Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHH3_LEIDO

TriTrypDb:

LdBPK_323980.1 , LdCL_320045800 , LDHU3_32.5110

Length:

183

Annotations

Annotations by Jardim et al.

Intracellular signaling, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	20
GO:0110165	cellular anatomical entity	1	20

Expansion

Sequence features

A0A3Q8IHH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHH3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	20
GO:0016192	vesicle-mediated transport	4	20
GO:0051179	localization	1	20
GO:0051234	establishment of localization	2	20

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.498
CLV_NRD_NRD_1	24	26	PF00675	0.440
CLV_PCSK_KEX2_1	26	28	PF00082	0.440
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.459
CLV_PCSK_SKI1_1	8	12	PF00082	0.464
DEG_Nend_UBRbox_1	1	4	PF02207	0.615
DOC_CYCLIN_yClb1_LxF_4	44	50	PF00134	0.269
DOC_MAPK_gen_1	131	139	PF00069	0.336
DOC_MAPK_gen_1	25	34	PF00069	0.518
DOC_MAPK_MEF2A_6	153	161	PF00069	0.303
DOC_MAPK_MEF2A_6	25	34	PF00069	0.546
DOC_MAPK_NFAT4_5	27	35	PF00069	0.551
DOC_MAPK_RevD_3	122	136	PF00069	0.269
LIG_BRCT_BRCA1_1	171	175	PF00533	0.269
LIG_FHA_1	121	127	PF00498	0.405
LIG_FHA_1	62	68	PF00498	0.431
LIG_GBD_Chelix_1	163	171	PF00786	0.269
LIG_LIR_Gen_1	118	129	PF02991	0.434
LIG_LIR_Gen_1	154	164	PF02991	0.302
LIG_LIR_Gen_1	172	181	PF02991	0.269
LIG_LIR_Gen_1	96	106	PF02991	0.481
LIG_LIR_Nem_3	118	124	PF02991	0.390
LIG_LIR_Nem_3	154	159	PF02991	0.286
LIG_LIR_Nem_3	172	178	PF02991	0.293
LIG_LIR_Nem_3	96	101	PF02991	0.457
LIG_PCNA_yPIPBox_3	89	99	PF02747	0.551
LIG_Pex14_2	111	115	PF04695	0.450
LIG_Pex14_2	49	53	PF04695	0.401
LIG_SH2_CRK	29	33	PF00017	0.438
LIG_SH2_PTP2	98	101	PF00017	0.474
LIG_SH2_SRC	138	141	PF00017	0.333
LIG_SH2_STAP1	70	74	PF00017	0.360
LIG_SH2_STAT5	138	141	PF00017	0.307
LIG_SH2_STAT5	35	38	PF00017	0.322
LIG_SH2_STAT5	98	101	PF00017	0.456
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.243
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.305
LIG_SUMO_SIM_anti_2	64	69	PF11976	0.442
LIG_SUMO_SIM_par_1	122	128	PF11976	0.410
LIG_SUMO_SIM_par_1	167	172	PF11976	0.312
LIG_WRC_WIRS_1	112	117	PF05994	0.466
MOD_CK1_1	176	182	PF00069	0.562
MOD_CK1_1	18	24	PF00069	0.659
MOD_CK1_1	78	84	PF00069	0.557
MOD_CK2_1	146	152	PF00069	0.351
MOD_CK2_1	3	9	PF00069	0.662
MOD_CK2_1	80	86	PF00069	0.558
MOD_GlcNHglycan	20	23	PF01048	0.476
MOD_GlcNHglycan	37	40	PF01048	0.281
MOD_GlcNHglycan	50	53	PF01048	0.604
MOD_GSK3_1	111	118	PF00069	0.336
MOD_GSK3_1	169	176	PF00069	0.269
MOD_NEK2_1	111	116	PF00069	0.348
MOD_NEK2_1	120	125	PF00069	0.357
MOD_NEK2_1	169	174	PF00069	0.378
MOD_PIKK_1	146	152	PF00454	0.343
MOD_PIKK_1	15	21	PF00454	0.724
MOD_PIKK_1	3	9	PF00454	0.686
MOD_Plk_1	146	152	PF00069	0.280
MOD_Plk_1	78	84	PF00069	0.522
MOD_Plk_4	115	121	PF00069	0.345
MOD_Plk_4	125	131	PF00069	0.323
MOD_Plk_4	169	175	PF00069	0.405
MOD_Plk_4	54	60	PF00069	0.327
MOD_Plk_4	61	67	PF00069	0.265
MOD_SUMO_rev_2	18	28	PF00179	0.666
TRG_DiLeu_BaEn_2	151	157	PF01217	0.351
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.530
TRG_ENDOCYTIC_2	29	32	PF00928	0.317
TRG_ENDOCYTIC_2	98	101	PF00928	0.456
TRG_ER_diArg_1	130	133	PF00400	0.261
TRG_Pf-PMV_PEXEL_1	135	140	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W0	Leptomonas seymouri	29%	97%
A0A0N1HVI2	Leptomonas seymouri	75%	100%
A0A0S4IRN3	Bodo saltans	25%	84%
A0A1X0NSL9	Trypanosomatidae	45%	99%
A0A1X0P478	Trypanosomatidae	20%	97%
A0A3Q8IH86	Leishmania donovani	23%	100%
A0A3R7KL43	Trypanosoma rangeli	24%	97%
A0A3R7KRD8	Trypanosoma rangeli	42%	99%
A4HL20	Leishmania braziliensis	85%	100%
A4HL21	Leishmania braziliensis	25%	100%
A4I8K1	Leishmania infantum	100%	100%
A4I8K2	Leishmania infantum	23%	100%
D0AAL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B3G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9B3G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q4N8	Leishmania major	25%	100%
Q4Q4N9	Leishmania major	98%	100%
V5BLE0	Trypanosoma cruzi	43%	99%