MEF2A_6	206	214	PF00069	0.276
DOC_MAPK_MEF2A_6	236	245	PF00069	0.472
DOC_MAPK_MEF2A_6	395	404	PF00069	0.406
DOC_PP2B_LxvP_1	113	116	PF13499	0.328
DOC_PP2B_LxvP_1	210	213	PF13499	0.314
DOC_PP2B_LxvP_1	31	34	PF13499	0.298
DOC_PP2B_LxvP_1	413	416	PF13499	0.339
DOC_PP4_FxxP_1	142	145	PF00568	0.352
DOC_PP4_FxxP_1	435	438	PF00568	0.333
DOC_USP7_MATH_1	131	135	PF00917	0.363
DOC_WW_Pin1_4	127	132	PF00397	0.333
LIG_14-3-3_CanoR_1	236	240	PF00244	0.497
LIG_14-3-3_CanoR_1	72	76	PF00244	0.504
LIG_14-3-3_CanoR_1	8	15	PF00244	0.541
LIG_APCC_ABBA_1	107	112	PF00400	0.187
LIG_BRCT_BRCA1_1	222	226	PF00533	0.333
LIG_BRCT_BRCA1_1	330	334	PF00533	0.508
LIG_Clathr_ClatBox_1	107	111	PF01394	0.374
LIG_FHA_1	120	126	PF00498	0.345
LIG_FHA_1	164	170	PF00498	0.302
LIG_FHA_1	188	194	PF00498	0.263
LIG_FHA_1	249	255	PF00498	0.405
LIG_FHA_1	333	339	PF00498	0.504
LIG_FHA_1	404	410	PF00498	0.349
LIG_FHA_1	44	50	PF00498	0.369
LIG_FHA_1	77	83	PF00498	0.480
LIG_GBD_Chelix_1	224	232	PF00786	0.374
LIG_IRF3_LxIS_1	152	158	PF10401	0.484
LIG_IRF3_LxIS_1	394	401	PF10401	0.492
LIG_LIR_Apic_2	432	438	PF02991	0.329
LIG_LIR_Gen_1	137	146	PF02991	0.398
LIG_LIR_Gen_1	158	168	PF02991	0.255
LIG_LIR_Gen_1	331	338	PF02991	0.484
LIG_LIR_Gen_1	59	70	PF02991	0.274
LIG_LIR_Gen_1	74	83	PF02991	0.489
LIG_LIR_Nem_3	137	142	PF02991	0.370
LIG_LIR_Nem_3	158	163	PF02991	0.255
LIG_LIR_Nem_3	166	171	PF02991	0.264
LIG_LIR_Nem_3	223	229	PF02991	0.310
LIG_LIR_Nem_3	331	337	PF02991	0.484
LIG_LIR_Nem_3	59	65	PF02991	0.311
LIG_LIR_Nem_3	74	78	PF02991	0.500
LIG_LYPXL_yS_3	207	210	PF13949	0.201
LIG_OCRL_FandH_1	361	373	PF00620	0.368
LIG_PCNA_PIPBox_1	118	127	PF02747	0.281
LIG_PCNA_yPIPBox_3	118	132	PF02747	0.308
LIG_PDZ_Class_2	483	488	PF00595	0.265
LIG_Pex14_1	203	207	PF04695	0.184
LIG_Pex14_1	443	447	PF04695	0.462
LIG_Pex14_2	138	142	PF04695	0.366
LIG_Pex14_2	464	468	PF04695	0.211
LIG_SH2_CRK	293	297	PF00017	0.317
LIG_SH2_CRK	369	373	PF00017	0.378
LIG_SH2_CRK	447	451	PF00017	0.469
LIG_SH2_NCK_1	319	323	PF00017	0.424
LIG_SH2_NCK_1	37	41	PF00017	0.304
LIG_SH2_PTP2	62	65	PF00017	0.214
LIG_SH2_SRC	124	127	PF00017	0.379
LIG_SH2_SRC	37	40	PF00017	0.304
LIG_SH2_STAT3	441	444	PF00017	0.374
LIG_SH2_STAT5	106	109	PF00017	0.294
LIG_SH2_STAT5	124	127	PF00017	0.270
LIG_SH2_STAT5	177	180	PF00017	0.326
LIG_SH2_STAT5	263	266	PF00017	0.291
LIG_SH2_STAT5	290	293	PF00017	0.310
LIG_SH2_STAT5	62	65	PF00017	0.389
LIG_SH3_3	113	119	PF00018	0.276
LIG_SH3_3	176	182	PF00018	0.299
LIG_SUMO_SIM_anti_2	341	348	PF11976	0.508
LIG_SUMO_SIM_anti_2	420	426	PF11976	0.277
LIG_SUMO_SIM_anti_2	46	51	PF11976	0.404
LIG_SUMO_SIM_par_1	265	272	PF11976	0.197
LIG_SUMO_SIM_par_1	29	35	PF11976	0.326
LIG_SUMO_SIM_par_1	398	403	PF11976	0.238
LIG_SUMO_SIM_par_1	417	423	PF11976	0.191
LIG_SUMO_SIM_par_1	53	59	PF11976	0.305
LIG_TRAF2_1	74	77	PF00917	0.504
LIG_TYR_ITIM	104	109	PF00017	0.313
LIG_TYR_ITIM	445	450	PF00017	0.580
LIG_TYR_ITIM	60	65	PF00017	0.294
