Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF563), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHF7_LEIDO

TriTrypDb:

LdBPK_110530.1 , LdCL_110011000 , LDHU3_11.0700

Length:

647

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3Q8IHF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHF7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016740	transferase activity	2	10
GO:0016757	glycosyltransferase activity	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.465
CLV_MEL_PAP_1	585	591	PF00089	0.575
CLV_NRD_NRD_1	100	102	PF00675	0.729
CLV_NRD_NRD_1	327	329	PF00675	0.715
CLV_NRD_NRD_1	332	334	PF00675	0.659
CLV_NRD_NRD_1	387	389	PF00675	0.792
CLV_NRD_NRD_1	44	46	PF00675	0.512
CLV_NRD_NRD_1	6	8	PF00675	0.528
CLV_PCSK_FUR_1	629	633	PF00082	0.511
CLV_PCSK_KEX2_1	115	117	PF00082	0.682
CLV_PCSK_KEX2_1	327	329	PF00082	0.747
CLV_PCSK_KEX2_1	387	389	PF00082	0.792
CLV_PCSK_KEX2_1	44	46	PF00082	0.468
CLV_PCSK_KEX2_1	631	633	PF00082	0.567
CLV_PCSK_KEX2_1	8	10	PF00082	0.539
CLV_PCSK_KEX2_1	99	101	PF00082	0.725
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.692
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.517
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.539
CLV_PCSK_SKI1_1	415	419	PF00082	0.563
CLV_PCSK_SKI1_1	477	481	PF00082	0.478
CLV_PCSK_SKI1_1	600	604	PF00082	0.618
DEG_APCC_DBOX_1	414	422	PF00400	0.307
DOC_CYCLIN_RxL_1	474	484	PF00134	0.284
DOC_MAPK_FxFP_2	613	616	PF00069	0.430
DOC_MAPK_gen_1	259	267	PF00069	0.396
DOC_MAPK_gen_1	48	58	PF00069	0.512
DOC_MAPK_gen_1	548	555	PF00069	0.396
DOC_MAPK_JIP1_4	475	481	PF00069	0.249
DOC_MAPK_MEF2A_6	266	275	PF00069	0.431
DOC_MAPK_MEF2A_6	523	531	PF00069	0.332
DOC_PP2B_LxvP_1	308	311	PF13499	0.526
DOC_PP4_FxxP_1	102	105	PF00568	0.465
DOC_PP4_FxxP_1	196	199	PF00568	0.466
DOC_PP4_FxxP_1	345	348	PF00568	0.389
DOC_PP4_FxxP_1	613	616	PF00568	0.430
DOC_USP7_MATH_1	11	15	PF00917	0.794
DOC_USP7_MATH_1	114	118	PF00917	0.447
DOC_USP7_MATH_1	188	192	PF00917	0.476
DOC_USP7_MATH_1	206	210	PF00917	0.428
DOC_USP7_MATH_1	294	298	PF00917	0.422
DOC_USP7_MATH_1	355	359	PF00917	0.538
DOC_USP7_MATH_1	392	396	PF00917	0.533
DOC_USP7_MATH_1	489	493	PF00917	0.359
DOC_WW_Pin1_4	12	17	PF00397	0.737
DOC_WW_Pin1_4	198	203	PF00397	0.488
DOC_WW_Pin1_4	20	25	PF00397	0.700
DOC_WW_Pin1_4	212	217	PF00397	0.401
DOC_WW_Pin1_4	344	349	PF00397	0.478
DOC_WW_Pin1_4	351	356	PF00397	0.493
DOC_WW_Pin1_4	379	384	PF00397	0.601
DOC_WW_Pin1_4	429	434	PF00397	0.306
DOC_WW_Pin1_4	542	547	PF00397	0.386
LIG_14-3-3_CanoR_1	103	112	PF00244	0.479
LIG_14-3-3_CanoR_1	181	186	PF00244	0.486
LIG_14-3-3_CanoR_1	223	231	PF00244	0.459
LIG_14-3-3_CanoR_1	39	47	PF00244	0.624
