Pre-mRNA branch site protein p14, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-mRNA branch site protein p14, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHF1_LEIDO

TriTrypDb:

LdBPK_363190.1 , LdCL_360038500 , LDHU3_36.4400

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005686	U2 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071011	precatalytic spliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8IHF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHF1

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003723	RNA binding	4	5
GO:0005488	binding	1	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.592
CLV_NRD_NRD_1	17	19	PF00675	0.493
CLV_PCSK_FUR_1	155	159	PF00082	0.535
CLV_PCSK_KEX2_1	155	157	PF00082	0.592
CLV_PCSK_KEX2_1	159	161	PF00082	0.511
CLV_PCSK_KEX2_1	17	19	PF00082	0.493
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.528
CLV_PCSK_PC7_1	13	19	PF00082	0.501
CLV_PCSK_PC7_1	155	161	PF00082	0.528
CLV_PCSK_SKI1_1	150	154	PF00082	0.524
CLV_PCSK_SKI1_1	69	73	PF00082	0.440
DEG_Nend_UBRbox_1	1	4	PF02207	0.511
DOC_MAPK_gen_1	135	143	PF00069	0.530
DOC_MAPK_gen_1	17	24	PF00069	0.469
DOC_MAPK_MEF2A_6	135	143	PF00069	0.495
DOC_MAPK_MEF2A_6	17	26	PF00069	0.471
LIG_14-3-3_CanoR_1	140	144	PF00244	0.459
LIG_14-3-3_CanoR_1	17	25	PF00244	0.485
LIG_14-3-3_CanoR_1	56	61	PF00244	0.496
LIG_APCC_ABBA_1	141	146	PF00400	0.468
LIG_APCC_ABBAyCdc20_2	140	146	PF00400	0.473
LIG_FHA_1	27	33	PF00498	0.515
LIG_LIR_Gen_1	84	93	PF02991	0.525
LIG_LIR_Nem_3	84	90	PF02991	0.525
LIG_MAD2	69	77	PF02301	0.375
LIG_NRBOX	27	33	PF00104	0.474
LIG_SH2_CRK	93	97	PF00017	0.525
LIG_SH2_SRC	85	88	PF00017	0.525
LIG_SH2_STAP1	44	48	PF00017	0.489
LIG_SH2_STAT5	85	88	PF00017	0.525
LIG_SH3_3	32	38	PF00018	0.473
LIG_SUMO_SIM_anti_2	67	74	PF11976	0.455
LIG_SUMO_SIM_par_1	67	74	PF11976	0.455
LIG_SxIP_EBH_1	69	82	PF03271	0.375
MOD_CK1_1	104	110	PF00069	0.544
MOD_CK1_1	51	57	PF00069	0.562
MOD_CK2_1	139	145	PF00069	0.460
MOD_GlcNHglycan	44	47	PF01048	0.504
MOD_GSK3_1	100	107	PF00069	0.566
MOD_GSK3_1	44	51	PF00069	0.497
MOD_GSK3_1	52	59	PF00069	0.490
MOD_GSK3_1	71	78	PF00069	0.423
MOD_N-GLC_1	56	61	PF02516	0.516
MOD_NEK2_1	139	144	PF00069	0.454
MOD_NEK2_1	26	31	PF00069	0.462
MOD_NEK2_1	42	47	PF00069	0.410
MOD_NEK2_1	71	76	PF00069	0.457
MOD_NEK2_2	85	90	PF00069	0.543
MOD_PIKK_1	48	54	PF00454	0.476
MOD_PK_1	56	62	PF00069	0.493
MOD_PKA_2	139	145	PF00069	0.460
MOD_PKA_2	16	22	PF00069	0.491
MOD_Plk_1	56	62	PF00069	0.512
MOD_Plk_4	139	145	PF00069	0.460
MOD_Plk_4	26	32	PF00069	0.484
MOD_Plk_4	85	91	PF00069	0.558
MOD_SUMO_rev_2	145	153	PF00179	0.510
TRG_DiLeu_BaEn_1	68	73	PF01217	0.446
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.477
TRG_ENDOCYTIC_2	87	90	PF00928	0.525
TRG_ENDOCYTIC_2	93	96	PF00928	0.487
TRG_ER_diArg_1	155	158	PF00400	0.585
TRG_NLS_MonoCore_2	155	160	PF00514	0.532
TRG_NLS_MonoExtC_3	155	160	PF00514	0.532
TRG_NLS_MonoExtN_4	155	160	PF00514	0.532
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HPH0	Leishmania braziliensis	88%	100%
A4ID92	Leishmania infantum	100%	100%
Q4Q1B5	Leishmania major	91%	100%