Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHG5_LEIDO

TriTrypDb:

LdBPK_110740.1 , LdCL_110012800 , LDHU3_11.0940

Length:

1268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1021	1025	PF00656	0.659
CLV_C14_Caspase3-7	240	244	PF00656	0.603
CLV_C14_Caspase3-7	345	349	PF00656	0.646
CLV_C14_Caspase3-7	44	48	PF00656	0.653
CLV_C14_Caspase3-7	54	58	PF00656	0.594
CLV_C14_Caspase3-7	673	677	PF00656	0.623
CLV_MEL_PAP_1	497	503	PF00089	0.647
CLV_NRD_NRD_1	1003	1005	PF00675	0.600
CLV_NRD_NRD_1	1205	1207	PF00675	0.591
CLV_NRD_NRD_1	134	136	PF00675	0.591
CLV_NRD_NRD_1	597	599	PF00675	0.658
CLV_NRD_NRD_1	655	657	PF00675	0.667
CLV_PCSK_KEX2_1	1003	1005	PF00082	0.600
CLV_PCSK_KEX2_1	1205	1207	PF00082	0.591
CLV_PCSK_KEX2_1	133	135	PF00082	0.600
CLV_PCSK_KEX2_1	655	657	PF00082	0.667
CLV_PCSK_SKI1_1	1075	1079	PF00082	0.652
CLV_PCSK_SKI1_1	109	113	PF00082	0.736
CLV_PCSK_SKI1_1	144	148	PF00082	0.704
CLV_PCSK_SKI1_1	479	483	PF00082	0.686
CLV_PCSK_SKI1_1	567	571	PF00082	0.592
CLV_PCSK_SKI1_1	732	736	PF00082	0.571
DEG_APCC_DBOX_1	566	574	PF00400	0.607
DEG_SPOP_SBC_1	265	269	PF00917	0.636
DEG_SPOP_SBC_1	276	280	PF00917	0.602
DEG_SPOP_SBC_1	367	371	PF00917	0.659
DEG_SPOP_SBC_1	781	785	PF00917	0.692
DEG_SPOP_SBC_1	857	861	PF00917	0.566
DEG_SPOP_SBC_1	967	971	PF00917	0.675
DOC_ANK_TNKS_1	493	500	PF00023	0.582
DOC_CDC14_PxL_1	175	183	PF14671	0.619
DOC_CKS1_1	1006	1011	PF01111	0.582
DOC_CKS1_1	1216	1221	PF01111	0.485
DOC_CKS1_1	823	828	PF01111	0.650
DOC_CYCLIN_yCln2_LP_2	215	221	PF00134	0.693
DOC_CYCLIN_yCln2_LP_2	605	611	PF00134	0.688
DOC_CYCLIN_yCln2_LP_2	615	621	PF00134	0.612
DOC_MAPK_DCC_7	174	182	PF00069	0.766
DOC_MAPK_gen_1	383	392	PF00069	0.504
DOC_MAPK_gen_1	696	705	PF00069	0.571
DOC_MAPK_MEF2A_6	174	182	PF00069	0.766
DOC_PP2B_LxvP_1	284	287	PF13499	0.685
DOC_PP2B_LxvP_1	471	474	PF13499	0.713
DOC_PP2B_LxvP_1	605	608	PF13499	0.680
DOC_PP2B_LxvP_1	615	618	PF13499	0.620
DOC_PP2B_LxvP_1	648	651	PF13499	0.551
DOC_PP2B_LxvP_1	929	932	PF13499	0.633
DOC_PP4_FxxP_1	1083	1086	PF00568	0.590
DOC_PP4_FxxP_1	331	334	PF00568	0.574
DOC_PP4_FxxP_1	678	681	PF00568	0.611
DOC_SPAK_OSR1_1	500	504	PF12202	0.655
DOC_USP7_MATH_1	1237	1241	PF00917	0.598