LIG_14-3-3_CanoR_1	48	54	PF00244	0.601
LIG_Actin_WH2_2	280	298	PF00022	0.372
LIG_APCC_ABBA_1	622	627	PF00400	0.348
LIG_BRCT_BRCA1_1	358	362	PF00533	0.444
LIG_deltaCOP1_diTrp_1	423	429	PF00928	0.332
LIG_eIF4E_1	356	362	PF01652	0.488
LIG_eIF4E_1	474	480	PF01652	0.267
LIG_FHA_1	105	111	PF00498	0.477
LIG_FHA_1	247	253	PF00498	0.396
LIG_FHA_1	287	293	PF00498	0.435
LIG_FHA_1	310	316	PF00498	0.450
LIG_FHA_1	405	411	PF00498	0.472
LIG_FHA_1	482	488	PF00498	0.315
LIG_FHA_1	563	569	PF00498	0.465
LIG_FHA_1	617	623	PF00498	0.386
LIG_FHA_2	299	305	PF00498	0.455
LIG_Integrin_RGD_1	328	330	PF01839	0.636
LIG_KLC1_Yacidic_2	506	511	PF13176	0.307
LIG_LIR_Apic_2	194	199	PF02991	0.411
LIG_LIR_Gen_1	123	133	PF02991	0.477
LIG_LIR_Gen_1	282	292	PF02991	0.444
LIG_LIR_Nem_3	282	288	PF02991	0.449
LIG_MYND_3	410	414	PF01753	0.271
LIG_PTB_Apo_2	204	211	PF02174	0.452
LIG_PTB_Phospho_1	204	210	PF10480	0.454
LIG_SH2_CRK	577	581	PF00017	0.376
LIG_SH2_SRC	524	527	PF00017	0.292
LIG_SH2_STAP1	524	528	PF00017	0.292
LIG_SH2_STAT3	419	422	PF00017	0.332
LIG_SH2_STAT5	126	129	PF00017	0.450
LIG_SH2_STAT5	169	172	PF00017	0.502
LIG_SH2_STAT5	204	207	PF00017	0.490
LIG_SH2_STAT5	225	228	PF00017	0.411
LIG_SH2_STAT5	509	512	PF00017	0.337
LIG_SH3_2	383	388	PF14604	0.480
LIG_SH3_3	18	24	PF00018	0.684
LIG_SH3_3	196	202	PF00018	0.527
LIG_SH3_3	380	386	PF00018	0.582
LIG_SH3_3	561	567	PF00018	0.452
LIG_SH3_3	577	583	PF00018	0.421
LIG_SH3_3	590	596	PF00018	0.359
LIG_SUMO_SIM_anti_2	242	247	PF11976	0.346
LIG_SUMO_SIM_par_1	567	572	PF11976	0.391
LIG_TRAF2_1	439	442	PF00917	0.343
LIG_TRAF2_1	596	599	PF00917	0.436
LIG_WRC_WIRS_1	615	620	PF05994	0.405
LIG_WRPW_2	555	558	PF00400	0.374
LIG_WW_3	384	388	PF00397	0.507
LIG_WW_3	545	549	PF00397	0.383
MOD_CDC14_SPxK_1	545	548	PF00782	0.414
MOD_CDK_SPK_2	198	203	PF00069	0.488
MOD_CDK_SPxK_1	542	548	PF00069	0.391
MOD_CK1_1	179	185	PF00069	0.490
MOD_CK1_1	191	197	PF00069	0.413
MOD_CK1_1	254	260	PF00069	0.510
MOD_CK1_1	390	396	PF00069	0.488
MOD_CK1_1	454	460	PF00069	0.311
MOD_CK1_1	461	467	PF00069	0.286
MOD_CK1_1	468	474	PF00069	0.370
MOD_CK1_1	562	568	PF00069	0.449
MOD_CK2_1	343	349	PF00069	0.446
MOD_CK2_1	436	442	PF00069	0.288
MOD_GlcNHglycan	112	115	PF01048	0.672
MOD_GlcNHglycan	116	119	PF01048	0.646
MOD_GlcNHglycan	188	191	PF01048	0.685
MOD_GlcNHglycan	193	196	PF01048	0.690
MOD_GlcNHglycan	296	299	PF01048	0.631
MOD_GlcNHglycan	336	340	PF01048	0.672
MOD_GlcNHglycan	454	457	PF01048	0.409
MOD_GlcNHglycan	605	608	PF01048	0.612
MOD_GSK3_1	110	117	PF00069	0.577
MOD_GSK3_1	127	134	PF00069	0.462
MOD_GSK3_1	206	213	PF00069	0.415
MOD_GSK3_1	251	258	PF00069	0.489
MOD_GSK3_1	294	301	PF00069	0.444
