Tuzin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Tuzin-like protein

Gene product:

tuzin, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHH1_LEIDO

TriTrypDb:

LdBPK_080740.1 , LdCL_340024000 , LDHU3_34.2690

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3Q8IHH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHH1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.440
CLV_NRD_NRD_1	215	217	PF00675	0.517
CLV_NRD_NRD_1	288	290	PF00675	0.521
CLV_NRD_NRD_1	372	374	PF00675	0.470
CLV_NRD_NRD_1	413	415	PF00675	0.647
CLV_NRD_NRD_1	479	481	PF00675	0.642
CLV_NRD_NRD_1	52	54	PF00675	0.442
CLV_NRD_NRD_1	55	57	PF00675	0.434
CLV_NRD_NRD_1	587	589	PF00675	0.580
CLV_NRD_NRD_1	599	601	PF00675	0.522
CLV_NRD_NRD_1	63	65	PF00675	0.485
CLV_NRD_NRD_1	656	658	PF00675	0.613
CLV_NRD_NRD_1	90	92	PF00675	0.460
CLV_PCSK_FUR_1	53	57	PF00082	0.387
CLV_PCSK_FUR_1	60	64	PF00082	0.399
CLV_PCSK_KEX2_1	149	151	PF00082	0.439
CLV_PCSK_KEX2_1	207	209	PF00082	0.502
CLV_PCSK_KEX2_1	215	217	PF00082	0.473
CLV_PCSK_KEX2_1	372	374	PF00082	0.470
CLV_PCSK_KEX2_1	413	415	PF00082	0.676
CLV_PCSK_KEX2_1	479	481	PF00082	0.665
CLV_PCSK_KEX2_1	52	54	PF00082	0.442
CLV_PCSK_KEX2_1	55	57	PF00082	0.434
CLV_PCSK_KEX2_1	587	589	PF00082	0.580
CLV_PCSK_KEX2_1	599	601	PF00082	0.522
CLV_PCSK_KEX2_1	62	64	PF00082	0.473
CLV_PCSK_KEX2_1	656	658	PF00082	0.637
CLV_PCSK_KEX2_1	90	92	PF00082	0.458
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.496
CLV_PCSK_SKI1_1	290	294	PF00082	0.443
CLV_PCSK_SKI1_1	382	386	PF00082	0.421
CLV_PCSK_SKI1_1	450	454	PF00082	0.628
CLV_PCSK_SKI1_1	528	532	PF00082	0.644
CLV_PCSK_SKI1_1	600	604	PF00082	0.660
CLV_PCSK_SKI1_1	726	730	PF00082	0.668
DEG_APCC_DBOX_1	347	355	PF00400	0.556
DEG_APCC_DBOX_1	449	457	PF00400	0.441
DEG_Nend_UBRbox_1	1	4	PF02207	0.563
DOC_CDC14_PxL_1	591	599	PF14671	0.265
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.373
DOC_MAPK_DCC_7	483	492	PF00069	0.362
DOC_MAPK_gen_1	2	11	PF00069	0.385
DOC_MAPK_gen_1	325	334	PF00069	0.589
DOC_MAPK_gen_1	479	489	PF00069	0.423
DOC_MAPK_MEF2A_6	2	11	PF00069	0.385
DOC_MAPK_MEF2A_6	313	322	PF00069	0.553
DOC_MAPK_MEF2A_6	483	492	PF00069	0.343
DOC_MAPK_RevD_3	276	290	PF00069	0.506
DOC_MAPK_RevD_3	574	588	PF00069	0.261
DOC_PP1_RVXF_1	585	592	PF00149	0.378
DOC_PP2B_LxvP_1	23	26	PF13499	0.380
DOC_PP2B_LxvP_1	572	575	PF13499	0.408
