Ran gtpase-activating protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHF2_LEIDO

TriTrypDb:

LdBPK_341400.1 , LdCL_340020000 , LDHU3_34.2170

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

A0A3Q8IHF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHF2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.517
CLV_NRD_NRD_1	30	32	PF00675	0.499
CLV_NRD_NRD_1	410	412	PF00675	0.595
CLV_NRD_NRD_1	580	582	PF00675	0.731
CLV_NRD_NRD_1	623	625	PF00675	0.758
CLV_NRD_NRD_1	7	9	PF00675	0.532
CLV_NRD_NRD_1	715	717	PF00675	0.691
CLV_PCSK_FUR_1	4	8	PF00082	0.549
CLV_PCSK_KEX2_1	121	123	PF00082	0.507
CLV_PCSK_KEX2_1	30	32	PF00082	0.499
CLV_PCSK_KEX2_1	409	411	PF00082	0.601
CLV_PCSK_KEX2_1	6	8	PF00082	0.500
CLV_PCSK_KEX2_1	623	625	PF00082	0.758
CLV_PCSK_KEX2_1	71	73	PF00082	0.562
CLV_PCSK_KEX2_1	715	717	PF00082	0.659
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.603
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.585
CLV_PCSK_PC7_1	2	8	PF00082	0.585
CLV_PCSK_PC7_1	405	411	PF00082	0.613
CLV_PCSK_SKI1_1	230	234	PF00082	0.504
CLV_PCSK_SKI1_1	295	299	PF00082	0.519
CLV_PCSK_SKI1_1	488	492	PF00082	0.481
CLV_PCSK_SKI1_1	638	642	PF00082	0.768
CLV_PCSK_SKI1_1	7	11	PF00082	0.499
DEG_APCC_DBOX_1	6	14	PF00400	0.521
DEG_APCC_DBOX_1	611	619	PF00400	0.682
DEG_Nend_UBRbox_1	1	4	PF02207	0.557
DOC_CDC14_PxL_1	349	357	PF14671	0.457
DOC_CKS1_1	226	231	PF01111	0.490
DOC_CKS1_1	34	39	PF01111	0.586
DOC_CYCLIN_RxL_1	160	169	PF00134	0.413
DOC_CYCLIN_RxL_1	264	273	PF00134	0.452
DOC_CYCLIN_yCln2_LP_2	310	316	PF00134	0.399
DOC_MAPK_DCC_7	278	287	PF00069	0.644
DOC_MAPK_gen_1	440	450	PF00069	0.423
DOC_MAPK_MEF2A_6	443	450	PF00069	0.500
DOC_PP1_RVXF_1	228	235	PF00149	0.489
DOC_PP2B_LxvP_1	542	545	PF13499	0.654
DOC_USP7_MATH_1	149	153	PF00917	0.676
DOC_USP7_MATH_1	19	23	PF00917	0.654
DOC_USP7_MATH_1	301	305	PF00917	0.549
DOC_USP7_MATH_1	323	327	PF00917	0.454
DOC_USP7_MATH_1	519	523	PF00917	0.717
DOC_USP7_MATH_1	567	571	PF00917	0.680
DOC_USP7_MATH_1	607	611	PF00917	0.649
DOC_USP7_MATH_1	652	656	PF00917	0.737
DOC_USP7_MATH_1	706	710	PF00917	0.704
DOC_WW_Pin1_4	130	135	PF00397	0.506
DOC_WW_Pin1_4	225	230	PF00397	0.490
DOC_WW_Pin1_4	246	251	PF00397	0.485
DOC_WW_Pin1_4	33	38	PF00397	0.642
DOC_WW_Pin1_4	563	568	PF00397	0.694
DOC_WW_Pin1_4	622	627	PF00397	0.724
DOC_WW_Pin1_4	654	659	PF00397	0.608
LIG_14-3-3_CanoR_1	121	130	PF00244	0.535
LIG_14-3-3_CanoR_1	197	206	PF00244	0.602
LIG_14-3-3_CanoR_1	334	342	PF00244	0.448
LIG_14-3-3_CanoR_1	405	412	PF00244	0.620
LIG_14-3-3_CanoR_1	458	466	PF00244	0.411
LIG_14-3-3_CanoR_1	488	495	PF00244	0.484
LIG_14-3-3_CanoR_1	574	579	PF00244	0.668
LIG_14-3-3_CanoR_1	676	682	PF00244	0.678
LIG_FHA_1	131	137	PF00498	0.566
LIG_FHA_1	226	232	PF00498	0.481
LIG_FHA_1	252	258	PF00498	0.426
LIG_FHA_1	328	334	PF00498	0.399