LIG_Vh1_VBS_1	239	257	PF01044	0.384
LIG_WRC_WIRS_1	135	140	PF05994	0.310
LIG_WRC_WIRS_1	157	162	PF05994	0.376
LIG_WRC_WIRS_1	216	221	PF05994	0.309
MOD_CDK_SPK_2	127	132	PF00069	0.308
MOD_CK1_1	10	16	PF00069	0.533
MOD_CK1_1	134	140	PF00069	0.218
MOD_CK1_1	164	170	PF00069	0.303
MOD_CK1_1	186	192	PF00069	0.229
MOD_CK1_1	320	326	PF00069	0.425
MOD_CK1_1	420	426	PF00069	0.308
MOD_CK2_1	368	374	PF00069	0.466
MOD_CK2_1	71	77	PF00069	0.490
MOD_Cter_Amidation	83	86	PF01082	0.262
MOD_GlcNHglycan	10	13	PF01048	0.348
MOD_GlcNHglycan	101	104	PF01048	0.265
MOD_GlcNHglycan	163	166	PF01048	0.326
MOD_GlcNHglycan	184	188	PF01048	0.471
MOD_GlcNHglycan	198	201	PF01048	0.447
MOD_GlcNHglycan	320	323	PF01048	0.209
MOD_GlcNHglycan	34	37	PF01048	0.362
MOD_GSK3_1	127	134	PF00069	0.210
MOD_GSK3_1	144	151	PF00069	0.285
MOD_GSK3_1	17	24	PF00069	0.329
MOD_GSK3_1	183	190	PF00069	0.280
MOD_GSK3_1	244	251	PF00069	0.334
MOD_GSK3_1	328	335	PF00069	0.508
MOD_GSK3_1	398	405	PF00069	0.300
MOD_N-GLC_1	194	199	PF02516	0.444
MOD_NEK2_1	120	125	PF00069	0.306
MOD_NEK2_1	155	160	PF00069	0.449
MOD_NEK2_1	161	166	PF00069	0.312
MOD_NEK2_1	21	26	PF00069	0.302
MOD_NEK2_1	235	240	PF00069	0.476
MOD_NEK2_1	248	253	PF00069	0.324
MOD_NEK2_1	291	296	PF00069	0.201
MOD_NEK2_1	398	403	PF00069	0.312
MOD_NEK2_1	428	433	PF00069	0.285
MOD_NEK2_1	7	12	PF00069	0.652
MOD_NEK2_2	53	58	PF00069	0.392
MOD_PKA_2	235	241	PF00069	0.502
MOD_PKA_2	308	314	PF00069	0.508
MOD_PKA_2	7	13	PF00069	0.606
MOD_PKA_2	71	77	PF00069	0.504
MOD_Plk_1	183	189	PF00069	0.296
MOD_Plk_1	332	338	PF00069	0.570
MOD_Plk_4	10	16	PF00069	0.512
MOD_Plk_4	120	126	PF00069	0.241
MOD_Plk_4	131	137	PF00069	0.235
MOD_Plk_4	156	162	PF00069	0.452
MOD_Plk_4	164	170	PF00069	0.332
MOD_Plk_4	220	226	PF00069	0.335
MOD_Plk_4	308	314	PF00069	0.509
MOD_Plk_4	417	423	PF00069	0.243
MOD_Plk_4	43	49	PF00069	0.343
MOD_Plk_4	53	59	PF00069	0.313
MOD_ProDKin_1	127	133	PF00069	0.333
MOD_SUMO_for_1	372	375	PF00179	0.521
TRG_DiLeu_BaEn_1	342	347	PF01217	0.508
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.225
TRG_ENDOCYTIC_2	106	109	PF00928	0.314
TRG_ENDOCYTIC_2	207	210	PF00928	0.439
TRG_ENDOCYTIC_2	229	232	PF00928	0.477
TRG_ENDOCYTIC_2	369	372	PF00928	0.492
TRG_ENDOCYTIC_2	447	450	PF00928	0.480
TRG_ENDOCYTIC_2	62	65	PF00928	0.291
TRG_ENDOCYTIC_2	75	78	PF00928	0.466
TRG_ER_diArg_1	235	237	PF00400	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5D2	Leptomonas seymouri	25%	100%
A0A0N1IAJ0	Leptomonas seymouri	30%	100%
A0A0N1IJ81	Leptomonas seymouri	76%	100%
A0A0N1PA98	Leptomonas seymouri	20%	79%
A0A0S4IV32	Bodo saltans	30%	99%
A0A1X0P1N2	Trypanosomatidae	56%	100%
A0A1X0P4S1	Trypanosomatidae	40%	100%
A0A3Q8ICL1	Leishmania donovani	20%	100%
A0A3Q8ID74	Leishmania donovani	24%	91%
A0A3Q8IGE6	Leishmania donovani	20%	100%
A0A3R7MWF1	Trypanosoma rangeli	49%	100%
A0A3S7X443	Leishmania donovani	27%	100%
A0A3S7X4L2	Leishmania donovani	20%	81%
A0A3S7X4N4	Leishmania donovani	20%	81%