DOC_PP2B_LxvP_1	662	665	PF13499	0.477
DOC_PP4_FxxP_1	134	137	PF00568	0.573
DOC_USP7_MATH_1	107	111	PF00917	0.627
DOC_USP7_MATH_1	123	127	PF00917	0.761
DOC_USP7_MATH_1	159	163	PF00917	0.719
DOC_USP7_MATH_1	285	289	PF00917	0.536
DOC_USP7_MATH_1	300	304	PF00917	0.472
DOC_USP7_MATH_1	32	36	PF00917	0.363
DOC_USP7_MATH_1	41	45	PF00917	0.348
DOC_USP7_MATH_1	432	436	PF00917	0.394
DOC_USP7_MATH_1	467	471	PF00917	0.489
DOC_USP7_MATH_1	575	579	PF00917	0.337
DOC_USP7_MATH_1	645	649	PF00917	0.312
DOC_WW_Pin1_4	121	126	PF00397	0.761
DOC_WW_Pin1_4	150	155	PF00397	0.776
DOC_WW_Pin1_4	577	582	PF00397	0.393
DOC_WW_Pin1_4	664	669	PF00397	0.407
LIG_14-3-3_CanoR_1	171	175	PF00244	0.744
LIG_14-3-3_CanoR_1	192	198	PF00244	0.760
LIG_14-3-3_CanoR_1	230	234	PF00244	0.604
LIG_14-3-3_CanoR_1	450	458	PF00244	0.457
LIG_14-3-3_CanoR_1	528	533	PF00244	0.459
LIG_14-3-3_CanoR_1	674	680	PF00244	0.379
LIG_14-3-3_CanoR_1	71	78	PF00244	0.577
LIG_Actin_WH2_2	487	504	PF00022	0.381
LIG_BIR_III_4	688	692	PF00653	0.442
LIG_BRCT_BRCA1_1	677	681	PF00533	0.440
LIG_CaM_IQ_9	283	299	PF13499	0.500
LIG_Clathr_ClatBox_1	489	493	PF01394	0.365
LIG_deltaCOP1_diTrp_1	712	716	PF00928	0.363
LIG_eIF4E_1	646	652	PF01652	0.325
LIG_FHA_1	130	136	PF00498	0.688
LIG_FHA_1	262	268	PF00498	0.597
LIG_FHA_1	404	410	PF00498	0.531
LIG_FHA_2	421	427	PF00498	0.416
LIG_Integrin_RGD_1	216	218	PF01839	0.513
LIG_LIR_Apic_2	132	137	PF02991	0.576
LIG_LIR_Apic_2	590	595	PF02991	0.369
LIG_LIR_Gen_1	44	51	PF02991	0.205
LIG_LIR_Nem_3	44	48	PF02991	0.205
LIG_LIR_Nem_3	590	594	PF02991	0.374
LIG_NRBOX	162	168	PF00104	0.663
LIG_NRBOX	185	191	PF00104	0.568
LIG_PDZ_Class_2	725	730	PF00595	0.420
LIG_Pex14_2	323	327	PF04695	0.587
LIG_SH2_CRK	592	596	PF00017	0.389
LIG_SH2_CRK	646	650	PF00017	0.450
LIG_SH2_CRK	707	711	PF00017	0.387
LIG_SH2_NCK_1	707	711	PF00017	0.414
LIG_SH2_PTP2	8	11	PF00017	0.186
LIG_SH2_SRC	707	710	PF00017	0.401
LIG_SH2_SRC	8	11	PF00017	0.186
LIG_SH2_STAP1	605	609	PF00017	0.318
LIG_SH2_STAP1	646	650	PF00017	0.347
LIG_SH2_STAT3	412	415	PF00017	0.408
LIG_SH2_STAT5	333	336	PF00017	0.580
LIG_SH2_STAT5	403	406	PF00017	0.421
LIG_SH2_STAT5	592	595	PF00017	0.398
LIG_SH2_STAT5	605	608	PF00017	0.393
LIG_SH2_STAT5	617	620	PF00017	0.319
LIG_SH2_STAT5	646	649	PF00017	0.375
LIG_SH2_STAT5	8	11	PF00017	0.186
LIG_SH3_2	665	670	PF14604	0.400