LIG_FHA_1	34	40	PF00498	0.552
LIG_FHA_1	377	383	PF00498	0.388
LIG_FHA_1	470	476	PF00498	0.475
LIG_FHA_2	101	107	PF00498	0.451
LIG_FHA_2	419	425	PF00498	0.639
LIG_FHA_2	487	493	PF00498	0.575
LIG_FHA_2	606	612	PF00498	0.651
LIG_LIR_Gen_1	179	188	PF02991	0.488
LIG_LIR_Gen_1	89	100	PF02991	0.460
LIG_LIR_Nem_3	179	183	PF02991	0.481
LIG_LIR_Nem_3	537	542	PF02991	0.684
LIG_LIR_Nem_3	573	578	PF02991	0.654
LIG_PCNA_yPIPBox_3	452	464	PF02747	0.386
LIG_PCNA_yPIPBox_3	484	494	PF02747	0.515
LIG_Pex14_1	29	33	PF04695	0.481
LIG_PTB_Apo_2	104	111	PF02174	0.460
LIG_SH2_CRK	539	543	PF00017	0.691
LIG_SH2_CRK	575	579	PF00017	0.648
LIG_SH2_NCK_1	420	424	PF00017	0.579
LIG_SH2_NCK_1	495	499	PF00017	0.541
LIG_SH2_STAT3	707	710	PF00017	0.721
LIG_SH2_STAT5	224	227	PF00017	0.482
LIG_SH2_STAT5	270	273	PF00017	0.376
LIG_SH2_STAT5	33	36	PF00017	0.563
LIG_SH2_STAT5	420	423	PF00017	0.646
LIG_SH2_STAT5	495	498	PF00017	0.438
LIG_SH3_1	443	449	PF00018	0.491
LIG_SH3_3	284	290	PF00018	0.647
LIG_SH3_3	443	449	PF00018	0.469
LIG_SH3_3	591	597	PF00018	0.703
LIG_SUMO_SIM_par_1	163	169	PF11976	0.475
LIG_SUMO_SIM_par_1	354	359	PF11976	0.339
LIG_SUMO_SIM_par_1	384	389	PF11976	0.406
LIG_SUMO_SIM_par_1	54	59	PF11976	0.546
LIG_TRAF2_1	439	442	PF00917	0.580
LIG_UBA3_1	447	456	PF00899	0.465
LIG_WRC_WIRS_1	177	182	PF05994	0.481
LIG_WRC_WIRS_1	231	236	PF05994	0.351
MOD_CDC14_SPxK_1	566	569	PF00782	0.679
MOD_CDK_SPK_2	225	230	PF00069	0.516
MOD_CDK_SPxK_1	563	569	PF00069	0.679
MOD_CK1_1	132	138	PF00069	0.534
MOD_CK1_1	154	160	PF00069	0.530
MOD_CK1_1	326	332	PF00069	0.402
MOD_CK1_1	389	395	PF00069	0.425
MOD_CK1_1	413	419	PF00069	0.589
MOD_CK1_1	432	438	PF00069	0.709
MOD_CK1_1	534	540	PF00069	0.618
MOD_CK1_1	547	553	PF00069	0.612
MOD_CK1_1	561	567	PF00069	0.619
MOD_CK1_1	592	598	PF00069	0.715
MOD_CK1_1	629	635	PF00069	0.740
MOD_CK1_1	689	695	PF00069	0.779
MOD_CK2_1	100	106	PF00069	0.449
MOD_CK2_1	418	424	PF00069	0.599
MOD_CK2_1	436	442	PF00069	0.598
MOD_CK2_1	486	492	PF00069	0.553
MOD_CK2_1	567	573	PF00069	0.723
MOD_CK2_1	625	631	PF00069	0.742
MOD_Cter_Amidation	292	295	PF01082	0.519
MOD_GlcNHglycan	137	140	PF01048	0.689
MOD_GlcNHglycan	199	202	PF01048	0.577
MOD_GlcNHglycan	213	216	PF01048	0.345
MOD_GlcNHglycan	263	266	PF01048	0.513
MOD_GlcNHglycan	431	434	PF01048	0.712
MOD_GlcNHglycan	44	47	PF01048	0.508
MOD_GlcNHglycan	483	487	PF01048	0.374
MOD_GlcNHglycan	521	524	PF01048	0.676
MOD_GlcNHglycan	549	552	PF01048	0.655
MOD_GlcNHglycan	58	61	PF01048	0.611
MOD_GlcNHglycan	654	657	PF01048	0.703
MOD_GlcNHglycan	694	697	PF01048	0.788
MOD_GlcNHglycan	96	99	PF01048	0.517
MOD_GSK3_1	145	152	PF00069	0.762
MOD_GSK3_1	19	26	PF00069	0.554
MOD_GSK3_1	322	329	PF00069	0.406
MOD_GSK3_1	410	417	PF00069	0.611
MOD_GSK3_1	428	435	PF00069	0.419
MOD_GSK3_1	482	489	PF00069	0.441
MOD_GSK3_1	493	500	PF00069	0.388