MOD_GSK3_1	351	358	PF00069	0.482
MOD_GSK3_1	451	458	PF00069	0.354
MOD_GSK3_1	461	468	PF00069	0.294
MOD_N-GLC_1	191	196	PF02516	0.671
MOD_N-GLC_1	206	211	PF02516	0.718
MOD_N-GLC_1	356	361	PF02516	0.665
MOD_N-GLC_1	374	379	PF02516	0.566
MOD_N-GLC_1	436	441	PF02516	0.537
MOD_N-GLC_1	489	494	PF02516	0.563
MOD_NEK2_1	110	115	PF00069	0.581
MOD_NEK2_1	335	340	PF00069	0.476
MOD_NEK2_1	361	366	PF00069	0.528
MOD_NEK2_1	40	45	PF00069	0.721
MOD_NEK2_1	403	408	PF00069	0.432
MOD_NEK2_1	465	470	PF00069	0.322
MOD_NEK2_1	602	607	PF00069	0.494
MOD_NEK2_1	71	76	PF00069	0.602
MOD_NEK2_2	32	37	PF00069	0.625
MOD_PIKK_1	127	133	PF00454	0.446
MOD_PIKK_1	136	142	PF00454	0.465
MOD_PIKK_1	309	315	PF00454	0.391
MOD_PIKK_1	361	367	PF00454	0.412
MOD_PIKK_1	387	393	PF00454	0.426
MOD_PIKK_1	465	471	PF00454	0.319
MOD_PIKK_1	562	568	PF00454	0.418
MOD_PIKK_1	69	75	PF00454	0.579
MOD_PKA_1	387	393	PF00069	0.426
MOD_PKA_2	176	182	PF00069	0.404
MOD_PKA_2	254	260	PF00069	0.529
MOD_PKA_2	387	393	PF00069	0.585
MOD_PKA_2	482	488	PF00069	0.325
MOD_PKB_1	37	45	PF00069	0.686
MOD_Plk_1	191	197	PF00069	0.498
MOD_Plk_1	206	212	PF00069	0.518
MOD_Plk_1	241	247	PF00069	0.400
MOD_Plk_1	356	362	PF00069	0.499
MOD_Plk_1	374	380	PF00069	0.368
MOD_Plk_1	436	442	PF00069	0.307
MOD_Plk_1	489	495	PF00069	0.363
MOD_Plk_2-3	147	153	PF00069	0.394
MOD_Plk_4	124	130	PF00069	0.384
MOD_Plk_4	241	247	PF00069	0.446
MOD_Plk_4	311	317	PF00069	0.451
MOD_Plk_4	356	362	PF00069	0.506
MOD_Plk_4	455	461	PF00069	0.341
MOD_ProDKin_1	12	18	PF00069	0.737
MOD_ProDKin_1	198	204	PF00069	0.485
MOD_ProDKin_1	20	26	PF00069	0.700
MOD_ProDKin_1	212	218	PF00069	0.397
MOD_ProDKin_1	344	350	PF00069	0.476
MOD_ProDKin_1	351	357	PF00069	0.497
MOD_ProDKin_1	379	385	PF00069	0.602
MOD_ProDKin_1	429	435	PF00069	0.306
MOD_ProDKin_1	542	548	PF00069	0.391
TRG_DiLeu_BaEn_1	598	603	PF01217	0.416
TRG_ENDOCYTIC_2	126	129	PF00928	0.478
TRG_ENDOCYTIC_2	524	527	PF00928	0.292
TRG_ENDOCYTIC_2	577	580	PF00928	0.367
TRG_ENDOCYTIC_2	615	618	PF00928	0.376
TRG_ER_diArg_1	36	39	PF00400	0.689
TRG_ER_diArg_1	386	388	PF00400	0.483
TRG_ER_diArg_1	445	448	PF00400	0.287
TRG_ER_diArg_1	547	550	PF00400	0.424
TRG_ER_diArg_1	6	9	PF00400	0.719
TRG_ER_diArg_1	99	101	PF00400	0.510
TRG_NLS_MonoExtC_3	6	12	PF00514	0.725
TRG_Pf-PMV_PEXEL_1	632	636	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV1	Leptomonas seymouri	27%	100%
A0A0N1PD55	Leptomonas seymouri	47%	100%
A0A1X0NW39	Trypanosomatidae	23%	100%
A4H6H9	Leishmania braziliensis	79%	100%
A4HUW3	Leishmania infantum	99%	100%
E9ANK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QH26	Leishmania major	93%	100%
V5BJI5	Trypanosoma cruzi	23%	100%