LIG_SH3_3	153	159	PF00018	0.811
LIG_SH3_3	242	248	PF00018	0.609
LIG_SH3_3	306	312	PF00018	0.637
LIG_SH3_3	455	461	PF00018	0.448
LIG_SH3_3	662	668	PF00018	0.403
LIG_SUMO_SIM_anti_2	264	270	PF11976	0.574
LIG_SUMO_SIM_anti_2	316	322	PF11976	0.550
LIG_SUMO_SIM_anti_2	336	342	PF11976	0.455
LIG_SUMO_SIM_anti_2	557	564	PF11976	0.407
LIG_SUMO_SIM_anti_2	611	617	PF11976	0.391
LIG_SUMO_SIM_anti_2	647	653	PF11976	0.250
LIG_SUMO_SIM_par_1	281	288	PF11976	0.561
LIG_SUMO_SIM_par_1	297	303	PF11976	0.454
LIG_SUMO_SIM_par_1	557	564	PF11976	0.344
LIG_TRAF2_1	435	438	PF00917	0.372
LIG_TRAF2_1	443	446	PF00917	0.437
LIG_TYR_ITIM	644	649	PF00017	0.514
LIG_TYR_ITIM	705	710	PF00017	0.456
LIG_UBA3_1	202	207	PF00899	0.470
MOD_CAAXbox	727	730	PF01239	0.524
MOD_CDC14_SPxK_1	667	670	PF00782	0.461
MOD_CDK_SPxK_1	664	670	PF00069	0.491
MOD_CK1_1	110	116	PF00069	0.605
MOD_CK1_1	191	197	PF00069	0.698
MOD_CK1_1	451	457	PF00069	0.528
MOD_CK1_1	560	566	PF00069	0.490
MOD_CK2_1	174	180	PF00069	0.604
MOD_CK2_1	344	350	PF00069	0.498
MOD_CK2_1	420	426	PF00069	0.513
MOD_CK2_1	432	438	PF00069	0.656
MOD_CK2_1	508	514	PF00069	0.429
MOD_Cter_Amidation	147	150	PF01082	0.508
MOD_Cter_Amidation	205	208	PF01082	0.619
MOD_GlcNHglycan	109	112	PF01048	0.505
MOD_GlcNHglycan	23	26	PF01048	0.459
MOD_GlcNHglycan	240	243	PF01048	0.618
MOD_GlcNHglycan	294	297	PF01048	0.613
MOD_GlcNHglycan	469	472	PF01048	0.600
MOD_GSK3_1	170	177	PF00069	0.632
MOD_GSK3_1	300	307	PF00069	0.420
MOD_GSK3_1	32	39	PF00069	0.437
MOD_GSK3_1	420	427	PF00069	0.516
MOD_GSK3_1	528	535	PF00069	0.548
MOD_GSK3_1	687	694	PF00069	0.519
MOD_N-GLC_1	261	266	PF02516	0.503
MOD_N-GLC_1	582	587	PF02516	0.507
MOD_NEK2_1	193	198	PF00069	0.535
MOD_NEK2_1	252	257	PF00069	0.574
MOD_NEK2_1	292	297	PF00069	0.592
MOD_NEK2_1	36	41	PF00069	0.286
MOD_NEK2_1	448	453	PF00069	0.561
MOD_NEK2_1	508	513	PF00069	0.414
MOD_NEK2_1	582	587	PF00069	0.528
MOD_OFUCOSY	120	127	PF10250	0.519
MOD_PIKK_1	451	457	PF00454	0.561
MOD_PKA_2	170	176	PF00069	0.669
MOD_PKA_2	191	197	PF00069	0.701
MOD_PKA_2	229	235	PF00069	0.592
MOD_PKA_2	41	47	PF00069	0.209
MOD_PKA_2	432	438	PF00069	0.703
MOD_PKA_2	624	630	PF00069	0.596
MOD_PKA_2	70	76	PF00069	0.552
MOD_PKB_1	544	552	PF00069	0.456
MOD_Plk_1	194	200	PF00069	0.516
MOD_Plk_1	261	267	PF00069	0.537
MOD_Plk_1	274	280	PF00069	0.469
MOD_Plk_1	497	503	PF00069	0.494