DOC_USP7_MATH_1	208	212	PF00917	0.644
DOC_USP7_MATH_1	229	233	PF00917	0.698
DOC_USP7_MATH_1	238	242	PF00917	0.596
DOC_USP7_MATH_1	24	28	PF00917	0.657
DOC_USP7_MATH_1	251	255	PF00917	0.566
DOC_USP7_MATH_1	263	267	PF00917	0.610
DOC_USP7_MATH_1	34	38	PF00917	0.582
DOC_USP7_MATH_1	367	371	PF00917	0.648
DOC_USP7_MATH_1	426	430	PF00917	0.668
DOC_USP7_MATH_1	434	438	PF00917	0.620
DOC_USP7_MATH_1	444	448	PF00917	0.541
DOC_USP7_MATH_1	53	57	PF00917	0.667
DOC_USP7_MATH_1	530	534	PF00917	0.624
DOC_USP7_MATH_1	58	62	PF00917	0.635
DOC_USP7_MATH_1	63	67	PF00917	0.579
DOC_USP7_MATH_1	632	636	PF00917	0.602
DOC_USP7_MATH_1	746	750	PF00917	0.665
DOC_USP7_MATH_1	781	785	PF00917	0.687
DOC_USP7_MATH_1	810	814	PF00917	0.659
DOC_USP7_MATH_1	857	861	PF00917	0.605
DOC_USP7_MATH_1	877	881	PF00917	0.566
DOC_USP7_MATH_1	949	953	PF00917	0.632
DOC_USP7_MATH_1	967	971	PF00917	0.602
DOC_USP7_MATH_1	973	977	PF00917	0.636
DOC_USP7_UBL2_3	829	833	PF12436	0.569
DOC_WW_Pin1_4	1005	1010	PF00397	0.586
DOC_WW_Pin1_4	1078	1083	PF00397	0.719
DOC_WW_Pin1_4	1087	1092	PF00397	0.633
DOC_WW_Pin1_4	1111	1116	PF00397	0.660
DOC_WW_Pin1_4	1126	1131	PF00397	0.489
DOC_WW_Pin1_4	1215	1220	PF00397	0.568
DOC_WW_Pin1_4	1260	1265	PF00397	0.608
DOC_WW_Pin1_4	249	254	PF00397	0.654
DOC_WW_Pin1_4	261	266	PF00397	0.606
DOC_WW_Pin1_4	269	274	PF00397	0.611
DOC_WW_Pin1_4	277	282	PF00397	0.573
DOC_WW_Pin1_4	32	37	PF00397	0.653
DOC_WW_Pin1_4	415	420	PF00397	0.658
DOC_WW_Pin1_4	462	467	PF00397	0.667
DOC_WW_Pin1_4	469	474	PF00397	0.654
DOC_WW_Pin1_4	548	553	PF00397	0.686
DOC_WW_Pin1_4	617	622	PF00397	0.623
DOC_WW_Pin1_4	822	827	PF00397	0.652
DOC_WW_Pin1_4	959	964	PF00397	0.671
LIG_14-3-3_CanoR_1	1075	1083	PF00244	0.657
LIG_14-3-3_CanoR_1	28	36	PF00244	0.654
LIG_14-3-3_CanoR_1	289	293	PF00244	0.617
LIG_14-3-3_CanoR_1	819	823	PF00244	0.662
LIG_Actin_WH2_2	1223	1238	PF00022	0.596
LIG_BIR_III_2	348	352	PF00653	0.572
LIG_BIR_III_2	864	868	PF00653	0.641
LIG_BIR_III_4	1102	1106	PF00653	0.592
LIG_BIR_III_4	425	429	PF00653	0.663
LIG_BIR_III_4	983	987	PF00653	0.596
LIG_BRCT_BRCA1_1	782	786	PF00533	0.658
LIG_BRCT_BRCA1_1	953	957	PF00533	0.578
LIG_CaM_NSCaTE_8	1211	1218	PF13499	0.558
