3-hydroxyisobutyryl-coenzyme A hydrolase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

enoyl-CoA hydratase/isomerase family protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHF8_LEIDO

TriTrypDb:

LdBPK_323830.1 , LdCL_320044300 , LDHU3_32.4960

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IHF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHF8

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006573	valine metabolic process	5	1
GO:0006574	valine catabolic process	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009063	amino acid catabolic process	4	1
GO:0009081	branched-chain amino acid metabolic process	4	1
GO:0009083	branched-chain amino acid catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0016054	organic acid catabolic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046395	carboxylic acid catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901605	alpha-amino acid metabolic process	4	1
GO:1901606	alpha-amino acid catabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003860	3-hydroxyisobutyryl-CoA hydrolase activity	6	12
GO:0016289	CoA hydrolase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016790	thiolester hydrolase activity	4	12
GO:0016829	lyase activity	2	6
GO:0016853	isomerase activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.420
CLV_C14_Caspase3-7	250	254	PF00656	0.445
CLV_C14_Caspase3-7	344	348	PF00656	0.445
CLV_PCSK_KEX2_1	288	290	PF00082	0.314
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.445
CLV_PCSK_SKI1_1	21	25	PF00082	0.293
CLV_PCSK_SKI1_1	289	293	PF00082	0.357
CLV_PCSK_SKI1_1	321	325	PF00082	0.298
CLV_PCSK_SKI1_1	86	90	PF00082	0.351
DEG_Nend_Nbox_1	1	3	PF02207	0.481
DOC_AGCK_PIF_2	88	93	PF00069	0.368
DOC_CKS1_1	217	222	PF01111	0.445
DOC_CKS1_1	293	298	PF01111	0.445
DOC_CKS1_1	352	357	PF01111	0.575
DOC_CYCLIN_yCln2_LP_2	293	299	PF00134	0.445
DOC_MAPK_gen_1	173	182	PF00069	0.375
DOC_MAPK_MEF2A_6	157	165	PF00069	0.328
DOC_MAPK_MEF2A_6	175	184	PF00069	0.163
DOC_PP4_FxxP_1	136	139	PF00568	0.275
DOC_USP7_MATH_1	200	204	PF00917	0.451
DOC_USP7_MATH_1	6	10	PF00917	0.524
DOC_USP7_UBL2_3	288	292	PF12436	0.429
DOC_WW_Pin1_4	216	221	PF00397	0.445
DOC_WW_Pin1_4	273	278	PF00397	0.298
DOC_WW_Pin1_4	292	297	PF00397	0.298
DOC_WW_Pin1_4	351	356	PF00397	0.534
LIG_14-3-3_CanoR_1	128	136	PF00244	0.296
LIG_14-3-3_CanoR_1	157	161	PF00244	0.419
LIG_14-3-3_CanoR_1	21	26	PF00244	0.202
LIG_14-3-3_CanoR_1	27	32	PF00244	0.115
LIG_14-3-3_CanoR_1	44	50	PF00244	0.438
LIG_14-3-3_CanoR_1	7	13	PF00244	0.484
LIG_Actin_WH2_2	160	177	PF00022	0.323
LIG_APCC_ABBA_1	143	148	PF00400	0.314
LIG_DLG_GKlike_1	27	34	PF00625	0.368
LIG_FHA_1	184	190	PF00498	0.285
LIG_FHA_1	216	222	PF00498	0.400
LIG_FHA_1	241	247	PF00498	0.334
LIG_FHA_1	259	265	PF00498	0.115
LIG_FHA_1	279	285	PF00498	0.365
LIG_FHA_2	293	299	PF00498	0.419
LIG_FHA_2	335	341	PF00498	0.346
LIG_LIR_Apic_2	152	156	PF02991	0.292
LIG_LIR_Apic_2	215	220	PF02991	0.445
LIG_LIR_Apic_2	347	352	PF02991	0.355
LIG_LIR_Nem_3	35	39	PF02991	0.232
LIG_LIR_Nem_3	87	93	PF02991	0.332
LIG_SH2_CRK	166	170	PF00017	0.445
LIG_SH2_CRK	217	221	PF00017	0.445
LIG_SH2_CRK	36	40	PF00017	0.360
LIG_SH2_STAT5	113	116	PF00017	0.286
LIG_SH2_STAT5	217	220	PF00017	0.425
LIG_SH2_STAT5	304	307	PF00017	0.355
LIG_SH2_STAT5	349	352	PF00017	0.399
