Ski2_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHH5_LEIDO

TriTrypDb:

LdBPK_110950.1 , LdCL_110015300 , LDHU3_11.1180

Length:

413

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHH5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.564
CLV_C14_Caspase3-7	322	326	PF00656	0.585
CLV_C14_Caspase3-7	57	61	PF00656	0.541
CLV_NRD_NRD_1	192	194	PF00675	0.503
CLV_NRD_NRD_1	205	207	PF00675	0.579
CLV_NRD_NRD_1	214	216	PF00675	0.578
CLV_NRD_NRD_1	305	307	PF00675	0.553
CLV_NRD_NRD_1	39	41	PF00675	0.565
CLV_PCSK_KEX2_1	205	207	PF00082	0.579
CLV_PCSK_KEX2_1	214	216	PF00082	0.578
CLV_PCSK_KEX2_1	305	307	PF00082	0.585
CLV_PCSK_KEX2_1	310	312	PF00082	0.612
CLV_PCSK_KEX2_1	39	41	PF00082	0.591
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.668
CLV_PCSK_PC7_1	306	312	PF00082	0.556
CLV_PCSK_SKI1_1	215	219	PF00082	0.546
CLV_PCSK_SKI1_1	46	50	PF00082	0.654
DEG_SPOP_SBC_1	3	7	PF00917	0.620
DOC_MAPK_DCC_7	218	228	PF00069	0.468
DOC_MAPK_gen_1	193	201	PF00069	0.517
DOC_MAPK_gen_1	211	221	PF00069	0.609
DOC_MAPK_MEF2A_6	214	223	PF00069	0.541
DOC_USP7_MATH_1	19	23	PF00917	0.508
DOC_USP7_MATH_1	2	6	PF00917	0.608
DOC_USP7_MATH_1	236	240	PF00917	0.637
DOC_USP7_MATH_2	54	60	PF00917	0.541
DOC_WW_Pin1_4	141	146	PF00397	0.621
LIG_14-3-3_CanoR_1	164	170	PF00244	0.495
LIG_EH_1	74	78	PF12763	0.497
LIG_FHA_1	166	172	PF00498	0.368
LIG_FHA_1	378	384	PF00498	0.670
LIG_FHA_2	112	118	PF00498	0.616
LIG_LIR_Gen_1	273	283	PF02991	0.589
LIG_LIR_Nem_3	273	279	PF02991	0.595
LIG_LIR_Nem_3	81	86	PF02991	0.675
LIG_PDZ_Class_2	408	413	PF00595	0.485
LIG_Pex14_2	48	52	PF04695	0.590
LIG_SH2_CRK	276	280	PF00017	0.592
LIG_SH2_NCK_1	276	280	PF00017	0.646
LIG_SH2_STAT5	300	303	PF00017	0.607
LIG_SH2_STAT5	47	50	PF00017	0.552
LIG_SH2_STAT5	79	82	PF00017	0.461
LIG_SH3_1	206	212	PF00018	0.568
LIG_SH3_2	142	147	PF14604	0.565
LIG_SH3_2	209	214	PF14604	0.563
LIG_SH3_3	101	107	PF00018	0.625
LIG_SH3_3	139	145	PF00018	0.574
LIG_SH3_3	166	172	PF00018	0.475
LIG_SH3_3	204	210	PF00018	0.577
LIG_SH3_3	216	222	PF00018	0.521
LIG_SH3_3	70	76	PF00018	0.579
LIG_SUMO_SIM_anti_2	281	288	PF11976	0.590
LIG_SUMO_SIM_par_1	176	182	PF11976	0.504
LIG_SUMO_SIM_par_1	245	250	PF11976	0.518
LIG_WW_3	208	212	PF00397	0.564
LIG_WW_3	41	45	PF00397	0.539
MOD_CDC14_SPxK_1	144	147	PF00782	0.613
MOD_CDK_SPxK_1	141	147	PF00069	0.621
MOD_CK1_1	14	20	PF00069	0.688
MOD_CK1_1	281	287	PF00069	0.568
MOD_CK2_1	122	128	PF00069	0.593
MOD_CK2_1	226	232	PF00069	0.543
MOD_CK2_1	60	66	PF00069	0.567
MOD_Cter_Amidation	303	306	PF01082	0.560
MOD_GlcNHglycan	121	125	PF01048	0.633
MOD_GlcNHglycan	13	16	PF01048	0.672
MOD_GlcNHglycan	181	184	PF01048	0.501
MOD_GlcNHglycan	228	231	PF01048	0.589
MOD_GlcNHglycan	272	275	PF01048	0.648
MOD_GlcNHglycan	280	283	PF01048	0.464
MOD_GlcNHglycan	302	305	PF01048	0.659
MOD_GlcNHglycan	330	333	PF01048	0.588
MOD_GlcNHglycan	337	341	PF01048	0.582
MOD_GlcNHglycan	346	349	PF01048	0.600
MOD_GSK3_1	13	20	PF00069	0.597
MOD_GSK3_1	270	277	PF00069	0.640
MOD_GSK3_1	344	351	PF00069	0.733
MOD_GSK3_1	56	63	PF00069	0.534
MOD_N-GLC_1	20	25	PF02516	0.566
MOD_NEK2_1	162	167	PF00069	0.468
MOD_NEK2_1	247	252	PF00069	0.600
MOD_NEK2_1	328	333	PF00069	0.576
MOD_NEK2_1	336	341	PF00069	0.584
MOD_NEK2_1	344	349	PF00069	0.602
MOD_PKA_2	11	17	PF00069	0.660
MOD_PKA_2	117	123	PF00069	0.645
MOD_PKA_2	146	152	PF00069	0.532
MOD_PKA_2	189	195	PF00069	0.492
MOD_Plk_1	173	179	PF00069	0.451
MOD_Plk_1	247	253	PF00069	0.599
MOD_Plk_2-3	60	66	PF00069	0.542
MOD_Plk_4	281	287	PF00069	0.635
MOD_ProDKin_1	141	147	PF00069	0.621
MOD_SUMO_for_1	102	105	PF00179	0.618
MOD_SUMO_for_1	132	135	PF00179	0.613
MOD_SUMO_rev_2	292	301	PF00179	0.563
TRG_DiLeu_BaLyEn_6	324	329	PF01217	0.576
TRG_ENDOCYTIC_2	276	279	PF00928	0.657
TRG_ENDOCYTIC_2	79	82	PF00928	0.503
TRG_ER_diArg_1	199	202	PF00400	0.545
TRG_ER_diArg_1	205	207	PF00400	0.579
TRG_ER_diArg_1	213	215	PF00400	0.452
TRG_ER_diArg_1	39	41	PF00400	0.565
TRG_ER_diArg_1	43	46	PF00400	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I1	Leptomonas seymouri	51%	79%
A4H6M1	Leishmania braziliensis	71%	100%
A4HV04	Leishmania infantum	99%	100%
E9ANN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QGY4	Leishmania major	90%	100%