LIG_Clathr_ClatBox_1	112	116	PF01394	0.646
LIG_CtBP_PxDLS_1	468	472	PF00389	0.665
LIG_eIF4E_1	142	148	PF01652	0.639
LIG_eIF4E_1	565	571	PF01652	0.558
LIG_EVH1_2	5	9	PF00568	0.698
LIG_EVH1_2	555	559	PF00568	0.615
LIG_FHA_1	1130	1136	PF00498	0.571
LIG_FHA_1	270	276	PF00498	0.649
LIG_FHA_1	549	555	PF00498	0.706
LIG_FHA_1	585	591	PF00498	0.626
LIG_FHA_1	666	672	PF00498	0.657
LIG_FHA_1	825	831	PF00498	0.687
LIG_FHA_1	960	966	PF00498	0.678
LIG_FHA_2	198	204	PF00498	0.687
LIG_FHA_2	343	349	PF00498	0.636
LIG_FHA_2	354	360	PF00498	0.573
LIG_FHA_2	74	80	PF00498	0.675
LIG_FHA_2	823	829	PF00498	0.694
LIG_FHA_2	901	907	PF00498	0.690
LIG_LIR_Apic_2	1081	1086	PF02991	0.657
LIG_LIR_Apic_2	252	258	PF02991	0.677
LIG_LIR_Apic_2	280	286	PF02991	0.699
LIG_LIR_Apic_2	385	391	PF02991	0.529
LIG_LIR_Apic_2	675	681	PF02991	0.608
LIG_LIR_Gen_1	1129	1139	PF02991	0.587
LIG_LIR_Gen_1	1241	1252	PF02991	0.561
LIG_LIR_Gen_1	152	163	PF02991	0.633
LIG_LIR_Nem_3	1078	1083	PF02991	0.592
LIG_LIR_Nem_3	1129	1134	PF02991	0.590
LIG_LIR_Nem_3	1241	1247	PF02991	0.591
LIG_LIR_Nem_3	323	329	PF02991	0.579
LIG_LIR_Nem_3	515	521	PF02991	0.605
LIG_LIR_Nem_3	595	600	PF02991	0.651
LIG_LIR_Nem_3	906	911	PF02991	0.554
LIG_LYPXL_yS_3	217	220	PF13949	0.693
LIG_MYND_1	552	556	PF01753	0.651
LIG_MYND_1	963	967	PF01753	0.641
LIG_NRBOX	1251	1257	PF00104	0.567
LIG_Pex14_2	331	335	PF04695	0.566
LIG_Pex14_2	9	13	PF04695	0.704
LIG_Pex14_2	953	957	PF04695	0.601
LIG_PTAP_UEV_1	1	6	PF05743	0.667
LIG_SH2_NCK_1	1125	1129	PF00017	0.525
LIG_SH2_NCK_1	150	154	PF00017	0.637
LIG_SH2_SRC	150	153	PF00017	0.644
LIG_SH2_STAP1	1138	1142	PF00017	0.545
LIG_SH2_STAT5	283	286	PF00017	0.694
LIG_SH2_STAT5	908	911	PF00017	0.548
LIG_SH3_1	1003	1009	PF00018	0.587
LIG_SH3_3	1003	1009	PF00018	0.587
LIG_SH3_3	1056	1062	PF00018	0.609
LIG_SH3_3	1085	1091	PF00018	0.645
LIG_SH3_3	117	123	PF00018	0.682
LIG_SH3_3	1213	1219	PF00018	0.478
LIG_SH3_3	1256	1262	PF00018	0.615
LIG_SH3_3	164	170	PF00018	0.653
LIG_SH3_3	215	221	PF00018	0.693
LIG_SH3_3	250	256	PF00018	0.645
LIG_SH3_3	270	276	PF00018	0.581
LIG_SH3_3	405	411	PF00018	0.571
LIG_SH3_3	470	476	PF00018	0.704
LIG_SH3_3	492	498	PF00018	0.615
LIG_SH3_3	549	555	PF00018	0.701