LIG_SH2_STAT5	46	49	PF00017	0.343
LIG_SH2_STAT5	57	60	PF00017	0.217
LIG_SH3_1	349	355	PF00018	0.437
LIG_SH3_3	349	355	PF00018	0.414
LIG_SH3_3	356	362	PF00018	0.414
LIG_SH3_3	44	50	PF00018	0.393
LIG_SH3_4	330	337	PF00018	0.368
LIG_SUMO_SIM_par_1	280	285	PF11976	0.419
LIG_SxIP_EBH_1	98	108	PF03271	0.368
LIG_TYR_ITIM	34	39	PF00017	0.360
LIG_ULM_U2AF65_1	329	334	PF00076	0.368
LIG_WRC_WIRS_1	272	277	PF05994	0.445
MOD_CK1_1	122	128	PF00069	0.407
MOD_CK1_1	232	238	PF00069	0.445
MOD_CK2_1	292	298	PF00069	0.355
MOD_CK2_1	334	340	PF00069	0.346
MOD_DYRK1A_RPxSP_1	351	355	PF00069	0.502
MOD_GlcNHglycan	124	127	PF01048	0.368
MOD_GlcNHglycan	190	193	PF01048	0.419
MOD_GlcNHglycan	8	11	PF01048	0.522
MOD_GSK3_1	225	232	PF00069	0.343
MOD_GSK3_1	240	247	PF00069	0.190
MOD_GSK3_1	258	265	PF00069	0.115
MOD_GSK3_1	271	278	PF00069	0.341
MOD_GSK3_1	57	64	PF00069	0.416
MOD_LATS_1	19	25	PF00433	0.419
MOD_NEK2_1	1	6	PF00069	0.563
MOD_NEK2_1	167	172	PF00069	0.298
MOD_NEK2_1	246	251	PF00069	0.325
MOD_PIKK_1	304	310	PF00454	0.393
MOD_PKA_2	156	162	PF00069	0.419
MOD_PKA_2	350	356	PF00069	0.575
MOD_PKA_2	6	12	PF00069	0.507
MOD_Plk_1	244	250	PF00069	0.307
MOD_Plk_4	149	155	PF00069	0.298
MOD_Plk_4	156	162	PF00069	0.298
MOD_Plk_4	247	253	PF00069	0.434
MOD_Plk_4	52	58	PF00069	0.419
MOD_Plk_4	8	14	PF00069	0.408
MOD_Plk_4	97	103	PF00069	0.450
MOD_ProDKin_1	216	222	PF00069	0.445
MOD_ProDKin_1	273	279	PF00069	0.298
MOD_ProDKin_1	292	298	PF00069	0.298
MOD_ProDKin_1	351	357	PF00069	0.527
MOD_SUMO_rev_2	326	331	PF00179	0.417
MOD_SUMO_rev_2	92	100	PF00179	0.442
TRG_ENDOCYTIC_2	166	169	PF00928	0.307
TRG_ENDOCYTIC_2	36	39	PF00928	0.320
TRG_Pf-PMV_PEXEL_1	321	326	PF00026	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P500	Leptomonas seymouri	40%	100%
A0A0N0P5E1	Leptomonas seymouri	67%	100%
A0A1X0NSC5	Trypanosomatidae	46%	100%
A0A1X0NTE8	Trypanosomatidae	48%	100%
A0A1X0NTM5	Trypanosomatidae	48%	100%
A0A381MRJ9	Leishmania infantum	38%	100%
A0A3Q8IDG7	Leishmania donovani	39%	100%
A0A3Q8ITQ0	Leishmania donovani	38%	100%
A2VDC2	Xenopus laevis	43%	96%
A4HHN0	Leishmania braziliensis	28%	100%
A4HL04	Leishmania braziliensis	39%	100%
A4HL05	Leishmania braziliensis	39%	100%
A4HL06	Leishmania braziliensis	83%	100%
A4I8I5	Leishmania infantum	39%	100%
A4I8I6	Leishmania infantum	100%	100%
D0AAN2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E8NHQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	99%
E9ALJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B3E6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O74802	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	86%
P28817	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	74%
Q1PEY5	Arabidopsis thaliana	37%	98%
Q28FR6	Xenopus tropicalis	43%	96%
Q2HJ73	Bos taurus	39%	96%
Q4Q4Q4	Leishmania major	95%	100%
Q4Q4Q5	Leishmania major	38%	100%
Q4Q4Q6	Leishmania major	38%	98%
Q55GS6	Dictyostelium discoideum	32%	97%
Q58EB4	Danio rerio	39%	97%
Q5XF59	Arabidopsis thaliana	33%	93%
Q5XIE6	Rattus norvegicus	39%	96%
Q5ZJ60	Gallus gallus	39%	96%
Q6NMB0	Arabidopsis thaliana	37%	98%
Q6NVY1	Homo sapiens	41%	96%
Q8QZS1	Mus musculus	40%	96%
Q8RXN4	Arabidopsis thaliana	31%	91%
Q9LK08	Arabidopsis thaliana	32%	89%
Q9LKJ1	Arabidopsis thaliana	37%	98%
Q9SHJ8	Arabidopsis thaliana	33%	96%
Q9T0K7	Arabidopsis thaliana	33%	88%
V5BQZ7	Trypanosoma cruzi	44%	96%