TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHE5_LEIDO

TriTrypDb:

LdBPK_323680.1 , LdCL_320042700 , LDHU3_32.4650

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHE5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.743
CLV_NRD_NRD_1	390	392	PF00675	0.484
CLV_NRD_NRD_1	431	433	PF00675	0.480
CLV_NRD_NRD_1	6	8	PF00675	0.599
CLV_PCSK_KEX2_1	12	14	PF00082	0.642
CLV_PCSK_KEX2_1	389	391	PF00082	0.450
CLV_PCSK_KEX2_1	431	433	PF00082	0.421
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.680
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.450
CLV_PCSK_SKI1_1	13	17	PF00082	0.673
CLV_PCSK_SKI1_1	225	229	PF00082	0.455
CLV_PCSK_SKI1_1	343	347	PF00082	0.472
CLV_PCSK_SKI1_1	362	366	PF00082	0.615
CLV_PCSK_SKI1_1	80	84	PF00082	0.433
DEG_APCC_DBOX_1	12	20	PF00400	0.675
DEG_APCC_DBOX_1	257	265	PF00400	0.448
DEG_APCC_DBOX_1	442	450	PF00400	0.473
DOC_CKS1_1	24	29	PF01111	0.584
DOC_CYCLIN_RxL_1	77	86	PF00134	0.452
DOC_CYCLIN_yClb5_NLxxxL_5	469	478	PF00134	0.501
DOC_MAPK_MEF2A_6	243	251	PF00069	0.445
DOC_MAPK_MEF2A_6	258	265	PF00069	0.432
DOC_MAPK_MEF2A_6	270	277	PF00069	0.361
DOC_MAPK_NFAT4_5	270	278	PF00069	0.403
DOC_PP2B_LxvP_1	19	22	PF13499	0.683
DOC_PP2B_LxvP_1	561	564	PF13499	0.457
DOC_PP4_FxxP_1	15	18	PF00568	0.668
DOC_USP7_MATH_1	11	15	PF00917	0.643
DOC_USP7_MATH_1	168	172	PF00917	0.524
DOC_USP7_MATH_1	381	385	PF00917	0.581
DOC_USP7_MATH_1	483	487	PF00917	0.624
DOC_USP7_MATH_1	496	500	PF00917	0.604
DOC_USP7_MATH_1	528	532	PF00917	0.431
DOC_USP7_MATH_1	617	621	PF00917	0.536
DOC_USP7_UBL2_3	361	365	PF12436	0.546
DOC_USP7_UBL2_3	8	12	PF12436	0.753
DOC_WW_Pin1_4	23	28	PF00397	0.739
LIG_14-3-3_CanoR_1	184	194	PF00244	0.371
LIG_14-3-3_CanoR_1	198	206	PF00244	0.470
LIG_14-3-3_CanoR_1	343	348	PF00244	0.403
LIG_14-3-3_CanoR_1	405	414	PF00244	0.459
LIG_14-3-3_CanoR_1	431	435	PF00244	0.445
LIG_14-3-3_CanoR_1	443	447	PF00244	0.407
LIG_14-3-3_CanoR_1	506	512	PF00244	0.693
LIG_14-3-3_CanoR_1	90	98	PF00244	0.580
LIG_BIR_II_1	1	5	PF00653	0.614
LIG_BRCT_BRCA1_1	522	526	PF00533	0.449
LIG_BRCT_BRCA1_1	608	612	PF00533	0.434
LIG_eIF4E_1	272	278	PF01652	0.440
LIG_FHA_1	142	148	PF00498	0.492
LIG_FHA_1	354	360	PF00498	0.356
LIG_FHA_1	418	424	PF00498	0.490
LIG_FHA_1	43	49	PF00498	0.433
LIG_FHA_1	496	502	PF00498	0.634
LIG_FHA_1	551	557	PF00498	0.440
LIG_FHA_2	200	206	PF00498	0.556
LIG_FHA_2	230	236	PF00498	0.592
LIG_FHA_2	344	350	PF00498	0.519
LIG_FHA_2	408	414	PF00498	0.475
LIG_FHA_2	97	103	PF00498	0.595
LIG_LIR_Apic_2	14	18	PF02991	0.668
LIG_LIR_Apic_2	181	186	PF02991	0.483
LIG_LIR_Gen_1	215	223	PF02991	0.355
LIG_LIR_Gen_1	433	442	PF02991	0.352
LIG_LIR_Gen_1	49	58	PF02991	0.496
LIG_LIR_Gen_1	508	517	PF02991	0.713
LIG_LIR_Gen_1	523	534	PF02991	0.294
LIG_LIR_Nem_3	215	220	PF02991	0.353
LIG_LIR_Nem_3	271	275	PF02991	0.385
LIG_LIR_Nem_3	433	437	PF02991	0.357
LIG_LIR_Nem_3	49	53	PF02991	0.503
LIG_LIR_Nem_3	508	512	PF02991	0.723
LIG_LIR_Nem_3	523	529	PF02991	0.307
LIG_LIR_Nem_3	608	613	PF02991	0.515
LIG_NRBOX	276	282	PF00104	0.307
LIG_Pex14_2	213	217	PF04695	0.363
LIG_SH2_CRK	183	187	PF00017	0.473
LIG_SH2_CRK	272	276	PF00017	0.439
LIG_SH2_NCK_1	288	292	PF00017	0.442
LIG_SH2_NCK_1	613	617	PF00017	0.499
LIG_SH2_SRC	288	291	PF00017	0.479
LIG_SH2_STAP1	613	617	PF00017	0.483
LIG_SH2_STAT3	633	636	PF00017	0.409