LIG_SH3_3	601	607	PF00018	0.672
LIG_SH3_3	608	614	PF00018	0.643
LIG_SH3_3	615	621	PF00018	0.578
LIG_SH3_3	820	826	PF00018	0.665
LIG_Sin3_3	892	899	PF02671	0.579
LIG_SUMO_SIM_anti_2	1250	1257	PF11976	0.571
LIG_SUMO_SIM_anti_2	850	856	PF11976	0.682
LIG_SUMO_SIM_par_1	337	343	PF11976	0.556
LIG_SUMO_SIM_par_1	467	472	PF11976	0.659
LIG_SUMO_SIM_par_1	569	575	PF11976	0.610
LIG_SUMO_SIM_par_1	749	757	PF11976	0.642
LIG_TRAF2_1	1063	1066	PF00917	0.663
LIG_TRAF2_1	320	323	PF00917	0.573
LIG_TRAF2_1	42	45	PF00917	0.583
LIG_TRAF2_1	447	450	PF00917	0.659
LIG_TRAF2_1	848	851	PF00917	0.685
LIG_TYR_ITIM	215	220	PF00017	0.695
LIG_UBA3_1	734	740	PF00899	0.652
LIG_UBA3_1	928	934	PF00899	0.635
MOD_CDK_SPK_2	1260	1265	PF00069	0.608
MOD_CDK_SPK_2	474	479	PF00069	0.639
MOD_CDK_SPxxK_3	282	289	PF00069	0.691
MOD_CDK_SPxxK_3	472	479	PF00069	0.699
MOD_CDK_SPxxK_3	822	829	PF00069	0.652
MOD_CK1_1	1035	1041	PF00069	0.547
MOD_CK1_1	1107	1113	PF00069	0.650
MOD_CK1_1	1126	1132	PF00069	0.429
MOD_CK1_1	1238	1244	PF00069	0.594
MOD_CK1_1	15	21	PF00069	0.677
MOD_CK1_1	197	203	PF00069	0.649
MOD_CK1_1	264	270	PF00069	0.704
MOD_CK1_1	27	33	PF00069	0.604
MOD_CK1_1	35	41	PF00069	0.545
MOD_CK1_1	368	374	PF00069	0.688
MOD_CK1_1	433	439	PF00069	0.674
MOD_CK1_1	472	478	PF00069	0.618
MOD_CK1_1	61	67	PF00069	0.629
MOD_CK1_1	763	769	PF00069	0.759
MOD_CK1_1	774	780	PF00069	0.729
MOD_CK1_1	782	788	PF00069	0.602
MOD_CK1_1	813	819	PF00069	0.731
MOD_CK1_1	821	827	PF00069	0.629
MOD_CK1_1	898	904	PF00069	0.608
MOD_CK1_1	951	957	PF00069	0.620
MOD_CK1_1	96	102	PF00069	0.610
MOD_CK2_1	1008	1014	PF00069	0.586
MOD_CK2_1	1147	1153	PF00069	0.668
MOD_CK2_1	197	203	PF00069	0.682
MOD_CK2_1	444	450	PF00069	0.660
MOD_CK2_1	617	623	PF00069	0.659
MOD_CK2_1	73	79	PF00069	0.694
MOD_CK2_1	797	803	PF00069	0.663
MOD_CK2_1	845	851	PF00069	0.667
MOD_CK2_1	857	863	PF00069	0.555
MOD_CK2_1	869	875	PF00069	0.554
MOD_CK2_1	900	906	PF00069	0.690
MOD_CK2_1	934	940	PF00069	0.659
MOD_CK2_1	96	102	PF00069	0.610
MOD_CK2_1	991	997	PF00069	0.663
MOD_GlcNHglycan	1020	1023	PF01048	0.681
MOD_GlcNHglycan	1075	1078	PF01048	0.661
MOD_GlcNHglycan	1125	1128	PF01048	0.553
MOD_GlcNHglycan	1220	1223	PF01048	0.614