MOD_Plk_1	582	588	PF00069	0.369
MOD_Plk_2-3	350	356	PF00069	0.434
MOD_Plk_4	174	180	PF00069	0.734
MOD_Plk_4	300	306	PF00069	0.288
MOD_Plk_4	41	47	PF00069	0.314
MOD_Plk_4	557	563	PF00069	0.444
MOD_Plk_4	645	651	PF00069	0.590
MOD_Plk_4	691	697	PF00069	0.585
MOD_ProDKin_1	121	127	PF00069	0.715
MOD_ProDKin_1	150	156	PF00069	0.731
MOD_ProDKin_1	577	583	PF00069	0.470
MOD_ProDKin_1	664	670	PF00069	0.491
TRG_DiLeu_BaEn_1	316	321	PF01217	0.524
TRG_DiLeu_BaEn_1	330	335	PF01217	0.399
TRG_DiLeu_BaEn_1	336	341	PF01217	0.370
TRG_DiLeu_BaEn_1	557	562	PF01217	0.489
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.599
TRG_ENDOCYTIC_2	555	558	PF00928	0.559
TRG_ENDOCYTIC_2	646	649	PF00928	0.559
TRG_ENDOCYTIC_2	707	710	PF00928	0.463
TRG_ENDOCYTIC_2	8	11	PF00928	0.186
TRG_ER_diArg_1	1	4	PF00400	0.435
TRG_ER_diArg_1	371	373	PF00400	0.591
TRG_ER_diArg_1	412	414	PF00400	0.591
TRG_ER_diArg_1	52	55	PF00400	0.566
TRG_ER_diArg_1	543	546	PF00400	0.460
TRG_ER_diArg_1	586	588	PF00400	0.461
TRG_ER_diArg_1	62	64	PF00400	0.672
TRG_ER_diArg_1	636	639	PF00400	0.554
TRG_ER_diArg_1	655	657	PF00400	0.565
TRG_ER_diArg_1	89	91	PF00400	0.568
TRG_NES_CRM1_1	339	352	PF08389	0.550
TRG_NES_CRM1_1	499	514	PF08389	0.443
TRG_Pf-PMV_PEXEL_1	16	21	PF00026	0.186
TRG_Pf-PMV_PEXEL_1	369	374	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	64%	100%
A0A0N1PB02	Leptomonas seymouri	40%	100%
A0A0S4J6C6	Bodo saltans	35%	100%
A0A3S5H668	Leishmania donovani	40%	100%
A0A3S5H669	Leishmania donovani	37%	100%
A0A3S7X835	Leishmania donovani	38%	100%
A4H5C9	Leishmania braziliensis	41%	99%
A4H5D0	Leishmania braziliensis	40%	100%
A4HAZ9	Leishmania braziliensis	41%	100%
A4HB01	Leishmania braziliensis	41%	100%
A4HTM0	Leishmania infantum	39%	98%
A4HTM1	Leishmania infantum	36%	96%
A4IA57	Leishmania infantum	39%	100%
C6K3V8	Leptomonas seymouri	39%	100%
C6K3V9	Leptomonas seymouri	35%	100%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	95%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	98%
E9AME7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	99%
Q4Q1U8	Leishmania major	87%	100%
Q4Q2R4	Leishmania major	39%	100%
Q4Q310	Leishmania major	83%	100%
Q4Q312	Leishmania major	82%	100%
Q4Q340	Leishmania major	83%	100%
Q4Q342	Leishmania major	83%	100%
Q4QI90	Leishmania major	36%	96%
Q4QI91	Leishmania major	39%	98%