MOD_GSK3_1	530	537	PF00069	0.674
MOD_GSK3_1	561	568	PF00069	0.694
MOD_GSK3_1	622	629	PF00069	0.682
MOD_GSK3_1	652	659	PF00069	0.651
MOD_GSK3_1	692	699	PF00069	0.753
MOD_N-GLC_1	113	118	PF02516	0.543
MOD_N-GLC_1	130	135	PF02516	0.490
MOD_N-GLC_1	321	326	PF02516	0.416
MOD_N-GLC_1	456	461	PF02516	0.371
MOD_N-GLC_1	468	473	PF02516	0.396
MOD_N-GLC_1	486	491	PF02516	0.542
MOD_N-GLC_2	668	670	PF02516	0.526
MOD_NEK2_1	100	105	PF00069	0.416
MOD_NEK2_1	13	18	PF00069	0.513
MOD_NEK2_1	321	326	PF00069	0.433
MOD_NEK2_1	356	361	PF00069	0.416
MOD_NEK2_1	386	391	PF00069	0.375
MOD_NEK2_1	404	409	PF00069	0.541
MOD_NEK2_1	414	419	PF00069	0.628
MOD_NEK2_1	510	515	PF00069	0.524
MOD_NEK2_1	530	535	PF00069	0.688
MOD_NEK2_1	630	635	PF00069	0.693
MOD_NEK2_1	677	682	PF00069	0.640
MOD_PIKK_1	151	157	PF00454	0.607
MOD_PIKK_1	458	464	PF00454	0.420
MOD_PIKK_1	630	636	PF00454	0.755
MOD_PIKK_1	656	662	PF00454	0.676
MOD_PIKK_1	706	712	PF00454	0.715
MOD_PK_1	574	580	PF00069	0.622
MOD_PKA_1	410	416	PF00069	0.598
MOD_PKA_2	209	215	PF00069	0.492
MOD_PKA_2	404	410	PF00069	0.504
MOD_PKA_2	547	553	PF00069	0.654
MOD_PKA_2	573	579	PF00069	0.644
MOD_PKA_2	675	681	PF00069	0.666
MOD_Plk_1	301	307	PF00069	0.564
MOD_Plk_1	326	332	PF00069	0.414
MOD_Plk_1	356	362	PF00069	0.340
MOD_Plk_1	386	392	PF00069	0.396
MOD_Plk_1	456	462	PF00069	0.373
MOD_Plk_1	486	492	PF00069	0.482
MOD_Plk_1	670	676	PF00069	0.747
MOD_Plk_1	686	692	PF00069	0.619
MOD_Plk_4	100	106	PF00069	0.435
MOD_Plk_4	220	226	PF00069	0.414
MOD_Plk_4	230	236	PF00069	0.374
MOD_Plk_4	327	333	PF00069	0.431
MOD_Plk_4	410	416	PF00069	0.583
MOD_Plk_4	549	555	PF00069	0.621
MOD_Plk_4	589	595	PF00069	0.736
MOD_Plk_4	661	667	PF00069	0.651
MOD_Plk_4	670	676	PF00069	0.472
MOD_ProDKin_1	130	136	PF00069	0.517
MOD_ProDKin_1	225	231	PF00069	0.482
MOD_ProDKin_1	246	252	PF00069	0.480
MOD_ProDKin_1	33	39	PF00069	0.632
MOD_ProDKin_1	563	569	PF00069	0.696
MOD_ProDKin_1	622	628	PF00069	0.723
MOD_ProDKin_1	654	660	PF00069	0.607
MOD_SUMO_for_1	505	508	PF00179	0.418
MOD_SUMO_rev_2	15	25	PF00179	0.415
MOD_SUMO_rev_2	500	507	PF00179	0.451
TRG_DiLeu_BaLyEn_6	443	448	PF01217	0.415
TRG_ENDOCYTIC_2	539	542	PF00928	0.691
TRG_ENDOCYTIC_2	575	578	PF00928	0.649
TRG_ER_diArg_1	1	4	PF00400	0.606
TRG_ER_diArg_1	120	122	PF00400	0.514
TRG_ER_diArg_1	29	31	PF00400	0.474
TRG_ER_diArg_1	410	412	PF00400	0.622
TRG_ER_diArg_1	5	8	PF00400	0.532
TRG_ER_diArg_1	578	581	PF00400	0.739
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.347
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7T2	Leptomonas seymouri	53%	94%
A0A3R7MW53	Trypanosoma rangeli	29%	100%
A4HAP6	Leishmania braziliensis	73%	100%
A4I9U2	Leishmania infantum	100%	100%
E9B4V3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	97%
Q4Q373	Leishmania major	92%	99%
V5B3D0	Trypanosoma cruzi	28%	100%