LIG_SH2_STAT5	151	154	PF00017	0.428
LIG_SH2_STAT5	240	243	PF00017	0.346
LIG_SH2_STAT5	593	596	PF00017	0.427
LIG_SH2_STAT5	613	616	PF00017	0.231
LIG_SH2_STAT5	630	633	PF00017	0.229
LIG_SH3_3	21	27	PF00018	0.741
LIG_SH3_3	38	44	PF00018	0.505
LIG_SH3_3	461	467	PF00018	0.543
LIG_SH3_3	618	624	PF00018	0.392
LIG_SUMO_SIM_anti_2	305	311	PF11976	0.336
LIG_SUMO_SIM_par_1	274	279	PF11976	0.324
LIG_SUMO_SIM_par_1	68	77	PF11976	0.417
LIG_TRAF2_1	136	139	PF00917	0.637
LIG_TRAF2_1	333	336	PF00917	0.503
LIG_TRAF2_2	627	632	PF00917	0.343
LIG_TRFH_1	509	513	PF08558	0.501
LIG_UBA3_1	261	270	PF00899	0.394
MOD_CK1_1	123	129	PF00069	0.650
MOD_CK1_1	34	40	PF00069	0.757
MOD_CK1_1	353	359	PF00069	0.516
MOD_CK1_1	92	98	PF00069	0.539
MOD_CK2_1	106	112	PF00069	0.709
MOD_CK2_1	11	17	PF00069	0.612
MOD_CK2_1	229	235	PF00069	0.593
MOD_CK2_1	381	387	PF00069	0.512
MOD_CK2_1	407	413	PF00069	0.459
MOD_CK2_1	43	49	PF00069	0.493
MOD_CK2_1	612	618	PF00069	0.416
MOD_CK2_1	96	102	PF00069	0.613
MOD_GlcNHglycan	1	4	PF01048	0.661
MOD_GlcNHglycan	108	111	PF01048	0.715
MOD_GlcNHglycan	121	125	PF01048	0.686
MOD_GlcNHglycan	170	173	PF01048	0.494
MOD_GlcNHglycan	34	37	PF01048	0.610
MOD_GlcNHglycan	352	355	PF01048	0.504
MOD_GlcNHglycan	384	387	PF01048	0.614
MOD_GlcNHglycan	45	48	PF01048	0.433
MOD_GlcNHglycan	498	501	PF01048	0.655
MOD_GlcNHglycan	514	517	PF01048	0.525
MOD_GlcNHglycan	60	63	PF01048	0.423
MOD_GlcNHglycan	614	617	PF01048	0.396
MOD_GlcNHglycan	91	94	PF01048	0.602
MOD_GSK3_1	397	404	PF00069	0.497
MOD_GSK3_1	479	486	PF00069	0.682
MOD_GSK3_1	92	99	PF00069	0.553
MOD_NEK2_1	276	281	PF00069	0.320
MOD_NEK2_1	406	411	PF00069	0.469
MOD_NEK2_1	437	442	PF00069	0.383
MOD_NEK2_1	550	555	PF00069	0.439
MOD_NEK2_1	556	561	PF00069	0.436
MOD_NEK2_1	58	63	PF00069	0.492
MOD_NEK2_1	612	617	PF00069	0.420
MOD_NEK2_2	507	512	PF00069	0.554
MOD_PIKK_1	437	443	PF00454	0.412
MOD_PIKK_1	556	562	PF00454	0.440
MOD_PKA_1	360	366	PF00069	0.543
MOD_PKA_2	229	235	PF00069	0.553
MOD_PKA_2	430	436	PF00069	0.442
MOD_PKA_2	442	448	PF00069	0.422
MOD_PKA_2	505	511	PF00069	0.551
MOD_PKA_2	89	95	PF00069	0.597
MOD_Plk_1	556	562	PF00069	0.441
MOD_Plk_1	617	623	PF00069	0.470
MOD_Plk_2-3	229	235	PF00069	0.497
MOD_Plk_4	129	135	PF00069	0.679
MOD_Plk_4	268	274	PF00069	0.397
MOD_Plk_4	276	282	PF00069	0.292
MOD_Plk_4	442	448	PF00069	0.447
MOD_Plk_4	529	535	PF00069	0.393
MOD_Plk_4	545	551	PF00069	0.354
MOD_ProDKin_1	23	29	PF00069	0.740
MOD_SUMO_rev_2	84	89	PF00179	0.517
TRG_DiLeu_BaEn_1	545	550	PF01217	0.380
TRG_DiLeu_BaEn_1	68	73	PF01217	0.498
TRG_DiLeu_BaEn_3	68	74	PF01217	0.547
TRG_DiLeu_BaEn_3	76	82	PF01217	0.479
TRG_DiLeu_BaLyEn_6	516	521	PF01217	0.477
TRG_DiLeu_BaLyEn_6	551	556	PF01217	0.472
TRG_DiLeu_BaLyEn_6	621	626	PF01217	0.494
TRG_ENDOCYTIC_2	272	275	PF00928	0.440
TRG_ER_diArg_1	390	392	PF00400	0.484
TRG_ER_diArg_1	430	432	PF00400	0.549
TRG_ER_diArg_1	447	450	PF00400	0.288
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK53	Leptomonas seymouri	61%	99%
A0A1X0NRY3	Trypanosomatidae	28%	100%
A0A422P2Z2	Trypanosoma rangeli	27%	100%
A4HKZ1	Leishmania braziliensis	74%	100%
A4I8H2	Leishmania infantum	99%	100%
D0AAP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9B3D2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q4S4	Leishmania major	94%	100%
V5BQY9	Trypanosoma cruzi	25%	100%