MOD_GlcNHglycan	1237	1240	PF01048	0.431
MOD_GlcNHglycan	2	5	PF01048	0.664
MOD_GlcNHglycan	210	213	PF01048	0.692
MOD_GlcNHglycan	22	25	PF01048	0.541
MOD_GlcNHglycan	231	234	PF01048	0.662
MOD_GlcNHglycan	259	262	PF01048	0.716
MOD_GlcNHglycan	268	271	PF01048	0.645
MOD_GlcNHglycan	371	374	PF01048	0.543
MOD_GlcNHglycan	427	431	PF01048	0.698
MOD_GlcNHglycan	432	435	PF01048	0.662
MOD_GlcNHglycan	436	439	PF01048	0.633
MOD_GlcNHglycan	462	465	PF01048	0.653
MOD_GlcNHglycan	510	513	PF01048	0.577
MOD_GlcNHglycan	540	543	PF01048	0.709
MOD_GlcNHglycan	713	716	PF01048	0.598
MOD_GlcNHglycan	762	765	PF01048	0.689
MOD_GlcNHglycan	779	782	PF01048	0.588
MOD_GlcNHglycan	812	815	PF01048	0.723
MOD_GlcNHglycan	820	823	PF01048	0.643
MOD_GlcNHglycan	840	843	PF01048	0.556
MOD_GlcNHglycan	847	850	PF01048	0.637
MOD_GlcNHglycan	871	874	PF01048	0.623
MOD_GlcNHglycan	881	884	PF01048	0.564
MOD_GlcNHglycan	897	900	PF01048	0.531
MOD_GlcNHglycan	917	920	PF01048	0.560
MOD_GlcNHglycan	935	939	PF01048	0.529
MOD_GlcNHglycan	95	98	PF01048	0.675
MOD_GlcNHglycan	953	956	PF01048	0.529
MOD_GSK3_1	1078	1085	PF00069	0.700
MOD_GSK3_1	1103	1110	PF00069	0.693
MOD_GSK3_1	1142	1149	PF00069	0.598
MOD_GSK3_1	12	19	PF00069	0.686
MOD_GSK3_1	1214	1221	PF00069	0.601
MOD_GSK3_1	1235	1242	PF00069	0.597
MOD_GSK3_1	194	201	PF00069	0.640
MOD_GSK3_1	20	27	PF00069	0.614
MOD_GSK3_1	257	264	PF00069	0.616
MOD_GSK3_1	265	272	PF00069	0.633
MOD_GSK3_1	28	35	PF00069	0.562
MOD_GSK3_1	362	369	PF00069	0.654
MOD_GSK3_1	426	433	PF00069	0.589
MOD_GSK3_1	444	451	PF00069	0.534
MOD_GSK3_1	546	553	PF00069	0.679
MOD_GSK3_1	613	620	PF00069	0.706
MOD_GSK3_1	754	761	PF00069	0.672
MOD_GSK3_1	772	779	PF00069	0.660
MOD_GSK3_1	781	788	PF00069	0.678
MOD_GSK3_1	810	817	PF00069	0.726
MOD_GSK3_1	818	825	PF00069	0.646
MOD_N-GLC_1	1158	1163	PF02516	0.640
MOD_N-GLC_2	1166	1168	PF02516	0.637
MOD_NEK2_1	1198	1203	PF00069	0.593
MOD_NEK2_1	1235	1240	PF00069	0.596
MOD_NEK2_1	13	18	PF00069	0.646
MOD_NEK2_1	288	293	PF00069	0.618
MOD_NEK2_1	73	78	PF00069	0.754
MOD_NEK2_1	869	874	PF00069	0.644
MOD_NEK2_1	93	98	PF00069	0.608
MOD_PIKK_1	371	377	PF00454	0.672
MOD_PIKK_1	641	647	PF00454	0.703
MOD_PIKK_1	754	760	PF00454	0.621