A0A3S7XA86	Leishmania donovani	36%	100%
A0A3S7XCE3	Leishmania donovani	27%	100%
A1YG32	Pan paniscus	26%	96%
A2VE31	Bos taurus	25%	96%
A4HFT5	Leishmania braziliensis	26%	100%
A4HJ35	Leishmania braziliensis	26%	100%
A4HJF8	Leishmania braziliensis	21%	100%
A4HJF9	Leishmania braziliensis	21%	100%
A4HJG1	Leishmania braziliensis	21%	100%
A4HJG3	Leishmania braziliensis	22%	100%
A4HJG5	Leishmania braziliensis	22%	100%
A4HLK3	Leishmania braziliensis	85%	100%
A4HNJ6	Leishmania braziliensis	38%	87%
A4HNJ7	Leishmania braziliensis	39%	86%
A4I6J8	Leishmania infantum	23%	91%
A4I6J9	Leishmania infantum	27%	100%
A4I6W4	Leishmania infantum	20%	100%
A4I914	Leishmania infantum	100%	100%
A4IC53	Leishmania infantum	36%	86%
A4IC66	Leishmania infantum	38%	86%
A4ICC3	Leishmania infantum	26%	100%
C9ZMB9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZWR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E8NHF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E8NHS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9AD45	Leishmania major	24%	91%
E9ADD7	Leishmania major	27%	100%
E9AG08	Leishmania major	37%	86%
E9AG09	Leishmania major	38%	85%
E9AHD9	Leishmania infantum	24%	91%
E9AHL1	Leishmania infantum	20%	100%
E9AHL2	Leishmania infantum	21%	100%
E9AHL3	Leishmania infantum	20%	100%
E9AUB8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AZ62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B1I4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B1Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9B3X9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B761	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	86%
E9B762	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	86%
F4KBM7	Arabidopsis thaliana	24%	100%
G3UVW3	Mus musculus	24%	100%
P38176	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P40074	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P40501	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q28HE5	Xenopus tropicalis	27%	100%
Q3U1J0	Mus musculus	23%	100%
Q4Q072	Leishmania major	26%	100%
Q4Q445	Leishmania major	95%	100%
Q4Q680	Leishmania major	20%	100%
Q4Q683	Leishmania major	20%	100%
Q4Q6M9	Leishmania major	27%	100%
Q4Q6N1	Leishmania major	22%	91%
Q503G8	Danio rerio	26%	100%
Q5E9S9	Bos taurus	24%	100%
Q5F468	Gallus gallus	25%	97%
Q5R9F5	Pongo abelii	22%	100%
Q5XH90	Xenopus tropicalis	26%	99%
Q6DEL1	Danio rerio	22%	100%
Q6DFE7	Xenopus laevis	23%	100%
Q6JWR2	Rattus norvegicus	23%	100%
Q6WWW3	Rattus norvegicus	25%	100%
Q8BWH0	Mus musculus	24%	100%
Q8R1S9	Mus musculus	24%	89%
Q8WUX1	Homo sapiens	24%	100%
Q96QD8	Homo sapiens	26%	96%
Q99624	Homo sapiens	24%	97%
Q9DCP2	Mus musculus	25%	97%
Q9JHE5	Rattus norvegicus	27%	97%
Q9JHZ9	Rattus norvegicus	25%	97%
Q9LI61	Arabidopsis thaliana	23%	100%
Q9LYM2	Arabidopsis thaliana	24%	100%
Q9NVC3	Homo sapiens	22%	100%
V5AXD0	Trypanosoma cruzi	49%	100%
V5BQ72	Trypanosoma cruzi	23%	87%