MOD_PIKK_1	785	791	PF00454	0.685
MOD_PIKK_1	973	979	PF00454	0.716
MOD_PKA_2	27	33	PF00069	0.717
MOD_PKA_2	288	294	PF00069	0.619
MOD_PKA_2	453	459	PF00069	0.649
MOD_PKA_2	771	777	PF00069	0.739
MOD_PKA_2	818	824	PF00069	0.657
MOD_Plk_1	1198	1204	PF00069	0.553
MOD_Plk_1	444	450	PF00069	0.640
MOD_Plk_1	850	856	PF00069	0.667
MOD_Plk_1	934	940	PF00069	0.639
MOD_Plk_1	991	997	PF00069	0.664
MOD_Plk_2-3	1181	1187	PF00069	0.558
MOD_Plk_4	1181	1187	PF00069	0.603
MOD_Plk_4	1251	1257	PF00069	0.493
MOD_Plk_4	622	628	PF00069	0.701
MOD_Plk_4	748	754	PF00069	0.646
MOD_Plk_4	850	856	PF00069	0.684
MOD_Plk_4	924	930	PF00069	0.612
MOD_Plk_4	961	967	PF00069	0.632
MOD_ProDKin_1	1005	1011	PF00069	0.585
MOD_ProDKin_1	1078	1084	PF00069	0.675
MOD_ProDKin_1	1087	1093	PF00069	0.632
MOD_ProDKin_1	1111	1117	PF00069	0.657
MOD_ProDKin_1	1126	1132	PF00069	0.484
MOD_ProDKin_1	1215	1221	PF00069	0.564
MOD_ProDKin_1	1260	1266	PF00069	0.612
MOD_ProDKin_1	249	255	PF00069	0.656
MOD_ProDKin_1	261	267	PF00069	0.610
MOD_ProDKin_1	269	275	PF00069	0.610
MOD_ProDKin_1	277	283	PF00069	0.573
MOD_ProDKin_1	32	38	PF00069	0.651
MOD_ProDKin_1	415	421	PF00069	0.659
MOD_ProDKin_1	462	468	PF00069	0.665
MOD_ProDKin_1	469	475	PF00069	0.650
MOD_ProDKin_1	548	554	PF00069	0.681
MOD_ProDKin_1	617	623	PF00069	0.624
MOD_ProDKin_1	822	828	PF00069	0.650
MOD_ProDKin_1	959	965	PF00069	0.673
MOD_SUMO_for_1	639	642	PF00179	0.585
MOD_SUMO_rev_2	1150	1157	PF00179	0.651
MOD_SUMO_rev_2	54	64	PF00179	0.668
TRG_DiLeu_BaEn_1	1251	1256	PF01217	0.564
TRG_DiLeu_BaEn_2	321	327	PF01217	0.540
TRG_DiLeu_BaEn_4	322	328	PF01217	0.534
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.629
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.581
TRG_ENDOCYTIC_2	1138	1141	PF00928	0.465
TRG_ENDOCYTIC_2	217	220	PF00928	0.693
TRG_ER_diArg_1	1002	1004	PF00400	0.591
TRG_ER_diArg_1	1205	1208	PF00400	0.595
TRG_ER_diArg_1	132	135	PF00400	0.601
TRG_ER_diArg_1	401	404	PF00400	0.651
TRG_Pf-PMV_PEXEL_1	1048	1052	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H6J8	Leishmania braziliensis	58%	100%
A4HUY3	Leishmania infantum	99%	100%
E9ANL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4QH05	Leishmania major	84%	100%